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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 6-Chloro-5-(2-Chloroethyl)-1,3-Dihydro-2H-Indol-2-One supplier in China

Cas:118289-55-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one

Cas:118289-55-7

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 118289-55-7 5-Chloroethyl-6-Chloroindole-2-One Manufacturer

Cas:118289-55-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6-Chloro-5-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one

Cas:118289-55-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one

Cas:118289-55-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one 118289-55-7 5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one Basic information Product Name: 5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one

5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one 118289-55-7

Cas:118289-55-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one CAS 118289-55-7

Cas:118289-55-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 118289-55-7 with best quality

Cas:118289-55-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name 5-Chloroethyl-6-chloro-1 Synonyms 5-Chloroethyl-6-chloro-1;6-Chloro-5-(2-chloroethyl)-1 CAS: 118289-55-7 MF: - MW: -

5-Chloroethyl-6-Chloroindole-2-One CAS:118289-55-7

Cas:118289-55-7

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White or Yellow or Orange Powder Storage:Sealed in dry,2-8°C Package:25kg/Barrel Application:Intermediates and Fine Chemicals Transportation:Express/Sea/Air Port:Any port in China

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2H-Indol-2-one,6-chloro-5-(2-chloroethyl)-1,3-dihydro- 118289-55-7

Cas:118289-55-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

2H-Indol-2-one,6-chloro-5-(2-chloroethyl)-1,3-dihydro-/ LIDE PHARMA- Factory supply / Best price

Cas:118289-55-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one CAS:118289-55-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializi

5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one CAS:118289-55-7

Cas:118289-55-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2H-Indol-2-one,6-chloro-5-(2-chloroethyl)-1,3-dihydro-

Cas:118289-55-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2H-Indol-2-one,6-chloro-5-(2-chloroethyl)-1,3-dihydro-

Cas:118289-55-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one Synonyms: Ziprasidone Impurity A;2H-INDOLE-2-ONE,5-CHLOROETHYL-6-CHLORO-1,3-DIHYDRO;5-CHLOROETHYL-6-CHLORO-1,3-DIHYDRO-1H-INDOL-2-ONE;5-CHLOROETHYL-6-CHLORO-1,3-DIHYDRO-2H-INDOLE-2

5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one supplier best quality

Cas:118289-55-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

6-Chloro-5-(2-Chloroethyl)-1,3-Dihydro-2H-Indol-2-One

Cas:118289-55-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFU-CHEM - 5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one

Cas:118289-55-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c

5-Chloroethyl-6-Chloroindole-2-One

Cas:118289-55-7

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

'5-CHLOROETHYL-6-CHLORO-1,3-DIHYDRO-2H-INDOLE-2-ONE

Cas:118289-55-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one

Cas:118289-55-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one

Cas:118289-55-7

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

6-Chloro-5-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one

Cas:118289-55-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:brown powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide intermediates Tran

5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one

Cas:118289-55-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one

Cas:118289-55-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFU-CHEM - 5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one

Cas:118289-55-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one

Cas:118289-55-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFU-CHEM - 5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one

Cas:118289-55-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFU-CHEM - 5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one

Cas:118289-55-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Synthetic route

6-chloro-5-(2-hydroxyethyl)-2-oxindole

6-chloro-5-(2-hydroxyethyl)-2-oxindole

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
With triphenylphosphine In tetrahydrofuran; tetrachloromethane for 3h; Reflux;97%
C17H16ClNO4S

C17H16ClNO4S

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
With lithium chloride In N,N-dimethyl-formamide at 50℃; for 8h;95%
6-chloro-5-(2-chloroacetyl) indolin-2-one
118307-04-3

6-chloro-5-(2-chloroacetyl) indolin-2-one

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
With triethylsilane; trifluoroacetic acid
Stage #1: 6-chloro-5-(2-chloroacetyl) indolin-2-one With triethylsilane; trifluoroacetic acid at 0 - 35℃; for 7h;
Stage #2: With water at 5 - 10℃; for 1h;
With triethylsilane In trifluoroacetic acid at -5 - 45℃; for 7.5h;
6-chloro-2-oxindole
56341-37-8

