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inquiryGood quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
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inquiry5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one 118289-55-7 5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one Basic information Product Name: 5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:118289-55-7
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inquiryProduct Name 5-Chloroethyl-6-chloro-1 Synonyms 5-Chloroethyl-6-chloro-1;6-Chloro-5-(2-chloroethyl)-1 CAS: 118289-55-7 MF: - MW: -
Cas:118289-55-7
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inquiryAppearance:White or Yellow or Orange Powder Storage:Sealed in dry,2-8°C Package:25kg/Barrel Application:Intermediates and Fine Chemicals Transportation:Express/Sea/Air Port:Any port in China
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
Cas:118289-55-7
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inquiry5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one CAS:118289-55-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializi
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:118289-55-7
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryProduct Name: 5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one Synonyms: Ziprasidone Impurity A;2H-INDOLE-2-ONE,5-CHLOROETHYL-6-CHLORO-1,3-DIHYDRO;5-CHLOROETHYL-6-CHLORO-1,3-DIHYDRO-1H-INDOL-2-ONE;5-CHLOROETHYL-6-CHLORO-1,3-DIHYDRO-2H-INDOLE-2
Cas:118289-55-7
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:118289-55-7
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inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c
Cas:118289-55-7
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:118289-55-7
Min.Order:1 Gram
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:118289-55-7
Min.Order:100 Gram
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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Min.Order:10 Gram
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inquirySuperior quality, moderate price & quick delivery. Appearance:brown powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide intermediates Tran
Cas:118289-55-7
Min.Order:1 Gram
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:118289-55-7
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiry6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
With triphenylphosphine In tetrahydrofuran; tetrachloromethane for 3h; Reflux; | 97% |
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
With lithium chloride In N,N-dimethyl-formamide at 50℃; for 8h; | 95% |
6-chloro-5-(2-chloroacetyl) indolin-2-one
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
With triethylsilane; trifluoroacetic acid | |
Stage #1: 6-chloro-5-(2-chloroacetyl) indolin-2-one With triethylsilane; trifluoroacetic acid at 0 - 35℃; for 7h; Stage #2: With water at 5 - 10℃; for 1h; | |
With triethylsilane In trifluoroacetic acid at -5 - 45℃; for 7.5h; |
6-chloro-2-oxindole
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: AlCl3 / CS2 2: Et3SiH, CF3COOH View Scheme | |
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere 1.2: 35 - 37 °C / Inert atmosphere 2.1: trifluoroacetic acid / 0.25 h / 25 - 30 °C / Inert atmosphere 2.2: 0 - 35 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane / 20 h / Reflux; Inert atmosphere 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / dichloromethane / 0 °C / Inert atmosphere View Scheme |
6-chloro-5-(2-chloroacetyl) indolin-2-one
A
6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one
B
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
With triethylsilane; trifluoroacetic acid for 7h; | |
With aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane In dichloromethane at 0℃; Inert atmosphere; chemoselective reaction; |
6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
Stage #1: 6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one With trifluoroacetic acid at 20℃; for 1h; Stage #2: With triethylsilane at 35 - 40℃; for 13.5 - 15.5h; | |
Stage #1: 6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one With trifluoroacetic acid at 20℃; for 1h; Stage #2: With triethylsilane at 35 - 40℃; for 13.5 - 15.5h; |
2,5-dichloronitrobenzene
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium carbonate / dimethyl sulfoxide / 25 - 30 °C / Inert atmosphere 1.2: 16 h / 40 - 85 °C 2.1: hydrogenchloride; tin / water; methanol / 10 - 70 °C 3.1: aluminum (III) chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere 3.2: 35 - 37 °C / Inert atmosphere 4.1: trifluoroacetic acid / 0.25 h / 25 - 30 °C / Inert atmosphere 4.2: 0 - 35 °C / Inert atmosphere View Scheme |
