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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate

Cas:110543-98-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.

Cas:110543-98-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 110543-98-1 with best quality

Cas:110543-98-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Molecular formula:C15H15Br2NO4 Molecular Weight:433.09 CAS Number:110543-98-1 Alisa: ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.;Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate;Ethyl5-acetyloxy-6-bromo-2

Ethyl 5-Acetoxy-6-Bromo-2-(Bromomethyl)-1-Methylindole-3-Carboxylate

Cas:110543-98-1

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & dr

Arbidol hcl intermediate / CAS No 110543-98-1

Cas:110543-98-1

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Minstar Chemical Co., Ltd

Product Name: ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. CAS: 110543-98-1 MF: C15H15Br2NO4 MW: 433.09 EINECS: Mol File: 110543-98-1.mol ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. Structure ETHYL5-ACE

ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.

Cas:110543-98-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. CAS: 110543-98-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, s

ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. CAS: 110543-98-1

Cas:110543-98-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate

Cas:110543-98-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.

Cas:110543-98-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate

Cas:110543-98-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate

Cas:110543-98-1

Min.Order:0

Negotiable

Type:Manufacturers

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ETHYL 5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METH 110543-98-1

Cas:110543-98-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate

Cas:110543-98-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate

Cas:110543-98-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality Appearance:powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediates Transportation:as per your

ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.

Cas:110543-98-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate

Cas:110543-98-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.

Cas:110543-98-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate

Cas:110543-98-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.

Cas:110543-98-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

110543-98-1 CAS NO.110543-98-1

Cas:110543-98-1

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of service

SAGECHEM/ Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate /Manufacturer in China

Cas:110543-98-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate

Cas:110543-98-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Ethyl 5-Acetoxy-6-Bromo-2-(Bromomethyl)-1-Methylindole-3-Car...

Cas:110543-98-1

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Ethyl 5-acetyloxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylate

Cas:110543-98-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Ethyl 5-Acetoxy-6-Bromo-2-(Bromomethyl)-1-Methyl-1H-Indole-3-Carboxylate

Cas:110543-98-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.

Cas:110543-98-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Ethyl 5-Acetoxy-6-Bromo-2-(Bromomethyl)-1-Methylindole-3-Carboxylate

Cas:110543-98-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1h-indole-3-carboxylate

Cas:110543-98-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate

Cas:110543-98-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester
40945-79-7

1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With bromine In tetrachloromethane for 16h; Inert atmosphere; Reflux;99%
With bromine In tetrachloromethane for 2h; Heating;87%
With bromine; dibenzoyl peroxide In chloroform for 3h; Reagent/catalyst; Reflux;85%
1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester
40945-79-7

1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester

A

5-acetoxy-6,7-dibromo-2-bromomethyl-1-methyl-1H-indole-3-carboxylic acid ethyl ester
1312943-26-2

5-acetoxy-6,7-dibromo-2-bromomethyl-1-methyl-1H-indole-3-carboxylic acid ethyl ester

B

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With bromine In 1,2-dichloro-ethane at 85℃; for 4h;A 28%
B 20 %Chromat.
With bromine In 1,2-dichloro-ethane at 85℃; for 3h;A 23 %Chromat.
B 53 %Chromat.
mecarbinate
15574-49-9

mecarbinate

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine
2: bromine / tetrachloromethane / Heating
View Scheme
Multi-step reaction with 2 steps
1: sodium acetate / dichloromethane / 3 h / Reflux
2: hydrogen bromide; dihydrogen peroxide / 1,2-dichloro-ethane / 4.5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: 4 h / Reflux
2: [RhCl2(p-cymene)]2; N-Bromosuccinimide / water; N,N-dimethyl acetamide / 24 h / 90 °C / Inert atmosphere
View Scheme
C14H17NO4