6-chloro-2-oxindole

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: AlCl3 / CS2
2: Et3SiH, CF3COOH
View Scheme
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
1.2: 35 - 37 °C / Inert atmosphere
2.1: trifluoroacetic acid / 0.25 h / 25 - 30 °C / Inert atmosphere
2.2: 0 - 35 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: aluminum (III) chloride / dichloromethane / 20 h / Reflux; Inert atmosphere
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / dichloromethane / 0 °C / Inert atmosphere
View Scheme
6-chloro-5-(2-chloroacetyl) indolin-2-one
118307-04-3

6-chloro-5-(2-chloroacetyl) indolin-2-one

A

6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one
884305-06-0

6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one

B

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
With triethylsilane; trifluoroacetic acid for 7h;
With aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane In dichloromethane at 0℃; Inert atmosphere; chemoselective reaction;
6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one
884305-06-0

6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
Stage #1: 6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one With trifluoroacetic acid at 20℃; for 1h;
Stage #2: With triethylsilane at 35 - 40℃; for 13.5 - 15.5h;
Stage #1: 6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one With trifluoroacetic acid at 20℃; for 1h;
Stage #2: With triethylsilane at 35 - 40℃; for 13.5 - 15.5h;
2,5-dichloronitrobenzene
89-61-2

2,5-dichloronitrobenzene

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate / dimethyl sulfoxide / 25 - 30 °C / Inert atmosphere
1.2: 16 h / 40 - 85 °C
2.1: hydrogenchloride; tin / water; methanol / 10 - 70 °C
3.1: aluminum (III) chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
3.2: 35 - 37 °C / Inert atmosphere
4.1: trifluoroacetic acid / 0.25 h / 25 - 30 °C / Inert atmosphere
4.2: 0 - 35 °C / Inert atmosphere
View Scheme
dimethyl (4-chloro-2-nitrophenyl)malonate
147124-32-1

dimethyl (4-chloro-2-nitrophenyl)malonate

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride; tin / water; methanol / 10 - 70 °C
2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere
2.2: 35 - 37 °C / Inert atmosphere
3.1: trifluoroacetic acid / 0.25 h / 25 - 30 °C / Inert atmosphere
3.2: 0 - 35 °C / Inert atmosphere
View Scheme
6-chloro-5-(2-chloroacetyl) indolin-2-one
118307-04-3

6-chloro-5-(2-chloroacetyl) indolin-2-one

A

6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one
884305-06-0

6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one

B

6-chloro-5-ethylindolin-2-one

6-chloro-5-ethylindolin-2-one

C

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
With triethylsilane; aluminum (III) chloride In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere; Reflux;
6-chloro-5-(2-chloroacetyl) indolin-2-one
118307-04-3

6-chloro-5-(2-chloroacetyl) indolin-2-one

A

6-chloro-5-ethylindolin-2-one

6-chloro-5-ethylindolin-2-one

B

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
With aluminum (III) chloride; dimethylmonochlorosilane In dichloromethane at 0℃; Inert atmosphere; chemoselective reaction;
6-chloro-2-oxindole
56341-37-8

6-chloro-2-oxindole

A

6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one
884305-06-0

6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one

B

6-chloro-5-ethylindolin-2-one

6-chloro-5-ethylindolin-2-one

C

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aluminum (III) chloride / dichloromethane / 20 h / Reflux; Inert atmosphere
2: aluminum (III) chloride; triethylsilane / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Reflux
View Scheme
6-chloro-2-oxindole
56341-37-8

6-chloro-2-oxindole

A

6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one
884305-06-0

6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one

B

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aluminum (III) chloride / dichloromethane / 20 h / Reflux; Inert atmosphere
2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / dichloromethane / 0 °C / Inert atmosphere
View Scheme
5-chloro-2,4-difluoronitrobenzene
1481-68-1

