Piperonyl alcohol supplier

Name
Piperonyl alcohol
EINECS 207-808-4
CAS No. 495-76-1
Article Data175
CAS DataBase
Density 1.329 g/cm³
Solubility soluble in water
Melting Point 50-54 °C(lit.)
Formula C₈H₈O₃
Boiling Point 282.2 °C at 760 mmHg
Molecular Weight 152.15
Flash Point 124.5 °C
Transport Information
Appearance White crystals or crystalline powder
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms Piperonylalcohol (6CI,7CI,8CI);(Benzodioxol-5-yl)methanol;1-Hydroxymethyl-3,4-methylenedioxybenzene;3,4-(Methylenedioxy)benzenemethanol;3,4-Methylenedioxybenzyl alcohol;3,4-Methylenedioxyphenylmethanol;5-Hydroxymethyl-1,3-benzodioxole;Benzo[1,3]dioxol-5-ylmethanol;1,3-Benzodioxole-5-methanol;NSC26265;Piperonol;
PSA 38.69000
LogP 0.90760

Synthetic route

: 120-57-0
piperonal

: 495-76-1
piperonol

Conditions

Conditions	Yield
With diisopropoxytitanium(III) tetrahydroborate In dichloromethane at -20℃; for 0.133333h;	100%
With Zn(BH4)2(Ph3P)2 In tetrahydrofuran at 20℃; Reduction;	100%
With sodium tetrahydroborate In methanol at 20℃; for 1h;	100%

: 326-61-4
piperonyl acetate

: 495-76-1
piperonol

Conditions

Conditions	Yield
With methanol; potassium permanganate at 25℃; chemoselective reaction;	99%
With 2,2-dibutyl-1,3,2-dioxastannane; cesium fluoride In N,N-dimethyl-formamide at 20℃; for 1h;	83%

: C14H19BO5

: 495-76-1
piperonol

Conditions

Conditions	Yield
With silica gel In hexane; ethyl acetate	99%
With silica gel at 25℃; Inert atmosphere; Glovebox;	97%
With silica gel In hexane; ethyl acetate at 20℃;	143.1 mg
With air In diethyl ether	146 mg

: (benzo[d][1,3]dioxol-5-ylmethoxy)(tert-butyl)dimethylsilane

: 495-76-1
piperonol

Conditions

Conditions	Yield
With Decaborane In methanol at 20℃; for 0.416667h;	98%
With potassium hydrogensulfate In methanol at 20℃; for 2h;	90%
In water; dimethyl sulfoxide at 90℃; for 8h;	84%

: (benzo[1,3]dioxol-5-ylmethoxy)-triphenyl-silane

: 495-76-1
piperonol

Conditions

Conditions	Yield
With Decaborane In methanol at 20℃; for 0.1h;	97%

: 61040-76-4
3,4-(methylenedioxy)benzyl trimethylsilyl ether

: 495-76-1
piperonol

Conditions

Conditions	Yield
With Nafion-H(R); silica gel In hexane at 20℃; for 0.5h;	95%
With Kaolinitic clay; water for 0.0333333h; Irradiation; microwave;	63%

: benzo[d][1,3]dioxol-5-ylmethyl quinolin-8-ylcarbamate

: 495-76-1
piperonol

Conditions

Conditions	Yield
With methanol; sodium hydroxide for 6h; Reflux;	94%

: 85604-71-3
5-(tetrahydro-2H-pyran-2-yloxy)methylbenzo[d][1,3]dioxole

: 495-76-1
piperonol

Conditions

Conditions	Yield
With trichloroisocyanuric acid In methanol at 20℃; for 4h;	92%
With cerium(III) chloride In methanol at 20℃; for 0.5h; detetrahydropyranylation;	90%
With carbon tetrabromide In methanol at 65℃; for 0.5h; Heating;	89%

