Trifluoromethanesulfonyl chloride supplier

Name
TRIFLUOROMETHANESULFONYL CHLORIDE
EINECS 207-009-0
CAS No. 421-83-0
Article Data39
CAS DataBase
Density 1.795 g/cm³
Solubility Hydrolyzes with water.
Melting Point -26 °C
Formula CClF₃O₂S
Boiling Point 30.5 °C at 760 mmHg
Molecular Weight 168.524
Flash Point 32°C
Transport Information UN 3265 8/PG 2
Appearance Clear colorless to faintly colored liquid
Safety 25-36/37/39-45
Risk Codes 34-14
Molecular Structure
Hazard Symbols C
Synonyms Trifluoromethylsulfonyl chloride;Trifluoromethylsulfuryl chloride;Trifluoromethylsulphonyl chloride;trifluoromethanesulfonyl chloride;Methanesulfonyl chloride, 1,1,1-trifluoro-;Methanesulfonyl chloride, trifluoro-;
PSA 42.52000
LogP 2.15560

Synthetic route

: 421-17-0
Trifluoromethylsulfenyl chloride

: 7732-18-5
water

: 7782-50-5
chlorine

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
excess of Cl2 and H2O, 20°C, 7 days;	98%
excess of Cl2 and H2O, 20°C, 7 days;	98%

...Expand

: PCl5*ZnCl2

: 54010-75-2
zinc trifluoromethanesulfonate

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
260°C, 2 h;	94%
260°C, 2 h;	94%

: 1493-13-6
trifluorormethanesulfonic acid

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
With thionyl chloride; N,N-dimethyl-formamide at 40℃; for 12h; Cooling with ice; Green chemistry;	87.5%
With phosphorus pentachloride at 100℃;	85%
With phosphorus pentachloride

: 67-56-1
methanol

: 25030-42-6, 42179-04-4
trans-chlorotetrafluoro(trifluoromethyl)sulfur(VI)

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
in presence of (CH3)4N, 25°C, 10 h;	75%
in presence of (CH3)4N, 25°C, 10 h;	75%

: 7782-50-5
chlorine

: 344324-36-3
pentafluoroethanesulfinic acid

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
In acetic acid chlorination;	74.6%
In acetic acid chlorination;	74.6%

: 351-60-0
benzyl trifluoromethyl sulfide

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
With chlorine In water at 5℃; under 3040 Torr; for 2h;	70%

: 932-72-9
(Dichloroiodo)benzene

: 344324-36-3
pentafluoroethanesulfinic acid

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
chlorination;	65.7%
chlorination;	65.7%

: 1493-13-6
trifluorormethanesulfonic acid

: 10026-13-8, 874483-75-7
phosphorus pentachloride

A: 421-83-0
trifluoromethane sulfonyl chloride

B: 10025-87-3, 12599-09-6, 63736-95-8
trichlorophosphate

Conditions

Conditions	Yield
	A 63% B n/a
	A 63% B n/a

...Expand

: 54010-75-2
zinc trifluoromethanesulfonate

: 7646-85-7
zinc(II) chloride

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
anhydr. ZnCl2, heating, Fischer burner, 4 h; fractional distn.;	43%
anhydr. ZnCl2, heating, Fischer burner, 4 h; fractional distn.;	43%

: 421-17-0
Trifluoromethylsulfenyl chloride

: 7722-84-1
dihydrogen peroxide

A: 372-64-5
Bis(trifluoromethyl)disulfid

B: 1493-13-6
trifluorormethanesulfonic acid

C: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
35% H2O2 soln.;	A 35% B 7% C 40%
35% H2O2 soln.;	A 35% B 7% C 40%

...Expand

: 25030-42-6, 42179-04-4
trans-chlorotetrafluoro(trifluoromethyl)sulfur(VI)

: 124-41-4
sodium methylate

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
25°C, 10 h;	30%
25°C, 10 h;	30%

: 421-17-0
Trifluoromethylsulfenyl chloride

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
With water; chlorine

: 20621-29-8
trifluoromethylsulfinyl chloride

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
With water

: 812-12-4
trifluoromethanesulfinyl fluoride

A: 421-17-0
Trifluoromethylsulfenyl chloride

B: 421-83-0
trifluoromethane sulfonyl chloride

C: 20621-29-8
trifluoromethylsulfinyl chloride

Conditions

Conditions	Yield
With hydrogenchloride at -183℃;

