Tosyl chloride supplier | CasNO.98-59-9

Name
Tosyl chloride
EINECS 202-684-8
CAS No. 98-59-9
Article Data183
CAS DataBase
Density 1.339 g/cm³
Solubility hydrolyses in water
Melting Point 65-69 °C(lit.)
Formula C₇H₇ClO₂S
Boiling Point 265.3 °C at 760 mmHg
Molecular Weight 190.65
Flash Point 114.3 °C
Transport Information UN 3261 8/PG 2
Appearance White to yellow solid
Safety 26-36/37/39-45-27
Risk Codes 34-29
Molecular Structure
Hazard Symbols C
Synonyms 4-Methylbenzene-1-sulfonyl chloride;4-Methylbenzenesulfonylchloride;4-Methylphenylsulfonyl chloride;4-Toluenesulfonyl chloride;4-Toluensulfonyl chloride;4-Toluolsulfonyl chloride;4-Tosyl chloride;NSC175822;Toluenesulfonyl chloride;p-Methylbenzenesulfonylchloride;p-Methylphenylsulfonyl chloride;p-Toluenesulfochloride;p-Toluenesulfonic acid chloride;p-Toluenesulfonic chloride;p-Toluenesulphonylchloride;p-Tolylsulfonyl chloride;p-Tosyl chloride;p-Toluenesulfonylchloride (8CI);
PSA 42.52000
LogP 3.00330

Synthetic route

: 106-45-6
para-thiocresol

: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With dihydrogen peroxide; zirconium(IV) chloride In water; acetonitrile at 25℃; for 0.0166667h;	99%
With N,N,N',N'-tetrachlorobenzene-1,3-disulphonamide; tetrabutyl-ammonium chloride; water In acetonitrile at 0 - 20℃; for 0.333333h;	98%
With trichloroisocyanuric acid; water In acetonitrile at 0 - 20℃; for 0.333333h;	98%

: 15404-00-9
triethylammonium toluene-p-sulfonate

: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With sulfuryl dichloride; triphenylphosphine In dichloromethane for 1h; Ambient temperature;	99%

: 106-49-0
p-toluidine

: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
Stage #1: p-toluidine With hydrogenchloride; acetic acid; sodium nitrite In water; acetonitrile at 0 - 5℃; Stage #2: With sulfur dioxide; copper dichloride In water; acetonitrile at 20℃; for 16h;	99%
Stage #1: p-toluidine With hydrogenchloride; sodium nitrite Stage #2: With sulfur dioxide; copper(l) chloride In acetone

: 103-19-5
di(p-tolyl) disulfide

: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With dihydrogen peroxide; zirconium(IV) chloride In water; acetonitrile at 25℃; for 0.0166667h;	98%
With Oxone; potassium chloride In water at 20℃; for 0.166667h;	96%
With N,N,N',N'-tetrachlorobenzene-1,3-disulphonamide; tetrabutyl-ammonium chloride; water In acetonitrile at 0 - 20℃; for 0.333333h;	95%

: 104-15-4
toluene-4-sulfonic acid

: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With 1,3,5-trichloro-2,4,6-triazine; triethylamine In acetone for 20h; Heating;	96%
Stage #1: toluene-4-sulfonic acid With potassium phosphate; bis(trichloromethyl) carbonate In dichloromethane at 0 - 5℃; for 0.0833333h; Stage #2: With triethylamine In dichloromethane at 20℃; for 0.5h;	96%
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; potassium chloride at 25℃; for 0.0333333h; Neat (no solvent);	94%

: 146404-41-3
C15H17ClN2O2S

A: 32327-70-1
1-chloro-4-(2-chloroethyl)benzene

B: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With N-chloro-succinimide In tetrahydrofuran for 16h; Ambient temperature; Irradiation;	A 95% B n/a

: 657-84-1
sodium tosylate

: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With 1,3,5-trichloro-2,4,6-triazine; 18-crown-6 ether In acetone for 20h; Heating;	94%
Stage #1: sodium tosylate With potassium phosphate; bis(trichloromethyl) carbonate In dichloromethane at 0 - 5℃; for 0.0833333h; Stage #2: With triethylamine In dichloromethane at 20℃; for 0.5h;	93%
With trichlorophosphate In sulfolane; acetonitrile at 68 - 72℃; for 0.666667h;	87%