C14H17NO4

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C
2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
3: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
View Scheme
ethyl 5-acetyloxy-2-methyl-1H-indole-3-carboxylate
20862-91-3

ethyl 5-acetyloxy-2-methyl-1H-indole-3-carboxylate

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
2: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / Inert atmosphere; Cooling with ice
2: bromine / tetrachloromethane / 16 h / Inert atmosphere; Reflux
View Scheme
4-nitro-phenol
100-02-7

4-nitro-phenol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: pyridine / acetone / 4 h / 20 °C / Reflux
2: iron; ammonium chloride / ethanol; water / 2 h / Reflux
3: indium(III) bromide / dichloromethane / 3 h / Reflux
4: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C
5: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
6: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
View Scheme
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

thiophenol
108-98-5

thiophenol

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium hydroxide In methanol for 3h; Ambient temperature;96.4%
Stage #1: thiophenol With sodium hydroxide In methanol for 2h;
Stage #2: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester In methanol for 3h;
90.8%
Stage #1: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester; thiophenol With sodium hydroxide In methanol at 15 - 20℃; for 1h;
Stage #2: With acetic acid In methanol; acetone for 1h; Reflux;
88.6%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
In benzene for 22h; Ambient temperature;91.9%
4-nitro-phenol
100-02-7

4-nitro-phenol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

5-Acetoxy-6-bromo-1-methyl-2-(4-nitro-phenoxymethyl)-1H-indole-3-carboxylic acid ethyl ester
135980-83-5

5-Acetoxy-6-bromo-1-methyl-2-(4-nitro-phenoxymethyl)-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium hydroxide In acetone for 5h; Heating;79.2%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

2-mercapto-4-hydroxy-5-ethoxycarbonylpyrimidine sodium salt

2-mercapto-4-hydroxy-5-ethoxycarbonylpyrimidine sodium salt

1-methyl-2-(4-hydroxy-5-ethoxycarbonylpyrimidyl-2)thiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

1-methyl-2-(4-hydroxy-5-ethoxycarbonylpyrimidyl-2)thiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 0.5h; Ambient temperature;77.1%
4-chloro-aniline
106-47-8

4-chloro-aniline

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

5-Acetoxy-6-bromo-2-[(4-chloro-phenylamino)-methyl]-1-methyl-1H-indole-3-carboxylic acid ethyl ester
132629-02-8

5-Acetoxy-6-bromo-2-[(4-chloro-phenylamino)-methyl]-1-methyl-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In benzene at 20℃;76.8%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

phenol
108-95-2

phenol

A

5-Acetoxy-6-bromo-1-methyl-2-phenoxymethyl-1H-indole-3-carboxylic acid ethyl ester
135980-84-6

5-Acetoxy-6-bromo-1-methyl-2-phenoxymethyl-1H-indole-3-carboxylic acid ethyl ester

B

1-methyl-2-phenoxy-3-ethoxycarbonyl-5-(1-methyl-3-ethoxycarbonyl-5-acetoxy-6-bromoindolyl-2-methoxy)-6-bromoindole
135980-77-7

1-methyl-2-phenoxy-3-ethoxycarbonyl-5-(1-methyl-3-ethoxycarbonyl-5-acetoxy-6-bromoindolyl-2-methoxy)-6-bromoindole

Conditions
ConditionsYield
With potassium hydroxide In acetone for 5h; Heating;A 72.5%
B 4.1%
4-methoxy-aniline
104-94-9

4-methoxy-aniline

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

5-Acetoxy-6-bromo-2-[(4-methoxy-phenylamino)-methyl]-1-methyl-1H-indole-3-carboxylic acid ethyl ester
132629-01-7

5-Acetoxy-6-bromo-2-[(4-methoxy-phenylamino)-methyl]-1-methyl-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In benzene at 20℃;71.1%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

aniline
62-53-3

aniline

A

5-Acetoxy-6-bromo-1-methyl-2-phenylaminomethyl-1H-indole-3-carboxylic acid ethyl ester
132629-00-6

5-Acetoxy-6-bromo-1-methyl-2-phenylaminomethyl-1H-indole-3-carboxylic acid ethyl ester