...Expand

: 54010-75-2
zinc trifluoromethanesulfonate

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
With PCl5*2ZnCl2 at 260℃;

: 75-15-0
carbon disulfide

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
With sulfur tetrafluoride; hydrogen fluoride; water; chlorine 1.) 80 deg C, 16 h, 2.) 20 deg C, 24 h, 40-50 deg C, 24 h; Yield given. Multistep reaction;

: 358-23-6
trifluoromethylsulfonic anhydride

A: 421-83-0
trifluoromethane sulfonyl chloride

B: 117950-83-1
seleninyl bis(trifluorometanesulfonate)

Conditions

Conditions	Yield
With selenium oxychloride at 60℃;

: 2926-29-6
Langlois reagent

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
With chlorine In water at 0 - 10℃; under 2250.2 Torr; for 2h; Yield given;

: 37181-39-8
trifluoromethanesulfonate

A: 75-44-5
phosgene

B: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
distn.;

: 358-23-6
trifluoromethylsulfonic anhydride

: 7647-14-5
sodium chloride

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
In further solvent(s) solvent: tetramethylenesulfone, 3 h;

: PCl5*ZnCl2

: 2926-27-4
potassium trifluoromethansulfonate

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
260°C, 2 h;	80-85
260°C, 2 h;	80-85

: 335-05-7
Trifluoromethanesulfonyl fluoride

: 7782-50-5
chlorine

: 302-01-2
hydrazine

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
In further solvent(s) redn. of 95% N2H4 in CFCl2CF2Cl at 0-10°C, after addn. of Cl2;

...Expand

: 20621-29-8
trifluoromethylsulfinyl chloride

: 7732-18-5
water

A: 421-17-0
Trifluoromethylsulfenyl chloride

B: 421-83-0
trifluoromethane sulfonyl chloride

...Expand

: 22082-78-6
trifluoromethyl hypochlorite

: 20621-29-8
trifluoromethylsulfinyl chloride

A: 14177-25-4
thionyl chlorofluoride

B: 75-73-0
carbon tetrafluoride

C: 353-50-4
Carbonyl fluoride

D: 75-72-9
chlorotrifluoromethane

E: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
25°C, 2 h; further products;
25°C, 2 h; further products;

...Expand

: 25030-42-6, 42179-04-4
trans-chlorotetrafluoro(trifluoromethyl)sulfur(VI)

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
With NaOCH3 25°C, 10 h;
With CH3OH in presence of (CH3)3N, 25°C, 10 h;

: ortho-chlorobenzyl trifluoromethylsulfide

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
With water; chlorine at 10 - 30℃; under 73.5572 - 735.572 Torr;

: 75-46-7
trifluoromethan

: 421-83-0
trifluoromethane sulfonyl chloride

Conditions

Conditions	Yield
With rhodium(III) chloride; sulfuryl dichloride; sulfuric acid; dihydrogen peroxide; urea at 65℃; for 12h;

: 421-83-0
trifluoromethane sulfonyl chloride

: 75-72-9
chlorotrifluoromethane

Conditions

Conditions	Yield
With copper at 200℃; for 24h;	100%
With pyridine; copper dichloride In 1,4-dioxane at 100℃; for 1h; Inert atmosphere; Schlenk technique;	8 %Spectr.

: 69504-03-6
3',5'-bis-O-(tert-butyldimethylsilyl)-β-D-adenosine

: 421-83-0
trifluoromethane sulfonyl chloride

: 118525-28-3
9-[3,5-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-2-trifluoromethylsulfonyloxy-β-D-arabinofuranosyl]-9H-purin-6-amine

Conditions

Conditions	Yield
With dmap; triethylamine In pyridine at 0 - 20℃; for 3h; Esterification;	100%

: 421-83-0
trifluoromethane sulfonyl chloride

: 234436-48-7
9-[3-O-benzoyl-5-O-(triphenylmethyl)-β-D-ribofuranosyl]-6-chloro-9H-purine

: 339196-22-4
5'-O-trityl-3'-O-benzoyl-2'-O-trifluoromethanesulfonyl-6-chloropurine riboside