: C21H20O3Si

: 495-76-1
piperonol

Conditions

Conditions	Yield
With Nonafluorobutanesulfonyl fluoride; TPGS-750-M In propan-1-ol; water at 50℃; for 12h; Reagent/catalyst; Solvent; Temperature; Green chemistry;	92%

: 5-[(2-phenylallyloxy)methyl]benzo[d][1,3]dioxole

: 495-76-1
piperonol

Conditions

Conditions	Yield
With tert.-butyl lithium In tetrahydrofuran; pentane at -78℃; for 0.5h;	89%

: 67-56-1
methanol

: 120-57-0
piperonal

: 495-76-1
piperonol

Conditions

Conditions	Yield
Stage #1: piperonal With diisobutylaluminium hydride In dichloromethane at -78℃; for 1.5h; Stage #2: methanol at 20℃;	89%

: benzo[d][1,3]dioxol-5-yl(1H-pyrazol-1-yl)methanone

: 495-76-1
piperonol

Conditions

Conditions	Yield
With sodium tetrahydroborate In tetrahydrofuran; water at 0 - 25℃; for 12h;	89%

: 120-57-0
piperonal

A: 495-76-1
piperonol

B: 4543-59-3
1,2-bis(3,4-dioxymethylenephenyl)ethane-1,2-diol

Conditions

Conditions	Yield
With vanadium(II) chloride In ethanol; water at 17 - 22℃; for 0.416667h; sonication;	A 1% B 87%
With sodium hydroxide; aluminium In methanol at 20℃; for 0.5h; Irradiation;	A 6% B 70%
With magnesium In water at 20℃; for 4h; ultrasonic irradiation; Title compound not separated from byproducts;	A 5% B 60%
With naphthalene; lithium; manganese(ll) chloride In tetrahydrofuran at 50 - 54℃; for 1h; sonication;	A 9% B 41%
With water; zinc(II) chloride; zinc In tetrahydrofuran at 25 - 30℃; for 4h; ultrasonication;	A 11.5% B 33.1%

: 15777-88-5
dimetilamide dell'acido 3,4-metilendiossibenzoico

: 495-76-1
piperonol

Conditions

Conditions	Yield
With sodium hydride; sodium iodide; zinc(II) iodide In tetrahydrofuran; mineral oil at 40℃; for 7h; Sealed tube;	87%

: 7501-62-4
1,3-benzodioxol-5-yl--methanethione

: 495-76-1
piperonol

Conditions

Conditions	Yield
Stage #1: 1,3-benzodioxol-5-yl--methanethione With sodium iodide; Merrifield resin In water; N,N-dimethyl-formamide at 100℃; for 24h; Solid phase reaction; Stage #2: With lithium borohydride In tetrahydrofuran at 20℃; for 5h; Solid phase reaction;	83%

: 5-[(phenylmethoxy)methyl]-1,3-benzodioxole

A: 495-76-1
piperonol

B: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With bis(acetylacetonate)oxovanadium; methyl 3,5-bis((1H-1,2,4-triazol-1-yl)methyl)benzoate; oxygen; sodium acetate at 120℃; for 48h;	A 82% B 82%

: 120-57-0
piperonal

: 6642-34-8
6-bromopiperonyl alcohol

A: 495-76-1
piperonol

B: 473253-66-6
benzo[1,3]dioxol-5-yl-(6-(hydroxymethyl)benzo[1,3]dioxol-5-yl)methanol

Conditions

Conditions	Yield
Stage #1: 6-bromopiperonyl alcohol With n-butyllithium In tetrahydrofuran; hexane for 1h; Stage #2: piperonal In tetrahydrofuran; hexane at -78℃; for 0.666667h;	A 19% B 81%

...Expand

: iodo-acetic acid benzo[1,3]dioxol-5-ylmethyl ester

: 495-76-1
piperonol

Conditions

Conditions	Yield
Stage #1: iodo-acetic acid benzo[1,3]dioxol-5-ylmethyl ester With N-ethyl-N,N-diisopropylamine; aminomethyl polystyrene In N,N-dimethyl-formamide at 20℃; for 16h; Stage #2: With benzyl isothiocyanate In N,N-dimethyl-formamide; toluene at 20℃; for 8h; Stage #3: With diisopropylamine at 20℃; for 1h;	80%

