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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity (3beta)-Androsta-5,16-diene-3,17-diol 3-acetate 17-(trifluoromethanesulfonate) CAS:115375-60-5

Cas:115375-60-5

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(3β)-Androsta-5,16-diene-3,17-diol 3-acetate 17-(trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM (3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 115375-60-5 with competitive price

Cas:115375-60-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Androsta-5,16-diene-3,17-diol, 3-acetate 17-(trifluoromethanesulfonate), (3β)- 115375-60-5

Cas:115375-60-5

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate) CAS:115375-60-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chem

(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate) CAS:115375-60-5

Cas:115375-60-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Androsta-5,16-diene-3,17-diol, 3-acetate 17-(trifluoromethanesulfonate), (3β)-

Cas:115375-60-5

Min.Order:0

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Androsta-5,16-diene-3,17-diol, 3-acetate 17-(trifluoromethanesulfonate), (3β)-

Cas:115375-60-5

Min.Order:0

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

(3beta)-Androsta-5,16-diene-3,17-diol 3-acetate 17-(trifluor...

Cas:115375-60-5

Min.Order:0

Negotiable

Type:Other

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JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

(3-Beta)-Androsta-5,16-Diene-3,17-Diol 3-Acetate 17-(Trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package: 1g/bag, 5g/bag, 10g/bag, 100g/bag, 1kg/bag or as per your request Application:It

BOC Sciences

BOC Sciences is committed to supplying cost-effective products and services. We provide Abiraterone Related Compound 4 (Prasterone Acetate Triflate). An impurity of Abiraterone, a steroid hormone involved in the steroidogenesis of progesterone, min

Abiraterone Related Compound 4 (Prasterone Acetate Triflate)

Cas:115375-60-5

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:0

Negotiable

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Antimex Chemical Limied

factory?direct?sale Application:healing drugs

Androsta-5,16-diene-3,17-diol, 3-acetate 17-(trifluoromethanesulfonate), (3β)-

Cas:115375-60-5

Min.Order:0

Negotiable

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Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:0

Negotiable

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DB BIOTECH CO., LTD

best seller Application:API

(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:0

Negotiable

Type:Trading Company

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:0

Negotiable

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SAGECHEM LIMITED

115375-60-5 Application:intermediate

Androsta-5,16-diene-3,17-diol, 3-acetate 17-(trifluoromethanesulfonate), (3b)-

Cas:115375-60-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

115375-60-5

Cas:115375-60-5

Min.Order:0

Negotiable

Type:Trading Company

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Hebei Muhuang Technology Co., Ltd

best seller Application:API

(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:0

Negotiable

Type:Trading Company

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Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:0

Negotiable

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NUTROCHEM- MANUFACTURE PLACE

best seller Application:API

(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:0

Negotiable

Type:Trading Company

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HENAN SUNLAKE ENTERPRISE CORPORATION

iodomethyl (2S-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide Basic information Product Name: iodomethyl (2S-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-

115375-60-5 (3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Wuhan Sun-shine Bio-technology Corporation Limited

Wuhan Sun-shine Bio-technology Corporation Limited is specializing in the anticancer, antitumor,heart head blood-vessel,pharmaceutical intermediates,fine Chemicals production and customization..Company has strong ability of research and development

(3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)

Cas:115375-60-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

prasterone acetate
853-23-6

prasterone acetate

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

Conditions
ConditionsYield
Stage #1: prasterone acetate With potassium carbonate In toluene; benzene at 25℃; for 0.5h;
Stage #2: trifluoromethylsulfonic anhydride In toluene; benzene at -18 - -15℃; for 20.33h; Reagent/catalyst; Solvent; Temperature;
96%
Stage #1: prasterone acetate With potassium carbonate In toluene; benzene at 25℃; for 0.5h;
Stage #2: trifluoromethylsulfonic anhydride In toluene; benzene at -18 - -15℃; for 20.33h;
96%
Stage #1: trifluoromethylsulfonic anhydride; prasterone acetate In dichloromethane at 20℃; for 0.0833333h;
Stage #2: With 2-methoxypyridine In dichloromethane at 20 - 30℃; for 2.5h; Reagent/catalyst;
93%
N,N-phenylbistrifluoromethane-sulfonimide
37595-74-7

