Tetrabutylammonium hydroxide supplier

Name
Tetrabutylammonium hydroxide
EINECS 218-147-6
CAS No. 2052-49-5
Article Data25
CAS DataBase
Density 0.995 g/cm³
Solubility Soluble in water, methanol.
Melting Point 27-30 °C(lit.)
Formula C₁₆H₃₆N.OH
Boiling Point 100 °C
Molecular Weight 259.476
Flash Point 7 °C
Transport Information UN 3267 8/PG 2
Appearance Aqueous solution
Safety 7-16-26-36/37/39-45-36/37-62-27
Risk Codes 34-36/38-23/24/25-11-67-39/23/24/25-36-65-63-38
Molecular Structure
Hazard Symbols T, F, C
Synonyms 1-Butanaminium,N,N,N-tributyl-, hydroxide (9CI);Ammonium, tetrabutyl-, hydroxide (8CI);Tetrabutylammonium hydroxide (6CI);Tetrabutylammonium hydroxide solution;
PSA 23.06000
LogP 4.82680

Synthetic route

: 1643-19-2
tetrabutylammomium bromide

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

Conditions

Conditions	Yield
With potassium hydroxide In dichloromethane at 20℃; for 10h;	82%
With silver(l) oxide In water for 20h;
Multi-step reaction with 2 steps 1: potassium iodide / H2O 2: silver hydroxyde / H2O View Scheme

: 1033762-44-5
7-[(2E)-2-(2,3-dihydro-1H-inden-1-ylidene)ethyl]-8-([dimethyl(1,1,2-trimethylpropyl)silyl]oxy)-n,n,2,3-tetramethylimidazo[1,2-a]pyridine-6-carboxamide

: 429-41-4
tetrabutyl ammonium fluoride

A: 1033762-35-4
7-[(2E)-2-(2,3-dihydro-1H-inden-1-ylidene)ethyl]-8-hydroxy-n,n,2,3-tetramethylimidazo[1,2-a]pyridine-6-carboxamide

B: 2052-49-5
tetra(n-butyl)ammonium hydroxide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 1h;	A 71% B n/a

...Expand

: 311-28-4
tetra-(n-butyl)ammonium iodide

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

Conditions

Conditions	Yield
In water for 4h; electrolysis in a divided cell with Nafion membrane, -1.0 V;
With AgOH In water
With (Cy3P)2Pd(Ph)(OH); water In tetrahydrofuran at 20℃; Equilibrium constant; Inert atmosphere; Sealed vial;
With water; silver(l) oxide at 20℃;

: C34H51NOSi

A: 2052-49-5
tetra(n-butyl)ammonium hydroxide

B: 791-31-1
triphenylhydroxysilane

Conditions

Conditions	Yield
In acetonitrile at 25℃; Equilibrium constant;

: tetra-n-butylammonium bis(ortho-hydroxymethylphenolato)borate

A: 90-01-7
salicylic alcohol

B: 2052-49-5
tetra(n-butyl)ammonium hydroxide

Conditions

Conditions	Yield
With water; boric acid In dimethylsulfoxide-d6 at 30℃; Equilibrium constant;

: tetrabutyl-ammonium; benzo[1,3,2]dioxaborol-2-olate

A: 2052-49-5
tetra(n-butyl)ammonium hydroxide

B: 120-80-9
benzene-1,2-diol

Conditions

Conditions	Yield
With water; boric acid In dimethylsulfoxide-d6 at 30℃; Equilibrium constant;

: tetrabutyl-ammonium; 4H-benzo[1,3,2]dioxaborinin-2-olate

A: 90-01-7
salicylic alcohol

B: 2052-49-5
tetra(n-butyl)ammonium hydroxide

Conditions

Conditions	Yield
With water; boric acid In dimethylsulfoxide-d6 at 30℃; Equilibrium constant;

: tetra-n-butylammonium bis[catecholato(2-)-O,O']borate

A: 2052-49-5
tetra(n-butyl)ammonium hydroxide

B: 120-80-9
benzene-1,2-diol

Conditions

Conditions	Yield
With water; boric acid In dimethylsulfoxide-d6 at 30℃; Equilibrium constant;

