N-(n-butyl)-2,4-dinitrotrifluoroacetanilide
A
2,4-dinitro-N-butylaniline
B
trifluoroacetic anhydride
Conditions | Yield |
---|---|
With tris buffers; cetyltrimethylammonim bromide at 25℃; Rate constant; hydrolysis, other quaterner amines; | A 99.7% B n/a |
Conditions | Yield |
---|---|
With fuming sulphuric acid at 130℃; Large scale; | 99% |
With fuming sulphuric acid at 78 - 130℃; Large scale; | 99% |
With sulfuric acid; sulfur trioxide at 130℃; | 99% |
trifluoromethyldiiodophosphine
silver trifluoroacetate
A
Trifluormethylphosphonigsaeure-bis(trifluoressigsaeure)anhydrid
B
trifluoroacetic anhydride
Conditions | Yield |
---|---|
within 10 h; | A n/a B 98% |
10 min; isolation from volatile part of product; | A n/a B 72% |
trifluorormethanesulfonic acid
trifluoroacetic acid
A
trifluoroacetic anhydride
B
trifluoroacetyl triflate
Conditions | Yield |
---|---|
With phosphorus pentoxide at -20 - 240℃; for 3.5h; | A n/a B 75% |
Cl2SNTeF5
silver trifluoroacetate
A
F5TeNSO
B
trifluoroacetic anhydride
Conditions | Yield |
---|---|
In neat (no solvent) Cl2S=NTeF5 and CF3COOAg stirred at room temp. and warmed to 45°Cand stirred for 1 h; O=S=NTeF5 and (CF3CO)2O condensed into -196°C trap under vac., separation achieved by trap-to-trap distillation through -45 (O=S=NTeF5) and -78°C cooled traps; elem. anal.; | A 68% B n/a |
2,2,2-trifluoroethyl trifluoroacetate
A
Carbonyl fluoride
B
trifluoroacetic anhydride
Conditions | Yield |
---|---|
With chlorine at 22.84℃; under 760 Torr; Irradiation; Synthetic gas; | A 35% B 45% |
mercury(II) trifluoroacetate
chloro(chlorosulfanyl)methanone
trifluoroacetic anhydride
Conditions | Yield |
---|---|
at 50 - 55℃; for 3h; | 30% |
O,O-Diethyl O-Trifluoroacetyl Phosphate
A
Tetraethyl pyrophosphate
B
trifluoroacetic anhydride
Conditions | Yield |
---|---|
Erhitzen im Vakuum; |
tris(trifluoro acetyloxy)borane
A
tetrakis-trifluoroacetoxy-diboroxane
B
trifluoroacetic anhydride
Conditions | Yield |
---|---|
at 100℃; under 0.0001 Torr; | |
at 100℃; under 0.0001 Torr; |
Conditions | Yield |
---|---|
With phosphorus at 180℃; | |
With sulfur at 300℃; |
calcium bistrifluoroacetate
A
trifluoroacetyl fluoride
B
trifluoroacetic anhydride
trifluoroacetic acid
A
trifluoroacetyl fluoride
B
trifluoroacetic anhydride
Conditions | Yield |
---|---|
Erhitzen des Lithium-Salzes; |
Bis(trifluormethyl)phosphinigsaeure-trifluoressigsaeureanhydrid
A
Tetrakis(trifluormethyl)disphosphoxan
B
trifluoroacetic anhydride
Conditions | Yield |
---|---|
at 40℃; Equilibrium constant; | |
within 24 h; | |
equil.; |
trifluoromethyl isocyanide
trifluoroacetic acid
A
N-(trifluoromethyl)formamide
B
trifluoroacetic anhydride
Conditions | Yield |
---|---|
Ambient temperature; Yield given. Yields of byproduct given; |
trifluoroacetic acid
trifluoroacetyl triflate
A
trifluorormethanesulfonic acid
B
trifluoroacetic anhydride
Conditions | Yield |
---|---|
Equilibrium constant; |
N-Allyl-9-anthracenemethanimine
A
2-(Trifluoroacetyl)-1,2,3,3a,4,5-hexahydro-5,9b-o-benzenobenzisoindol-1-ol
B
trifluoroacetic anhydride
Conditions | Yield |