dimethyl (4-chloro-2-nitrophenyl)malonate
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride; tin / water; methanol / 10 - 70 °C 2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere 2.2: 35 - 37 °C / Inert atmosphere 3.1: trifluoroacetic acid / 0.25 h / 25 - 30 °C / Inert atmosphere 3.2: 0 - 35 °C / Inert atmosphere View Scheme |
6-chloro-5-(2-chloroacetyl) indolin-2-one
A
6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one
C
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
With triethylsilane; aluminum (III) chloride In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere; Reflux; |
6-chloro-5-(2-chloroacetyl) indolin-2-one
B
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
With aluminum (III) chloride; dimethylmonochlorosilane In dichloromethane at 0℃; Inert atmosphere; chemoselective reaction; |
6-chloro-2-oxindole
A
6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one
C
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane / 20 h / Reflux; Inert atmosphere 2: aluminum (III) chloride; triethylsilane / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Reflux View Scheme |
6-chloro-2-oxindole
A
6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one
B
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane / 20 h / Reflux; Inert atmosphere 2: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / dichloromethane / 0 °C / Inert atmosphere View Scheme |
5-chloro-2,4-difluoronitrobenzene
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: N,N-dimethyl-formamide / 12 h / 100 °C 2: hydrogenchloride; acetic acid / water / 18 h / Reflux 3: thionyl chloride / 4 h / 20 °C 4: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr 5: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux 6: triphenylphosphine / tetrahydrofuran; tetrachloromethane / 3 h / Reflux View Scheme | |
Multi-step reaction with 7 steps 1: N,N-dimethyl-formamide / 12 h / 100 °C 2: hydrogenchloride; acetic acid / water / 18 h / Reflux 3: thionyl chloride / 4 h / 20 °C 4: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr 5: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux 6: triethylamine; dmap / dichloromethane / 5 h / Reflux 7: lithium chloride / N,N-dimethyl-formamide / 8 h / 50 °C View Scheme |
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrogenchloride; acetic acid / water / 18 h / Reflux 2: thionyl chloride / 4 h / 20 °C 3: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr 4: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux 5: triphenylphosphine / tetrahydrofuran; tetrachloromethane / 3 h / Reflux View Scheme | |
Multi-step reaction with 6 steps 1: hydrogenchloride; acetic acid / water / 18 h / Reflux 2: thionyl chloride / 4 h / 20 °C 3: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr 4: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux 5: triethylamine; dmap / dichloromethane / 5 h / Reflux 6: lithium chloride / N,N-dimethyl-formamide / 8 h / 50 °C View Scheme |
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: thionyl chloride / 4 h / 20 °C 2: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr 3: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux 4: triphenylphosphine / tetrahydrofuran; tetrachloromethane / 3 h / Reflux View Scheme | |
Multi-step reaction with 5 steps 1: thionyl chloride / 4 h / 20 °C 2: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr 3: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux 4: triethylamine; dmap / dichloromethane / 5 h / Reflux 5: lithium chloride / N,N-dimethyl-formamide / 8 h / 50 °C View Scheme |
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr 2: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux 3: triphenylphosphine / tetrahydrofuran; tetrachloromethane / 3 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr 2: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux 3: triethylamine; dmap / dichloromethane / 5 h / Reflux 4: lithium chloride / N,N-dimethyl-formamide / 8 h / 50 °C View Scheme |
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux 2: triphenylphosphine / tetrahydrofuran; tetrachloromethane / 3 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux 2: triethylamine; dmap / dichloromethane / 5 h / Reflux 3: lithium chloride / N,N-dimethyl-formamide / 8 h / 50 °C View Scheme |
2,4,5-Trichloronitrobenzene