: 1112-67-0
tetrabutyl-ammonium chloride

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

Conditions

Conditions	Yield
With (Cy3P)2Pd(Ph)(OH); water In tetrahydrofuran at 20℃; Equilibrium constant; Inert atmosphere; Sealed vial;
With potassium hydroxide In ethanol at 40℃; for 12h; Inert atmosphere;
With potassium hydroxide In ethanol at 20℃; for 12h; Inert atmosphere;
With sodium hydroxide In dichloromethane

: 102-82-9
tributyl-amine

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetonitrile / 33 h / 82 °C 2: potassium hydroxide / acetonitrile; ethanol / 50 h / 4 °C View Scheme

: 64-18-6
formic acid

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 35733-58-5
tetra(n-butyl)ammonium formate

Conditions

Conditions	Yield
In water pH=Ca. 8.45; Glovebox;	100%
In methanol; water at 20 - 60℃;	99%
In methanol at 20℃; for 2h; Inert atmosphere;	85%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 128208-12-8
(2S,3R)-cis-endo-3-(phenylsulfonylmethyl)bicyclo<2.2.1>heptane-2-carboxylic acid

: 128298-87-3
(1S,2S,3R,4R)-3-Benzenesulfonylmethyl-bicyclo[2.2.1]heptane-2-carboxylatetetrabutyl-ammonium;

Conditions

Conditions	Yield
In methanol Ambient temperature;	100%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 4-(dicyanomethyl)-4'-nitrobiphenyl

: tetrabutylammonium 4'-nitrobiphenylmalononitrile

Conditions

Conditions	Yield
In methanol; water Heating;	100%

: 107-35-7
Tau

: 24424-99-5
di-tert-butyl dicarbonate

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: tetrabutylammonium 2-((tert-butoxycarbonyl)amino)ethane-1-sulfonate

Conditions

Conditions	Yield
In water; acetone at 20℃;	100%
In water; acetone at 20℃;	100%
	99%

...Expand

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 66224-66-6, 66224-67-7, 66224-68-8, 66224-69-9, 134434-48-3, 134434-49-4, 134454-76-5, 134461-75-9
adenine

: tetrabutylammonium salt of adenine

Conditions

Conditions	Yield
In dichloromethane; water at 20℃; for 0.333333h;	100%
In dichloromethane; water at 20℃;	80%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 314740-80-2
benzyl 2-cyanoethyl 3,7,11,15-tetramethylhexadecylphosphate

: tetrabutylammonium benzyl 3,7,11,15-tetramethylhexadecylphosphate

Conditions

Conditions	Yield
In dichloromethane; water for 1h;	100%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: [cinchonidinium][Δ-Trisphat]

: tetra(n-butyl)ammonium Δ-tris(tetrachloro-1,2-benzenediolato)phosphate(V)

Conditions

Conditions	Yield
In ethanol	100%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 223449-25-0
5-methoxycarbonyl-m-xylylene bisphosphonic acid tetramethyl ester

: 3C16H36N(1+)*C11H13O8P2(3-)

Conditions

Conditions	Yield
In water for 168h; Heating;	100%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 262863-44-5
5-nitro-m-xylylene bisphosphonic acid tetramethyl ester

: 2C16H36N(1+)*C10H13NO8P2(2-)

Conditions

Conditions	Yield
In water for 168h; Heating;	100%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 367927-25-1
5-methoxy-m-xylylene bisphosphonic acid tetramethyl ester

: 2C16H36N(1+)*C11H16O7P2(2-)

Conditions

Conditions	Yield
In water for 168h; Heating;	100%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 147-85-3
L-proline

: proline, tetrabutylammonium carboxylate salt

Conditions

Conditions	Yield
In methanol at 0 - 20℃; for 3h; Inert atmosphere;	100%
In methanol	97%
In water at 20℃; for 2h;	95%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: potassium phenyltrifluoborate

: tetra-n-butylammonium phenyltrifluoroborate

Conditions

Conditions	Yield
In dichloromethane; water for 0.5h;	100%
In dichloromethane; water at 20℃; for 0.0166667h;

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 149104-90-5
4-acetylphenylboronic acid