---|---|
In dichloromethane for 24h; Ambient temperature; Title compound not separated from byproducts; |
3,6-dehydrohomoadamantane
chromyl trifluoroacetate
A
trifluoroacetic anhydride
Conditions | Yield |
---|---|
In tetrachloromethane at 0℃; for 0.5h; | A 17 % Spectr. B 34 % Spectr. C 42 % Spectr. |
Caesium; 2,3,3,3-tetrafluoro-2-methoxy-propionate
A
Carbonyl fluoride
B
trifluoroacetyl fluoride
C
methyl 1,2,2-trifluorovinyl ether
D
2-fluoro-2-methoxy trifluoropropanoic acid methyl ester
E
α-methoxytetrafluoropropionyl fluoride
F
trifluoroacetic anhydride
Conditions | Yield |
---|---|
at 250℃; under 0.01 Torr; for 1.5h; Product distribution; Mechanism; |
iodine
silver trifluoroacetate
benzene
A
iodobenzene
B
trifluoroacetic anhydride
iodo-bis-trifluoromethyl-phosphine
silver trifluoroacetate
A
Bis(trifluormethyl)phosphinigsaeure-trifluoressigsaeureanhydrid
B
Tetrakis(trifluormethyl)disphosphoxan
C
trifluoroacetic anhydride
Conditions | Yield |
---|---|
byproducts: AgI; below 20°C; further react. in equil.; distn.; main product as medium fraction at 0°C / 55 Torr; |
Trifluormethylphosphonigsaeure-bis(trifluoressigsaeure)anhydrid
A
Tetrakis(trifluormethyl)disphosphoxan
B
trifluoroacetic anhydride
Conditions | Yield |
---|---|
18.5 degree.C; equil.; value for equil. const. given at 40°C; |
Trifluormethylphosphonigsaeure-bis(trifluoressigsaeure)anhydrid
trifluoroacetic anhydride
Conditions | Yield |
---|---|
With (CH3)3N formation from unidentified intermediate product; |
A
yttrium(III) fluoride
B
carbon dioxide
C
carbon monoxide
D
trifluoroacetic anhydride
Conditions | Yield |
---|---|
With O2 or Ar In neat (no solvent) decompn. at 300 ° C in Ar and at 230-270 ° C in O2; YF3 formed; |
Conditions | Yield |
---|---|
In neat (no solvent) pyrolysis at 240°C within 24 hours;; |
ethyl trifluoroacetate,
hydrazine
A
1,2-bis(trifluoroacetyl)hydrazine
B
trifluoroacetic acid
C
trifluoroacetic anhydride
Conditions | Yield |
---|---|
In ethanol dropping of soln. of CF3COOC2H5 in abs. alc. to N2H4 soln. in anhydrous C2H5OH by cooling, stirring at 20°C (12 h); evapn. of C2H5OH, stirring at 20°C (12 h); |
S-trifluoromethylcarbonothioic trifluoroacetic anhydride
S,S'-Bis(trifluormethyl)dithiocarbonat
B
trifluoroacetic anhydride
Conditions | Yield |
---|---|
Irradiation (UV/VIS); photolysis; | |
Irradiation (UV/VIS); photolysis; |
Trifluoromethyliodine(III) bis-trifluoroacetate
A
iodotrifluoromethane
B
trifluoromethyliodine dioxide
C
trifluoroacetic anhydride
Conditions | Yield |
---|---|
above -6°C; |
Conditions | Yield |
---|---|
100% | |
With benzene | |
With 1H-imidazole |
4-chloro-aniline
trifluoroacetic anhydride
N-(4-chlorophenyl)-2,2,2-trifluoroacetamide
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0 - 20℃; for 0.75h; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; for 2h; | 88% |
In diethyl ether for 1h; Ambient temperature; | 84% |
4-methoxy-aniline
trifluoroacetic anhydride
2,2,2-trifluoro-N-(4-methoxy-phenyl)-acetamide
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 20℃; | 100% |