5-chloro-2,4-difluoronitrobenzene

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N,N-dimethyl-formamide / 12 h / 100 °C
2: hydrogenchloride; acetic acid / water / 18 h / Reflux
3: thionyl chloride / 4 h / 20 °C
4: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr
5: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux
6: triphenylphosphine / tetrahydrofuran; tetrachloromethane / 3 h / Reflux
View Scheme
Multi-step reaction with 7 steps
1: N,N-dimethyl-formamide / 12 h / 100 °C
2: hydrogenchloride; acetic acid / water / 18 h / Reflux
3: thionyl chloride / 4 h / 20 °C
4: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr
5: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux
6: triethylamine; dmap / dichloromethane / 5 h / Reflux
7: lithium chloride / N,N-dimethyl-formamide / 8 h / 50 °C
View Scheme
tetraethyl 4-chloro-6-nitro-1,3-benzenedimalonate

tetraethyl 4-chloro-6-nitro-1,3-benzenedimalonate

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogenchloride; acetic acid / water / 18 h / Reflux
2: thionyl chloride / 4 h / 20 °C
3: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr
4: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux
5: triphenylphosphine / tetrahydrofuran; tetrachloromethane / 3 h / Reflux
View Scheme
Multi-step reaction with 6 steps
1: hydrogenchloride; acetic acid / water / 18 h / Reflux
2: thionyl chloride / 4 h / 20 °C
3: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr
4: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux
5: triethylamine; dmap / dichloromethane / 5 h / Reflux
6: lithium chloride / N,N-dimethyl-formamide / 8 h / 50 °C
View Scheme
4-chloro-6-nitro-1,3-benzenediacetic acid

4-chloro-6-nitro-1,3-benzenediacetic acid

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: thionyl chloride / 4 h / 20 °C
2: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr
3: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux
4: triphenylphosphine / tetrahydrofuran; tetrachloromethane / 3 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1: thionyl chloride / 4 h / 20 °C
2: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr
3: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux
4: triethylamine; dmap / dichloromethane / 5 h / Reflux
5: lithium chloride / N,N-dimethyl-formamide / 8 h / 50 °C
View Scheme
dimethyl 4-chloro-6-nitro-1,3-benzenediacetate

dimethyl 4-chloro-6-nitro-1,3-benzenediacetate

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr
2: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux
3: triphenylphosphine / tetrahydrofuran; tetrachloromethane / 3 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr
2: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux
3: triethylamine; dmap / dichloromethane / 5 h / Reflux
4: lithium chloride / N,N-dimethyl-formamide / 8 h / 50 °C
View Scheme
methyl 6-chloro-(2-oxindol-5-yl)acetate

methyl 6-chloro-(2-oxindol-5-yl)acetate

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux
2: triphenylphosphine / tetrahydrofuran; tetrachloromethane / 3 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux
2: triethylamine; dmap / dichloromethane / 5 h / Reflux
3: lithium chloride / N,N-dimethyl-formamide / 8 h / 50 °C
View Scheme
2,4,5-Trichloronitrobenzene
89-69-0

2,4,5-Trichloronitrobenzene

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: potassium fluoride / N,N-dimethyl-formamide / 12 h / 125 °C / Inert atmosphere
2: N,N-dimethyl-formamide / 12 h / 100 °C
3: hydrogenchloride; acetic acid / water / 18 h / Reflux
4: thionyl chloride / 4 h / 20 °C
5: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr
6: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux
7: triphenylphosphine / tetrahydrofuran; tetrachloromethane / 3 h / Reflux
View Scheme
Multi-step reaction with 8 steps
1: potassium fluoride / N,N-dimethyl-formamide / 12 h / 125 °C / Inert atmosphere
2: N,N-dimethyl-formamide / 12 h / 100 °C
3: hydrogenchloride; acetic acid / water / 18 h / Reflux
4: thionyl chloride / 4 h / 20 °C
5: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr
6: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux
7: triethylamine; dmap / dichloromethane / 5 h / Reflux
8: lithium chloride / N,N-dimethyl-formamide / 8 h / 50 °C
View Scheme
3-(1-piperazinyl)-1,2-benzisothiazole
87691-87-0