: tetra-n-butylammonium 4-acetylphenyltrifluoroborate

Conditions

Conditions	Yield
Stage #1: 4-acetylphenylboronic acid With hydrogen fluoride In water at 20℃; for 1h; Stage #2: tetra(n-butyl)ammonium hydroxide In water at 20℃; for 1h;	100%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: benzyl 2-cyanoethyl 4,8,12,16,20-pentamethylpentacosylphosphate

: tetrabutylammonium benzyl 4,8,12,16,20-pentamethylpentacosylphosphate

Conditions

Conditions	Yield
In dichloromethane; water for 1h;	100%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 5,11,17,23,29,35-hexakis(dimethoxyphosphonoyl)methyl-37,38,39,40,41,42-hexamethoxycalix[6]arene

: 37,38,39,40,41,42-hexamethoxy-5,11,17,23,29,35-hexa(hydroxymethoxyphosphoryl)methylcalix[6]arene tetrabutylammonium salt

Conditions

Conditions	Yield
In water for 480h; Heating;	100%

: 848486-27-1
1,4,5,8-tetrahydro-1,4:5,8-dimethanoanthracene-9,10-bis(phenylphosphonic acid ester)

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: bis(tetra-n-butylammonium) 1,4,5,8-tetrahydro-1,4:5,8-dimethanoanthracene-9,10-bisphenylphosphonate

Conditions

Conditions	Yield
In dichloromethane; water at 20℃; for 2h;	100%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 848486-23-7
1,4,5,8-tetrahydro-1,4:5,8-dimethanoanthracene-9,10-bis(methylphosphonic acid ester)

: bis(tetra-n-butylammonium) 1,4,5,8-tetrahydro-1,4:5,8-dimethanoanthracene-9,10-bismethylphosphonate

Conditions

Conditions	Yield
In dichloromethane; water at 20℃; for 2h;	100%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: potassium trifluoro(prop-1-en-2-yl)borate

: tetra-n-butylammonium allyltrifluoroborate

Conditions

Conditions	Yield
In water for 0.0833333h; cooling;	100%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 274911-40-9
2,5-di-tert-butyl-6-hydroxyphenalenone

: tetrabutylammonium 5,8-di-tert-butyl-6-oxophenalenolate

Conditions

Conditions	Yield
In tetrahydrofuran; water at 20℃; for 0.833333h;	100%

: 498-40-8
L-Cysteic acid

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 1004287-85-7
TBCys

Conditions

Conditions	Yield
In water at 20℃; for 0.5h; Product distribution / selectivity;	100%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 147-93-3
Thiosalicylic acid

: tetrabutyllammonium bis(2-thiobenzoyl)borate

Conditions

Conditions	Yield
With boric acid In water at 100℃; for 0.25h; Heating / reflux;	100%

: 142-08-5
2-Pyridone

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: tetrabutylammonium pyridin-2-olate

Conditions

Conditions	Yield
In water; toluene at 55℃; Product distribution / selectivity; distilled under reduced pressure;	100%
In water; toluene at 0 - 55℃; for 0.5h; Product distribution / selectivity; Heating / reflux;	38%
In water; toluene at 0 - 20℃; for 0.5h; Product distribution / selectivity; Dean-Stark apparatus;	38%

: 554-95-0
benzene-1,3,5-tricarboxylic acid

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 1,3,5-benzenetricarboxylic acid tetra(n-butyl)ammonium salt

Conditions

Conditions	Yield
In methanol; water at 20℃;	100%
In methanol; water at 20℃;
In methanol at 20℃; for 2h;

: potassium (4-nitrophenyl)trifluoroborate

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: tetra-n-butylammonium p-nitrophenyltrifluoroborate

Conditions

Conditions	Yield
In dichloromethane; water for 0.5h;	100%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: potassium (4-methylphenyl)trifluoroborate

: tetra-n-butylammonium p-tolyltrifluoroborate

Conditions

Conditions	Yield
In dichloromethane; water for 0.5h;	100%

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: potassium trifluoro(methyl)boranuide

: tetra-n-butylammonium methyltrifluoroborate

Conditions

Conditions	Yield
In dichloromethane; water for 0.5h;	100%

: 1200440-78-3
C31H34NO9P

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 1200440-91-0
C16H36N(1+)*C28H30O9P(1-)

Conditions

Conditions	Yield
In dichloromethane; water at 20℃;	100%

: 1200440-73-8
C22H30NO9P

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 1200440-81-8
C16H36N(1+)*C19H26O9P(1-)