With triethylamine In tetrahydrofuran at 0 - 20℃; for 0.75h; | 100% |
at 20℃; for 1h; | 98.3% |
isopropylamine
trifluoroacetic anhydride
2,2,2-trifluoro-N-(1-methylethyl)acetamide
Conditions | Yield |
---|---|
With pyridine; dmap In tetrahydrofuran at 20℃; for 15h; | 100% |
With diethyl ether | |
In diethyl ether | |
at 0℃; than Rt, 3 h; | |
In dichloromethane at 20℃; Inert atmosphere; Schlenk technique; Glovebox; |
Conditions | Yield |
---|---|
erbium(III) triflate In acetonitrile at 20℃; for 8h; | 100% |
at 100℃; Cooling with ice; | 93% |
Conditions | Yield |
---|---|
erbium(III) triflate In acetonitrile at 20℃; for 0.166667h; | 100% |
With erbium(III) chloride for 2h; Heating; | 99% |
In diethyl ether at 0℃; for 2h; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
With water-d2 at -78℃; | 100% |
With water-d2 | |
With water-d2 1.) 0 deg C, 2.) reflux, 30 min; |
m-Anisidine
trifluoroacetic anhydride
N-(3-methoxyphenyl)-2,2,2-trifluoroacetamide
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0 - 20℃; for 0.75h; | 100% |
In diethyl ether | |
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere; | |
With triethylamine | |
at 20℃; for 3h; Inert atmosphere; |
2-methoxy-phenylamine
trifluoroacetic anhydride
N-(2-methoxyphenyl)-2,2,2-trifluoro-acetamide
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0 - 20℃; for 0.75h; | 100% |
With pyridine In dichloromethane at 0 - 20℃; for 72h; Inert atmosphere; | 99% |
In diethyl ether | |
Stage #1: 2-methoxy-phenylamine With pyridine In dichloromethane at 0℃; for 0.5h; Stage #2: trifluoroacetic anhydride In dichloromethane at 0 - 30℃; for 1.25h; | |
With pyridine In dichloromethane at 0 - 20℃; for 1.25h; |
anthranilic acid
trifluoroacetic anhydride
2-trifluoromethyl-4H-3,1-benzoxazin-4-one
Conditions | Yield |
---|---|
In neat (no solvent) at 130℃; for 6h; Sealed tube; Inert atmosphere; | 100% |
In chloroform for 1h; Reflux; | 56% |
In ethyl acetate |
2,3-Dimethylaniline
trifluoroacetic anhydride
N-(2,3-dimethylphenyl)-2,2,2-trifluoroacetamide
Conditions | Yield |
---|---|
In dichloromethane for 1h; Further stages; | 100% |
With triethylamine In dichloromethane for 1h; Ambient temperature; | 87% |
In diethyl ether | |
In dichloromethane at 0 - 20℃; for 12h; |
Conditions | Yield |
---|---|
erbium(III) triflate In acetonitrile at 20℃; for 4h; | 100% |
Conditions | Yield |
---|---|
With pyridine; dmap In dichloromethane at 0℃; for 0.333333h; | 100% |
L-cystine dimethyl ester dihydrochloride
trifluoroacetic anhydride
N,N'-bis(trifluoroacetyl)-L-cystine dimethyl ester
Conditions | Yield |
---|---|
With trifluoroacetic acid at -5 - 20℃; | 100% |
In trifluoroacetic acid Ambient temperature; | 98% |
90% | |
In trifluoroacetic acid |
1-indoline
trifluoroacetic anhydride
2,2,2-trifluoro-1-(indolin-1-yl)ethan-1-one
Conditions | Yield |
---|---|
With triethylamine In dichloromethane | 100% |
In dichloromethane at 0℃; for 1h; Inert atmosphere; | 100% |
In benzene at 0 - 5℃; | 96% |
1,2,3,4-tetrahydroisoquinoline
trifluoroacetic anhydride
1-(3,4-dihydroquinolin-1(2H)-yl)-2,2,2-trifluoroethanone
