Tert-butyl carbamate supplier

Name
tert-Butyl carbamate
EINECS 224-209-3
CAS No. 4248-19-5
Article Data72
CAS DataBase
Density 0.99 g/cm³
Solubility Soluble in methylene chloride, chloroform, and alcohols. Slightly soluble in petroleum ether and water.
Melting Point 105-108 °C(lit.)
Formula C₅H₁₁NO₂
Boiling Point 195.979 °C at 760 mmHg
Molecular Weight 117.148
Flash Point 82.407 °C
Transport Information
Appearance White to slightly yellow needles
Safety 39-26
Risk Codes 36
Molecular Structure
Hazard Symbols Xi
Synonyms Carbamicacid, tert-butyl ester (6CI,7CI,8CI);Carbamic acid tert-butyl ester;NSC131089;O-tert-Butyl carbamate;N-T-Butoxycarbonyl-Amide;
PSA 52.32000
LogP 1.58050

Synthetic route

: 24424-99-5
di-tert-butyl dicarbonate

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
With ammonia In ethanol at 0 - 20℃;	98%
With ammonium hydroxide In ethanol; water at -10 - 20℃; for 18.5833h;	95%
With ammonia In methanol at 0 - 20℃; for 7h;	94%

: 57-13-6
urea

: 75-65-0
tert-butyl alcohol

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
With merrifield anchored iron(II)-anthra catalyst In 1,4-dioxane at 120℃; for 6.5h;	81%
With cholin chloride ZnCl2; iron oxide at 130℃; for 6h; Green chemistry;	69%

: 70678-13-6
1,2-bis(1-isocyanato-1-methylethyl)diazene

: 75-65-0
tert-butyl alcohol

A: 4248-19-5
tert-butyl carbamate

B: 112700-85-3
5,5-dimethyl-Δ1-1,2,4-triazolin-3-one

Conditions

Conditions	Yield
for 22h; Heating;	A 29% B 74%

...Expand

: 917-61-3
sodium isocyanate

: 75-65-0
tert-butyl alcohol

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
With perchloric acid on silica gel at 20℃; for 0.75h;	74%
With trifluoroacetic acid 2.) CH2Cl2; Multistep reaction;

: 1330763-30-8
(4-aminotetrahydrofuran-3-yl)carbamic acid tert-butyl ester

: 335276-54-5
4-[(4-fluorophenyl)methyl]-cyclohexanone

A: 335388-53-9
tert-butyl (3S,4S)-4-{[4-(4-fluorobenzyl)cyclohexyl]amino}tetrahydro-3-furanylcarbamate

B: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In methanol; dichloromethane; 1,2-dichloro-ethane	A 53% B n/a

...Expand

: 590-28-3
potassium cyanate

: 75-65-0
tert-butyl alcohol

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
With para-dodecylbenzenesulfonic acid In neat (no solvent) at 60℃; for 0.5h; Green chemistry;	52%
With DBSA at 60℃; for 1h;
With DBSA at 60℃; for 1h;
With DBSA at 60℃; for 1h;

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 24424-99-5
di-tert-butyl dicarbonate

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
With dmap In hexane; dichloromethane; ethyl acetate	36%

: 85535-53-1
Boc-Lys-NH2 hemioxalate

A: 4248-19-5
tert-butyl carbamate

B: 373-04-6
6-aminocaproic amide

C: 85535-54-2
tert-butyl (S)-(6-amino-1-hydroxyhexan-2-yl)carbamate

Conditions

Conditions	Yield
With ammonia; sodium	A 14.7% B 22% C 20 % Chromat.
With ammonia; sodium Product distribution;	A 14.7% B 22% C 20 % Chromat.