3-(1-piperazinyl)-1,2-benzisothiazole

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
With Morwet D425 In water Reflux; Inert atmosphere;92%
In water Inert atmosphere; Reflux; dispersing agent;92%
With potassium carbonate; potassium iodide In sulfolane at 75 - 100℃; for 2h; Product distribution / selectivity;75%
3-(1-piperazinyl)-1,2-benzoisothiazole hydrochloride

3-(1-piperazinyl)-1,2-benzoisothiazole hydrochloride

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
With Morwet D425 In water Product distribution / selectivity; Reflux; Inert atmosphere;92%
With sodium carbonate In water Product distribution / selectivity; Inert atmosphere; Reflux; Morwet D425;90%
Stage #1: 3-(piperazin-1-yl)-1,2-benzisothiazole hydrochloride With potassium carbonate In acetonitrile for 0.5h;
Stage #2: 6-chloro-5-(2-chloroethyl)-2-oxindole With sodium iodide In acetonitrile for 2h; Reflux;
767 g
6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

7-bromo-3-piperazinyl-1,2-benzisothiazole
155167-98-9

7-bromo-3-piperazinyl-1,2-benzisothiazole

5-(2-(4-(7-bromo-1,2-benzisothiazol-3-yl)piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one
155167-99-0

5-(2-(4-(7-bromo-1,2-benzisothiazol-3-yl)piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one

Conditions
ConditionsYield
With sodium carbonate In water at 115℃; for 20h;89%
3-(1-piperazinyl)-1,2-benzisothiazole hydrochloride
87691-88-1

3-(1-piperazinyl)-1,2-benzisothiazole hydrochloride

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
With sodium carbonate In 1-methyl-pyrrolidin-2-one at 130 - 135℃; for 24h; Product distribution / selectivity;88.2%
With sodium carbonate In poly(ethylene glycol) methyl ether at 120 - 125℃; for 48h; Product distribution / selectivity;88%
With sodium carbonate; sodium iodide In toluene for 22.5h; Product distribution / selectivity; Heating / reflux;86%
4-(benzo[b]thiophen-4-yl)piperidine trifluoroacetate

4-(benzo[b]thiophen-4-yl)piperidine trifluoroacetate

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

5-(2-(4-(benzo[b]thiophen-4-yl)piperidin-1-yl)ethyl)-6-chloroindolin-2-one

5-(2-(4-(benzo[b]thiophen-4-yl)piperidin-1-yl)ethyl)-6-chloroindolin-2-one

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In water at 105℃; for 12h;58%
1-(2,3-dihydrobenzo[b]thiophen-4-yl)piperazine hydrochloride

1-(2,3-dihydrobenzo[b]thiophen-4-yl)piperazine hydrochloride

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

6-chloro-5-(2-(4-(2,3-dihydrobenzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)indolin-2-one

6-chloro-5-(2-(4-(2,3-dihydrobenzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)indolin-2-one

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 85℃;56%
1-(benzo[b]thiophen-4-yl)piperazine hydrochloride

1-(benzo[b]thiophen-4-yl)piperazine hydrochloride

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

5-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one hydrochloride

5-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one hydrochloride

Conditions
ConditionsYield
With sodium carbonate; sodium iodide In water for 24h; Reflux;51%
4-(piperazin-1-yl)thieno[2,3-c]pyridine trifluoroacetate