: 873-55-2
sodium benzenesulfonate

: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With chlorine In water; toluene Product distribution / selectivity;	93.9%

: 37091-73-9
2-chloro-1,3-dimethylimidazolinium chloride

: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene	93.2%

: 4358-63-8
phenyl benzenesulfonate

: 5720-05-8
4-methylphenylboronic acid

: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With phenylchlorosulfate; C43H43NO3PPdS; sodium carbonate In acetone at 20 - 50℃; Inert atmosphere; Sealed tube;	93%

: 108-88-3
toluene

: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With chlorosulfonic acid at 0℃; for 4h;	92%
With chlorosulfonic acid at 0 - 20℃;	84.21%
With chlorosulfonic acid

: 61124-61-6
3-phenylpropanal p-tosylhydrazone

A: p-toluenesulfonyl hydrazide hydrochloride

B: 80491-28-7
5-Benzyl-1,2,3-thiadiazole

C: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With disulfur dichloride In dichloromethane at 20℃; for 0.5h; Product distribution; other reagents (SOCl2, SCl2) and time;	A n/a B 89% C n/a

...Expand

: 146404-40-2
1-tosyl-1-hexadecylhydrazine

A: 4860-03-1
1-Chlorohexadecan

B: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With N-chloro-succinimide In tetrahydrofuran for 16h; Ambient temperature; Irradiation;	A 88% B n/a
With N-chloro-succinimide In tetrahydrofuran for 16h; Product distribution; Mechanism; Ambient temperature; Irradiation; reactions of N-substituted-N-tosylhydrazines with NCS and NBS;	A 88% B n/a

: 5362-76-5
mesityl oxide p-tosylhydrazone

A: 70-55-3
toluene-4-sulfonamide

B: 98-59-9
p-toluenesulfonyl chloride

C: 4-(2-Chloro-2-methyl-propyl)-[1,2,3]thiadiazole

D: 5-(1-Chloro-1-methyl-ethyl)-4-methyl-[1,2,3]thiadiazole

Conditions

Conditions	Yield
With sulfur dichloride In dichloromethane at 20℃; for 0.5h; Product distribution; other reagents (SOCl2, S2Cl2), products and time;	A n/a B n/a C 9% D 85%

...Expand

: 1666-13-3
diphenyl diselenide

: 1576-35-8
toluene-4-sulfonic acid hydrazide

A: 68819-94-3
p-tolyl benzeneselenosulfonate

B: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With sulfuryl dichloride; triethylamine In pyridine; dichloromethane at 0℃; Product distribution; various reagents for preparation of diverse selenosulfonates; mechanism is proposed;	A 83% B 11%

...Expand

: 1950-78-3
p-toluenesulfonyl iodide

: 981-18-0
triphenyl(phenylazo)methane

A: 591-50-4
iodobenzene

B: 2943-42-2
di(4-methyl)phenylthiosulfonate

C: 4124-41-8
p-toluenesulfonylanhydride

D: 42756-18-3
p-tolyl triphenylmethyl sulphone

E: 108-90-7
chlorobenzene

F: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
In tetrachloromethane at 0℃; for 2h; Product distribution;	A 82% B n/a C n/a D 78% E 1% F n/a

...Expand

: 141666-87-7
1-Tosyl-1-<2-(4-methoxyphenyl)ethyl>hydrazine

A: 98-59-9
p-toluenesulfonyl chloride

B: 18217-00-0
1-(2-Chloroethyl)-4-methoxybenzene

Conditions

Conditions	Yield
With N-chloro-succinimide In tetrahydrofuran for 16h; Ambient temperature; Irradiation;	A n/a B 82%

: 536-57-2
p-toluene sulfinic acid

: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With tert-butylhypochlorite In dichloromethane for 2h; Ambient temperature; chloramine-T, CH2Cl2, RT;	81%
With water; chlorine
With N-chloro-succinimide In tetrahydrofuran Ambient temperature; Irradiation; Yield given;
Multi-step reaction with 2 steps 1: 81 percent / CH2Cl2 / 2 h / Ambient temperature 2: 1.) n-butyllithium, 2.) SO2Cl2 / 1.) THF, hexane, -78 deg C, 2.) -78 deg C, 20 min View Scheme

: 110-91-8
morpholine

A: 934-34-9
2(3H)-Benzothiazolone

B: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
In pyridine 1)50 deg C, 2h 2)room temp., 20h;	A 13% B 81%