...Expand

: 83351-75-1
tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate

A: 4248-19-5
tert-butyl carbamate

B: 23838-70-2
3-(4-hydroxyphenyl)propanoic acid amide

C: 83345-46-4
N-(tert-butyloxycarbonyl)-L-tyrosinol

Conditions

Conditions	Yield
With sodium; ammonium chloride In ammonia	A 8% B 12% C n/a

...Expand

: 1070-19-5
N-(tert-butyloxycarbonyl) azide

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
With ammonia; water
With diiron nonacarbonyl In benzene

: 24608-52-4
tert-butyl chloroformate

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
With ammonia

: 16326-62-8
nitrobiuret

: 75-65-0
tert-butyl alcohol

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
With water

: 57022-34-1
tert-butyl cyanoformate

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
With ammonium hydroxide

: 99768-94-2
3-Brom-propionylcarbamidsaeure-tert.-butylester

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
With sodium hydroxide

: 507-40-4
tert-butylhypochlorite

: 3173-53-3
Cyclohexyl isocyanate

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
In Petroleum ether

: 507-40-4
tert-butylhypochlorite

: 4203-28-5
phenyl-diazenecarboxylic acid amide

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
In chloroform

: 143-33-9
sodium cyanide

: 75-65-0
tert-butyl alcohol

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
With trifluoroacetic acid In benzene

: 88463-18-7
(S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropionamide

A: 4248-19-5
tert-butyl carbamate

B: 102-93-2
3-phenylpropionamide

C: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

Conditions

Conditions	Yield
With sodium; ammonium chloride In ammonia

...Expand

: 78497-71-9
N-(1-aminoisobityl)carbamic acid tert-butyl ester hydrochloride

A: 4248-19-5
tert-butyl carbamate

B: 7664-41-7
ammonia

C: 78-84-2
isobutyraldehyde

Conditions

Conditions	Yield
With phosphoric acid at 40 - 45℃; Product distribution; Rate constant; Mechanism; influence of pH;

...Expand

: 83351-75-1
tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate

A: 4248-19-5
tert-butyl carbamate

B: 102-93-2
3-phenylpropionamide

C: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

Conditions

Conditions	Yield
With sodium; ammonium chloride In ammonia

...Expand

: 98115-12-9
Nα,Nca-di-tert-butyloxycarbonylasparagine

A: 4248-19-5
tert-butyl carbamate

B: 13726-67-5
Boc-Asp-OH

Conditions

Conditions	Yield
With sodium hydroxide

: 98115-14-1
Nα,Nca-di-tert-butyloxycarbonylglutamine

A: 4248-19-5
tert-butyl carbamate

B: 2419-94-5
Boc-Glu

Conditions

Conditions	Yield
With sodium hydroxide

: 5663-07-0
hydroxy sulfonylurea

: 75-65-0
tert-butyl alcohol

A: 4248-19-5
tert-butyl carbamate

B ammonium salt of/the/ tert-butylsulfuric acid: ammonium salt of/the/ tert-butylsulfuric acid

Conditions

Conditions	Yield
With diethyl ether

...Expand

: 73017-98-8
N-<(tert-butoxycarbonyl)amino>methylamine hydrochloride

A: 50-00-0
formaldehyd

B: 4248-19-5
tert-butyl carbamate

C NH3: NH3

Conditions

Conditions	Yield
With water-d2 Rate constant;

...Expand

: 24424-99-5
di-tert-butyl dicarbonate

: 150-13-0
4-amino-benzoic acid

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; methanol; water	28.11 g (68%)

: 50903-59-8
N-t-butyloxycarbonyl-Nε-benzyloxycarbonyl-lysine pentafluorophenyl ester

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 90.5 percent / 25percent NH4OH / dioxane / 1 h 2: 94 percent / 1) 10percent Pd/C, H2 / methanol / Ambient temperature; 1) 1 h 3: 14.7 percent / Na, liq. NH3 View Scheme

: 55592-81-9
Nε-(benzyloxycarbonyl)-Nα-(tert-butoxycarbonyl)-L-lysinamide

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 94 percent / 1) 10percent Pd/C, H2 / methanol / Ambient temperature; 1) 1 h 2: 14.7 percent / Na, liq. NH3 View Scheme

: 35454-04-7
oxalamic Acid Tert-butyl Ester

: 4248-19-5
tert-butyl carbamate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: (CF3CO)2O / pyridine 2: aq. NH3 View Scheme