B

C30H31Br2N3O8

C30H31Br2N3O8

Conditions
ConditionsYield
With triethylamine In benzene at 20℃;A 69.1%
B 3.2%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

4-methoxy-phenol
150-76-5

4-methoxy-phenol

5-Acetoxy-6-bromo-2-(4-methoxy-phenoxymethyl)-1-methyl-1H-indole-3-carboxylic acid ethyl ester
135980-85-7

5-Acetoxy-6-bromo-2-(4-methoxy-phenoxymethyl)-1-methyl-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium hydroxide In acetone for 5h; Heating;68.3%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

N-methylaniline
100-61-8

N-methylaniline

5-Acetoxy-6-bromo-1-methyl-2-[(methyl-phenyl-amino)-methyl]-1H-indole-3-carboxylic acid ethyl ester
132628-99-0

5-Acetoxy-6-bromo-1-methyl-2-[(methyl-phenyl-amino)-methyl]-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In benzene at 20℃;65%
4-bromo-phenol
106-41-2

4-bromo-phenol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

5-Acetoxy-6-bromo-2-(4-bromo-phenoxymethyl)-1-methyl-1H-indole-3-carboxylic acid ethyl ester
135980-82-4

5-Acetoxy-6-bromo-2-(4-bromo-phenoxymethyl)-1-methyl-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium hydroxide In acetone for 5h; Heating;64.5%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

thiourea
17356-08-0

thiourea

1-methyl-2-thioureidomethyl-3-ethoxycarbonyl-5-acetoxy-6-bromoindole hydrobromide

1-methyl-2-thioureidomethyl-3-ethoxycarbonyl-5-acetoxy-6-bromoindole hydrobromide

Conditions
ConditionsYield
In ethanol for 24h; Heating;64.2%
3-aminothiophenol
22948-02-3

3-aminothiophenol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

ethyl 2-(((3-aminophenyl)thio)methyl)-6-bromo-5-hydroxy-1-methyl-1H-indole-3-carboxylate

ethyl 2-(((3-aminophenyl)thio)methyl)-6-bromo-5-hydroxy-1-methyl-1H-indole-3-carboxylate

Conditions
ConditionsYield
Stage #1: 3-aminothiophenol With potassium hydroxide In methanol at 20℃; for 0.25h; Inert atmosphere;
Stage #2: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester In methanol; dichloromethane for 3h; Inert atmosphere; Cooling with ice;
62%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

4-nitro-aniline
100-01-6

4-nitro-aniline

5-Acetoxy-6-bromo-1-methyl-2-[(4-nitro-phenylamino)-methyl]-1H-indole-3-carboxylic acid ethyl ester
132629-03-9

5-Acetoxy-6-bromo-1-methyl-2-[(4-nitro-phenylamino)-methyl]-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In benzene at 20℃;60.1%
1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester
40945-79-7

1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With bromine In tetrachloromethane for 16h; Inert atmosphere; Reflux;99%
With bromine In tetrachloromethane for 2h; Heating;87%
With bromine; dibenzoyl peroxide In chloroform for 3h; Reagent/catalyst; Reflux;85%
1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester
40945-79-7

1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester

A

5-acetoxy-6,7-dibromo-2-bromomethyl-1-methyl-1H-indole-3-carboxylic acid ethyl ester
1312943-26-2

5-acetoxy-6,7-dibromo-2-bromomethyl-1-methyl-1H-indole-3-carboxylic acid ethyl ester

B

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With bromine In 1,2-dichloro-ethane at 85℃; for 4h;A 28%
B 20 %Chromat.
With bromine In 1,2-dichloro-ethane at 85℃; for 3h;A 23 %Chromat.
B 53 %Chromat.
mecarbinate
15574-49-9

mecarbinate

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine
2: bromine / tetrachloromethane / Heating
View Scheme
Multi-step reaction with 2 steps
1: sodium acetate / dichloromethane / 3 h / Reflux
2: hydrogen bromide; dihydrogen peroxide / 1,2-dichloro-ethane / 4.5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: 4 h / Reflux
2: [RhCl2(p-cymene)]2; N-Bromosuccinimide / water; N,N-dimethyl acetamide / 24 h / 90 °C / Inert atmosphere
View Scheme
C14H17NO4