Conditions | Yield |
---|---|
With triethylamine In diethyl ether at 0 - 20℃; for 5h; | 100% |
With triethylamine In diethyl ether at 20℃; for 5h; | 100% |
With triethylamine In diethyl ether at 0 - 20℃; | 98% |
4,6-di-O-acetyl-3-O-methyl-D-glucal
trifluoroacetic anhydride
Trifluoro-acetic acid (4R,5S,6R)-5-acetoxy-6-acetoxymethyl-4-methoxy-3-nitro-tetrahydro-pyran-2-yl ester
Conditions | Yield |
---|---|
With ammonium nitrate for 1h; | 100% |
Conditions | Yield |
---|---|
In benzene 1) 0 degC, 3 h, 2) 20 degC, 1 h; | 100% |
1-(3-aminophenyl)ethanone
trifluoroacetic anhydride
3-trifluoroacetamidoacetophenone
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0℃; for 0.5h; | 100% |
In N,N-dimethyl-formamide for 48h; Ambient temperature; | 80% |
With trifluoroacetic acid Heating; |
3-trifluoromethylaniline
trifluoroacetic anhydride
2,2,2-trifluoro-N-(3-(trifluoromethyl)phenyl)acetamide
Conditions | Yield |
---|---|
With triethylamine In 2-methyltetrahydrofuran | 100% |
Stage #1: 3-trifluoromethylaniline; trifluoroacetic anhydride With pyridine In dichloromethane at 0 - 20℃; Stage #2: With sodium hydrogencarbonate In dichloromethane | 98% |
In N,N-dimethyl-formamide for 48h; Ambient temperature; | 70% |
With triethylamine In tetrahydrofuran at 0 - 20℃; | 51.1% |
In dichloromethane |
Conditions | Yield |
---|---|
for 0.5h; | 100% |
2-(5,8-Dimethoxy-quinolin-4-yl)-phenylamine
N-ethyl-N,N-diisopropylamine
trifluoroacetic anhydride
N-[2-(5,8-Dimethoxy-quinolin-4-yl)-phenyl]-2,2,2-trifluoro-acetamide
Conditions | Yield |
---|---|
at 0℃; for 0.5h; | 100% |
3-nitro-aniline
trifluoroacetic anhydride
N-trifluoroacetic-3-nitroaniline
Conditions | Yield |
---|---|
In pyridine; dichloromethane | 100% |
With pyridine In dichloromethane at 20℃; for 3h; | 95% |
In acetonitrile for 2h; Ambient temperature; |
4-Methyl-2H-1,4-thiazin-3-one
trifluoroacetic anhydride
6-Trifluoroacetyl-4-methyl-2H-1,4-thiazin-3-one
Conditions | Yield |
---|---|
With pyridine In chloroform for 1080h; Ambient temperature; | 100% |
2-methyl-8-nitroindolizine
trifluoroacetic anhydride
2,2,2-Trifluoro-1-(2-methyl-8-nitro-indolizin-3-yl)-ethanone
Conditions | Yield |
---|---|
100% |
1,2-O-isopropylidene-3-amino-3,5-dideoxy-α-D-ribofuranoside
trifluoroacetic anhydride
3,5-dideoxy-3-(trifluoroacetamido)-1,2-O-isopropylidene-α-D-ribofuranose
Conditions | Yield |
---|---|
In diethyl ether 1.) 0 deg C, 0.5 h, 2.) RT, 30 min; | 100% |
N,N-dimethyl-1-naphthalenamine
trifluoroacetic anhydride
N,N-Dimethyl-2,4-bis(trifluoroacetyl)-1-naphthylamine
Conditions | Yield |
---|---|
With pyridine In chloroform for 18h; Ambient temperature; | 100% |
With pyridine In chloroform for 19h; Ambient temperature; 2.5 eq. (CF3CO)2O; |
2,3,4,6-tetra-O-benzyl-D-glucopyranose
trifluoroacetic anhydride
2,3,4,6-tetra-O-benzyl-1-O-(trifluoroacetyl)-α-D-glucopyranose
Conditions | Yield |
---|---|
With sodium 2,2,2-trifluoroacetate for 0.5h; Heating; | 100% |
3,4,6-tri-O-acetyl-D-glucal
trifluoroacetic anhydride