4-(piperazin-1-yl)thieno[2,3-c]pyridine trifluoroacetate

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

6-chloro-5-(2-(4-(thieno[2,3-c]pyridin-4-yl)piperazin-1-yl)ethyl)indolin-2-one

6-chloro-5-(2-(4-(thieno[2,3-c]pyridin-4-yl)piperazin-1-yl)ethyl)indolin-2-one

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 80℃;8.7%
3-(1-piperazinyl)-1,2-benzisothiazole
87691-87-0

3-(1-piperazinyl)-1,2-benzisothiazole

acetone
67-64-1

acetone

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

5-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)ethyl]-6-chloro-3-isopropylidene-1,3-dihydro-indol-2-one

5-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)ethyl]-6-chloro-3-isopropylidene-1,3-dihydro-indol-2-one

Conditions
ConditionsYield
With potassium carbonate In water at 100℃; for 24h; Heating / reflux;3%
6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one
884305-06-0

6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one

3-(1-piperazinyl)-1,2-benzisothiazole
87691-87-0

3-(1-piperazinyl)-1,2-benzisothiazole

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

6-chloro-5-(2-chloroacetyl) indolin-2-one
118307-04-3

6-chloro-5-(2-chloroacetyl) indolin-2-one

A

5-(2-(4-(1,2-benzisothiazole-3-yl)-1-piperazinyl)-1-hydroxyethyl)-6-chloro-1,3-dihydro-2H-indole-2-one
884305-08-2

5-(2-(4-(1,2-benzisothiazole-3-yl)-1-piperazinyl)-1-hydroxyethyl)-6-chloro-1,3-dihydro-2H-indole-2-one

B

5-(2-(4-(1,2-benzisothiazole-3-yl)-1-piperazinyl)-1-oxoethyl)-6-chloro-1,3-dihydro-2H-indole-2-one
884305-07-1

5-(2-(4-(1,2-benzisothiazole-3-yl)-1-piperazinyl)-1-oxoethyl)-6-chloro-1,3-dihydro-2H-indole-2-one

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium carbonate; sodium iodide In cyclohexane Heating / reflux;
4-trimethylsilyl-1-(benzo[d]isothiazol-3-yl)piperazine

4-trimethylsilyl-1-(benzo[d]isothiazol-3-yl)piperazine

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

Conditions
ConditionsYield
With water; sodium carbonate; sodium iodide In N,N-dimethyl-formamide at 110℃; for 0.5h; Product distribution / selectivity;
With water; sodium carbonate; sodium iodide at 95 - 100℃; for 7.66667h; Product distribution / selectivity;
3-(1-piperazinyl)-1,2-benzisothiazole
87691-87-0

3-(1-piperazinyl)-1,2-benzisothiazole

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

ziprasidone hydrochloride

ziprasidone hydrochloride

Conditions
ConditionsYield
Stage #1: 3-(1-piperazinyl)-1,2-benzisothiazole; 6-chloro-5-(2-chloroethyl)-2-oxindole With sodium carbonate; sodium iodide In water; dimethyl sulfoxide at 115 - 125℃; for 2.75h;
Stage #2: With hydrogenchloride In water for 0.166667h;
1-(benzo[d]isoxazol-3-yl)piperazine hydrochloride
87691-90-5

1-(benzo[d]isoxazol-3-yl)piperazine hydrochloride

6-chloro-5-(2-chloroethyl)-2-oxindole
118289-55-7

6-chloro-5-(2-chloroethyl)-2-oxindole

5-(2-(4-(1,2-benziso-thiazol-3-yl)piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one

5-(2-(4-(1,2-benziso-thiazol-3-yl)piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one

Conditions
ConditionsYield
Stage #1: 1-(benzo[d]isoxazol-3-yl)piperazine hydrochloride With sodium carbonate In water at 20℃; for 1h;
Stage #2: 6-chloro-5-(2-chloroethyl)-2-oxindole With sodium iodide In water at 20 - 90℃; for 21 - 31h;
Stage #3: In water at 45 - 80℃; for 1h; Product distribution / selectivity;

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