Conditions

Conditions	Yield
With dmap In toluene	100%
With dmap In toluene

: 649724-98-1
(2-hydroxy-6-methoxy-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

: 421-83-0
trifluoromethane sulfonyl chloride

: 648905-79-7
trifluoro-methanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-naphthalen-2-yl ester

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0℃; for 0.25h;	100%
With pyridine In dichloromethane at 0℃; for 0.25h;	100%
Stage #1: (2-hydroxy-6-methoxy-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone; trifluoromethane sulfonyl chloride With pyridine In dichloromethane for 0.5h; Stage #2: With water In dichloromethane	100%

: 583047-16-9
7-hydroxy-8-nitro-1,2,4,5-tetrahydrobenzo[d]azepine-3-carboxylic acid tert-butyl ester

: 421-83-0
trifluoromethane sulfonyl chloride

: 583047-17-0
7-nitro-8-trifluoromethanesulfonyloxy-1,2,4,5-tetrahydrobenzo[d]azepine-3-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In acetone at 20℃; for 1h;	100%
With triethylamine In acetone at 0℃; for 0.5h;	87%
In acetone at 0 - 20℃; for 2h; Product distribution / selectivity;

: [trans-4-(4-hydroxyphenyl)cyclohexyl]acetic acid methyl ester

: 421-83-0
trifluoromethane sulfonyl chloride

: methyl [trans-4-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)cyclohexyl]acetate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 4 - 15℃; for 17.25h;	100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 4 - 15℃; for 17.25h;	100%

: 701232-67-9
trans-[4-(4-hydroxyphenyl)cyclohexyl]acetic methyl ester

: 421-83-0
trifluoromethane sulfonyl chloride

: 701232-68-0
(trans)-methyl 2-(4-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)cyclohexyl)acetate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 4 - 15℃; for 17.25h;	100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 4 - 15℃; for 17.25h;	100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;

: 339091-27-9
9-(3,5-O-isopropylidene-β-L-xylofuranosyl)adenine

: 421-83-0
trifluoromethane sulfonyl chloride

: 339091-34-8
9-(3,5-O-isopropylidene-2-O-triflyl-β-L-xylofuranosyl)adenine

Conditions

Conditions	Yield
With pyridine at 20℃;	100%

: 421-83-0
trifluoromethane sulfonyl chloride

: 648905-79-7
trifluoro-methanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-naphthalen-2-yl ester

Conditions

Conditions	Yield
Stage #1: (2-hydroxy-6-methoxy-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone With pyridine In dichloromethane at 0℃; Stage #2: trifluoromethane sulfonyl chloride In dichloromethane for 0.5h; Stage #3: With water In dichloromethane	100%

: 1005482-75-6
9-[2'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-xylofuranosyl]adenine

: 421-83-0
trifluoromethane sulfonyl chloride

: 1005482-78-9
9-[2'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-trifluoromethanesulfonyl-xylofuranosyl]adenine

Conditions

Conditions	Yield
With dmap In dichloromethane at 0℃; for 1h;	100%

: 421-83-0
trifluoromethane sulfonyl chloride

: 121-44-8
triethylamine

: 123-54-6
acetylacetone

: 33657-50-0
3,3-dichloropentane-2,4-dione

Conditions

Conditions	Yield
In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%
In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%

...Expand

: 421-83-0
trifluoromethane sulfonyl chloride

: 121-44-8
triethylamine

: 108-59-8
malonic acid dimethyl ester

: 29653-30-3
dimethyl 2,2-dichloromalonate

Conditions

Conditions	Yield
In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%
In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%

...Expand

: 421-83-0
trifluoromethane sulfonyl chloride

: 141-97-9
ethyl acetoacetate

: 121-44-8
triethylamine

: 6134-66-3
ethyl 2,2-dichloroacetoacetate

Conditions

Conditions	Yield
In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%
In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%

...Expand

: 421-83-0
trifluoromethane sulfonyl chloride

: 121-44-8
triethylamine

: 105-34-0
methyl 2-cyanoacetate

: 25761-68-6
methyl dichlorocyanoacetate

Conditions

Conditions	Yield
In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%
In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%