Conditions

Conditions	Yield
In dichloromethane; water at 20℃;	100%

: 1200440-79-4
C38H42NO9P

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: 1200440-93-2
C16H36N(1+)*C35H38O9P(1-)

Conditions

Conditions	Yield
In dichloromethane; water at 20℃;	100%

: 1212018-73-9
C18H22O8S2

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: ((n-butyl)4N)2((OSO2(CH2)3OC6H4)2)

Conditions

Conditions	Yield
In methanol at 20℃; for 0.25h;	100%

Tetrabutylammonium hydroxide Chemical Properties

IUPAC Name: Tetrabutylazanium hydroxide
Synonyms of Tetrabutylammonium hydroxide (CAS NO.2052-49-5): N,N,N-Tributyl-1-butanaminium hydroxide ; Tetra-n-butylammonium hydroxide ; Tetrabutylammonium hydroxide ;1-Butanaminium, N,N,N-tributyl-, hydroxide ;1-Butanaminium, N,N,N-tributyl-, hydroxide (1:1) ; Ammonium, tetrabutyl-, hydroxide
CAS NO: 2052-49-5
Molecular Formula: C₁₆H₃₆N.OH
Molecular Weight: 259.47
Molecular Structure:
H bond acceptors: 1
H bond donors: 0
Freely Rotating Bonds: 12
Polar Surface Area: 0 Å²
EINECS: 218-147-6
Melting point : 27-30 °C(lit.)
Boiling point : 100 °C
Density: 0.995
Refractive index: 1.4
Flash Point: 7°C
Storage temp: 2-8°C
Appearance: Aqueous solution
Sensitive: Air Sensitive/Hygroscopic
Product Categories: quarternary ammonium bases;Ammonium Hydroxides (Quaternary);Analytical Chemistry;HPLC Ion-Pair Reagents for Acidic Samples;Ion-Pair Reagents for HPLC;Quaternary Ammonium Compounds;Organic BasesEssential Chemicals;Reagent GradeVolumetric Solutions;Base Solutions;Titration;Organic BasesVolumetric Solutions;ACS GradeChemical Synthesis;Essential Chemicals;Routine Reagents

Tetrabutylammonium hydroxide Uses

Tetrabutylammonium hydroxide (CAS NO.2052-49-5) is commonly used as a base in organic chemistry.

Tetrabutylammonium hydroxide Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LDLo	subcutaneous	19mg/kg (19mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 28, Pg. 367, 1926.

Tetrabutylammonium hydroxide Consensus Reports

Reported in EPA TSCA Inventory.

Tetrabutylammonium hydroxide Safety Profile

Safety Information about Tetrabutylammonium hydroxide (CAS NO.2052-49-5):
Hazard Codes: Corrosive C, Toxic T,F
Risk Statements: 34-36/38-11-67-39/23/24/25-65-63
R34: Causes burns.
R36/38: Irritating to eyes and skin.
R11: Highly flammable.
R67: Vapours may cause drowsiness and dizziness.
R63: Possible risk of harm to the unborn child.
R65: Harmful: may cause lung damage if swallowed.
R39/23/24/25: Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
Safety Statements: 7-16-26-36/37/39-45-62-27
S7: Keep container tightly closed.
S16: Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27: Take off immediately all contaminated clothing.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S62: If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 3267 8/PG 2
WGK Germany: 1
RTECS: BS5425000
F: 9-34
Hazard: Note Highly Flammable/Toxic/Corrosive/Air Sensitive/Hygroscopic
HazardClass: 3
PackingGroup: II

Tetrabutylammonium hydroxide Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use foam, dry chemical, or carbon dioxide.
Handling: Avoid contact with eyes, skin, and clothing. Do not breathe dust, vapor, mist, or gas. Use only in a chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area.

Product Name

Tetrabutylammonium hydroxide

Synthetic route

Tetrabutylammonium hydroxide Chemical Properties

Tetrabutylammonium hydroxide Uses

Tetrabutylammonium hydroxide Toxicity Data With Reference

Tetrabutylammonium hydroxide Consensus Reports

Tetrabutylammonium hydroxide Safety Profile

Tetrabutylammonium hydroxide Specification

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