: 85604-71-3
5-(tetrahydro-2H-pyran-2-yloxy)methylbenzo[d][1,3]dioxole

A: 495-76-1
piperonol

B: 5-Ethylsulfanylmethyl-benzo[1,3]dioxole

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; ethanethiol In dichloromethane at -20 - 0℃; for 0.5h;	A 77% B 23%

: 85604-71-3
5-(tetrahydro-2H-pyran-2-yloxy)methylbenzo[d][1,3]dioxole

: 75-08-1
ethanethiol

A: 495-76-1
piperonol

B: 5-Ethylsulfanylmethyl-benzo[1,3]dioxole

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at -20 - 0℃; for 0.5h;	A 77% B 23%

...Expand

: 120-57-0
piperonal

: 75-09-2
dichloromethane

A: 7315-32-4
5-vinyl-1,3-benzodioxole

B: 495-76-1
piperonol

Conditions

Conditions	Yield
With titanium tetrachloride; magnesium In tetrahydrofuran at 0 - 20℃; for 0.833333h;	A 75% B 8%

...Expand

: 91475-97-7
5-(2-Methoxy-ethoxymethoxymethyl)-benzo[1,3]dioxole

A: 495-76-1
piperonol

B: 157766-09-1
5-(iodomethyl)benzo[d][1,3]dioxole

Conditions

Conditions	Yield
With chloro-trimethyl-silane; sodium iodide In acetonitrile at -20℃; for 2.5h;	A 71% B n/a

: 6642-34-8
6-bromopiperonyl alcohol

: 120-14-9
3,4-dimethoxy-benzaldehyde

A: 495-76-1
piperonol

B: 473253-67-7
(3,4-dimethoxyphenyl)-(6-hydroxymethyl-benzo[1,3]dioxol-5-yl)methanol

Conditions

Conditions	Yield
Stage #1: 6-bromopiperonyl alcohol With n-butyllithium In tetrahydrofuran; hexane for 1h; Stage #2: 3,4-dimethoxy-benzaldehyde In tetrahydrofuran; hexane for 0.666667h;	A 30% B 69%

...Expand

: 2620-50-0
1,3-benzodioxol-5-ylmethyl amine

: 495-76-1
piperonol

Conditions

Conditions	Yield
With [Ir(κ2O,O-CH3COO)(I)2{κC,C'-methylenebis(N-methyl)imidazole-2-ylidene}]; water; glycerol; potassium hydroxide at 120℃; for 16h;	67%

: 120-57-0
piperonal

: 775-12-2
diphenylsilane

A: 495-76-1
piperonol

B: bis-(benzo[1,3]dioxol-5-ylmethoxy)-diphenyl-silane

Conditions

Conditions	Yield
bis(benzene)chromium(0) In benzene at 70℃; for 3h; Reduction;	A 65% B n/a

...Expand

: 86215-81-8
2-(benzo[d][1,3]dioxol-6-yl)-2-hydroxyacetonitrile

: 495-76-1
piperonol

Conditions

Conditions	Yield
With sodium tetrahydroborate; ethanol at 20℃; for 0.75h;	65%

: 4405-18-9
5-[1,3]dioxolan-2-yl-benzo[1,3]dioxole

A: 120-57-0
piperonal

B: 495-76-1
piperonol

Conditions

Conditions	Yield
With sodium tetrahydroborate; nickel(II) chloride hexahydrate In methanol for 0.25h; chemoselective reaction;	A 28% B 61%

: 6642-34-8
6-bromopiperonyl alcohol

A: 495-76-1
piperonol

B: 79422-40-5
6,6'-bis(hydroxymethyl)-5,5'-bi-1,3-benzodioxole

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel (0) In N,N-dimethyl-formamide	A 59% B 15%