N,N-phenylbistrifluoromethane-sulfonimide

prasterone acetate
853-23-6

prasterone acetate

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

Conditions
ConditionsYield
Stage #1: prasterone acetate With potassium hexamethylsilazane In tetrahydrofuran at -78℃; for 1h;
Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at -78℃; for 2h;
85%
Stage #1: prasterone acetate With potassium hexamethylsilazane In tetrahydrofuran for 0.5h; Inert atmosphere;
Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran for 8h; Inert atmosphere;
70%
With potassium hexamethylsilazane In tetrahydrofuran; toluene at -80 - 0℃; for 4h;850 mg
With potassium hexamethylsilazane In tetrahydrofuran; toluene at -80 - 5℃; for 2.5h;64.8 g
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

prasterone acetate
853-23-6

prasterone acetate

A

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

B

androsta-3,5,16-trien-17-yl trifluoromethanesulfonate
154229-36-4

androsta-3,5,16-trien-17-yl trifluoromethanesulfonate

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-methylpyridine In dichloromethane for 12h;A 58%
B 10%
With 2,6-di-tert-butyl-4-methylpyridine In dichloromethane for 3 - 16h; Product distribution / selectivity;
Stage #1: trifluoromethylsulfonic anhydride; prasterone acetate With 2,6-dimethylpyridine In ethyl acetate for 0.25h;
Stage #2: With 2,6-dimethylpyridine In ethyl acetate for 2h; Product distribution / selectivity;
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

prasterone acetate
853-23-6

prasterone acetate

A

dehydroepiandrosterone
53-43-0

dehydroepiandrosterone

B

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

Conditions
ConditionsYield
Stage #1: trifluoromethylsulfonic anhydride; prasterone acetate In 2-Methylpentane for 0.25h;
Stage #2: With triethylamine In 2-Methylpentane for 2h; Product distribution / selectivity;
Stage #1: trifluoromethylsulfonic anhydride; prasterone acetate In ethyl acetate for 0.25h;
Stage #2: With 1,4-diaza-bicyclo[2.2.2]octane In ethyl acetate for 2h; Product distribution / selectivity;
Stage #1: trifluoromethylsulfonic anhydride; prasterone acetate In 1,2-dichloro-ethane for 0.25h;
Stage #2: With sodium hydride In 1,2-dichloro-ethane for 2h; Product distribution / selectivity;
Stage #1: trifluoromethylsulfonic anhydride; prasterone acetate for 0.25h;
Stage #2: With triethylamine for 2h; Product distribution / selectivity;
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

prasterone acetate
853-23-6

prasterone acetate

A

dehydroepiandrosterone
53-43-0

dehydroepiandrosterone

B

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

C

androsta-3,5,16-trien-17-yl trifluoromethanesulfonate
154229-36-4

androsta-3,5,16-trien-17-yl trifluoromethanesulfonate

Conditions
ConditionsYield
Stage #1: trifluoromethylsulfonic anhydride; prasterone acetate In dichloromethane for 0.25h;
Stage #2: With pyridine In dichloromethane for 2h; Product distribution / selectivity;
Stage #1: trifluoromethylsulfonic anhydride; prasterone acetate In ethyl acetate for 0.25h;
Stage #2: With pyridine In ethyl acetate for 2h; Product distribution / selectivity;
dehydroepiandrosterone
53-43-0

dehydroepiandrosterone

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 2 h / 105 - 110 °C / Inert atmosphere
2.1: potassium carbonate / toluene; benzene / 0.5 h / 25 °C
2.2: 20.33 h / -18 - -15 °C
View Scheme
Multi-step reaction with 2 steps
1.1: pyridine; dmap / 0.25 h / 20 °C
1.2: 6 h / 20 °C
2.1: triethylamine / dichloromethane / 2 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1.1: pyridine / 20 °C
2.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C
2.2: 2 h / -78 °C
View Scheme
prasterone acetate
853-23-6

prasterone acetate

1,1,1-trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)-sulfonyl)methanesulfonamide
145100-50-1

1,1,1-trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)-sulfonyl)methanesulfonamide

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at -80 - -70℃; for 2h; Reagent/catalyst; Large scale;112 kg
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3-Diethylboranylpyridine
89878-14-8

3-Diethylboranylpyridine

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In tetrahydrofuran at 65℃; for 4h; Reflux;95%
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In tetrahydrofuran; water for 1h; Reflux;95%
With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate In tetrahydrofuran; water at 60℃; for 1h;94%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

phenylboronic acid
98-80-6

phenylboronic acid

17-phenylandrosta-5,6-dien-3β-ol 3-acetate
76208-39-4

17-phenylandrosta-5,6-dien-3β-ol 3-acetate

Conditions
ConditionsYield
Stage #1: 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate With copper(l) iodide; palladium dichloride In water at 20℃; for 0.0833333h; Suzuki Coupling; Inert atmosphere; Green chemistry;
Stage #2: phenylboronic acid With sodium carbonate In water at 75℃; Catalytic behavior; Reagent/catalyst; Time; Suzuki Coupling; Inert atmosphere; Green chemistry;
92%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 100℃; for 6h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Suzuki Coupling; Inert atmosphere;85%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 20 - 100℃; for 6.08333h; Inert atmosphere;85%
With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate In tetrahydrofuran; water at 60℃; for 23h; Suzuki Coupling; Inert atmosphere;70%
5-methoxy-3-pyridinylboronic acid
850991-69-4

