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Hangzhou Think Chemical Co. Ltd

Ixazomib CAS No.:1072833-77-2 Name: Ixazomib Synonyms: MLN 2238; B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid Molecular Structure Molecular Fo

High purity Ixazomib CAS No.:1072833-77-2

Cas:1072833-77-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing ne

Ixazomib

Cas:1072833-77-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

MLN2238,MLN 2238,MLN-2238

Cas:1072833-77-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ixazomib

Cas:1072833-77-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM---(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid

Cas:1072833-77-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 1072833-77-2 with best quality

Cas:1072833-77-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 1072833-77-2 IxazoMib with best price

Cas:1072833-77-2

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Qingdao Beluga Import and Export Co., LTD

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid CAS:1072833-77-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical inter

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid CAS:1072833-77-2

Cas:1072833-77-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

MLN-2238

Cas:1072833-77-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By Se

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid

Cas:1072833-77-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Ixazomib cas 1072833-77-2

Cas:1072833-77-2

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

MLN-2238

Cas:1072833-77-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Ixazomib/High quality/Best price

Cas:1072833-77-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

cas:1072833-77-2

Cas:1072833-77-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

MLN2238

Cas:1072833-77-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Siwei Development Group Ltd.

Product name: Ixazomib CAS No.:1072833-77-2 Molecule Formula:C14H19BCl2N2O4 Molecule Weight:361.00 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Best Quality Ixazomib with good supplier

Cas:1072833-77-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid

Cas:1072833-77-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

MLN2238

Cas:1072833-77-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

Ixazomib MLN2238

Cas:1072833-77-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid

Cas:1072833-77-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid

Cas:1072833-77-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Our company advantages: 1 The highest quality with the competitive price. 2、 Professional human services. 3、 The fastest and safest delivery service. 4、Our old customers all around the world. 5、 The high purity products. 6、We have a suf

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid

Cas:1072833-77-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/ixazomib/SAGECHEM/Manufacturer in China

Cas:1072833-77-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid

Cas:1072833-77-2

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid

Cas:1072833-77-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Ixazomib

Cas:1072833-77-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

BOC Sciences

BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. https:

Ixazomib

Cas:1072833-77-2

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

factory?direct?sale Application:healing drugs

MLN-2238

Cas:1072833-77-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

dihydroxy-methyl-borane
13061-96-6

dihydroxy-methyl-borane

(R)-2,5-dichloro-N-(2-((3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)amino)2-oxoethyl)benzamide

(R)-2,5-dichloro-N-(2-((3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)amino)2-oxoethyl)benzamide

Ixazomib
1072833-77-2

Ixazomib

Conditions
ConditionsYield
With hydrogenchloride In water; acetone at 20℃;93%
dihydroxy-methyl-borane
13061-96-6

dihydroxy-methyl-borane

2,5-dichloro-N-[2-({(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexa-hydro-2H-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-2-oxoethyl]benzamide
1201903-02-7

2,5-dichloro-N-[2-({(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexa-hydro-2H-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-2-oxoethyl]benzamide

Ixazomib
1072833-77-2

Ixazomib

Conditions
ConditionsYield
With hydrogenchloride In water; acetone at 20℃; for 40h;92%
2,5-dichloro-N-[2-({(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexa-hydro-2H-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-2-oxoethyl]benzamide
1201903-02-7

2,5-dichloro-N-[2-({(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexa-hydro-2H-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-2-oxoethyl]benzamide

boric acid
11113-50-1

boric acid

Ixazomib
1072833-77-2

Ixazomib

Conditions
ConditionsYield
With hydrogenchloride In di-isopropyl ether at 20℃; for 5h;86.5%
2,5-dichloro-N-[2-({(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexa-hydro-2H-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-2-oxoethyl]benzamide
1201903-02-7

2,5-dichloro-N-[2-({(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexa-hydro-2H-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-2-oxoethyl]benzamide

Ixazomib
1072833-77-2

Ixazomib

Conditions
ConditionsYield
With hydrogenchloride; Dihydroxy-isobutyl-boran In methanol; hexane; water76.5%
With hydrogenchloride; Dihydroxy-isobutyl-boran In methanol; hexane at 20℃;63%
N-(fluoren-9-ylmethoxycarbonyl)glycine
29022-11-5

