The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
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inquiryOur company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryMolecular formula:C15H15Br2NO4 Molecular Weight:433.09 CAS Number:110543-98-1 Alisa: ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-.;Ethyl 5-acetoxy-6-bromo-2-(bromomethyl)-1-methyl-1H-indole-3-carboxylate;Ethyl5-acetyloxy-6-bromo-2
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & dr
Cas:110543-98-1
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inquiryProduct Name: ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. CAS: 110543-98-1 MF: C15H15Br2NO4 MW: 433.09 EINECS: Mol File: 110543-98-1.mol ETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. Structure ETHYL5-ACE
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inquiryETHYL5-ACETOXY-6-BROMO-2-(BROMOMETHYL)-1-METHYLINDOLE-3-. CAS: 110543-98-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, s
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:110543-98-1
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inquirySuperior quality Appearance:powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediates Transportation:as per your
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:110543-98-1
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:110543-98-1
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inquiryHunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:110543-98-1
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inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of service
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
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inquiryhigh purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier
Cas:110543-98-1
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inquiryOur clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
Cas:110543-98-1
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inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiryWe product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate
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inquiry1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With bromine In tetrachloromethane for 16h; Inert atmosphere; Reflux; | 99% |
With bromine In tetrachloromethane for 2h; Heating; | 87% |
With bromine; dibenzoyl peroxide In chloroform for 3h; Reagent/catalyst; Reflux; | 85% |
1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester
A
5-acetoxy-6,7-dibromo-2-bromomethyl-1-methyl-1H-indole-3-carboxylic acid ethyl ester
B
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With bromine In 1,2-dichloro-ethane at 85℃; for 4h; | A 28% B 20 %Chromat. |
With bromine In 1,2-dichloro-ethane at 85℃; for 3h; | A 23 %Chromat. B 53 %Chromat. |
mecarbinate
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine 2: bromine / tetrachloromethane / Heating View Scheme | |
Multi-step reaction with 2 steps 1: sodium acetate / dichloromethane / 3 h / Reflux 2: hydrogen bromide; dihydrogen peroxide / 1,2-dichloro-ethane / 4.5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: 4 h / Reflux 2: [RhCl2(p-cymene)]2; N-Bromosuccinimide / water; N,N-dimethyl acetamide / 24 h / 90 °C / Inert atmosphere View Scheme |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C 2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C 3: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux View Scheme |
ethyl 5-acetyloxy-2-methyl-1H-indole-3-carboxylate
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C 2: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / Inert atmosphere; Cooling with ice 2: bromine / tetrachloromethane / 16 h / Inert atmosphere; Reflux View Scheme |
4-nitro-phenol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: pyridine / acetone / 4 h / 20 °C / Reflux 2: iron; ammonium chloride / ethanol; water / 2 h / Reflux 3: indium(III) bromide / dichloromethane / 3 h / Reflux 4: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C 5: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C 6: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux View Scheme |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
thiophenol
6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide In methanol for 3h; Ambient temperature; | 96.4% |
Stage #1: thiophenol With sodium hydroxide In methanol for 2h; Stage #2: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester In methanol for 3h; | 90.8% |
Stage #1: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester; thiophenol With sodium hydroxide In methanol at 15 - 20℃; for 1h; Stage #2: With acetic acid In methanol; acetone for 1h; Reflux; | 88.6% |
Conditions | Yield |
---|---|
In benzene for 22h; Ambient temperature; | 91.9% |
4-nitro-phenol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
5-Acetoxy-6-bromo-1-methyl-2-(4-nitro-phenoxymethyl)-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide In acetone for 5h; Heating; | 79.2% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide for 0.5h; Ambient temperature; | 77.1% |
4-chloro-aniline
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
5-Acetoxy-6-bromo-2-[(4-chloro-phenylamino)-methyl]-1-methyl-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In benzene at 20℃; | 76.8% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
phenol
A
5-Acetoxy-6-bromo-1-methyl-2-phenoxymethyl-1H-indole-3-carboxylic acid ethyl ester
B
1-methyl-2-phenoxy-3-ethoxycarbonyl-5-(1-methyl-3-ethoxycarbonyl-5-acetoxy-6-bromoindolyl-2-methoxy)-6-bromoindole
Conditions | Yield |
---|---|
With potassium hydroxide In acetone for 5h; Heating; | A 72.5% B 4.1% |
4-methoxy-aniline
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
5-Acetoxy-6-bromo-2-[(4-methoxy-phenylamino)-methyl]-1-methyl-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In benzene at 20℃; | 71.1% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