5-methoxy-3-pyridinylboronic acid

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3β-acetoxy-17-(5-methoxylpyridin-3-yl)androsta-5,16-diene

3β-acetoxy-17-(5-methoxylpyridin-3-yl)androsta-5,16-diene

Conditions
ConditionsYield
Stage #1: 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate With copper(l) iodide; palladium dichloride In water at 20℃; for 0.0833333h; Suzuki Coupling; Inert atmosphere; Green chemistry;
Stage #2: 5-methoxy-3-pyridinylboronic acid With sodium carbonate In water at 75℃; Suzuki Coupling; Inert atmosphere; Green chemistry;
88%
petroleum-diethyl ether

petroleum-diethyl ether

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3-Diethylboranylpyridine
89878-14-8

3-Diethylboranylpyridine

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
With sodium carbonate In tetrahydrofuran; bis(triphenylphosphine)palladium(II)-chloride84%
3-fluorophenylboronic acid
768-35-4

3-fluorophenylboronic acid

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3β-acetoxy-17-(3-fluorophenyl)androsta-5,16-diene

3β-acetoxy-17-(3-fluorophenyl)androsta-5,16-diene

Conditions
ConditionsYield
Stage #1: 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate With copper(l) iodide; palladium dichloride In water at 20℃; for 0.0833333h; Suzuki Coupling; Inert atmosphere; Green chemistry;
Stage #2: 3-fluorophenylboronic acid With sodium carbonate In water at 75℃; Suzuki Coupling; Inert atmosphere; Green chemistry;
83%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 100℃; for 6h; Suzuki Coupling; Inert atmosphere;52%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 20 - 100℃; for 6.08333h; Inert atmosphere;52%
5-fluoropyridine-3-boronic acid
872041-86-6

5-fluoropyridine-3-boronic acid

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3β-acetoxy-17-(5-fluoropyridin-3-yl)androsta-5,16-diene

3β-acetoxy-17-(5-fluoropyridin-3-yl)androsta-5,16-diene

Conditions
ConditionsYield
Stage #1: 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate With copper(l) iodide; palladium dichloride In water at 20℃; for 0.0833333h; Suzuki Coupling; Inert atmosphere; Green chemistry;
Stage #2: 5-fluoropyridine-3-boronic acid With sodium carbonate In water at 75℃; Suzuki Coupling; Inert atmosphere; Green chemistry;
83%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

pyrimidine 5-boronic acid
109299-78-7

pyrimidine 5-boronic acid

3β-acetoxy-17-(pyrimidin-5-yl)androsta-5,16-diene
428861-51-2

3β-acetoxy-17-(pyrimidin-5-yl)androsta-5,16-diene

Conditions
ConditionsYield
Stage #1: 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate With copper(l) iodide; palladium dichloride In water at 20℃; for 0.0833333h; Suzuki Coupling; Inert atmosphere; Green chemistry;
Stage #2: pyrimidine 5-boronic acid With sodium carbonate In water at 75℃; Suzuki Coupling; Inert atmosphere; Green chemistry;
83%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

ethyl vinyl ether
109-92-2

ethyl vinyl ether

A

(Z/E)-3β-Acetoxypregna-5,17(20)-dien-21-al
16934-48-8

(Z/E)-3β-Acetoxypregna-5,17(20)-dien-21-al

B

16-dehydropregnenolone acetate
979-02-2

16-dehydropregnenolone acetate

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); triethylamine In dimethyl sulfoxide at 60℃; for 4h;A 8%
B 82%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

5-methylpyridine-3-boronic acid
173999-18-3

5-methylpyridine-3-boronic acid

C27H35NO2
154229-44-4

C27H35NO2

Conditions
ConditionsYield
With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane; water at 80℃; for 1h; Suzuki Coupling; Inert atmosphere;82%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