: 4248-19-5
tert-butyl carbamate

: 54957-94-7
tert-butyl N,N-dichlorocarbamate

Conditions

Conditions	Yield
With hydrogenchloride; calcium hypochlorite In dichloromethane; water at 0 - 1℃; for 0.916667h;	100%
With sodium hypochlorite; acetic acid at 0 - 5℃; for 0.266667h;	86%
With hydrogenchloride; calcium hypochlorite In dichloromethane; water at 0℃; for 1.75h; regiospecific reaction;	84%
With hydrogenchloride; calcium hypochlorite In dichloromethane

: 4248-19-5
tert-butyl carbamate

: 298-12-4
Glyoxilic acid

: 96625-24-0
Nα-(tert-butoxycarbonyl)-α-hydroxyglycine

Conditions

Conditions	Yield
In acetone for 4h; Heating;	100%
In diethyl ether for 72h; Ambient temperature;	2.5 g
In diethyl ether for 72h; Ambient temperature;
In acetone for 5h; Heating;
In acetone Heating;

: 4248-19-5
tert-butyl carbamate

: 873-55-2
sodium benzenesulfonate

: 100-52-7
benzaldehyde

: 155396-71-7
tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate

Conditions

Conditions	Yield
With formic acid In methanol; water at 20℃; for 72h;	100%
In methanol; formic acid; water at 20℃; for 72h;	99%
In methanol; formic acid; water at 20℃; for 72h;	98%

...Expand

: 4248-19-5
tert-butyl carbamate

: 358365-86-3
tert-butyl N,N-dibromocarbamate

Conditions

Conditions	Yield
With bromine; sodium hydroxide In water at 20℃; for 2h;	100%
With bromine; potassium carbonate In water at 20℃; for 2h;

: 446026-44-4
4-benzyloxy-3-formyl-benzonitrile

: 4248-19-5
tert-butyl carbamate

: 758710-64-4
4-benzyloxy-3-tert-butoxycarbonylaminomethylbenzonitrile

Conditions

Conditions	Yield
With triethylsilane; trifluoroacetic acid In acetonitrile at 20℃; for 2h;	100%

: C17H24BrNO3Si

: 4248-19-5
tert-butyl carbamate

: A-cis

Conditions

Conditions	Yield
With caesium carbonate; 4,5-bis-(di-tert-butyl-phosphanyl)-9,9-dimethyl-9H-xanthene; palladium diacetate In 1,4-dioxane at 110℃; for 16h;	100%

: 2-benzyl-1,2,3,3a,8,8a-hexahydro-2,7a-diaza-cyclopenta[a]inden-7-one

: 4248-19-5
tert-butyl carbamate

: 891772-49-9
7-oxo-3a,7,8,8a-tetrahydro-1H,3H-2,7a-diaza-cyclopenta[a]indene-2-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With hydrogen; palladium(II) hydroxide/carbon In methanol at 50℃; under 2327.23 Torr; for 3h;	100%

: 4248-19-5
tert-butyl carbamate

: 1146732-04-8
3-[6'-chloro-4'-(3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]-7-methoxy-1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one

: 1146733-74-5
tert-butyl [4'-(3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-yl]-carbamate

Conditions

Conditions	Yield
With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane for 15h; Reflux;	100%

: 4248-19-5
tert-butyl carbamate

: 1365992-18-2
4-(4-bromothiazolo[5,4-c]pyridin-2-yl)-3-chloro-5-fluorobenzonitrile

: 1365992-31-9
[2-(2-chloro-4-cyano-6-fluorophenyl)thiazolo[5,4-c]pyridin-4-yl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In water; toluene at 60℃; for 4h; Inert atmosphere;	100%

: 4248-19-5
tert-butyl carbamate

: 1380331-16-7
4-(7-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-yl)morpholine

: 1380331-17-8
tert-butyl 2-morpholino-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamate

Conditions

Conditions	Yield
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 20h; Inert atmosphere; Sealed tube;	100%
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 20h; Inert atmosphere;