N-(fluoren-9-ylmethoxycarbonyl)glycine

C23H27BNO5Pol

C23H27BNO5Pol

2,5-dichlorobenzoic acid
50-79-3

2,5-dichlorobenzoic acid

Ixazomib
1072833-77-2

Ixazomib

Conditions
ConditionsYield
Stage #1: C23H27BNO5Pol With piperidine In N,N-dimethyl-formamide for 0.333333h; 1-glycerol polystyrene resin;
Stage #2: N-(fluoren-9-ylmethoxycarbonyl)glycine With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide for 2h; 1-glycerol polystyrene resin;
Stage #3: 2,5-dichlorobenzoic acid Further stages;
49%
(R)-2,5-dichloro-N-(2-((3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)amino)2-oxoethyl)benzamide

(R)-2,5-dichloro-N-(2-((3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)amino)2-oxoethyl)benzamide

Ixazomib
1072833-77-2

Ixazomib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethyl acetate / 12 h / 120 °C
2: hydrogenchloride; water / ethyl acetate / 0.5 h / 20 °C
View Scheme
Stage #1: (R)-2,5-dichloro-N-(2-((3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)amino)2-oxoethyl)benzamide With boron trichloride In dichloromethane at -78℃; Inert atmosphere;
Stage #2: With methanol for 0.166667h;
23.0 mg
(R)-[N-(2,5-dichlorobenzoyl)glycyl]leucine borate diethanolamine ester

(R)-[N-(2,5-dichlorobenzoyl)glycyl]leucine borate diethanolamine ester

Ixazomib
1072833-77-2

Ixazomib

Conditions
ConditionsYield
With hydrogenchloride; water In ethyl acetate at 20℃; for 0.5h;
2,5-dichlorobenzoic acid
50-79-3

2,5-dichlorobenzoic acid

Ixazomib
1072833-77-2

Ixazomib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.5 h
1.2: 12 h / 20 °C
2.1: lithium hydroxide; water / tetrahydrofuran / 0.5 h / 20 °C
3.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine / 20 °C
4.1: ethyl acetate / 12 h / 120 °C
5.1: hydrogenchloride; water / ethyl acetate / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: benzotriazol-1-ol / dichloromethane / 0.17 h / -10 °C
1.2: 0.5 h
1.3: 20 °C
2.1: lithium hydroxide monohydrate / methanol; water / 2 h
3.1: benzotriazol-1-ol / dichloromethane / 0.17 h / -10 °C
3.2: 0.5 h
4.1: Dihydroxy-isobutyl-boran; hydrogenchloride / methanol; water; hexane
View Scheme
Multi-step reaction with 5 steps
1: acetonitrile / 1 h / 20 °C / Inert atmosphere
2: sodium hydroxide; water / 1 h / 0 - 10 °C
3: acetonitrile / 20 - 30 °C
4: 1 h / 0 - 10 °C
5: hydrogenchloride / di-isopropyl ether / 5 h / 20 °C
View Scheme
(S)-N-(2,5-dichlorobenzoyl)glycine methyl ester

(S)-N-(2,5-dichlorobenzoyl)glycine methyl ester

Ixazomib
1072833-77-2

Ixazomib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium hydroxide; water / tetrahydrofuran / 0.5 h / 20 °C
2: benzotriazol-1-ol; dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine / 20 °C
3: ethyl acetate / 12 h / 120 °C
4: hydrogenchloride; water / ethyl acetate / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: lithium hydroxide monohydrate / methanol; water / 2 h
2.1: benzotriazol-1-ol / dichloromethane / 0.17 h / -10 °C
2.2: 0.5 h
3.1: Dihydroxy-isobutyl-boran; hydrogenchloride / methanol; water; hexane
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / water; acetone / 2 h / 0 °C
2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -10 - -5 °C
3: hydrogenchloride / water; acetone / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / water; acetone / 2 h / 0 °C
2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -10 - -5 °C
3: hydrogenchloride / water; acetone / 40 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: lithium hydroxide monohydrate / methanol; water / 3 h / 20 °C / Cooling with ice
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.67 h / -5 °C
2.2: 6.67 h / 20 °C
3.1: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; hexane / 20 °C
View Scheme
2-[(2,5-dichlorobenzoyl)amino]acetic acid
667403-46-5