(6-fluoropyridin-3-yl)boronic acid
351019-18-6

(6-fluoropyridin-3-yl)boronic acid

3β-acetoxy-17-(6-fluoropyridin-3-yl)androsta-5,16-diene

3β-acetoxy-17-(6-fluoropyridin-3-yl)androsta-5,16-diene

Conditions
ConditionsYield
Stage #1: 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate With copper(l) iodide; palladium dichloride In water at 20℃; for 0.0833333h; Suzuki Coupling; Inert atmosphere; Green chemistry;
Stage #2: (6-fluoropyridin-3-yl)boronic acid With sodium carbonate In water at 75℃; Suzuki Coupling; Inert atmosphere; Green chemistry;
81%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3-pyridylboronic acid
1692-25-7

3-pyridylboronic acid

abiraterone acetate
154229-18-2

abiraterone acetate

Conditions
ConditionsYield
Stage #1: 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate With copper(l) iodide; palladium dichloride In water at 20℃; for 0.0833333h; Suzuki Coupling; Inert atmosphere; Green chemistry;
Stage #2: 3-pyridylboronic acid With sodium carbonate In water at 75℃; Suzuki Coupling; Inert atmosphere; Green chemistry;
79%
With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane; water at 80℃; for 1h; Suzuki Coupling; Inert atmosphere;73%
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In water at -5 - 5℃; Inert atmosphere; Reflux;4.5 g
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

(meta-(trifluoromethyl)phenyl)boronic acid
1423-26-3

(meta-(trifluoromethyl)phenyl)boronic acid

3β-acetoxy-17-(2-trifluoromethylphenyl)androsta-5,16-diene

3β-acetoxy-17-(2-trifluoromethylphenyl)androsta-5,16-diene

Conditions
ConditionsYield
Stage #1: 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate With copper(l) iodide; palladium dichloride In water at 20℃; for 0.0833333h; Suzuki Coupling; Inert atmosphere; Green chemistry;
Stage #2: [3-(trifluoromethyl) phenyl] boronic acid With sodium carbonate In water at 75℃; Suzuki Coupling; Inert atmosphere; Green chemistry;
79%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 100℃; for 6h; Suzuki Coupling; Inert atmosphere;61%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 20 - 100℃; for 6.08333h; Inert atmosphere;61%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 20 - 100℃; for 6.25h; Inert atmosphere;61%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

(2-tert-butoxy-2-oxoethyl)zinc(II) bromide
51656-70-3

(2-tert-butoxy-2-oxoethyl)zinc(II) bromide

((3S,8R,9S,10R,13S,14S)-3-Acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-acetic acid tert-butyl ester
115375-66-1

((3S,8R,9S,10R,13S,14S)-3-Acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-acetic acid tert-butyl ester

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; diisobutylaluminium hydride In tetrahydrofuran; toluene 1.) 0 deg C, 5 min, 2.) room temperature, overnight;77%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3β-acetoxy-17-O-triflyl-androst-16-en-6-ol

3β-acetoxy-17-O-triflyl-androst-16-en-6-ol

Conditions
ConditionsYield
Stage #1: 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate With borane-THF In tetrahydrofuran at -10 - 20℃; for 8h; Inert atmosphere;
Stage #2: With sodium perborate In tetrahydrofuran; water at 0 - 20℃;
76%
o-fluorophenylboronic acid
1993-03-9

o-fluorophenylboronic acid

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3β-acetoxy-17-(2-fluorophenyl)androsta-5,16-diene

3β-acetoxy-17-(2-fluorophenyl)androsta-5,16-diene

Conditions
ConditionsYield
Stage #1: 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate With copper(l) iodide; palladium dichloride In water at 20℃; for 0.0833333h; Suzuki Coupling; Inert atmosphere; Green chemistry;
Stage #2: o-fluorophenylboronic acid With sodium carbonate In water at 75℃; Suzuki Coupling; Inert atmosphere; Green chemistry;
75%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 100℃; for 6h; Suzuki Coupling; Inert atmosphere;68%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 20 - 100℃; for 6.08333h; Inert atmosphere;68%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3,4-Dimethoxyphenylboronic acid
122775-35-3

3,4-Dimethoxyphenylboronic acid

3β-acetoxy-17-(3,4-dimethoxyphenyl)androsta-5,16-diene

3β-acetoxy-17-(3,4-dimethoxyphenyl)androsta-5,16-diene

Conditions
ConditionsYield
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 100℃; for 6h; Suzuki Coupling; Inert atmosphere;65%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 20 - 100℃; for 6.08333h; Inert atmosphere;65%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 20 - 100℃; for 6.25h; Inert atmosphere;65%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

ethyl vinyl ether
109-92-2

ethyl vinyl ether

A

16-dehydropregnenolone acetate
979-02-2

16-dehydropregnenolone acetate

B

3β-acetoxypregna-5,17(20)-dien-21-al

3β-acetoxypregna-5,17(20)-dien-21-al

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); triethylamine In dimethyl sulfoxide at 60℃; for 4h;A 62%
B 11%
4-methylphenylboronic acid
5720-05-8