: 495-76-1
piperonol

: 20850-43-5
5-(chloromethyl)-1,3-benzodioxole

Conditions

Conditions	Yield
With 1,3,5-trichloro-2,4,6-triazine; dimethyl sulfoxide at 20℃; for 0.333333h; chemoselective reaction;	100%
With thionyl chloride; triethylamine In benzene at 0℃; for 24h;	100%
With thionyl chloride In benzene	98%

: 495-76-1
piperonol

: 2606-51-1
3,4-Methylenedioxybenzyl bromide

Conditions

Conditions	Yield
With phosphorus tribromide In benzene at 20℃;	100%
With carbon tetrabromide; triphenylphosphine In dichloromethane at 0 - 20℃; for 2h;	97%
With phosphorus tribromide In diethyl ether at 0℃; for 0.75h; Inert atmosphere;	96%

: 495-76-1
piperonol

: 69048-76-6
6-iodo-1,3-benzodioxole-5-methanol

Conditions

Conditions	Yield
With iodine; silver trifluoroacetate In methanol; dichloromethane at 0 - 20℃; for 14h; Inert atmosphere;	100%
With iodine; silver trifluoroacetate In methanol; dichloromethane at 0 - 20℃; for 14h; Inert atmosphere;	100%
With iodine; silver trifluoroacetate In chloroform at 20℃;	99%

: 495-76-1
piperonol

: 120-57-0
piperonal

Conditions

Conditions	Yield
With bis(2,2'-bipyridyl) copper(II) permanganate In dichloromethane for 0.5h; Ambient temperature;	100%
With 2,2'-bipyridylchromium peroxide In benzene for 1.25h; Heating;	100%
With dipyridinium dichromate; chloro-trimethyl-silane In dichloromethane for 0.25h;	100%

: 495-76-1
piperonol

: 210358-11-5
Phosphorous acid tribenzo[1,3]dioxol-5-ylmethyl ester

Conditions

Conditions	Yield
With Hexamethylphosphorous triamide at 100℃; for 2h;	100%

: 495-76-1
piperonol

: 6642-34-8
6-bromopiperonyl alcohol

Conditions

Conditions	Yield
With N-Bromosuccinimide In dichloromethane at 5℃; for 2h;	100%
With N-Bromosuccinimide In dichloromethane
With N-Bromosuccinimide

: 495-76-1
piperonol

: 4421-09-4
piperonylonitrile

Conditions

Conditions	Yield
With 2,3'-bipyridine; ammonium hydroxide; copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen In ethanol at 20℃; for 24h;	100%
Stage #1: piperonol With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione In dichloromethane at 20℃; for 0.5h; Inert atmosphere; Stage #2: With ammonia; iodine In dichloromethane; water at 20℃; for 2h; Inert atmosphere;	99%
With ammonia; oxygen In tert-Amyl alcohol; water at 100℃; under 3750.38 Torr; for 4h; Autoclave; High pressure;	99%

: 495-76-1
piperonol

: 36669-02-0
2,3-bis(methoxycarbonyl)phenol

: 1061606-11-8
3-(benzo[1,3]dioxol-5-ylmethoxy)-phthalic acid dimethyl ester

Conditions

Conditions	Yield
With PS-triphenylphosphine; di-isopropyl azodicarboxylate In tetrahydrofuran at 0 - 20℃; not specified;	100%

: 495-76-1
piperonol

: 75-36-5
acetyl chloride

: 326-61-4
piperonyl acetate

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%
With triethylamine In dichloromethane at 20℃;	97%

: 495-76-1
piperonol

: 603-35-0
triphenylphosphine

: 58005-36-0
(benzo[d][1,3]dioxol-5-ylmethyl)triphenylphosphonium bromide

Conditions

Conditions	Yield
With N-Bromosuccinimide In dichloromethane at 0 - 20℃; for 6.5h; Inert atmosphere;	100%