: 108-88-3
toluene

A: 98-59-9
p-toluenesulfonyl chloride

B: 133-59-5
Toluene-2-sulfonyl chloride

Conditions

Conditions	Yield
With chlorosulfonic acid; sodium chloride at -0.16℃;	A 80% B 20%
With chlorosulfonic acid for 3h; Cooling with ice;	A n/a B 72.04%
With sulfuric acid; sodium chloride Edukt 4: SO3;

: 41780-85-2
1-acetylcyclohexene p-tosylhydrazone

A: 70-55-3
toluene-4-sulfonamide

B: 98-59-9
p-toluenesulfonyl chloride

C: 4-(2-Chloro-cyclohexyl)-[1,2,3]thiadiazole

Conditions

Conditions	Yield
With sulfur dichloride In dichloromethane at 20℃; for 0.5h; Product distribution; other reagents (SOCl2, S2Cl2) and time;	A n/a B n/a C 80%

...Expand

: 100-83-4
meta-hydroxybenzaldehyde

: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With potassium carbonate	77%

: 23328-69-0
4-chloromorpholine

: 536-57-2
p-toluene sulfinic acid

A: 6339-26-0
4-tosylmorpholine

B: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
In dichloromethane for 0.5h; Ambient temperature;	A 76% B 10%

...Expand

: 824-79-3
sodium 4-methylbenzenesulfinate

: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With pyridine; (Dichloroiodo)benzene In 1,2-dichloro-ethane at 20 - 88℃; for 0.0166667h; Inert atmosphere; Reflux;	74%

: cis-2-hydroxymethyl-1-(2,4-dimethoxybenzyl)-3-(4,5-diphenyl-2-oxo-4-oxazolin-3-yl)-4-oxoazetidine

A: cis-3-(4,5-diphenyl-2-oxo-4-oxazolin-3-yl)-4-oxo-2-azetidinylmethyl mesylate

B: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
	A 73% B n/a

: 56410-24-3
N,N'-bis(p-toluenesulfonyl)hydroxylamine

A: 62419-04-9
bis(4-methylphenylsulfonyl)amino 4-methylbenzenesulfonate

B: 104-15-4
toluene-4-sulfonic acid

C: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With air In chloroform for 12h; Product distribution; Mechanism; Ambient temperature; various reaction conditions;	A 20% B 70% C 5%

...Expand

: 151259-26-6
C19H34N2O2S

A: 98-59-9
p-toluenesulfonyl chloride

B: 112-52-7
1-chlorododecane

Conditions

Conditions	Yield
With N-chloro-succinimide In tetrahydrofuran for 16h; Ambient temperature; Irradiation;	A n/a B 68%

: 1950-69-2
toluene-p-sulfonyl bromide

: 981-18-0
triphenyl(phenylazo)methane

A: 108-86-1
bromobenzene

B: 2943-42-2
di(4-methyl)phenylthiosulfonate

C: 42756-18-3
p-tolyl triphenylmethyl sulphone

D: 108-90-7
chlorobenzene

E: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
In tetrachloromethane for 30h; Product distribution; Heating;	A 67% B n/a C 56% D 6% E n/a

...Expand

: 10439-23-3
4-methylbenzenesulfinyl chloride

: 2696-32-4
but-3-en-1-ynyl-trimethyl-silane

A: 98-59-9
p-toluenesulfonyl chloride

B: [3-Chloro-4-(toluene-4-sulfinyl)-but-1-ynyl]-trimethyl-silane

C: [1-Chloro-4-(toluene-4-sulfinyl)-buta-1,2-dienyl]-trimethyl-silane

Conditions

Conditions	Yield
aluminium trichloride In diethyl ether Ambient temperature;	A n/a B 66% C n/a

...Expand

: 97-99-4
Tetrahydrofurfuryl alcohol

: 98-59-9
p-toluenesulfonyl chloride

: 34583-63-6
rac-(tetrahydrofuran-2-yl)methyl 4-methylbenzenesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 1h;	100%
With potassium hydroxide	93%
With potassium iodide; silver(l) oxide In dichloromethane at 40℃;	91%

: 504-29-0
2-aminopyridine

: 98-59-9
p-toluenesulfonyl chloride

: 52776-76-8
N-(2-pyridyl)-p-toluenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 4℃;	100%
at 20℃; for 0.1h;	88%
With sodium carbonate In water	82.1%