2-[(2,5-dichlorobenzoyl)amino]acetic acid

Ixazomib
1072833-77-2

Ixazomib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: benzotriazol-1-ol; dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine / 20 °C
2: ethyl acetate / 12 h / 120 °C
3: hydrogenchloride; water / ethyl acetate / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: benzotriazol-1-ol / dichloromethane / 0.17 h / -10 °C
1.2: 0.5 h
2.1: Dihydroxy-isobutyl-boran; hydrogenchloride / methanol; water; hexane
View Scheme
Multi-step reaction with 3 steps
1: acetonitrile / 20 - 30 °C
2: 1 h / 0 - 10 °C
3: hydrogenchloride / di-isopropyl ether / 5 h / 20 °C
View Scheme
C12H9Cl2N3O2

C12H9Cl2N3O2

Ixazomib
1072833-77-2

Ixazomib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1 h / 0 - 10 °C
2: hydrogenchloride / di-isopropyl ether / 5 h / 20 °C
View Scheme
C10H6Cl2N2O

C10H6Cl2N2O

Ixazomib
1072833-77-2

Ixazomib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide; water / 1 h / 0 - 10 °C
2: acetonitrile / 20 - 30 °C
3: 1 h / 0 - 10 °C
4: hydrogenchloride / di-isopropyl ether / 5 h / 20 °C
View Scheme
Ixazomib
1072833-77-2

Ixazomib

2,2'-iminobis[ethanol]
111-42-2

2,2'-iminobis[ethanol]

2,5-dichloro-N-[(2-((1R)-3-methyl-1-[1,3,6,2]-dioxaborolan-2-yl)-butylamino)-2-oxyethyl]benzamide

2,5-dichloro-N-[(2-((1R)-3-methyl-1-[1,3,6,2]-dioxaborolan-2-yl)-butylamino)-2-oxyethyl]benzamide

Conditions
ConditionsYield
In ethyl acetate at 20℃; for 2h; Product distribution / selectivity;100%
Ixazomib
1072833-77-2

Ixazomib

citric acid
77-92-9

citric acid

2,2’-{2-[(1R)-1-({[(2,5-dichlorobenzoyl)amino]acetyl}amino)-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diyl}diacetic acid

2,2’-{2-[(1R)-1-({[(2,5-dichlorobenzoyl)amino]acetyl}amino)-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diyl}diacetic acid

Conditions
ConditionsYield
In acetone at 20℃; for 0.5h;95%
In ethyl acetate at 60℃; for 0.5h;
Ixazomib
1072833-77-2

Ixazomib

citric acid
77-92-9

citric acid

4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
1201902-80-8

4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid

Conditions
ConditionsYield
In ethyl acetate at 60 - 74℃; for 3h;94%
Ixazomib
1072833-77-2

Ixazomib

2,2'-iminobis[ethanol]
111-42-2

2,2'-iminobis[ethanol]

N-(R)-(2-((1-(1,3,6,2-dioxazaborocan-2-yl)-3-methylbutyl)amino)-2-oxoethyl)-2,5-dichlorobenzamide

N-(R)-(2-((1-(1,3,6,2-dioxazaborocan-2-yl)-3-methylbutyl)amino)-2-oxoethyl)-2,5-dichlorobenzamide

Conditions
ConditionsYield
In ethyl acetate at 20 - 74℃; for 3h;85.4%
In ethyl acetate at 60 - 74℃; for 3h;557 mg
Ixazomib
1072833-77-2

Ixazomib

N-methylimino diacetic acid

N-methylimino diacetic acid

2,5-dichloro-N-{[(R)-3-methyl-1-(6-methyl-4,8-dioxo-[1,3,6,2]dioxazaborolan-2-yl)-butylcarbamoyl]methyl}-benzamide

2,5-dichloro-N-{[(R)-3-methyl-1-(6-methyl-4,8-dioxo-[1,3,6,2]dioxazaborolan-2-yl)-butylcarbamoyl]methyl}-benzamide

Conditions
ConditionsYield
In dimethyl sulfoxide; toluene for 18h; Reflux;83.4%
Ixazomib
1072833-77-2

Ixazomib

C14H29N3O6

C14H29N3O6

C28H44BCl2N5O8

C28H44BCl2N5O8

Conditions
ConditionsYield
In chloroform-d167%
N-Methyldiethanolamine
105-59-9

N-Methyldiethanolamine

Ixazomib
1072833-77-2

Ixazomib

2,5-dichloro-N-{[(R)-3-methyl-1-(6-methyl-[1,3,6,2]dioxazaborolan-2-yl)-butylcarbamoyl]methyl}-benzamide

