DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:118292-40-3
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inquiryUnique advantages of Tazarotene Cas 118292-40-3 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to light yellow crystal or crystalline powder Storage:Cool dry place
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inquiryTazarotene CAS No.:118292-40-3 Name: Tazarotene Synonyms: Ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxylate Molecular Structure Molecular Formula: C21H21NO2S
Cas:118292-40-3
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:118292-40-3
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inquiryProduct Name: Tazarotene Synonyms: 3-pyridinecarboxylicacid,6-((3,4-dihydro-4,4-dimethyl-2h-1-benzothiopyran-6-y;agn190168;ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxyla
Cas:118292-40-3
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:118292-40-3
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inquiryFunction Tazarotene is an acetylenic retinoid prodrug converted to the active metabolite, Tazarotenic acid, with selective affinity for retinoic acid receptors RARβ and RARγ. Tazarotene also upregulates TIGs (Tazarotene-induced g
Tazarotene Basic information Description Dermatology drugs Adverse reactions and precautions Chemical P
Cas:118292-40-3
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inquiryTazarotene CAS:118292-40-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
Cas:118292-40-3
Min.Order:1 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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Cas:118292-40-3
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inquiryAppearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Por
Cas:118292-40-3
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:118292-40-3
Min.Order:5 Gram
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inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:118292-40-3
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:118292-40-3
Min.Order:10 Gram
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Product name: Tazarotene CAS No.:118292-40-3 Molecule Formula:C21H21NO2S Molecule Weight:351.46 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPE
Cas:118292-40-3
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
6-chloro-3-pyridinecarboxylic acid ethyl ester
tazarotene
Conditions | Yield |
---|---|
With palladium on activated charcoal; potassium acetate; triphenylphosphine In N,N-dimethyl-formamide at 80℃; for 5h; Temperature; Reagent/catalyst; Solvent; Sonogashira Cross-Coupling; Inert atmosphere; | 86.3% |
(4,4-dimethylthiochroman-6-yl)acetylene
6-chloro-3-pyridinecarboxylic acid ethyl ester
tazarotene
Conditions | Yield |
---|---|
Stage #1: 6-chloro-3-pyridinecarboxylic acid ethyl ester With potassium carbonate; triphenylphosphine; 5%-palladium/activated carbon In toluene at 45 - 50℃; Stage #2: (4,4-dimethylthiochroman-6-yl)acetylene; copper(l) iodide In toluene at 45 - 115℃; Product distribution / selectivity; | 60% |
Stage #1: 6-chloro-3-pyridinecarboxylic acid ethyl ester With palladium on activated charcoal; potassium carbonate; sodium sulfate; triphenylphosphine In toluene at 50 - 55℃; for 2h; Sonogashira Cross-Coupling; Inert atmosphere; Stage #2: (4,4-dimethylthiochroman-6-yl)acetylene With copper(l) iodide In toluene at 105 - 115℃; | 9 g |
tazarotene
Conditions | Yield |
---|---|
With N,N-dimethyl-formamide; phosphorus trichloride at -20℃; for 1h; | 59% |
With phosphorus trichloride In N,N-dimethyl-formamide at -20℃; for 1h; | 59% |
With phosphorus trichloride In N,N-dimethyl-formamide at -20℃; for 1h; | 59% |
tazarotene
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; ethyl acetate at 20℃; for 2h; pH=7.5 - 8; | 55% |
With sodium hydrogencarbonate In water; ethyl acetate for 2 - 4h; Product distribution / selectivity; |
(4,4-dimethylthiochroman-6-yl)acetylene
tazarotene
Conditions | Yield |
---|---|
With copper(l) iodide; potassium carbonate; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine In tetrahydrofuran for 5h; Product distribution / selectivity; Heating / reflux; | |
With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine In tetrahydrofuran at 25 - 30℃; for 24h; Product distribution / selectivity; |