: 578-66-5
8-amino quinoline

: 98-59-9
p-toluenesulfonyl chloride

: 10304-39-9
4-methyl-N-quinolin-8-yl-benzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 4℃;	100%
With pyridine at 130℃; for 0.05h; Microwave irradiation; Inert atmosphere;	97%
With pyridine at 130℃; for 0.166667h;	90%

: 61-54-1
tryptamine

: 98-59-9
p-toluenesulfonyl chloride

: 86658-78-8
N-tosyl tryptamine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	100%
With triethylamine In dichloromethane at 0 - 20℃;	99%
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	99%

: 536-90-3
m-Anisidine

: 98-59-9
p-toluenesulfonyl chloride

: 58750-87-1
N-tosyl-m-anisidine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 28h;	100%
With triethylamine In dichloromethane at 4℃;	100%
With triethylamine In tetrahydrofuran at 20℃; for 15h;	95%

: 551-93-9
2-aminoacetophenone

: 98-59-9
p-toluenesulfonyl chloride

: 1859-70-7
N-(2-acetylphenyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 10.5h;	100%
With triethylamine In dichloromethane at 4℃;	100%
With pyridine In dichloromethane at 20℃; for 1h;	97%

: 134-32-7
1-amino-naphthalene

: 98-59-9
p-toluenesulfonyl chloride

: 18271-17-5
N-tosyl-1-naphthylamine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 4℃;	100%
With pyridine	98%
at 20℃; for 0.166667h;	94%

: 92-67-1
4-Aminobiphenyl

: 98-59-9
p-toluenesulfonyl chloride

: 65690-69-9
N-([1,1'-biphenyl]-4-yl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 4℃;	100%
With pyridine at 0 - 20℃; for 15h; Inert atmosphere;	75%
With pyridine

: 108-91-8
cyclohexylamine

: 98-59-9
p-toluenesulfonyl chloride

: 80-30-8
N-cyclohexyl-p-toluenesulfonamide

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 0.5h; Inert atmosphere;	100%
With pyridine at 0 - 25℃; Inert atmosphere; Schlenk technique;	99%
With triethylamine In tetrahydrofuran at 0 - 20℃;	95%

: 106-49-0
p-toluidine

: 98-59-9
p-toluenesulfonyl chloride

: 599-86-0
4-methyl-N-(4-methylphenyl)benzenesulfonamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 16h;	100%
With pyridine at 0 - 25℃;	100%
In water at 110℃; for 0.0833333h; Microwave irradiation; Green chemistry; chemoselective reaction;	98%

: 106-47-8
4-chloro-aniline

: 98-59-9
p-toluenesulfonyl chloride

: 2903-34-6
4-methyl-N-(4-chlorophenyl)benzenesulfonamide

Conditions

Conditions	Yield
In pyridine; acetonitrile at 20℃; for 16h;	100%
In ethanol; water at 25℃; for 0.333333h;	96%
With (Na1752K0.144Ca0365Mg0.065)(Al2044Si2774O96)*19.16H2O In ethanol at 25 - 30℃; for 0.25h; Sonication; Green chemistry;	95%

: 104-94-9
4-methoxy-aniline

: 98-59-9
p-toluenesulfonyl chloride

: 1150-26-1
N-(4-Methoxy-phenyl)-4-methyl-benzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 4℃;	100%
With pyridine for 16h; Reflux;	97%
With dendritic fibrous nanosilica KCC-1 3-aminopropyl-functionalized supported on Fe3O4 magnetic nanocatalyst In water at 20℃; for 0.5h; Solvent; Temperature; Reagent/catalyst; Time; Green chemistry;	97%

: 90-41-5
2-phenylaniline

: 98-59-9
p-toluenesulfonyl chloride

: 24310-30-3
N-biphenyl-2-yl-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 4℃;	100%
With sodium hydrogencarbonate In water; acetone at 25℃; for 0.25h;	97%
With pyridine at 0 - 25℃; for 1h;	92%

: 141-43-5
ethanolamine

: 98-59-9
p-toluenesulfonyl chloride

: 14316-14-4
N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 24h;	99%
With pyridine at 5 - 20℃;	96%

: 110-58-7
1-pentanamine

: 98-59-9
p-toluenesulfonyl chloride

: 106011-68-1
4-methyl-N-pentylbenzenesulfonamide

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 12h;	100%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;	89%
With triethylamine In dichloromethane at 0℃; for 0.0833333h;	85%

