high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Cas:106685-41-0
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:106685-41-0
Min.Order:1
Negotiable
Type:Other
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
Cas:106685-41-0
Min.Order:1 Gram
FOB Price: $5.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:106685-41-0
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryCAS No.106685-41-0 Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher S
Cas:106685-41-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:106685-41-0
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:106685-41-0
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:106685-41-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryMehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate CAS:106685-41-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, speci
Cas:106685-41-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:106685-41-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryMehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate CAS: 106685-41-0 Specification product name: mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate synonyms: methyl 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoate;m
Cas:106685-41-0
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:106685-41-0
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:106685-41-0
Min.Order:0
Negotiable
Type:Manufacturers
inquiryWe product this chemical more than 10 years .  We are very experience to export it to many countries, Our superior & stable  quality , competitive price gain warm reception from our customers.   Specificat
Cas:106685-41-0
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:106685-41-0
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:106685-41-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:106685-41-0
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be
Cas:106685-41-0
Min.Order:1 Gram
Negotiable
Type:Other
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:106685-41-0
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:106685-41-0
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:white to off white crystal Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide inte
Cas:106685-41-0
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryProduct name: Methyl 6-[3-(1-Adamanty)-4-Methoxyphenyl]-2-Naphthoate CAS No.: 106685-41-0 Molecule Formula:C29H30O3 Molecule Weight:426.55 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Stan
Cas:106685-41-0
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:106685-41-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:106685-41-0
Min.Order:1 Milligram
Negotiable
Type:Trading Company
inquiryMehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate Chemical Properties Melting point 223-225°C Boiling point 589.6±50.0 °C(Predicted) density 1.185±0.06 g/cm3(Predicted) storage temp. Sealed in dry,Room Tem
Cas:106685-41-0
Min.Order:1 Gram
FOB Price: $66.0
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:106685-41-0
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryHangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
Cas:106685-41-0
Min.Order:0
Negotiable
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:106685-41-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:106685-41-0
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
Cas:106685-41-0
Min.Order:0
Negotiable
Type:Manufacturers
inquiry3-(1-adamantyl)-4-methoxyphenylboronic acid
methyl 6-bromo-2-naphthoate
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With sodium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran; water Product distribution / selectivity; Suzuki-Miyaura cross-coupling; Inert atmosphere; Reflux; | 92% |
Suzuki-Miyaura coupling; |
3-(1-adamantyl)-4-methoxyphenylboronic acid
2-methoxycarbonyl-6-(p-tolylsulfonyl)naphthalene
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: tris(3-hydroxypropyl)phosphine; nickel dichloride In tetrahydrofuran for 1h; Heating / reflux; Stage #2: 3-(1-adamantyl)-4-methoxyphenylboronic acid; 2-methoxycarbonyl-6-(p-tolylsulfonyl)naphthalene With water; potassium carbonate In tetrahydrofuran at 50℃; for 24h; Product distribution / selectivity; Heating / reflux; | 90% |
Stage #1: tris(3-hydroxypropyl)phosphine; nickel dichloride In tetrahydrofuran for 1h; Heating / reflux; Stage #2: 3-(1-adamantyl)-4-methoxyphenylboronic acid; 2-methoxycarbonyl-6-(p-tolylsulfonyl)naphthalene With potassium phosphate; water In tetrahydrofuran at 50℃; for 24h; Product distribution / selectivity; Heating / reflux; | 82% |
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride; tricyclohexylphosphine In tetrahydrofuran for 24h; Product distribution / selectivity; Heating / reflux; | 78% |
methyl 6-bromo-2-naphthoate
2-(1-adamantyl)-4-bromoanisole
A
3,3'-diadamantyl-4,4'-dimethoxybiphenyl