aniline
A
5-Acetoxy-6-bromo-1-methyl-2-phenylaminomethyl-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In benzene at 20℃; | A 69.1% B 3.2% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
4-methoxy-phenol
5-Acetoxy-6-bromo-2-(4-methoxy-phenoxymethyl)-1-methyl-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide In acetone for 5h; Heating; | 68.3% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
N-methylaniline
5-Acetoxy-6-bromo-1-methyl-2-[(methyl-phenyl-amino)-methyl]-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In benzene at 20℃; | 65% |
4-bromo-phenol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
5-Acetoxy-6-bromo-2-(4-bromo-phenoxymethyl)-1-methyl-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide In acetone for 5h; Heating; | 64.5% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
thiourea
Conditions | Yield |
---|---|
In ethanol for 24h; Heating; | 64.2% |
3-aminothiophenol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: 3-aminothiophenol With potassium hydroxide In methanol at 20℃; for 0.25h; Inert atmosphere; Stage #2: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester In methanol; dichloromethane for 3h; Inert atmosphere; Cooling with ice; | 62% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
4-nitro-aniline
5-Acetoxy-6-bromo-1-methyl-2-[(4-nitro-phenylamino)-methyl]-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In benzene at 20℃; | 60.1% |
1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With bromine In tetrachloromethane for 16h; Inert atmosphere; Reflux; | 99% |
With bromine In tetrachloromethane for 2h; Heating; | 87% |
With bromine; dibenzoyl peroxide In chloroform for 3h; Reagent/catalyst; Reflux; | 85% |
1,2-dimethyl-5-acetoxy-1H-indole-3-carboxylic acid ethyl ester
A
5-acetoxy-6,7-dibromo-2-bromomethyl-1-methyl-1H-indole-3-carboxylic acid ethyl ester
B
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With bromine In 1,2-dichloro-ethane at 85℃; for 4h; | A 28% B 20 %Chromat. |
With bromine In 1,2-dichloro-ethane at 85℃; for 3h; | A 23 %Chromat. B 53 %Chromat. |
mecarbinate
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine 2: bromine / tetrachloromethane / Heating View Scheme | |
Multi-step reaction with 2 steps 1: sodium acetate / dichloromethane / 3 h / Reflux 2: hydrogen bromide; dihydrogen peroxide / 1,2-dichloro-ethane / 4.5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: 4 h / Reflux 2: [RhCl2(p-cymene)]2; N-Bromosuccinimide / water; N,N-dimethyl acetamide / 24 h / 90 °C / Inert atmosphere View Scheme |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C 2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C 3: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux View Scheme |
ethyl 5-acetyloxy-2-methyl-1H-indole-3-carboxylate
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C 2: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / Inert atmosphere; Cooling with ice 2: bromine / tetrachloromethane / 16 h / Inert atmosphere; Reflux View Scheme |
4-nitro-phenol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: pyridine / acetone / 4 h / 20 °C / Reflux 2: iron; ammonium chloride / ethanol; water / 2 h / Reflux 3: indium(III) bromide / dichloromethane / 3 h / Reflux 4: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C 5: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C 6: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux View Scheme |
4-nitrophenol acetate
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: iron; ammonium chloride / ethanol; water / 2 h / Reflux 2: indium(III) bromide / dichloromethane / 3 h / Reflux 3: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C 4: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C 5: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux View Scheme |
p-aminophenyl acetate
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: indium(III) bromide / dichloromethane / 3 h / Reflux 2: potassium carbonate; palladium diacetate; copper diacetate / N,N-dimethyl-formamide / 3 h / 80 °C 3: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C 4: dibenzoyl peroxide; bromine / chloroform / 3 h / Reflux View Scheme |
ethyl 3-methylaminocrotonate
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1,2-dichloro-ethane / 8 h / Reflux 2: pyridine / acetone / 4 h / 30 °C 3: dibenzoyl peroxide; bromine / tetrachloromethane / 5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 2: bromine View Scheme |
ethyl 5-hydroxy-2-methylindole-3-carboxylate
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine / 1 h / Inert atmosphere; Reflux 2: sodium hydride / N,N-dimethyl-formamide / 1.5 h / Inert atmosphere; Cooling with ice 3: bromine / tetrachloromethane / 16 h / Inert atmosphere; Reflux View Scheme |
ethyl acetoacetate
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide 3: bromine View Scheme | |
Multi-step reaction with 4 steps 1: 3 h / 20 - 30 °C / Cooling with ice 2: zinc(II) chloride / dichloromethane / 4 h / 10 - 20 °C 3: sodium acetate / dichloromethane / 3 h / Reflux 4: hydrogen bromide; dihydrogen peroxide / 1,2-dichloro-ethane / 4.5 h / Reflux View Scheme |
ethyl N-methyl β-aminocrotonate
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: zinc(II) chloride / dichloromethane / 4 h / 10 - 20 °C 2: sodium acetate / dichloromethane / 3 h / Reflux 3: hydrogen bromide; dihydrogen peroxide / 1,2-dichloro-ethane / 4.5 h / Reflux View Scheme |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
thiophenol
6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide In methanol for 3h; Ambient temperature; | 96.4% |
Stage #1: thiophenol With sodium hydroxide In methanol for 2h; Stage #2: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester In methanol for 3h; | 90.8% |