: 107-19-7
propargyl alcohol

: 98-59-9
p-toluenesulfonyl chloride

: 6165-76-0
propargyl p-toluenesulfonate

Conditions

Conditions	Yield
With sodium hydroxide In diethyl ether; water at 0 - 20℃; for 17h;	100%
With potassium hydroxide In diethyl ether at -5 - 20℃;	96%
With potassium hydroxide In diethyl ether at -5 - 0℃; for 0.5h;	95%

: 108-69-0
3,5-dimethylaminoaniline

: 98-59-9
p-toluenesulfonyl chloride

: 114097-28-8
N-(3,5-dimethylphenyl)-4-methyl-benzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 4℃;	100%
With silica gel at 20℃;	95%
With triethylamine In dichloromethane at 0 - 20℃;	82%

: 99-98-9
4-amino-N,N-dimethylaniline

: 98-59-9
p-toluenesulfonyl chloride

: 19766-55-3
N-(4-(dimethylamino)phenyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With pyridine for 1h; Reflux;	100%
With caesium carbonate In acetonitrile at 25℃; for 0.333333h;	93%
indium In acetonitrile at 20℃; for 6h;	90%

: 100-01-6
4-nitro-aniline

: 98-59-9
p-toluenesulfonyl chloride

: 734-25-8
N-(4-nitrophenyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 4℃;	100%
With (Na1752K0.144Ca0365Mg0.065)(Al2044Si2774O96)*19.16H2O In ethanol at 25 - 30℃; for 2h; Sonication; Green chemistry;	96%
With pyridine In dichloromethane at 20℃; for 12h;	94%

: 88-74-4
2-nitro-aniline

: 98-59-9
p-toluenesulfonyl chloride

: 6380-13-8
4-methyl-N-(2-nitrophenyl)benzene sulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 4℃;	100%
With pyridine In dichloromethane at 20℃; for 48h;	90%
With pyridine In dichloromethane at 20℃; for 16h;	75%

: 124-40-3
dimethyl amine

: 98-59-9
p-toluenesulfonyl chloride

: 599-69-9
N,N,4-trimethylbenzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 25℃; for 1h;	100%
	99%
With cesium fluoride supported on Celite at 50℃; for 0.75h; chemoselective reaction;	91%

: 75-31-0
isopropylamine

: 98-59-9
p-toluenesulfonyl chloride

: 21230-07-9
N-isopropyl-p-toluenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%
With pyridine; dmap In dichloromethane at 0 - 20℃; for 16h;	99%
With pyridine at 0 - 25℃; Inert atmosphere; Schlenk technique;	99%

: 107-15-3
ethylenediamine

: 98-59-9
p-toluenesulfonyl chloride

: 4403-78-5
ditosylethylenediamine

Conditions

Conditions	Yield
In pyridine at 20℃;	100%
With pyridine at 0 - 20℃;	95%
With sodium hydroxide In diethyl ether at 20℃;	94%

: 109-76-2
Trimethylenediamine

: 98-59-9
p-toluenesulfonyl chloride

: 53364-99-1
N,N'-ditoluenesulfonyl-1,3-diaminopropane

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran; water at 0.2℃; for 3h; Inert atmosphere;	100%
at 80℃; for 0.5h;	95%
With potassium carbonate In tetrahydrofuran; water at 23℃; for 10h;	95%

: 62-53-3
aniline

: 98-59-9
p-toluenesulfonyl chloride

: 68-34-8
phenyl toluenesulfonamide

Conditions

Conditions	Yield
With pyridine for 16h; Reflux;	100%
With pyridine In dichloromethane at 20℃; for 16h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere;	100%

: 134-20-3
2-carbomethoxyaniline

: 98-59-9
p-toluenesulfonyl chloride

: 50998-74-8
methyl N-tosylanthranilate

Conditions

Conditions	Yield
In pyridine at 25℃;	100%
Stage #1: 2-carbomethoxyaniline With pyridine In dichloromethane at 25℃; for 1h; Inert atmosphere; Stage #2: p-toluenesulfonyl chloride In dichloromethane at 25℃; for 24h; Inert atmosphere;	99%
In pyridine at 0℃; for 1h;	98%