B
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 2-(1-adamantyl)-4-bromoanisole With magnesium; ethylene dibromide In tetrahydrofuran at 45 - 55℃; for 1.5h; Stage #2: With zinc(II) chloride In tetrahydrofuran at 20 - 25℃; for 1h; Stage #3: methyl 6-bromo-2-naphthoate; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran at 20℃; for 2h; | A n/a B 88.83% |
2-(3-adamantan-1-yl-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
methyl 6-bromo-2-naphthoate
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate In tetrahydrofuran; water Product distribution / selectivity; Suzuki-Miyaura cross-coupling; Inert atmosphere; Reflux; | 87% |
With sodium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran; water Product distribution / selectivity; Suzuki-Miyaura coupling; Inert atmosphere; | 85% |
methyl 6-bromo-2-naphthoate
2-(1-adamantyl)-4-bromoanisole
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 2-(1-adamantyl)-4-bromoanisole With iodine; magnesium In tetrahydrofuran at 40℃; for 1h; Inert atmosphere; Stage #2: methyl 6-bromo-2-naphthoate With bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride In tetrahydrofuran at 55℃; for 0.75h; Negishi Coupling; | 86% |
Stage #1: 2-(1-adamantyl)-4-bromoanisole With magnesium; ethylene dibromide In tetrahydrofuran at 20 - 40℃; for 0.5h; Heating / reflux; Stage #2: With zinc(II) chloride In tetrahydrofuran for 1.25h; Heating / reflux; Stage #3: methyl 6-bromo-2-naphthoate; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran for 2.16667h; | 50% |
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; iodine; magnesium; zinc(II) chloride Yield given. Multistep reaction; |
C19H25BO3
methyl 6-bromo-2-naphthoate
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With potassium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran; water Product distribution / selectivity; Suzuki-Miyaura cross-coupling; Inert atmosphere; Reflux; | 86% |
3-(1-adamantyl)-4-methoxybenzene magnesium bromide
methyl 6-bromo-2-naphthoate
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride at 55℃; for 0.75h; Negishi coupling reaction; | 86% |
methyl 6-iodonaphthalene-2-carboxylate
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
for 21h; Suzuki-Miyaura Coupling; Flow reactor; | 86% |
1-adamanthanol
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With sulfuric acid In chloroform at 20℃; Solvent; | 83% |
6-(3-adamantan-1-yl-4-hydroxyphenyl)naphthalene-2-carboxylic acid methyl ester
methyl iodide
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 6-(3-adamantan-1-yl-4-hydroxyphenyl)naphthalene-2-carboxylic acid methyl ester With sodium hydride In N,N-dimethyl-formamide at 0℃; for 1h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 1.5h; | 82% |
adapalene
diazomethyl-trimethyl-silane
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
In tetrahydrofuran; methanol at 0 - 20℃; for 1h; | 79% |
methyl 6-bromo-2-naphthoate
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: bis(pinacol)diborane; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 100 °C 1.2: 80 - 100 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 2.2: 1.5 h / 20 °C View Scheme |
4-bromo-phenol
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 86 percent / conc. H2SO4 / CH2Cl2 / 8 h / Ambient temperature 2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 20 deg C, 2 h 3: 1.) Mg, I2, 2.) ZnCl2, 3.) NiCl2*1,2-bis(diphenylphosphino)ethane View Scheme |
1-adamanthanol
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 86 percent / conc. H2SO4 / CH2Cl2 / 8 h / Ambient temperature 2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 20 deg C, 2 h 3: 1.) Mg, I2, 2.) ZnCl2, 3.) NiCl2*1,2-bis(diphenylphosphino)ethane View Scheme | |
Multi-step reaction with 4 steps 1: sulfuric acid; acetic acid / 48 h / 20 °C 2: potassium carbonate / acetone / 8 h / Reflux 3: magnesium / tetrahydrofuran / 1 h / 40 °C 4: bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride / 0.75 h / 55 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sulfuric acid; acetic acid / 4.17 h / 20 - 70 °C 2.1: potassium carbonate / acetone / 4.25 - 6.25 h / 20 °C / Heating / reflux 3.1: magnesium; ethylene dibromide / tetrahydrofuran / 0.5 h / 20 - 40 °C / Heating / reflux 3.2: 1.25 h / Heating / reflux 3.3: 2.17 h View Scheme |
2-(1-adamantyl)-4-bromophenol
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 20 deg C, 2 h 2: 1.) Mg, I2, 2.) ZnCl2, 3.) NiCl2*1,2-bis(diphenylphosphino)ethane View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / acetone / 8 h / Reflux 2: magnesium / tetrahydrofuran / 1 h / 40 °C 3: bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride / 0.75 h / 55 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: bis(pinacol)diborane; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 100 °C 1.2: 80 - 100 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 2.2: 1.5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetone / 4.25 - 6.25 h / 20 °C / Heating / reflux 2.1: magnesium; ethylene dibromide / tetrahydrofuran / 0.5 h / 20 - 40 °C / Heating / reflux 2.2: 1.25 h / Heating / reflux 2.3: 2.17 h View Scheme |