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: potassium fluoride / N,N-dimethyl-formamide / 12 h / 125 °C / Inert atmosphere 2: N,N-dimethyl-formamide / 12 h / 100 °C 3: hydrogenchloride; acetic acid / water / 18 h / Reflux 4: thionyl chloride / 4 h / 20 °C 5: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr 6: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux 7: triphenylphosphine / tetrahydrofuran; tetrachloromethane / 3 h / Reflux View Scheme | |
Multi-step reaction with 8 steps 1: potassium fluoride / N,N-dimethyl-formamide / 12 h / 125 °C / Inert atmosphere 2: N,N-dimethyl-formamide / 12 h / 100 °C 3: hydrogenchloride; acetic acid / water / 18 h / Reflux 4: thionyl chloride / 4 h / 20 °C 5: acetic acid; hydrogen / 3 h / 20 °C / 2327.23 Torr 6: sodium tetrahydroborate; lithium bromide; Trimethyl borate / tetrahydrofuran / 18 h / Reflux 7: triethylamine; dmap / dichloromethane / 5 h / Reflux 8: lithium chloride / N,N-dimethyl-formamide / 8 h / 50 °C View Scheme |
3-(1-piperazinyl)-1,2-benzisothiazole
6-chloro-5-(2-chloroethyl)-2-oxindole
ziprazidone
Conditions | Yield |
---|---|
With Morwet D425 In water Reflux; Inert atmosphere; | 92% |
In water Inert atmosphere; Reflux; dispersing agent; | 92% |
With potassium carbonate; potassium iodide In sulfolane at 75 - 100℃; for 2h; Product distribution / selectivity; | 75% |
6-chloro-5-(2-chloroethyl)-2-oxindole
ziprazidone
Conditions | Yield |
---|---|
With Morwet D425 In water Product distribution / selectivity; Reflux; Inert atmosphere; | 92% |
With sodium carbonate In water Product distribution / selectivity; Inert atmosphere; Reflux; Morwet D425; | 90% |
Stage #1: 3-(piperazin-1-yl)-1,2-benzisothiazole hydrochloride With potassium carbonate In acetonitrile for 0.5h; Stage #2: 6-chloro-5-(2-chloroethyl)-2-oxindole With sodium iodide In acetonitrile for 2h; Reflux; | 767 g |
6-chloro-5-(2-chloroethyl)-2-oxindole
7-bromo-3-piperazinyl-1,2-benzisothiazole
5-(2-(4-(7-bromo-1,2-benzisothiazol-3-yl)piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one
Conditions | Yield |
---|---|
With sodium carbonate In water at 115℃; for 20h; | 89% |
3-(1-piperazinyl)-1,2-benzisothiazole hydrochloride
6-chloro-5-(2-chloroethyl)-2-oxindole
ziprazidone
Conditions | Yield |
---|---|
With sodium carbonate In 1-methyl-pyrrolidin-2-one at 130 - 135℃; for 24h; Product distribution / selectivity; | 88.2% |
With sodium carbonate In poly(ethylene glycol) methyl ether at 120 - 125℃; for 48h; Product distribution / selectivity; | 88% |
With sodium carbonate; sodium iodide In toluene for 22.5h; Product distribution / selectivity; Heating / reflux; | 86% |
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In water at 105℃; for 12h; | 58% |
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile at 85℃; | 56% |
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
With sodium carbonate; sodium iodide In water for 24h; Reflux; | 51% |
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile at 80℃; | 8.7% |
3-(1-piperazinyl)-1,2-benzisothiazole
acetone
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
With potassium carbonate In water at 100℃; for 24h; Heating / reflux; | 3% |
6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one
3-(1-piperazinyl)-1,2-benzisothiazole
6-chloro-5-(2-chloroethyl)-2-oxindole
6-chloro-5-(2-chloroacetyl) indolin-2-one
A
5-(2-(4-(1,2-benzisothiazole-3-yl)-1-piperazinyl)-1-hydroxyethyl)-6-chloro-1,3-dihydro-2H-indole-2-one
B
5-(2-(4-(1,2-benzisothiazole-3-yl)-1-piperazinyl)-1-oxoethyl)-6-chloro-1,3-dihydro-2H-indole-2-one
C
ziprazidone
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; sodium carbonate; sodium iodide In cyclohexane Heating / reflux; |
6-chloro-5-(2-chloroethyl)-2-oxindole
ziprazidone
Conditions | Yield |
---|---|
With water; sodium carbonate; sodium iodide In N,N-dimethyl-formamide at 110℃; for 0.5h; Product distribution / selectivity; | |
With water; sodium carbonate; sodium iodide at 95 - 100℃; for 7.66667h; Product distribution / selectivity; |
3-(1-piperazinyl)-1,2-benzisothiazole
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
Stage #1: 3-(1-piperazinyl)-1,2-benzisothiazole; 6-chloro-5-(2-chloroethyl)-2-oxindole With sodium carbonate; sodium iodide In water; dimethyl sulfoxide at 115 - 125℃; for 2.75h; Stage #2: With hydrogenchloride In water for 0.166667h; |
1-(benzo[d]isoxazol-3-yl)piperazine hydrochloride
6-chloro-5-(2-chloroethyl)-2-oxindole
Conditions | Yield |
---|---|
Stage #1: 1-(benzo[d]isoxazol-3-yl)piperazine hydrochloride With sodium carbonate In water at 20℃; for 1h; Stage #2: 6-chloro-5-(2-chloroethyl)-2-oxindole With sodium iodide In water at 20 - 90℃; for 21 - 31h; Stage #3: In water at 45 - 80℃; for 1h; Product distribution / selectivity; |
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