: 4248-19-5
tert-butyl carbamate

: 1279461-93-6
5-((5-bromopyridin-3-yl)oxy)pyrimidine

: 1279461-97-0
tert-butyl (5-(pyrimidin-5-yloxy)pyridin-3-yl)carbamate

Conditions

Conditions	Yield
With sodium t-butanolate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium(0) chloroform complex In toluene at 20℃;	100%

: 940289-71-4
2,2,5-trimethyl-4-oxo-4H-1,3-benzodioxin-7-yl trifluoromethanesulfonate

: 4248-19-5
tert-butyl carbamate

: C16H21NO5

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 80℃; for 5h; Inert atmosphere;	100%

: 4248-19-5
tert-butyl carbamate

: methyl 2-{N-[(1RS)-cyclohex-2-en-1-yl]acetamido}acetate

: tert-butyl (2-{N-acetyl-N-[(1RS)-cyclohex-2-en-1-yl]amino}acetyl)carbamate

Conditions

Conditions	Yield
With lithium tert-butoxide In tetrahydrofuran at -23 - 20℃; for 48h; Inert atmosphere;	100%

: 4248-19-5
tert-butyl carbamate

: methyl 2-{N-[(1RS)-cyclohex-2-en-1-yl]-N-(methoxycarbonyl)amino}acetate

: tert-butyl N-(2-{N-(methoxycarbonyl)-N-[(1RS)-cyclohex-2-en-1-yl]amino}acetyl)carbamate

Conditions

Conditions	Yield
With lithium tert-butoxide In tetrahydrofuran at -23 - 20℃; for 48h; Inert atmosphere;	100%

: 4248-19-5
tert-butyl carbamate

: 2-chloro-4-methyl-6-(trifluoromethyl)pyridine

: tert-butyl (4-methyl-6-(trifluoromethyl)pyridin-2-yl)carbamate

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; XPhos In 1,4-dioxane at 80℃; for 2h; Inert atmosphere;	100%

: 4248-19-5
tert-butyl carbamate

: acetic acid 3-bromo-5-tert-butylbenzyl ester

: acetic acid 3-tert-butoxycarbonylamino-5-tert-butylbenzyl ester

Conditions

Conditions	Yield
With palladium diacetate; caesium carbonate; XPhos In 1,4-dioxane at 95℃; for 18h;	100%

: ethyl 5-bromo-2-methyl-pyridine-3-carboxylate

: 4248-19-5
tert-butyl carbamate

: 301666-75-1
ethyl 5-((tert-butoxycarbonyl)amino)-2-methylnicotinate

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 85℃; for 18h; Inert atmosphere;	100%

: 4248-19-5
tert-butyl carbamate

: 7432-21-5
N-carbobenzyloxy-L-tryptophane

: tert-butyl 2-(((benzyloxy)carbonyl)-L-tryptophyl)hydrazine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 3h;	100%

: 4248-19-5
tert-butyl carbamate

: (S)-N-(1-(3-bromophenyl)ethyl)-3-chloro-2-methylbenzenesulfonamide

: (S)-tert-butyl (3-(1-(3-chloro-2-methylphenylsulfonamido)ethyl)phenyl)carbamate

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; tert-butyl XPhos In toluene for 16h; Sealed tube;	100%

: (S)-2-methyl-1-[(2-nitrophenyl)sulfonyl]aziridine

: 4248-19-5
tert-butyl carbamate

: tert-butyl (S)-{2-[(2-nitrophenyl)sulfonamido]propyl}carbamate

Conditions

Conditions	Yield
Stage #1: tert-butyl carbazate With potassium hexamethylsilazane In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: (S)-2-methyl-1-[(2-nitrophenyl)sulfonyl]aziridine In tetrahydrofuran; dichloromethane at 20℃; for 18h; Inert atmosphere;	100%

: 4248-19-5
tert-butyl carbamate

: ethyl 6-chloro-3-(3-((6-fluoro-3-((4-methoxybenzyl)thio)naphthalen-1-yl)oxy)propyl)-7-(2-formyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1-methyl-1H-indole-2-carboxylate