Conditions | Yield |
---|---|
With sulfuric acid In ethanol; cyclohexane; nitrogen |
Conditions | Yield |
---|---|
Stage #1: 6-(3-adamantan-1-yl-4-hydroxyphenyl)naphthalene-2-carboxylic acid methyl ester With sodium hydride In N,N-dimethyl-formamide at 0℃; for 1h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 1.5h; |
Conditions | Yield |
---|---|
With sodium carbonate In water at 80℃; for 4h; Inert atmosphere; |
4-bromo-phenol
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid; acetic acid / 48 h / 20 °C 2: potassium carbonate / acetone / 8 h / Reflux 3: magnesium / tetrahydrofuran / 1 h / 40 °C 4: bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride / 0.75 h / 55 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sulfuric acid; acetic acid / 4.17 h / 20 - 70 °C 2.1: potassium carbonate / acetone / 4.25 - 6.25 h / 20 °C / Heating / reflux 3.1: magnesium; ethylene dibromide / tetrahydrofuran / 0.5 h / 20 - 40 °C / Heating / reflux 3.2: 1.25 h / Heating / reflux 3.3: 2.17 h View Scheme |
2-(1-adamantyl)-4-bromoanisole
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: magnesium / tetrahydrofuran / 1 h / 40 °C 2: bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride / 0.75 h / 55 °C View Scheme | |
Multi-step reaction with 2 steps 1: n-butyllithium 2: 21 h / Flow reactor View Scheme |
adapalene
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 80 °C 2: potassium carbonate / ethyl acetate; water / 4 h / 0 - 20 °C View Scheme |
6-[3-(1-adamantyl)-4-methoxy phenyl]-2-naphthoic acid chloride
N-methoxylamine hydrochloride
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With potassium carbonate In water; ethyl acetate at 0 - 20℃; for 4h; |
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium phosphate tribasic trihydrate; bis(triphenylphosphine)nickel(II) chloride; 1-n-butyl-3-methylimidazolim bromide / toluene / 6 h / 110 °C / Inert atmosphere 2: sulfuric acid / chloroform / 20 °C View Scheme |
4-methoxyphenylboronic acid
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium phosphate tribasic trihydrate; bis(triphenylphosphine)nickel(II) chloride; 1-n-butyl-3-methylimidazolim bromide / toluene / 6 h / 110 °C / Inert atmosphere 2: sulfuric acid / chloroform / 20 °C View Scheme |
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With potassium hydroxide; tetrabutylammomium bromide In methanol; toluene for 3h; Heating / reflux; | 99.18% |
With potassium hydroxide; water In tetrahydrofuran; 1,4-dioxane at 90℃; for 6h; Product distribution / selectivity; Heating / reflux; | 94% |
With potassium hydroxide; water In 1,4-dioxane for 2.25 - 4.25h; Product distribution / selectivity; Heating / reflux; |
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
adapalene
Conditions | Yield |
---|---|
Stage #1: 6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester With ethylene glycol; sodium hydroxide Stage #2: With hydrogenchloride In water Product distribution / selectivity; | 97% |
Stage #1: 6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester With ethylene glycol; sodium hydroxide Stage #2: With hydrogenchloride In water Product distribution / selectivity; | 96% |
With water; sodium hydroxide In propylene glycol | 89% |
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With sodium hydroxide; water In tetrahydrofuran for 6h; Heating / reflux; | 94% |
With sodium hydroxide; water In tetrahydrofuran; 1,4-dioxane at 90℃; for 6h; Heating / reflux; | 94% |
3-(1-adamantyl)-4-methoxyphenylboronic acid
methyl 6-bromo-2-naphthoate
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With sodium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran; water Product distribution / selectivity; Suzuki-Miyaura cross-coupling; Inert atmosphere; Reflux; | 92% |
Suzuki-Miyaura coupling; |
3-(1-adamantyl)-4-methoxyphenylboronic acid
2-methoxycarbonyl-6-(p-tolylsulfonyl)naphthalene
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: tris(3-hydroxypropyl)phosphine; nickel dichloride In tetrahydrofuran for 1h; Heating / reflux; Stage #2: 3-(1-adamantyl)-4-methoxyphenylboronic acid; 2-methoxycarbonyl-6-(p-tolylsulfonyl)naphthalene With water; potassium carbonate In tetrahydrofuran at 50℃; for 24h; Product distribution / selectivity; Heating / reflux; | 90% |
Stage #1: tris(3-hydroxypropyl)phosphine; nickel dichloride In tetrahydrofuran for 1h; Heating / reflux; Stage #2: 3-(1-adamantyl)-4-methoxyphenylboronic acid; 2-methoxycarbonyl-6-(p-tolylsulfonyl)naphthalene With potassium phosphate; water In tetrahydrofuran at 50℃; for 24h; Product distribution / selectivity; Heating / reflux; | 82% |