C14H17NO4

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C
2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
3: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
View Scheme
ethyl 5-acetyloxy-2-methyl-1H-indole-3-carboxylate
20862-91-3

ethyl 5-acetyloxy-2-methyl-1H-indole-3-carboxylate

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
2: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / Inert atmosphere; Cooling with ice
2: bromine / tetrachloromethane / 16 h / Inert atmosphere; Reflux
View Scheme
4-nitro-phenol
100-02-7

4-nitro-phenol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: pyridine / acetone / 4 h / 20 °C / Reflux
2: iron; ammonium chloride / ethanol; water / 2 h / Reflux
3: indium(III) bromide / dichloromethane / 3 h / Reflux
4: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C
5: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
6: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
View Scheme
4-nitrophenol acetate
830-03-5

4-nitrophenol acetate

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: iron; ammonium chloride / ethanol; water / 2 h / Reflux
2: indium(III) bromide / dichloromethane / 3 h / Reflux
3: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C
4: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
5: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
View Scheme
p-aminophenyl acetate
13871-68-6

p-aminophenyl acetate

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: indium(III) bromide / dichloromethane / 3 h / Reflux
2: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C
3: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C
4: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux
View Scheme
ethyl 3-methylaminocrotonate
870-85-9

ethyl 3-methylaminocrotonate

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1,2-dichloro-ethane / 8 h / Reflux
2: pyridine / acetone / 4 h / 30 °C
3: dibenzoyl peroxide; bromine / tetrachloromethane / 5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
2: bromine
View Scheme
ethyl 5-hydroxy-2-methylindole-3-carboxylate
7598-91-6

ethyl 5-hydroxy-2-methylindole-3-carboxylate

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine / 1 h / Inert atmosphere; Reflux
2: sodium hydride / N,N-dimethyl-formamide / 1.5 h / Inert atmosphere; Cooling with ice
3: bromine / tetrachloromethane / 16 h / Inert atmosphere; Reflux
View Scheme
ethyl acetoacetate
141-97-9

ethyl acetoacetate

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide
3: bromine
View Scheme
Multi-step reaction with 4 steps
1: 3 h / 20 - 30 °C / Cooling with ice
2: zinc(II) chloride / dichloromethane / 4 h / 10 - 20 °C
3: sodium acetate / dichloromethane / 3 h / Reflux
4: hydrogen bromide; dihydrogen peroxide / 1,2-dichloro-ethane / 4.5 h / Reflux
View Scheme
ethyl N-methyl β-aminocrotonate
65578-36-1

ethyl N-methyl β-aminocrotonate

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: zinc(II) chloride / dichloromethane / 4 h / 10 - 20 °C
2: sodium acetate / dichloromethane / 3 h / Reflux
3: hydrogen bromide; dihydrogen peroxide / 1,2-dichloro-ethane / 4.5 h / Reflux
View Scheme
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

thiophenol
108-98-5

thiophenol

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
131707-24-9

6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium hydroxide In methanol for 3h; Ambient temperature;96.4%
Stage #1: thiophenol With sodium hydroxide In methanol for 2h;
Stage #2: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester In methanol for 3h;
90.8%
Stage #1: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester; thiophenol With sodium hydroxide In methanol at 15 - 20℃; for 1h;
Stage #2: With acetic acid In methanol; acetone for 1h; Reflux;
88.6%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

dibutylamine
111-92-2

dibutylamine

1-Methyl-2-dibutylaminomethyl-3-ethoxycarbonyl-5-acetoxy-6-bromoindole
110566-59-1

1-Methyl-2-dibutylaminomethyl-3-ethoxycarbonyl-5-acetoxy-6-bromoindole

Conditions
ConditionsYield
In benzene for 22h; Ambient temperature;91.9%
4-nitro-phenol
100-02-7