: 495-76-1
piperonol

: 20980-22-7
N-(2-pyridinyl)piperazine

: 3605-01-4
piribedil

Conditions

Conditions	Yield
With 2,2,2-trifluoroethanol; chloro-(pentamethylcyclopentadienyl)-{5-methoxy-2-{1-[(4-methoxyphenyl)imino-N]ethyl}phenyl-C}-iridium(lll); potassium carbonate at 100℃; for 24h; Inert atmosphere; Sealed tube;	99%
With polystyrene supported triphenylphosphine ruthenium complex In toluene at 140℃; for 48h; Sealed tube; Flow reactor;	98%
With NiCuFeO(x) In 5,5-dimethyl-1,3-cyclohexadiene for 24h; Inert atmosphere; Sealed tube; Reflux;	93%

: 495-76-1
piperonol

: 70-55-3
toluene-4-sulfonamide

: 22102-40-5
N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-methyl-benzenesulfonamide

Conditions

Conditions	Yield
With potassium tert-butylate; copper diacetate In toluene at 150℃; for 120h; Inert atmosphere;	99%
With potassium hydroxide In toluene at 130℃; for 96h; Inert atmosphere;	99%
With palladium diacetate; potassium carbonate In toluene at 150℃; for 8h;	97%
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether In 5,5-dimethyl-1,3-cyclohexadiene at 20 - 150℃; for 24.1667h; Inert atmosphere;	88%

: 59-48-3
2-oxoindole

: 495-76-1
piperonol

: 3-benzo[1,3]dioxol-5-ylmethyl-1,3-dihydroindol-2-one

Conditions

Conditions	Yield
With potassium hydroxide; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] at 110℃; for 15h; Inert atmosphere; Neat (no solvent);	99%
With rhodium(III) chloride hydrate; triphenylphosphine; sodium hydroxide at 110℃; for 20h; Inert atmosphere;	79%
With rhodium(III) chloride hydrate; triphenylphosphine; sodium hydroxide at 110 - 115℃; Sealed tube; Inert atmosphere;	74%

: 504-24-5
4-aminopyridine

: 495-76-1
piperonol

: 1301628-37-4
N-(benzo[d][1,3]dioxol-5-ylmethyl)pyridin-4-amine

Conditions

Conditions	Yield
With potassium tert-butylate; copper diacetate In 1,4-dioxane at 130℃; for 48h; Inert atmosphere;	99%
With cesium hydroxide; palladium diacetate In toluene at 150℃; for 12h;	99%

: 495-76-1
piperonol

: 77-78-1
dimethyl sulfate

: 86633-25-2
benzo[d][1,3]dioxol-5-ylmethyl methyl ether

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium hydroxide In dichloromethane	99%

: 108-05-4
vinyl acetate

: 495-76-1
piperonol

: 326-61-4
piperonyl acetate

Conditions

Conditions	Yield
With pseudomonas fuorescens lipase immobilized on multiwall carbon nano-tubes at 50℃; for 4.5h; Green chemistry;	99%

: 495-76-1
piperonol

: 14752-65-9
sodium S-(4-chlorobenzyl) thiosulfate

: 5-(((4-chlorobenzyl)thio)methyl)benzo[d][1,3]dioxole

Conditions

Conditions	Yield
With hydrogenchloride In water at 100℃; for 12h;	99%

: 495-76-1
piperonol

: 95-55-6
2-amino-phenol

: 3315-20-6
2‐(benzo[d][1,3]dioxol‐5‐yl)benzo[d]oxazole

Conditions

Conditions	Yield
Stage #1: piperonol With oxygen at 106℃; under 3800.26 Torr; for 0.216667h; Flow reactor; Green chemistry; Stage #2: 2-amino-phenol at 106℃; Flow reactor; Green chemistry; Stage #3: at 106℃; for 0.666667h; Flow reactor; Green chemistry;	99%

: 495-76-1
piperonol

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 85262-96-0
benzo[d][1,3]dioxol-5-ylmethyl formate

Conditions

Conditions	Yield
With fluorosulfonyl fluoride; caesium carbonate at 20℃; for 12h; Sealed tube;	99%