Trifluoro-acetic acid (4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-nitro-tetrahydro-pyran-2-yl ester
Conditions | Yield |
---|---|
With ammonium nitrate for 1h; | 100% |
Conditions | Yield |
---|---|
erbium(III) triflate In acetonitrile at 20℃; for 2.5h; | 100% |
With erbium(III) chloride for 1.5h; Heating; | 99% |
With triethylamine In benzene at 25 - 30℃; for 1h; |
Product Name: Trifluoroacetic anhydride
Molecular Formula: C4F6O3
Molecular Weight: 210.03g/mol
Mol File: 407-25-0.mol
Einecs: 206-982-9
Appearance: Clear, colorless liquid
Melting Point: -65 °C, 208 K, -85 °F
Boiling point: 40 °C, 313 K, 104 °F
Storage Temperature: 2-8°C
Density: 1.641 g/cm3
Index of Refraction: 1.291
Water Solubility: Hydrolysis
Sensitive: Moisture Sensitive
Surface Tension: 19.3 dyne/cm
Enthalpy of Vaporization: 28.41 kJ/mol
Vapour Pressure of Trifluoroacetic anhydride (CAS NO.407-25-0): 439 mmHg at 25 °C
Product Categories: Halogen compounds; Organics; Organic Fluorides; Acylation (GC Derivatizing Reagents); Analytical Chemistry; Fluorinated Building Blocks; Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds; GC Derivatizing Reagents; Synthetic Organic Chemistry
Trifluoroacetic anhydride (CAS NO.407-25-0) may be prepared from trifluoroacetic acid by dehydrating with excess α-halogenated acid chlorides. For example, with dichloroacetyl chloride:
2 CF3COOH + Cl2CHCOCl → (CF3CO)2O + Cl2CHCOOH + HCl
Trifluoroacetic anhydride (CAS NO.407-25-0) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.
Safety Information of Trifluoroacetic anhydride (CAS NO.407-25-0):
Hazard Codes: C,T
Risk Statements: 14-20-35-52/53-34-23/24/25
14: Reacts violently with water
20: Harmful by inhalation
23: Toxic by inhalation
24: Toxic in contact with skin
25: Toxic if swallowed
34: Causes burns
35: Causes severe burns
52: Harmful to aquatic organisms
53: May cause long-term adverse effects in the aquatic environment
Safety Statements: 26-36/37/39-43-45-61-9-8-28A-27
8: Keep container dry
9: Keep container in a well-ventilated
place
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27: Take off immediately all contaminated clothing
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
43: In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add - Never use water)
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
Trifluoroacetic anhydride , its CAS NO. is 407-25-0,the synonyms is Aceticacid,trifluoro-,anhydride ; Anhydrid kyseliny trifluoroctove ; Anhydridkyselinytrifluoroctove ; Hexafluoroacetic anhydride ; Hexafluoroaceticanhydride ; Perfluoroacetic anhydride ; Perfluoroaceticanhydride ; Trifluoroacetic . In addition, Trifluoroacetic anhydride (CAS NO.407-25-0) could be stable under normal temperatures and pressures, and it absorbs moisture or water from the air. It is not compatible with water, metals, strong oxidizing agents, strong acids, strong bases, alcohols, alkali metals. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide, hydrogen fluoride gas, fluorine. It will not occur hazardous polymerization.
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