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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Tazarotene Manufacturer/High quality/Best price/In stock

Cas:118292-40-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Tazarotene supplier in China

Cas:118292-40-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Tazarotene Cas 118292-40-3 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to light yellow crystal or crystalline powder Storage:Cool dry place

Factory supply Tazarotene Cas 118292-40-3 with high quality and best price

Cas:118292-40-3

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Tazarotene CAS No.:118292-40-3 Name: Tazarotene Synonyms: Ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxylate Molecular Structure Molecular Formula: C21H21NO2S

High purity Tazarotene CAS No.:118292-40-3

Cas:118292-40-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Tazarotene

Cas:118292-40-3

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Tazarotene 118292-40-3 GMP Manufacturer

Cas:118292-40-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Tazarotene

Cas:118292-40-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Tazarotene

Cas:118292-40-3

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Product Name: Tazarotene Synonyms: 3-pyridinecarboxylicacid,6-((3,4-dihydro-4,4-dimethyl-2h-1-benzothiopyran-6-y;agn190168;ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxyla

Tazarotene 118292-40-3

Cas:118292-40-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

High Quality Pharmaceutical Intermediate Tazarotene CAS 118292-40-3

Cas:118292-40-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 118292-40-3 with best quality

Cas:118292-40-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Function Tazarotene is an acetylenic retinoid prodrug converted to the active metabolite, Tazarotenic acid, with selective affinity for retinoic acid receptors RARβ and RARγ. Tazarotene also upregulates TIGs (Tazarotene-induced g

Tazarotene

Cas:118292-40-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Leader Biochemical Group

Tazarotene Basic information Description Dermatology drugs Adverse reactions and precautions Chemical P

High Quality Tazarotene CAS 118292-40-3 for Research Use only

Cas:118292-40-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Tazarotene 118292-40-3

Cas:118292-40-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Tazarotene CAS:118292-40-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Tazarotene CAS:118292-40-3

Cas:118292-40-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Tazarotene

Cas:118292-40-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Tazarotene

Cas:118292-40-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Tazarotene 118292-40-3

Cas:118292-40-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Por

Tazarotene

Cas:118292-40-3

Min.Order:10 Metric Ton

FOB Price: $10.0

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Tazarotene

Cas:118292-40-3

Min.Order:1 Gram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

tazarotene cas 118292-40-3

Cas:118292-40-3

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

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Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Tazarotene CAS 118292-40-3

Cas:118292-40-3

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

tazarotene

Cas:118292-40-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Tazarotene

Cas:118292-40-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products tazarotene

Cas:118292-40-3

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Tazarotene

Cas:118292-40-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Tazarotene

Cas:118292-40-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Tazarotene CAS No.:118292-40-3 Molecule Formula:C21H21NO2S Molecule Weight:351.46 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPE

Best Quality Tazarotene with good supplier

Cas:118292-40-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Tazarotene

Cas:118292-40-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Buy Top Purity Tazarotene

Cas:118292-40-3

Min.Order:0

Negotiable

Type:Trading Company

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Synthetic route

4,4-dimethylbenzothiopyran-6-ylacetylene

4,4-dimethylbenzothiopyran-6-ylacetylene

6-chloro-3-pyridinecarboxylic acid ethyl ester
49608-01-7

6-chloro-3-pyridinecarboxylic acid ethyl ester

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
With palladium on activated charcoal; potassium acetate; triphenylphosphine In N,N-dimethyl-formamide at 80℃; for 5h; Temperature; Reagent/catalyst; Solvent; Sonogashira Cross-Coupling; Inert atmosphere;86.3%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

6-chloro-3-pyridinecarboxylic acid ethyl ester
49608-01-7

6-chloro-3-pyridinecarboxylic acid ethyl ester

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
Stage #1: 6-chloro-3-pyridinecarboxylic acid ethyl ester With potassium carbonate; triphenylphosphine; 5%-palladium/activated carbon In toluene at 45 - 50℃;
Stage #2: (4,4-dimethylthiochroman-6-yl)acetylene; copper(l) iodide In toluene at 45 - 115℃; Product distribution / selectivity;
60%
Stage #1: 6-chloro-3-pyridinecarboxylic acid ethyl ester With palladium on activated charcoal; potassium carbonate; sodium sulfate; triphenylphosphine In toluene at 50 - 55℃; for 2h; Sonogashira Cross-Coupling; Inert atmosphere;
Stage #2: (4,4-dimethylthiochroman-6-yl)acetylene With copper(l) iodide In toluene at 105 - 115℃;
9 g
6-[2-(4,4-dimethylthiochroman-6yl)ethynyl]nicotinic acid ethyl ester S-oxide