...Expand

: 421-83-0
trifluoromethane sulfonyl chloride

: 123-54-6
acetylacetone

: 33657-50-0
3,3-dichloropentane-2,4-dione

Conditions

Conditions	Yield
With 1,5-Diazabicyclo[5.4.0]undec-5-ene In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%
With 1,5-diazabicyclo(5.4.0)undec-5-ene In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%

: 421-83-0
trifluoromethane sulfonyl chloride

: 762-04-9
phosphonic acid diethyl ester

: 814-49-3
diethyl chlorophosphate

Conditions

Conditions	Yield
With 1,5-Diazabicyclo[5.4.0]undec-5-ene In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%
With 1,5-diazabicyclo(5.4.0)undec-5-ene In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%

: 421-83-0
trifluoromethane sulfonyl chloride

: 108-59-8
malonic acid dimethyl ester

: 29653-30-3
dimethyl 2,2-dichloromalonate

Conditions

Conditions	Yield
With 1,5-Diazabicyclo[5.4.0]undec-5-ene In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%
With 1,5-diazabicyclo(5.4.0)undec-5-ene In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%

: 421-83-0
trifluoromethane sulfonyl chloride

: 141-97-9
ethyl acetoacetate

: 6134-66-3
ethyl 2,2-dichloroacetoacetate

Conditions

Conditions	Yield
With 1,5-Diazabicyclo[5.4.0]undec-5-ene In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%
With 1,5-diazabicyclo(5.4.0)undec-5-ene In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%

: 421-83-0
trifluoromethane sulfonyl chloride

: 105-34-0
methyl 2-cyanoacetate

: 25761-68-6
methyl dichlorocyanoacetate

Conditions

Conditions	Yield
With 1,5-Diazabicyclo[5.4.0]undec-5-ene In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%
With 1,5-diazabicyclo(5.4.0)undec-5-ene In dichloromethane 1:1 molar mixture of educts per acidic hydrogen, 20-25°C, 1 h;	100%

: 421-83-0
trifluoromethane sulfonyl chloride

: 105-53-3
diethyl malonate

A: 20165-81-5
diethyl dichloromalonate

B: 34642-42-7
trifluoromethanesulfinic acid

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 10 - 50℃; Mechanism; Reagent/catalyst; Solvent;	A 100% B n/a

...Expand

: 421-83-0
trifluoromethane sulfonyl chloride

: 95-54-5
1,2-diamino-benzene

: 98-59-9
p-toluenesulfonyl chloride

: 4-methyl-N-{[2-(trifluoromethyl)sulfonamide]phenyl}benzenesulfonamide

Conditions

Conditions	Yield
With trifluoromethylsulfonic anhydride In dichloromethane at -78℃;	100%

...Expand

: 421-83-0
trifluoromethane sulfonyl chloride

: 53-16-7
Estrone

: 92817-04-4
estrone triflate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 0.25h; Inert atmosphere;	99%
With triethylamine	91%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 6h; Inert atmosphere;	82%

: 421-83-0
trifluoromethane sulfonyl chloride

: 189581-08-6
hydroxy(phenyl)-λ3-iodanyl diphenylphosphinate

: C19H15F3IO5PS

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 0.25h;	99%

: 421-83-0
trifluoromethane sulfonyl chloride

: 81097-24-7
N-tosyl-(4-pentenyl)amine

: 1569453-40-2
N-(4-chloro-6,6,6-trifluorohexyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate; tris(1,10-phenanthroline)ruthenium(II) dichloride In acetonitrile at 25℃; for 15h; Reagent/catalyst; Solvent; Inert atmosphere; Irradiation; regioselective reaction;	99%
With dipotassium hydrogenphosphate; tris(1,10-phenanthroline)ruthenium(II) dichloride In acetonitrile at 25℃; for 15h; Catalytic behavior; Reagent/catalyst; Solvent; Photolysis; Inert atmosphere; regioselective reaction;	32 mg

: 421-83-0
trifluoromethane sulfonyl chloride

: 1569453-21-9
N-(but-3-en-1-yl)-4-chlorobenzamide

: 1569453-73-1
4-chloro-N-(3-chloro-5,5,5-trifluoropentyl)benzamide

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate; tris(1,10-phenanthroline)ruthenium(II) dichloride In acetonitrile at 25℃; for 15h; Inert atmosphere; Irradiation; Sealed tube; regioselective reaction;	99%