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride; tricyclohexylphosphine In tetrahydrofuran for 24h; Product distribution / selectivity; Heating / reflux; | 78% |
methyl 6-bromo-2-naphthoate
2-(1-adamantyl)-4-bromoanisole
A
3,3'-diadamantyl-4,4'-dimethoxybiphenyl
B
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 2-(1-adamantyl)-4-bromoanisole With magnesium; ethylene dibromide In tetrahydrofuran at 45 - 55℃; for 1.5h; Stage #2: With zinc(II) chloride In tetrahydrofuran at 20 - 25℃; for 1h; Stage #3: methyl 6-bromo-2-naphthoate; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran at 20℃; for 2h; | A n/a B 88.83% |
2-(3-adamantan-1-yl-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
methyl 6-bromo-2-naphthoate
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate In tetrahydrofuran; water Product distribution / selectivity; Suzuki-Miyaura cross-coupling; Inert atmosphere; Reflux; | 87% |
With sodium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran; water Product distribution / selectivity; Suzuki-Miyaura coupling; Inert atmosphere; | 85% |
methyl 6-bromo-2-naphthoate
2-(1-adamantyl)-4-bromoanisole
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 2-(1-adamantyl)-4-bromoanisole With iodine; magnesium In tetrahydrofuran at 40℃; for 1h; Inert atmosphere; Stage #2: methyl 6-bromo-2-naphthoate With bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride In tetrahydrofuran at 55℃; for 0.75h; Negishi Coupling; | 86% |
Stage #1: 2-(1-adamantyl)-4-bromoanisole With magnesium; ethylene dibromide In tetrahydrofuran at 20 - 40℃; for 0.5h; Heating / reflux; Stage #2: With zinc(II) chloride In tetrahydrofuran for 1.25h; Heating / reflux; Stage #3: methyl 6-bromo-2-naphthoate; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In tetrahydrofuran for 2.16667h; | 50% |
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; iodine; magnesium; zinc(II) chloride Yield given. Multistep reaction; |
C19H25BO3
methyl 6-bromo-2-naphthoate
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With potassium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran; water Product distribution / selectivity; Suzuki-Miyaura cross-coupling; Inert atmosphere; Reflux; | 86% |
3-(1-adamantyl)-4-methoxybenzene magnesium bromide
methyl 6-bromo-2-naphthoate
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride at 55℃; for 0.75h; Negishi coupling reaction; | 86% |
methyl 6-iodonaphthalene-2-carboxylate
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
for 21h; Suzuki-Miyaura Coupling; Flow reactor; | 86% |
1-adamanthanol
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With sulfuric acid In chloroform at 20℃; Solvent; | 83% |
6-(3-adamantan-1-yl-4-hydroxyphenyl)naphthalene-2-carboxylic acid methyl ester
methyl iodide
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 6-(3-adamantan-1-yl-4-hydroxyphenyl)naphthalene-2-carboxylic acid methyl ester With sodium hydride In N,N-dimethyl-formamide at 0℃; for 1h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 1.5h; | 82% |
adapalene
diazomethyl-trimethyl-silane
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
In tetrahydrofuran; methanol at 0 - 20℃; for 1h; | 79% |
methyl 6-bromo-2-naphthoate
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: bis(pinacol)diborane; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 100 °C 1.2: 80 - 100 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 2.2: 1.5 h / 20 °C View Scheme |
4-bromo-phenol
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 86 percent / conc. H2SO4 / CH2Cl2 / 8 h / Ambient temperature 2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 20 deg C, 2 h 3: 1.) Mg, I2, 2.) ZnCl2, 3.) NiCl2*1,2-bis(diphenylphosphino)ethane View Scheme |
1-adamanthanol
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 86 percent / conc. H2SO4 / CH2Cl2 / 8 h / Ambient temperature 2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 20 deg C, 2 h 3: 1.) Mg, I2, 2.) ZnCl2, 3.) NiCl2*1,2-bis(diphenylphosphino)ethane View Scheme | |
Multi-step reaction with 4 steps 1: sulfuric acid; acetic acid / 48 h / 20 °C 2: potassium carbonate / acetone / 8 h / Reflux 3: magnesium / tetrahydrofuran / 1 h / 40 °C 4: bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride / 0.75 h / 55 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sulfuric acid; acetic acid / 4.17 h / 20 - 70 °C 2.1: potassium carbonate / acetone / 4.25 - 6.25 h / 20 °C / Heating / reflux 3.1: magnesium; ethylene dibromide / tetrahydrofuran / 0.5 h / 20 - 40 °C / Heating / reflux 3.2: 1.25 h / Heating / reflux 3.3: 2.17 h View Scheme |
2-(1-adamantyl)-4-bromophenol