6-[2-(4,4-dimethylthiochroman-6yl)ethynyl]nicotinic acid ethyl ester S-oxide

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
With N,N-dimethyl-formamide; phosphorus trichloride at -20℃; for 1h;59%
With phosphorus trichloride In N,N-dimethyl-formamide at -20℃; for 1h;59%
With phosphorus trichloride In N,N-dimethyl-formamide at -20℃; for 1h;59%
6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl] nicotinic acid ethyl ester hydrochloride

6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl] nicotinic acid ethyl ester hydrochloride

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; ethyl acetate at 20℃; for 2h; pH=7.5 - 8;55%
With sodium hydrogencarbonate In water; ethyl acetate for 2 - 4h; Product distribution / selectivity;
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine In tetrahydrofuran for 5h; Product distribution / selectivity; Heating / reflux;
With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine In tetrahydrofuran at 25 - 30℃; for 24h; Product distribution / selectivity;
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

ethyl 6-chloronicotinoate

ethyl 6-chloronicotinoate

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
With n-butyllithium; tetrakis(triphenylphosphine)palladium (0); zinc(II) chloride In tetrahydrofuran; hexane; ethyl acetate
With n-butyllithium; tetrakis(triphenylphosphine)palladium (0); zinc(II) chloride In tetrahydrofuran; hexane; ethyl acetate
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

bis(triphenylphosphine)palladium(II) dichloride

bis(triphenylphosphine)palladium(II) dichloride

6-chloro-3-pyridinecarboxylic acid ethyl ester
49608-01-7

6-chloro-3-pyridinecarboxylic acid ethyl ester

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
In ethyl acetate; triethylamine
ethanol
64-17-5

ethanol

6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]nicotinic acid
118292-41-4

6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]nicotinic acid

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
With sulfuric acid Heating / reflux;
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]nicotinic acid
118292-41-4

6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]nicotinic acid

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
In toluene at 110 - 120℃; Product distribution / selectivity;
6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl] nicotinic acid hydrochloride
952294-18-7

6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl] nicotinic acid hydrochloride

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
In toluene at 110 - 120℃; Product distribution / selectivity;
6-bromo-4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran
112110-44-8

6-bromo-4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C
2.1: potassium carbonate; copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon / 1,2-dimethoxyethane; water / 0.5 h / 20 °C
2.2: 5 h / 80 °C
3.1: sodium hydride / toluene; mineral oil / Reflux
4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere
5.1: phosphorus trichloride / N,N-dimethyl-formamide / 1 h / -20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C
2.1: potassium carbonate; copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon / 1,2-dimethoxyethane; water / 0.5 h / 20 °C
2.2: 5 h / 80 °C
3.1: sodium hydride / toluene; mineral oil / Reflux
4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere
5.1: phosphorus trichloride / N,N-dimethyl-formamide / 1 h / -20 °C
View Scheme
4,4-dimethyl-6-bromothiochromane S-oxide

4,4-dimethyl-6-bromothiochromane S-oxide

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate; copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon / 1,2-dimethoxyethane; water / 0.5 h / 20 °C
1.2: 5 h / 80 °C
2.1: sodium hydride / toluene; mineral oil / Reflux
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere
4.1: phosphorus trichloride / N,N-dimethyl-formamide / 1 h / -20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate; copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon / 1,2-dimethoxyethane; water / 0.5 h / 20 °C
1.2: 5 h / 80 °C
2.1: sodium hydride / toluene; mineral oil / Reflux
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere
4.1: phosphorus trichloride / N,N-dimethyl-formamide / 1 h / -20 °C
View Scheme
4-(4,4-dimethylthiochroman-6yl)-2-methyl-3-butyn-2-ol S-oxide
864841-54-3