4-nitro-phenol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

5-Acetoxy-6-bromo-1-methyl-2-(4-nitro-phenoxymethyl)-1H-indole-3-carboxylic acid ethyl ester
135980-83-5

5-Acetoxy-6-bromo-1-methyl-2-(4-nitro-phenoxymethyl)-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium hydroxide In acetone for 5h; Heating;79.2%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

2-mercapto-4-hydroxy-5-ethoxycarbonylpyrimidine sodium salt

2-mercapto-4-hydroxy-5-ethoxycarbonylpyrimidine sodium salt

1-methyl-2-(4-hydroxy-5-ethoxycarbonylpyrimidyl-2)thiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

1-methyl-2-(4-hydroxy-5-ethoxycarbonylpyrimidyl-2)thiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 0.5h; Ambient temperature;77.1%
4-chloro-aniline
106-47-8

4-chloro-aniline

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

5-Acetoxy-6-bromo-2-[(4-chloro-phenylamino)-methyl]-1-methyl-1H-indole-3-carboxylic acid ethyl ester
132629-02-8

5-Acetoxy-6-bromo-2-[(4-chloro-phenylamino)-methyl]-1-methyl-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In benzene at 20℃;76.8%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

phenol
108-95-2

phenol

A

5-Acetoxy-6-bromo-1-methyl-2-phenoxymethyl-1H-indole-3-carboxylic acid ethyl ester
135980-84-6

5-Acetoxy-6-bromo-1-methyl-2-phenoxymethyl-1H-indole-3-carboxylic acid ethyl ester

B

1-methyl-2-phenoxy-3-ethoxycarbonyl-5-(1-methyl-3-ethoxycarbonyl-5-acetoxy-6-bromoindolyl-2-methoxy)-6-bromoindole
135980-77-7

1-methyl-2-phenoxy-3-ethoxycarbonyl-5-(1-methyl-3-ethoxycarbonyl-5-acetoxy-6-bromoindolyl-2-methoxy)-6-bromoindole

Conditions
ConditionsYield
With potassium hydroxide In acetone for 5h; Heating;A 72.5%
B 4.1%
4-methoxy-aniline
104-94-9

4-methoxy-aniline

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

5-Acetoxy-6-bromo-2-[(4-methoxy-phenylamino)-methyl]-1-methyl-1H-indole-3-carboxylic acid ethyl ester
132629-01-7

5-Acetoxy-6-bromo-2-[(4-methoxy-phenylamino)-methyl]-1-methyl-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In benzene at 20℃;71.1%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

aniline
62-53-3

aniline

A

5-Acetoxy-6-bromo-1-methyl-2-phenylaminomethyl-1H-indole-3-carboxylic acid ethyl ester
132629-00-6

5-Acetoxy-6-bromo-1-methyl-2-phenylaminomethyl-1H-indole-3-carboxylic acid ethyl ester

B

C30H31Br2N3O8

C30H31Br2N3O8

Conditions
ConditionsYield
With triethylamine In benzene at 20℃;A 69.1%
B 3.2%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

4-methoxy-phenol
150-76-5

4-methoxy-phenol

5-Acetoxy-6-bromo-2-(4-methoxy-phenoxymethyl)-1-methyl-1H-indole-3-carboxylic acid ethyl ester
135980-85-7

5-Acetoxy-6-bromo-2-(4-methoxy-phenoxymethyl)-1-methyl-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium hydroxide In acetone for 5h; Heating;68.3%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

N-methylaniline
100-61-8

N-methylaniline

5-Acetoxy-6-bromo-1-methyl-2-[(methyl-phenyl-amino)-methyl]-1H-indole-3-carboxylic acid ethyl ester
132628-99-0

5-Acetoxy-6-bromo-1-methyl-2-[(methyl-phenyl-amino)-methyl]-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In benzene at 20℃;65%
4-bromo-phenol
106-41-2

4-bromo-phenol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

5-Acetoxy-6-bromo-2-(4-bromo-phenoxymethyl)-1-methyl-1H-indole-3-carboxylic acid ethyl ester
135980-82-4