: 495-76-1
piperonol

: 86-73-7
9H-fluorene

: 5-fluoren-9-ylmethyl-benzo[1,3]dioxole

Conditions

Conditions	Yield
With potassium tert-butylate In toluene at 120℃; for 3h; Inert atmosphere;	99%

: 67-56-1
methanol

: 495-76-1
piperonol

: 326-56-7
methyl 3,4-methylenedioxybenzoate

Conditions

Conditions	Yield
With potassium carbonate at 60℃; under 750.075 Torr; for 2h; Temperature; Pressure;	98.8%
With oxygen at 70℃; under 750.075 Torr; for 16h;	98%
With oxygen; potassium carbonate at 60℃; under 750.075 Torr; for 20h;	87%

: 495-76-1
piperonol

: 107-45-9
tert-Octylamine

: 1137195-75-5
(E)-N-(benzo[d][1,3]dioxol-5-ylmethylene)-2,4,4-trimethylpentan-2-amine

Conditions

Conditions	Yield
With palladium on aluminium oxyhydroxide; oxygen at 90℃; under 760.051 Torr; for 24h;	98%

: 495-76-1
piperonol

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 425652-61-5
5-((benzo[d][1,3]dioxol-5-ylmethyl)thio)-1-phenyl-1H-tetrazole

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 0.55h;	98%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 0.5h; Mitsunobu type reaction; Inert atmosphere;	95%

: 495-76-1
piperonol

: 1129-26-6
4-methoxybenzene sulfonamide

: 349622-44-2
N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-methoxybenzenesulfonamide

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate In toluene at 150℃; for 8h;	98%
With potassium tert-butylate; copper diacetate In toluene at 150℃; for 120h; Inert atmosphere;	89%

: 495-76-1
piperonol

: 7664-41-7
ammonia

: 4421-09-4
piperonylonitrile

Conditions

Conditions	Yield
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; [{Cu(NO3)}(μ-3-(6-(1H-pyrazol-1-yl)pyridin-2-yl)pyrazol-1-ide)]2; oxygen; potassium carbonate at 50℃; for 24h;	98%

Piperonyl alcohol Chemical Properties

Molecular Structure:

Molecular Formula: C₈H₈O₃
Molecular Weight: 152.1473
IUPAC Name: 1,3-Benzodioxol-5-ylmethanol
Synonyms of Piperonyl alcohol (CAS NO.495-76-1): 1-Hydroxymethyl-3,4-methylenedioxybenzene ; 5-Hydroxymethyl-1,3-benzodioxole ; AI3-05702 ; Benzyl alcohol, 3,4-(methylenedioxy)- ; EINECS 207-808-4 ; Heliotropyl alcohol ; NSC 26265 ; Piperonol ; 1,3-Benzodioxole-5-methanol
CAS NO: 495-76-1
Classification Code: Benzhydrols, Benzyl & Special Alcohols
Melting point: 50-54 °C
H bond acceptors: 3
H bond donors: 1
Freely Rotating Bonds: 2
Polar Surface Area: 27.69 Å²
Index of Refraction: 1.594
Molar Refractivity: 38.86 cm³
Molar Volume: 114.4 cm³
Surface Tension: 58.2 dyne/cm
Density: 1.329 g/cm³
Flash Point: 124.5 °C
Enthalpy of Vaporization: 55.04 kJ/mol
Boiling Point: 282.2 °C at 760 mmHg
Vapour Pressure of Piperonyl alcohol (CAS NO.495-76-1): 0.00161 mmHg at 25°C

Piperonyl alcohol Safety Profile

Hazard Codes of Piperonyl alcohol (CAS NO.495-76-1): Xi
Safety Statements: 24/25
S24/25: Avoid contact with skin and eyes.
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29329970

Product Name

Piperonyl alcohol

Synthetic route

Piperonyl alcohol Chemical Properties

Piperonyl alcohol Safety Profile

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