: ethyl 7-(2-(((tert-butoxycarbonyl)amino)methyl)-5,6-dihydro-4H- pyrrolo[1,2-b]pyrazol-3-yl)-6-chloro-3-(3-((6-fluoro-3-((4-methoxybenzyl)thio)naphthalen-1-yl)oxy)propyl)-1-methyl-1H-indole-2-carboxylate

Conditions

Conditions	Yield
With triethylsilane; trifluoroacetic acid In dichloromethane at 0 - 20℃; Inert atmosphere;	100%

: 4248-19-5
tert-butyl carbamate

: methyl 3-chloropyridazine-5-carboxylate

: methyl 6-(tert-butoxycarbonylamino)pyridazine-4-carboxylate

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis(di-tertbutylphosphino)ferrocene; potassium carbonate In toluene at 75℃; for 6h; Inert atmosphere;	100%

: 18292-38-1
2-methallyltrimethylsilane

: 4248-19-5
tert-butyl carbamate

: 913388-24-6
tert-butyl 5-(dimethoxymethyl)-1H-indole-1-carboxylate

: (+)-(R)-N-Boc-3-methyl-1-(N-Boc-5-indolyl)but-3-en-1-amine

Conditions

Conditions	Yield
With triethylsilyl trifluoromethyl sulfonate; C35H31F6N3OS In diethyl ether at -78 - -50℃; for 6h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Sealed tube; enantioselective reaction;	100%

...Expand

: 1745-46-6
6,11-dihydrodibenzo[b,e]thiepin-11-ol

: 4248-19-5
tert-butyl carbamate

: 51065-32-8
(5,11-Dihydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In acetic acid 1) 37 deg C, 6h; 2) room temp., overnight;	99%

: 4248-19-5
tert-butyl carbamate

: (1S,2S)-1-Phenyl-2-((E)-3-phenylselanyl-propenyl)-cyclopropanecarboxylic acid diethylamide

: [1-((1R,2S)-2-Diethylcarbamoyl-2-phenyl-cyclopropyl)-allyl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With N-chloro-succinimide; isopropylamine In methanol for 2h; Ambient temperature;	99%

: 104-92-7
1-bromo-4-methoxy-benzene

: 4248-19-5
tert-butyl carbamate

: 18437-68-8
tert-butyl N-(4-methoxyphenyl)carbamate

Conditions

Conditions	Yield
With di-tert-butyl(2,2-diphenyl-1-methyl-1-cyclopropyl)phosphine; bis(η3-allyl-μ-chloropalladium(II)); sodium t-butanolate In water at 50℃; for 24h; Inert atmosphere; Green chemistry;	99%
With di-tert-butyl{2′-isopropoxy-[1,1′-binaphthalen]-2-yl}phosphane; caesium carbonate; bis(dibenzylideneacetone)-palladium(0) In tert-butyl alcohol at 100℃; for 20h; Inert atmosphere;	98%
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium t-butanolate; tert-butyl XPhos In toluene at 17 - 22℃; for 30h; Inert atmosphere;	76%

: 1436-34-6
1,2-Epoxyhexane

: 4248-19-5
tert-butyl carbamate

A: 1436-34-6, 122922-40-1, 130404-08-9, 104898-06-8
(R)-1,2-epoxyhexane

B: ((S)-2-hydroxyhexyl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With air; 4-nitro-benzoic acid; (R,R)-((t-Bu)4-salen)Co(II) In various solvent(s) at 20℃; for 24h;	A n/a B 99%
With (1R,2R)-(-)-N,N'-bis(3,5-di-tert-butylsalicydene)-1,2-cyclohexanediaminocobalt(II); 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; 4-nitro-benzoic acid at 20℃; for 10h; optical yield given as %ee; enantioselective reaction;