4-methylphenylboronic acid

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3β-acetoxy-17-(4-methylphenyl)androsta-5,16-diene

3β-acetoxy-17-(4-methylphenyl)androsta-5,16-diene

Conditions
ConditionsYield
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 100℃; for 6h; Suzuki Coupling; Inert atmosphere;58%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 20 - 100℃; for 6.08333h; Inert atmosphere;58%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 20 - 100℃; for 6.25h; Inert atmosphere;58%
4-Bromophenylboronic acid
5467-74-3

4-Bromophenylboronic acid

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3β-acetoxy-17-(4-bromophenyl)androsta-5,16-diene

3β-acetoxy-17-(4-bromophenyl)androsta-5,16-diene

Conditions
ConditionsYield
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 20 - 100℃; for 6.25h; Inert atmosphere;58%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 100℃; for 6h; Suzuki Coupling; Inert atmosphere;53%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 20 - 100℃; for 6.08333h; Inert atmosphere;53%
4-fluoroboronic acid
1765-93-1

4-fluoroboronic acid

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3β-acetoxy-17-(4-fluorophenyl)androsta-5,16-diene

3β-acetoxy-17-(4-fluorophenyl)androsta-5,16-diene

Conditions
ConditionsYield
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 100℃; for 6h; Suzuki Coupling; Inert atmosphere;57%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 20 - 100℃; for 6.08333h; Inert atmosphere;57%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride In toluene at 20 - 100℃; for 6.25h; Inert atmosphere;57%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

A

3β-acetoxyandrost-5,16-diene
1236-14-2

3β-acetoxyandrost-5,16-diene

B

Acetic acid (3S,8R,9S,10R,13S,14S)-17-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Acetic acid (3S,8R,9S,10R,13S,14S)-17-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Conditions
ConditionsYield
With [(Pd(PPh3)2)n]; diisobutylaluminium hydride; tert-butyl 2-bromozincpropionate In tetrahydrofuran; toluene 1.) 0 deg C, 5 min, 2.) room temperature, overnight;A 54%
B 9%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3β-acetoxy-5,6-seco-5-keto-17-O-triflyl-androstan-6-al

3β-acetoxy-5,6-seco-5-keto-17-O-triflyl-androstan-6-al

Conditions
ConditionsYield
Stage #1: 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate With pyridine; ozone In methanol; dichloromethane at -78 - 20℃;
Stage #2: With dimethylsulfide In methanol; dichloromethane at -78℃; for 0.5h;
53%
4-carboxyphenylboronic acid
14047-29-1

4-carboxyphenylboronic acid

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

C28H34O4

C28H34O4

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane; water at 80 - 85℃; Inert atmosphere;53%
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3β-acetoxy-6α-hydroxy-5α-androst-16-en-17-yl trifluoromethanesulfonate

3β-acetoxy-6α-hydroxy-5α-androst-16-en-17-yl trifluoromethanesulfonate

Conditions
ConditionsYield
Stage #1: 3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate With borane-THF In tetrahydrofuran at 0℃; for 4h; Inert atmosphere;
Stage #2: With sodium perborate tetrahydrate; water In tetrahydrofuran at 0 - 20℃; for 18h; Inert atmosphere;
28%
vinyl acetate
108-05-4

vinyl acetate

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

A

Acetic acid (Z)-2-((3S,8R,9S,10R,13S,14S)-3-acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-vinyl ester
134050-32-1

Acetic acid (Z)-2-((3S,8R,9S,10R,13S,14S)-3-acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-vinyl ester

B

Acetic acid (E)-2-((3S,8R,9S,10R,13S,14S)-3-acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-vinyl ester
16934-52-4

Acetic acid (E)-2-((3S,8R,9S,10R,13S,14S)-3-acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-vinyl ester

Conditions
ConditionsYield
With triethylamine; palladium diacetate; triphenylphosphine In N,N-dimethyl-formamide at 60℃; for 9h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
α-picoline
109-06-8

α-picoline

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
115375-60-5

3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate

3β-acetoxy-17-(2-pyridylmethyl)androsta-5,16-diene

3β-acetoxy-17-(2-pyridylmethyl)androsta-5,16-diene

Conditions
ConditionsYield
With n-butyllithium; bis(triphenylphosphine)palladium(II)-chloride; zinc(II) chloride Multistep reaction;

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