: 110-80-5
2-ethoxy-ethanol

: 98-59-9
p-toluenesulfonyl chloride

: 17178-11-9
2-ethoxyethyl p-toluenesulfonate

Conditions

Conditions	Yield
With pyridine at 0℃;	100%
With sodium hydroxide In tetrahydrofuran; water	85%
With triethylamine In dichloromethane at 20℃; for 4h;	81.1%

: 100-02-7
4-nitro-phenol

: 98-59-9
p-toluenesulfonyl chloride

: 1153-45-3
4-nitrophenyl 4-methylbenzenesulfonate

Conditions

Conditions	Yield
Stage #1: 4-nitro-phenol; p-toluenesulfonyl chloride With potassium carbonate In acetone at 20 - 25℃; for 2.5h; Stage #2: With hydrogenchloride In water; acetone	100%
With triethylamine In dichloromethane at 20℃; for 24h; Inert atmosphere;	99%
With potassium carbonate for 0.0833333h; microwave irradiation;	98%

: 77-85-0
2-(hydroxymethyl)-2-methylpropane-1,3-diol

: 98-59-9
p-toluenesulfonyl chloride

: 2387-43-1
2-methyl-2-((tosyloxy)methyl)propane-1,3-diyl bis(4-methylbenzenesulfonate)

Conditions

Conditions	Yield
With pyridine at 20℃; for 16h; Inert atmosphere;	100%
With pyridine at 0 - 20℃;	90%
With pyridine In chloroform	81%

: 122-99-6
2-Phenoxyethanol

: 98-59-9
p-toluenesulfonyl chloride

: 43224-81-3
2-phenoxyethanol tosylate

Conditions

Conditions	Yield
Stage #1: 2-Phenoxyethanol; p-toluenesulfonyl chloride With dmap In dichloromethane at 20℃; Stage #2: With triethylamine In dichloromethane at 20℃;	100%
With pyridine	86%
With pyridine at 20℃; for 4h;	24%

Tosyl chloride Chemical Properties

IUPAC Name: 4-Methylbenzenesulfonyl chloride
Following is the structure of Tosyl chloride (CAS NO.98-59-9):

Empirical Formula: C₇H₇ClO₂S
Molecular Weight: 190.6473
EINECS: 202-684-8
Index of Refraction: 1.545
Molar Refractivity: 45.02 cm³
Molar Volume: 142.3 cm³
Storage temp.: Store at RT.
Water Solubility: hydrolyses
Density: 1.339 g/cm³
Flash Point: 114.3 °C
Melting point: 65-69 °C(lit.)
Surface Tension: 41 dyne/cm
Enthalpy of Vaporization: 48.3 kJ/mol
Boiling Point: 265.3 °C at 760 mmHg
Vapour Pressure: 0.0151 mmHg at 25 °C
Appearance: White to yellow solid
Solubility of Tosyl chloride (CAS NO.98-59-9): Methylene chloride: 0.2 g/mL, clear
Product Categories of Tosyl chloride (CAS NO.98-59-9): Benzene derivatives; FINE Chemical & INTERMEDIATES; Protection & Derivatization Reagents (for Synthesis); Sulfur Compounds (for Synthesis); Synthetic Organic Chemistry
Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)Cl
InChI: InChI=1S/C7H7ClO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3
InChIKey: YYROPELSRYBVMQ-UHFFFAOYSA-N

Tosyl chloride Uses

Tosyl chloride (CAS NO.98-59-9) can be used as analytics reagents,and organic synthesis etc.

Tosyl chloride Safety Profile

Hazard Codes: Corrosive C
Risk Statements 34-29
R34:Causes burns.
R29:Contact with water liberates toxic gas.
Safety Statements 26-36/37/39-45-27
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S27:Take off immediately all contaminated clothing.
RIDADR: UN 3261 8/PG 2
WGK Germany: 1
F: 9-21
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: II
HS Code: 29049020
Hazardous Substances Data: 98-59-9(Hazardous Substances Data)

Tosyl chloride Specification

Tosyl chloride , its cas register number is 98-59-9. It also can be called 4-Toluene sulfochloride ; 4-Methylbenzenesulfonyl chloride ; p-Toluenesulfonyl chloride ; Toluene-4-sulfonyl chloride ; 4-Toluolsulfonyl chloride ; and p-Tosyl Chloride .

Product Name

Tosyl chloride

Synthetic route

Tosyl chloride Chemical Properties

Tosyl chloride Uses

Tosyl chloride Safety Profile

Tosyl chloride Specification

Related Products

Hot Products