...Expand

: 52485-73-1, 105205-70-7, 126872-17-1, 19600-63-6
1,2-epoxy-7-octene

: 4248-19-5
tert-butyl carbamate

A: 105205-70-7
(R)-1,2-epoxy-7-octene

B: ((S)-2-hydroxyoct-7-enyl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With air; 4-nitro-benzoic acid; (R,R)-((t-Bu)4-salen)Co(II) In various solvent(s) at 20℃; for 24h;	A n/a B 99%

...Expand

: 4248-19-5
tert-butyl carbamate

: 122-60-1
Phenyl glycidyl ether

A: 71031-03-3
(2R)-1,2-epoxy-3-phenoxypropane

B: ((S)-2-hydroxy-3-phenoxypropyl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With air; 4-nitro-benzoic acid; [(S,S)-N,N’-bis(3,5-di-tertbutylsalicylidene)-1,2-cyclohexanediaminato(2-)]cobalt(II) In various solvent(s) at 20℃; for 24h;	A n/a B 99%

...Expand

: 4248-19-5
tert-butyl carbamate

: 1196-90-3
4-bromo-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester

: 126092-96-4
methyl 4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrole-2-carboxylate

Conditions

Conditions	Yield
With potassium phosphate; N,N`-dimethylethylenediamine; copper(l) iodide In 1,4-dioxane at 110℃; for 48h;	99%

Tert-butyl carbamate Specification

The tert-Butyl carbamate, with the CAS registry number 4248-19-5, is also known as Carbamic acid, 1,1-dimethylethyl ester. It belongs to the product categories of Protected Amino Acids; Pharmacetical. Its EINECS registry number is 224-209-3. This chemical's molecular formula is C₅H₁₁NO₂ and molecular weight is 117.15. What's more, its systematic name is called 2-Methyl-2-propanyl carbamate. It should be stored in a cool, dry and well-ventilated place. This chemical can be prepared by tertiary butanol with sodium cyanate. This reaction needs reagent Trifluoroacetic acid and solvent benzene.

Physical properties about tert-Butyl carbamate are: (1)ACD/LogP: 0.57; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.57; (4)ACD/LogD (pH 7.4): 0.57; (5)ACD/BCF (pH 5.5): 1.60; (6)ACD/BCF (pH 7.4): 1.60; (7)ACD/KOC (pH 5.5): 48.66; (8)ACD/KOC (pH 7.4): 48.66; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12) Polar Surface Area: 52.32 Å²; (13)Index of Refraction: 1.429; (14)Molar Refractivity: 30.489 cm³; (15)Molar Volume: 118.277 cm³; (16)Polarizability: 12.087×10^-24 cm³; (17)Surface Tension: 31.38 dyne/cm; (18)Density: 0.99 g/cm³; (19)Flash Point: 82.407 °C; (20)Enthalpy of Vaporization: 43.218 kJ/mol; (21)Boiling Point: 195.979 °C at 760 mmHg; (22)Vapour Pressure: 0.408 mmHg at 25 °C.

Uses of tert-Butyl carbamate: (1) it is used as organic synthetic reagent and pharmaceutical intermediates; (2) it is used to produce other chemicals. For example, it can react with Methallyl(phenyl)selenid to get N-(tert-butoxycarbonyl)-2-methyl-2-propenylamine. This reaction needs reagent diisopropylethylamine / N-chlorosuccinimide and solvent methanol at temperature of 0 °C. The yield is 92 %.

tert-Butyl carbamate can react with Methallyl(phenyl)selenid to get N-(tert-butoxycarbonyl)-2-methyl-2-propenylamine.

When you are dealing with this chemical, you should be very careful. This chemical is irritating to eyes and may cause inflammation to the skin or other mucous membranes. Therefore, you should wear suitable eye/face protection. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C(OC(C)(C)C)N
(2) InChI: InChI=1S/C5H11NO2/c1-5(2,3)8-4(6)7/h1-3H3,(H2,6,7)
(3) InChIKey: LFKDJXLFVYVEFG-UHFFFAOYSA-N

Product Name

tert-Butyl carbamate

Synthetic route

Tert-butyl carbamate Specification

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