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 20 deg C, 2 h 2: 1.) Mg, I2, 2.) ZnCl2, 3.) NiCl2*1,2-bis(diphenylphosphino)ethane View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / acetone / 8 h / Reflux 2: magnesium / tetrahydrofuran / 1 h / 40 °C 3: bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride / 0.75 h / 55 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: bis(pinacol)diborane; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 100 °C 1.2: 80 - 100 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 2.2: 1.5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetone / 4.25 - 6.25 h / 20 °C / Heating / reflux 2.1: magnesium; ethylene dibromide / tetrahydrofuran / 0.5 h / 20 - 40 °C / Heating / reflux 2.2: 1.25 h / Heating / reflux 2.3: 2.17 h View Scheme |
1-acetyloxyadamantane
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With sulfuric acid In ethanol; cyclohexane; nitrogen |
methyl iodide
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 6-(3-adamantan-1-yl-4-hydroxyphenyl)naphthalene-2-carboxylic acid methyl ester With sodium hydride In N,N-dimethyl-formamide at 0℃; for 1h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 1.5h; |
2-(3-adamantan-1-yl-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
methyl 6-bromonaphthalene-1-carboxylate
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With sodium carbonate In water at 80℃; for 4h; Inert atmosphere; |
4-bromo-phenol
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid; acetic acid / 48 h / 20 °C 2: potassium carbonate / acetone / 8 h / Reflux 3: magnesium / tetrahydrofuran / 1 h / 40 °C 4: bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride / 0.75 h / 55 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sulfuric acid; acetic acid / 4.17 h / 20 - 70 °C 2.1: potassium carbonate / acetone / 4.25 - 6.25 h / 20 °C / Heating / reflux 3.1: magnesium; ethylene dibromide / tetrahydrofuran / 0.5 h / 20 - 40 °C / Heating / reflux 3.2: 1.25 h / Heating / reflux 3.3: 2.17 h View Scheme |
2-(1-adamantyl)-4-bromoanisole
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: magnesium / tetrahydrofuran / 1 h / 40 °C 2: bis-triphenylphosphine-palladium(II) chloride; zinc(II) chloride / 0.75 h / 55 °C View Scheme | |
Multi-step reaction with 2 steps 1: n-butyllithium 2: 21 h / Flow reactor View Scheme |
adapalene
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 80 °C 2: potassium carbonate / ethyl acetate; water / 4 h / 0 - 20 °C View Scheme |
6-[3-(1-adamantyl)-4-methoxy phenyl]-2-naphthoic acid chloride
N-methoxylamine hydrochloride
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With potassium carbonate In water; ethyl acetate at 0 - 20℃; for 4h; |
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium phosphate tribasic trihydrate; bis(triphenylphosphine)nickel(II) chloride; 1-n-butyl-3-methylimidazolim bromide / toluene / 6 h / 110 °C / Inert atmosphere 2: sulfuric acid / chloroform / 20 °C View Scheme |
4-methoxyphenylboronic acid
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium phosphate tribasic trihydrate; bis(triphenylphosphine)nickel(II) chloride; 1-n-butyl-3-methylimidazolim bromide / toluene / 6 h / 110 °C / Inert atmosphere 2: sulfuric acid / chloroform / 20 °C View Scheme |
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With potassium hydroxide; tetrabutylammomium bromide In methanol; toluene for 3h; Heating / reflux; | 99.18% |
With potassium hydroxide; water In tetrahydrofuran; 1,4-dioxane at 90℃; for 6h; Product distribution / selectivity; Heating / reflux; | 94% |
With potassium hydroxide; water In 1,4-dioxane for 2.25 - 4.25h; Product distribution / selectivity; Heating / reflux; |
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
adapalene
Conditions | Yield |
---|---|
Stage #1: 6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester With ethylene glycol; sodium hydroxide Stage #2: With hydrogenchloride In water Product distribution / selectivity; | 97% |
Stage #1: 6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester With ethylene glycol; sodium hydroxide Stage #2: With hydrogenchloride In water Product distribution / selectivity; | 96% |
With water; sodium hydroxide In propylene glycol | 89% |
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With sodium hydroxide; water In tetrahydrofuran for 6h; Heating / reflux; | 94% |
With sodium hydroxide; water In tetrahydrofuran; 1,4-dioxane at 90℃; for 6h; Heating / reflux; | 94% |
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With silver hexafluoroantimonate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium acetate In 1,2-dichloro-ethane at 140℃; for 18h; Inert atmosphere; | 54% |
phenylacetonitrile
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester With lithium aluminium tetrahydride Stage #2: phenylacetonitrile | 40% |
6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / methanol / 8 h / Reflux 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; hydroxylamine hydrochloride / 20 °C / Inert atmosphere View Scheme |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View