5-Acetoxy-6-bromo-2-(4-bromo-phenoxymethyl)-1-methyl-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium hydroxide In acetone for 5h; Heating;64.5%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

thiourea
17356-08-0

thiourea

1-methyl-2-thioureidomethyl-3-ethoxycarbonyl-5-acetoxy-6-bromoindole hydrobromide

1-methyl-2-thioureidomethyl-3-ethoxycarbonyl-5-acetoxy-6-bromoindole hydrobromide

Conditions
ConditionsYield
In ethanol for 24h; Heating;64.2%
3-aminothiophenol
22948-02-3

3-aminothiophenol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

ethyl 2-(((3-aminophenyl)thio)methyl)-6-bromo-5-hydroxy-1-methyl-1H-indole-3-carboxylate

ethyl 2-(((3-aminophenyl)thio)methyl)-6-bromo-5-hydroxy-1-methyl-1H-indole-3-carboxylate

Conditions
ConditionsYield
Stage #1: 3-aminothiophenol With potassium hydroxide In methanol at 20℃; for 0.25h; Inert atmosphere;
Stage #2: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester In methanol; dichloromethane for 3h; Inert atmosphere; Cooling with ice;
62%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

4-nitro-aniline
100-01-6

4-nitro-aniline

5-Acetoxy-6-bromo-1-methyl-2-[(4-nitro-phenylamino)-methyl]-1H-indole-3-carboxylic acid ethyl ester
132629-03-9

5-Acetoxy-6-bromo-1-methyl-2-[(4-nitro-phenylamino)-methyl]-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In benzene at 20℃;60.1%
3-methoxybenzenethiol
15570-12-4

3-methoxybenzenethiol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

ethyl 5-acetyloxy-6-bromo-2-(((3-methoxyphenyl)thio)methyl)-1-methyl-1H-indole-3-carboxylate

ethyl 5-acetyloxy-6-bromo-2-(((3-methoxyphenyl)thio)methyl)-1-methyl-1H-indole-3-carboxylate

Conditions
ConditionsYield
With sodium carbonate In ethyl acetate at 50℃; for 2h; Inert atmosphere;59%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

2-Naphthalenethiol
91-60-1

2-Naphthalenethiol

C23H20BrNO3S

C23H20BrNO3S

Conditions
ConditionsYield
Stage #1: 2-Naphthalenethiol With potassium hydroxide In methanol at 20℃; for 0.25h; Inert atmosphere;
Stage #2: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester In methanol; dichloromethane for 3h; Inert atmosphere; Cooling with ice;
50%
3-mercaptophenol
40248-84-8

3-mercaptophenol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

ethyl 5-acetyloxy-6-bromo-2-(((3-hydroxyphenyl)thio)methyl)-1-methyl-1H-indole-3-carboxylate

ethyl 5-acetyloxy-6-bromo-2-(((3-hydroxyphenyl)thio)methyl)-1-methyl-1H-indole-3-carboxylate

Conditions
ConditionsYield
With sodium carbonate In ethyl acetate at 100℃; for 5h; Inert atmosphere;44%
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

5-acetoxy-6,7-dibromo-2-bromomethyl-1-methyl-1H-indole-3-carboxylic acid ethyl ester
1312943-26-2

5-acetoxy-6,7-dibromo-2-bromomethyl-1-methyl-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With bromine In 1,2-dichloro-ethane at 85℃; for 4.5h;28%
ortho-mercaptophenol
1121-24-0

ortho-mercaptophenol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

ethyl 6-bromo-5-hydroxy-2-(((2-hydroxyphenyl)thio)methyl)-1-methyl-1H-indole-3-carboxylate

ethyl 6-bromo-5-hydroxy-2-(((2-hydroxyphenyl)thio)methyl)-1-methyl-1H-indole-3-carboxylate