4-(4,4-dimethylthiochroman-6yl)-2-methyl-3-butyn-2-ol S-oxide

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / toluene; mineral oil / Reflux
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere
3: phosphorus trichloride / N,N-dimethyl-formamide / 1 h / -20 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium hydride / toluene; mineral oil / Reflux
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere
3: phosphorus trichloride / N,N-dimethyl-formamide / 1 h / -20 °C
View Scheme
4,4-dimethyl-6-ethynylthiochromane S-oxide
864841-55-4

4,4-dimethyl-6-ethynylthiochromane S-oxide

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere
2: phosphorus trichloride / N,N-dimethyl-formamide / 1 h / -20 °C
View Scheme
tazarotene hydrochloride

tazarotene hydrochloride

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; ethyl acetate at 25 - 30℃;9 g
tazarotene
118292-40-3

tazarotene

C21H25NO2S

C21H25NO2S

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol under 3800.26 Torr; for 16h;100%
tazarotene
118292-40-3

tazarotene

6-[2-(4,4-dimethylthiochroman-6yl)ethynyl]nicotinic acid ethyl ester S-oxide

6-[2-(4,4-dimethylthiochroman-6yl)ethynyl]nicotinic acid ethyl ester S-oxide

Conditions
ConditionsYield
With sodium periodate In methanol; water at 10 - 20℃; for 18.5h;90%
tazarotene
118292-40-3

tazarotene

ethyl (Z)-6-(2-(4,4-dimethylthiochroman-6-yl)vinyl)nicotinate

ethyl (Z)-6-(2-(4,4-dimethylthiochroman-6-yl)vinyl)nicotinate

Conditions
ConditionsYield
With hydrogen In methanol under 3800.26 Torr; for 16h; Reagent/catalyst; Solvent; Green chemistry; stereoselective reaction;85%
tazarotene
118292-40-3

tazarotene

A

ethyl (Z)-6-(2-(4,4-dimethylthiochroman-6-yl)vinyl)nicotinate

ethyl (Z)-6-(2-(4,4-dimethylthiochroman-6-yl)vinyl)nicotinate

B

C21H25NO2S

C21H25NO2S

Conditions
ConditionsYield
With hydrogen In methanol under 3800.26 Torr; for 15h;A 85%
B n/a
bromopentacarbonylmanganese(I)
14516-54-2

bromopentacarbonylmanganese(I)

acetone
67-64-1

acetone

tazarotene
118292-40-3

tazarotene

fac-[MnBr(CO)3(tazarotene)]*C3H6O

fac-[MnBr(CO)3(tazarotene)]*C3H6O

Conditions
ConditionsYield
for 0.166667h; Inert atmosphere; Darkness; Reflux;84%
tazarotene
118292-40-3

tazarotene

6-(2-(4,4-dimethylthiochroman-6-yl)-ethynyl)-pyridin-3-ylmethanol

6-(2-(4,4-dimethylthiochroman-6-yl)-ethynyl)-pyridin-3-ylmethanol

Conditions
ConditionsYield
In tetrahydrofuran; water; ethyl acetate
With hydrogenchloride In tetrahydrofuran; water; ethyl acetate
tazarotene
118292-40-3

tazarotene

dibenzoyl peroxide
94-36-0

dibenzoyl peroxide

Conditions
ConditionsYield
With dibenzoyl peroxide
tazarotene
118292-40-3

tazarotene

6-[4,4-dimethyl-2-(pyridine-3-carbonyloxy)thiochroman-6-ylethynyl]nicotinic acid ethyl ester
1262228-03-4

6-[4,4-dimethyl-2-(pyridine-3-carbonyloxy)thiochroman-6-ylethynyl]nicotinic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C
2: 5 h / 130 °C
3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C
4: triethylamine / dichloromethane / 18 h / 0 - 20 °C
View Scheme
tazarotene
118292-40-3

tazarotene

A

(R)-6-[4,4-dimethyl-2-(pyridine-3-carbonyloxy)thiochroman-6-ylethynyl]nicotinic acid ethyl ester
1262228-05-6

(R)-6-[4,4-dimethyl-2-(pyridine-3-carbonyloxy)thiochroman-6-ylethynyl]nicotinic acid ethyl ester