2,5-dichloro-N-{[(R)-3-methyl-1-(6-methyl-[1,3,6,2]dioxazaborolan-2-yl)-butylcarbamoyl]methyl}-benzamide

Conditions
ConditionsYield
In ethyl acetate at 20℃;66%
Ixazomib
1072833-77-2

Ixazomib

diisopropanolamine
110-97-4

diisopropanolamine

2,5-dichloro-N-[(R)-1-(4,8-dimethyl-[1,3,6,2]dioxazaborolan-2-yl)-3-methyl-(butylcarbamoyl)methyl]-benzamide

2,5-dichloro-N-[(R)-1-(4,8-dimethyl-[1,3,6,2]dioxazaborolan-2-yl)-3-methyl-(butylcarbamoyl)methyl]-benzamide

Conditions
ConditionsYield
In ethyl acetate at 20℃;64%
Ixazomib
1072833-77-2

Ixazomib

(R)-Mandelic Acid
611-71-2

(R)-Mandelic Acid

2-chloro-5-chloro-N-[2-({(1R)-3-methyl-1-[(5R)-4-oxo-5-phenyl-1,3,2-dioxaborolan-2-yl]butyl}amino)-2-oxoethyl]benzamide
1201902-85-3

2-chloro-5-chloro-N-[2-({(1R)-3-methyl-1-[(5R)-4-oxo-5-phenyl-1,3,2-dioxaborolan-2-yl]butyl}amino)-2-oxoethyl]benzamide

Conditions
ConditionsYield
In ethyl acetate for 0.666667h;57%
Ixazomib
1072833-77-2

Ixazomib

(R)-(1-(2-(2,5-dichlorobenzamido)-d2-acetamido)-3-methylbutyl)boronic acid

(R)-(1-(2-(2,5-dichlorobenzamido)-d2-acetamido)-3-methylbutyl)boronic acid

Conditions
ConditionsYield
With dimethylsulfoxide-d6; water-d2; potassium carbonate In tetrahydrofuran at 65℃; for 5h;55.6%
With water-d2; sodium methylate at 0℃; for 72h;630 mg
triethanolamine
102-71-6

triethanolamine

Ixazomib
1072833-77-2

Ixazomib

N-(R)-(2-((1-(6-(2-hydroxyethyl)-1,3,6,2-dioxazaborocan-2-yl)-3-methylbutyl)amino)-2-oxoethyl)-2,5-dichlorobenzamide

N-(R)-(2-((1-(6-(2-hydroxyethyl)-1,3,6,2-dioxazaborocan-2-yl)-3-methylbutyl)amino)-2-oxoethyl)-2,5-dichlorobenzamide

Conditions
ConditionsYield
In ethyl acetate at 20 - 74℃; for 3h;53.3%
Ixazomib
1072833-77-2

Ixazomib

C20H21(2)H2BCl2N2O9

C20H21(2)H2BCl2N2O9

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water-d2; sodium methylate / 72 h / 0 °C
2: ethyl acetate / 48 h / 40 °C
View Scheme
D2-citric acid
78468-60-7

D2-citric acid

Ixazomib
1072833-77-2

Ixazomib

C20H21(2)H2BCl2N2O9

C20H21(2)H2BCl2N2O9

Conditions
ConditionsYield
In acetic acid butyl ester at 90℃; for 14h;51 mg
Ixazomib
1072833-77-2

Ixazomib

D4-citric acid

D4-citric acid

C20H19(2)H4BCl2N2O9

C20H19(2)H4BCl2N2O9

Conditions
ConditionsYield
In acetic acid butyl ester at 90℃; for 14h;53 mg
Ixazomib
1072833-77-2

Ixazomib

C19H19N3O9

C19H19N3O9

C33H34BCl2N5O11

C33H34BCl2N5O11

Conditions
ConditionsYield
In ethyl acetate at 20℃;
Ixazomib
1072833-77-2

Ixazomib

Reaxys ID: 36479190

Reaxys ID: 36479190

Reaxys ID: 36479266

Reaxys ID: 36479266

Ixazomib
1072833-77-2

Ixazomib

Reaxys ID: 36479191

Reaxys ID: 36479191

Reaxys ID: 36479267

Reaxys ID: 36479267

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