: 17422-33-2
6-chloroindole

: 421-83-0
trifluoromethane sulfonyl chloride

: 6-chloro-3-((trifluoromethyl)thio)-1H-indole

Conditions

Conditions	Yield
With 1,2,2,3,4,4-hexamethylphosphetane 1-oxide; phenylsilane In 1,4-dioxane at 40℃; Schlenk technique; Sealed tube; Inert atmosphere;	99%
With triphenylphosphine; sodium iodide In acetonitrile at 60℃; for 4h; Schlenk technique; Inert atmosphere;	91%
With phosphonic acid diethyl ester In acetonitrile at 90℃; for 10h;	80%

: 421-83-0
trifluoromethane sulfonyl chloride

: 1011-65-0
5-methoxycarbonylindole

: 1045823-02-6
3-trifluoromethylsulfanyl-5,1H-indolecarboxylc acid methyl ester

Conditions

Conditions	Yield
With 1,2,2,3,4,4-hexamethylphosphetane 1-oxide; phenylsilane In 1,4-dioxane at 40℃; Schlenk technique; Sealed tube; Inert atmosphere;	99%
With triphenylphosphine; sodium iodide In acetonitrile at 60℃; for 22h; Schlenk technique; Inert atmosphere;	90%

: 1120-36-1
1-tetradecene

: 421-83-0
trifluoromethane sulfonyl chloride

: 3-chloro-1,1,1-trifluoropentadecane

Conditions

Conditions	Yield
With [5,10,15,20-tetraphenylporphyrin]cobalt(III) chloride; Langlois reagent In acetonitrile at 100℃; for 12h; Inert atmosphere; Sealed tube;	99%

: 421-83-0
trifluoromethane sulfonyl chloride

: trifluoromethylsulfonimide lithium salt

: 90076-65-6
bis(trifluoromethane)sulfonimide lithium

Conditions

Conditions	Yield
With lithium carbonate In acetonitrile Reagent/catalyst;	98.8%

Trifluoromethanesulfonyl chloride Specification

The Trifluoromethanesulfonyl chloride, with the CAS registry number 421-83-0 and EINECS registry number 207-009-0, is a kind of lachrymatory chemical with the apperance of clear colorless to faintly colored liquid. And the molecular formula of this chemical is CClF₃O₂S.

The physical properties of Trifluoromethanesulfonyl chloride are as following: (1)ACD/LogP: 1.76; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.76; (4)ACD/LogD (pH 7.4): 1.76; (5)ACD/BCF (pH 5.5): 12.77; (6)ACD/BCF (pH 7.4): 12.77; (7)ACD/KOC (pH 5.5): 215.51; (8)ACD/KOC (pH 7.4): 215.51; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 42.52 Å²; (13)Index of Refraction: 1.359; (14)Molar Refractivity: 20.68 cm³; (15)Molar Volume: 93.8 cm³; (16)Polarizability: 8.2×10^-24cm³; (17)Surface Tension: 28.6 dyne/cm; (18)Density: 1.795 g/cm³; (19)Enthalpy of Vaporization: 26.46 kJ/mol; (20)Boiling Point: 30.5 °C at 760 mmHg; (21)Vapour Pressure: 624 mmHg at 25°C.

Uses of Trifluoromethanesulfonyl chloride: It can react with 2-aziridin-1-yl-ethanol to produce 2-(1-aziridinyl)ethyl trifluoromethanesulfonate. This reaction will need reagent sodium hydride, and the solvent tetrahydrofuran. The reaction time is 4 hours with temperature of -80°C, and the yield is about 65%.

Trifluoromethanesulfonyl chloride can react with 2-aziridin-1-yl-ethanol to produce 2-(1-aziridinyl)ethyl trifluoromethanesulfonate

You should be cautious while dealing with this chemical. It reacts violently with water, and may also cause burns. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: FC(F)(F)S(Cl)(=O)=O
(2)InChI: InChI=1/CClF3O2S/c2-8(6,7)1(3,4)5
(3)InChIKey: GRGCWBWNLSTIEN-UHFFFAOYAL

Product Name

TRIFLUOROMETHANESULFONYL CHLORIDE

Synthetic route

Trifluoromethanesulfonyl chloride Specification

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