B

(S)-6-[4,4-dimethyl-2-(pyridine-3-carbonyloxy)thiochroman-6-ylethynyl]nicotinic acid ethyl ester
1262228-04-5

(S)-6-[4,4-dimethyl-2-(pyridine-3-carbonyloxy)thiochroman-6-ylethynyl]nicotinic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C
2: 5 h / 130 °C
3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C
4: triethylamine / dichloromethane / 18 h / 0 - 20 °C
5: OJH column / ethanol / Resolution of racemate
View Scheme
tazarotene
118292-40-3

tazarotene

ethyl 6-((4,4-dimethyl-2-oxothiochroman-6-yl)ethynyl)nicotinate
1262228-08-9

ethyl 6-((4,4-dimethyl-2-oxothiochroman-6-yl)ethynyl)nicotinate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C
2: 5 h / 130 °C
3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C
4: Dess-Martin periodane / dichloromethane / 1 h / 20 °C
View Scheme
tazarotene
118292-40-3

tazarotene

6-(2-acetoxy-4,4-dimethylthiochroman-6-ylethynyl)nicotinic acid ethyl ester
1262228-13-6

6-(2-acetoxy-4,4-dimethylthiochroman-6-ylethynyl)nicotinic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C
2: 5 h / 130 °C
View Scheme
tazarotene
118292-40-3

tazarotene

6-((2-hydroxy-4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid
1262228-06-7

6-((2-hydroxy-4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C
2.1: 5 h / 130 °C
3.1: potassium hydroxide; water / ethanol / 18.5 h / 20 °C
3.2: pH ~ 5
View Scheme
tazarotene
118292-40-3

tazarotene

6-((4,4-dimethyl-2-oxothiochroman-6-yl)ethynyl)nicotinic acid
1262228-07-8

6-((4,4-dimethyl-2-oxothiochroman-6-yl)ethynyl)nicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C
2.1: 5 h / 130 °C
3.1: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C
4.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C
5.1: potassium hydroxide; water / ethanol / 18 h / 20 °C
5.2: pH ~ 5
View Scheme
tazarotene
118292-40-3

tazarotene

C29H37NO5SSi
1338704-48-5

C29H37NO5SSi

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C
2: 5 h / 130 °C
3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C
4: triethylamine / dichloromethane / 17 h / 20 °C / Inert atmosphere
View Scheme
tazarotene
118292-40-3

tazarotene

6-[2-(2-hydroxy-acetoxy)-4,4-dimethyl-thiochroman-6-ylethynyl]-nicotinic acid ethyl ester
1262228-11-4

6-[2-(2-hydroxy-acetoxy)-4,4-dimethyl-thiochroman-6-ylethynyl]-nicotinic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C
2: 5 h / 130 °C
3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C
4: triethylamine / dichloromethane / 17 h / 20 °C / Inert atmosphere
5: water; tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1 h / 20 °C
View Scheme
tazarotene
118292-40-3

tazarotene

ethyl 6-[(2-hydroxy-4,4-dimethyl-3,4-dihydro-2-thiochromen-6-yl)ethynyl]pyridine-3-carboxylate
1262228-10-3

ethyl 6-[(2-hydroxy-4,4-dimethyl-3,4-dihydro-2-thiochromen-6-yl)ethynyl]pyridine-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C
2: 5 h / 130 °C
3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C
View Scheme
tazarotene
118292-40-3

tazarotene

6-(2-(2-benzoyloxy-4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid ethyl ester
1262228-00-1

6-(2-(2-benzoyloxy-4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C
2: 5 h / 130 °C
3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C
4: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
View Scheme
tazarotene
118292-40-3

tazarotene

A

(R)-6-(2-(2-benzoyloxy-4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid ethyl ester
1262228-02-3

(R)-6-(2-(2-benzoyloxy-4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid ethyl ester

B

(S)-6-(2-(2-benzoyloxy-4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid ethyl ester
1262228-01-2

(S)-6-(2-(2-benzoyloxy-4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C
2: 5 h / 130 °C
3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C
4: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
5: chiral ADH column / isopropyl alcohol; water / Resolution of racemate
View Scheme

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