Conditions
ConditionsYield
Stage #1: ortho-mercaptophenol; 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester With sodium carbonate In ethyl acetate at 50℃; for 2h; Inert atmosphere;
Stage #2: With methanol; potassium hydroxide at 20℃; for 3h; Inert atmosphere;
18%
aniline hydrochloride
142-04-1

aniline hydrochloride

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

C30H31Br2N3O8

C30H31Br2N3O8

Conditions
ConditionsYield
In water for 3h; Heating;10.6%
4-sulfanylphenol
637-89-8

4-sulfanylphenol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

ethyl 6-bromo-5-hydroxy-2-(((4-hydroxyphenyl)thio)methyl)-1-methyl-1H-indole-3-carboxylate

ethyl 6-bromo-5-hydroxy-2-(((4-hydroxyphenyl)thio)methyl)-1-methyl-1H-indole-3-carboxylate

Conditions
ConditionsYield
Stage #1: 4-sulfanylphenol; 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester With sodium carbonate In ethyl acetate at 50℃; for 2h; Inert atmosphere;
Stage #2: With methanol; potassium hydroxide at 20℃; for 3h; Inert atmosphere;
2%
morpholine
110-91-8

morpholine

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

5-Acetoxy-6-bromo-1-methyl-2-morpholin-4-ylmethyl-1H-indole-3-carboxylic acid ethyl ester
110543-92-5

5-Acetoxy-6-bromo-1-methyl-2-morpholin-4-ylmethyl-1H-indole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
In benzene for 22h; Ambient temperature;
In benzene for 1h;
Thiophene-2-thiol
7774-74-5

Thiophene-2-thiol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

1-methyl-2-(thienyl-2')-thiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

1-methyl-2-(thienyl-2')-thiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

Conditions
ConditionsYield
With potassium hydroxide 1.) MeOH, RT, 10 min, 2.) MeOH, RT, 3 h; Yield given. Multistep reaction;
thiophene-3-thiol
7774-73-4

thiophene-3-thiol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

1-methyl-2-(thienyl-3')-thiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

1-methyl-2-(thienyl-3')-thiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

Conditions
ConditionsYield
With potassium hydroxide 1.) MeOH, RT, 10 min, 2.) MeOH, RT, 3 h; Yield given. Multistep reaction;
2-Mercaptopyridine
2637-34-5

2-Mercaptopyridine

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

1-methyl-2-(pyridyl-2')-thiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

1-methyl-2-(pyridyl-2')-thiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

Conditions
ConditionsYield
With potassium hydroxide 1.) MeOH, RT, 10 min, 2.) MeOH, RT, 3 h; Yield given. Multistep reaction;
Cyclohexanethiol
1569-69-3

Cyclohexanethiol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

1-methyl-2-cyclohexylthiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

1-methyl-2-cyclohexylthiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

Conditions
ConditionsYield
With potassium hydroxide 1.) MeOH, RT, 10 min, 2.) MeOH, RT, 3 h; Yield given. Multistep reaction;
4-hydroxy-3,5-di-tert-butylthiophenol
950-59-4

4-hydroxy-3,5-di-tert-butylthiophenol

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

1-methyl-2-(3',5'-di-tert-butyl-4'-hydroxyphenyl)-thiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

1-methyl-2-(3',5'-di-tert-butyl-4'-hydroxyphenyl)-thiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

Conditions
ConditionsYield
With potassium hydroxide 1.) MeOH, RT, 10 min, 2.) MeOH, RT, 3 h; Yield given. Multistep reaction;
3-cyano-4,6-dimethyl-2-mercaptopyridine
54585-47-6

3-cyano-4,6-dimethyl-2-mercaptopyridine

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
110543-98-1

5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester

1-methyl-2-(3'-cyano-4',6'-dimethylpyridyl-2')-thiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

1-methyl-2-(3'-cyano-4',6'-dimethylpyridyl-2')-thiomethyl-3-ethoxycarbonyl-5-hydroxy-6-bromoindole

Conditions
ConditionsYield
With potassium hydroxide 1.) MeOH, RT, 10 min, 2.) MeOH, RT, 3 h; Yield given. Multistep reaction;

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