Stage #1: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester; thiophenol With sodium hydroxide In methanol at 15 - 20℃; for 1h; Stage #2: With acetic acid In methanol; acetone for 1h; Reflux; | 88.6% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
dibutylamine
1-Methyl-2-dibutylaminomethyl-3-ethoxycarbonyl-5-acetoxy-6-bromoindole
Conditions | Yield |
---|---|
In benzene for 22h; Ambient temperature; | 91.9% |
4-nitro-phenol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
5-Acetoxy-6-bromo-1-methyl-2-(4-nitro-phenoxymethyl)-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide In acetone for 5h; Heating; | 79.2% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide for 0.5h; Ambient temperature; | 77.1% |
4-chloro-aniline
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
5-Acetoxy-6-bromo-2-[(4-chloro-phenylamino)-methyl]-1-methyl-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In benzene at 20℃; | 76.8% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
phenol
A
5-Acetoxy-6-bromo-1-methyl-2-phenoxymethyl-1H-indole-3-carboxylic acid ethyl ester
B
1-methyl-2-phenoxy-3-ethoxycarbonyl-5-(1-methyl-3-ethoxycarbonyl-5-acetoxy-6-bromoindolyl-2-methoxy)-6-bromoindole
Conditions | Yield |
---|---|
With potassium hydroxide In acetone for 5h; Heating; | A 72.5% B 4.1% |
4-methoxy-aniline
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
5-Acetoxy-6-bromo-2-[(4-methoxy-phenylamino)-methyl]-1-methyl-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In benzene at 20℃; | 71.1% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
aniline
A
5-Acetoxy-6-bromo-1-methyl-2-phenylaminomethyl-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In benzene at 20℃; | A 69.1% B 3.2% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
4-methoxy-phenol
5-Acetoxy-6-bromo-2-(4-methoxy-phenoxymethyl)-1-methyl-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide In acetone for 5h; Heating; | 68.3% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
N-methylaniline
5-Acetoxy-6-bromo-1-methyl-2-[(methyl-phenyl-amino)-methyl]-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In benzene at 20℃; | 65% |
4-bromo-phenol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
5-Acetoxy-6-bromo-2-(4-bromo-phenoxymethyl)-1-methyl-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide In acetone for 5h; Heating; | 64.5% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
thiourea
Conditions | Yield |
---|---|
In ethanol for 24h; Heating; | 64.2% |
3-aminothiophenol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: 3-aminothiophenol With potassium hydroxide In methanol at 20℃; for 0.25h; Inert atmosphere; Stage #2: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester In methanol; dichloromethane for 3h; Inert atmosphere; Cooling with ice; | 62% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
4-nitro-aniline
5-Acetoxy-6-bromo-1-methyl-2-[(4-nitro-phenylamino)-methyl]-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With triethylamine In benzene at 20℃; | 60.1% |
3-methoxybenzenethiol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With sodium carbonate In ethyl acetate at 50℃; for 2h; Inert atmosphere; | 59% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
2-Naphthalenethiol
Conditions | Yield |
---|---|
Stage #1: 2-Naphthalenethiol With potassium hydroxide In methanol at 20℃; for 0.25h; Inert atmosphere; Stage #2: 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester In methanol; dichloromethane for 3h; Inert atmosphere; Cooling with ice; | 50% |
3-mercaptophenol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With sodium carbonate In ethyl acetate at 100℃; for 5h; Inert atmosphere; | 44% |
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
5-acetoxy-6,7-dibromo-2-bromomethyl-1-methyl-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With bromine In 1,2-dichloro-ethane at 85℃; for 4.5h; | 28% |
ortho-mercaptophenol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: ortho-mercaptophenol; 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester With sodium carbonate In ethyl acetate at 50℃; for 2h; Inert atmosphere; Stage #2: With methanol; potassium hydroxide at 20℃; for 3h; Inert atmosphere; | 18% |
aniline hydrochloride
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
In water for 3h; Heating; | 10.6% |
4-sulfanylphenol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: 4-sulfanylphenol; 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester With sodium carbonate In ethyl acetate at 50℃; for 2h; Inert atmosphere; Stage #2: With methanol; potassium hydroxide at 20℃; for 3h; Inert atmosphere; | 2% |
morpholine
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
5-Acetoxy-6-bromo-1-methyl-2-morpholin-4-ylmethyl-1H-indole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
In benzene for 22h; Ambient temperature; | |
In benzene for 1h; |
Thiophene-2-thiol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide 1.) MeOH, RT, 10 min, 2.) MeOH, RT, 3 h; Yield given. Multistep reaction; |
thiophene-3-thiol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide 1.) MeOH, RT, 10 min, 2.) MeOH, RT, 3 h; Yield given. Multistep reaction; |
2-Mercaptopyridine
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide 1.) MeOH, RT, 10 min, 2.) MeOH, RT, 3 h; Yield given. Multistep reaction; |
Cyclohexanethiol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide 1.) MeOH, RT, 10 min, 2.) MeOH, RT, 3 h; Yield given. Multistep reaction; |
4-hydroxy-3,5-di-tert-butylthiophenol
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide 1.) MeOH, RT, 10 min, 2.) MeOH, RT, 3 h; Yield given. Multistep reaction; |
3-cyano-4,6-dimethyl-2-mercaptopyridine
5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide 1.) MeOH, RT, 10 min, 2.) MeOH, RT, 3 h; Yield given. Multistep reaction; |
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