(4,4-dimethylthiochroman-6-yl)acetylene
tazarotene
Conditions | Yield |
---|---|
With n-butyllithium; tetrakis(triphenylphosphine)palladium (0); zinc(II) chloride In tetrahydrofuran; hexane; ethyl acetate | |
With n-butyllithium; tetrakis(triphenylphosphine)palladium (0); zinc(II) chloride In tetrahydrofuran; hexane; ethyl acetate |
(4,4-dimethylthiochroman-6-yl)acetylene
6-chloro-3-pyridinecarboxylic acid ethyl ester
tazarotene
Conditions | Yield |
---|---|
In ethyl acetate; triethylamine |
ethanol
6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]nicotinic acid
tazarotene
Conditions | Yield |
---|---|
With sulfuric acid Heating / reflux; |
Triethyl orthoacetate
6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]nicotinic acid
tazarotene
Conditions | Yield |
---|---|
In toluene at 110 - 120℃; Product distribution / selectivity; |
6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl] nicotinic acid hydrochloride
Triethyl orthoacetate
tazarotene
Conditions | Yield |
---|---|
In toluene at 110 - 120℃; Product distribution / selectivity; |
6-bromo-4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran
tazarotene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C 2.1: potassium carbonate; copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon / 1,2-dimethoxyethane; water / 0.5 h / 20 °C 2.2: 5 h / 80 °C 3.1: sodium hydride / toluene; mineral oil / Reflux 4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere 5.1: phosphorus trichloride / N,N-dimethyl-formamide / 1 h / -20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C 2.1: potassium carbonate; copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon / 1,2-dimethoxyethane; water / 0.5 h / 20 °C 2.2: 5 h / 80 °C 3.1: sodium hydride / toluene; mineral oil / Reflux 4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere 5.1: phosphorus trichloride / N,N-dimethyl-formamide / 1 h / -20 °C View Scheme |
tazarotene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium carbonate; copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon / 1,2-dimethoxyethane; water / 0.5 h / 20 °C 1.2: 5 h / 80 °C 2.1: sodium hydride / toluene; mineral oil / Reflux 3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere 4.1: phosphorus trichloride / N,N-dimethyl-formamide / 1 h / -20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate; copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon / 1,2-dimethoxyethane; water / 0.5 h / 20 °C 1.2: 5 h / 80 °C 2.1: sodium hydride / toluene; mineral oil / Reflux 3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere 4.1: phosphorus trichloride / N,N-dimethyl-formamide / 1 h / -20 °C View Scheme |
4-(4,4-dimethylthiochroman-6yl)-2-methyl-3-butyn-2-ol S-oxide
tazarotene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride / toluene; mineral oil / Reflux 2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere 3: phosphorus trichloride / N,N-dimethyl-formamide / 1 h / -20 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydride / toluene; mineral oil / Reflux 2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere 3: phosphorus trichloride / N,N-dimethyl-formamide / 1 h / -20 °C View Scheme |
4,4-dimethyl-6-ethynylthiochromane S-oxide
tazarotene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere 2: phosphorus trichloride / N,N-dimethyl-formamide / 1 h / -20 °C View Scheme |
tazarotene
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; ethyl acetate at 25 - 30℃; | 9 g |
tazarotene
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol under 3800.26 Torr; for 16h; | 100% |
tazarotene
Conditions | Yield |
---|---|
With sodium periodate In methanol; water at 10 - 20℃; for 18.5h; | 90% |
tazarotene
Conditions | Yield |
---|---|
With hydrogen In methanol under 3800.26 Torr; for 16h; Reagent/catalyst; Solvent; Green chemistry; stereoselective reaction; | 85% |
Conditions | Yield |
---|---|
With hydrogen In methanol under 3800.26 Torr; for 15h; | A 85% B n/a |
Conditions | Yield |
---|---|
for 0.166667h; Inert atmosphere; Darkness; Reflux; | 84% |
tazarotene
Conditions | Yield |
---|---|
In tetrahydrofuran; water; ethyl acetate | |
With hydrogenchloride In tetrahydrofuran; water; ethyl acetate |
tazarotene
dibenzoyl peroxide
Conditions | Yield |
---|---|
With dibenzoyl peroxide |
tazarotene
6-[4,4-dimethyl-2-(pyridine-3-carbonyloxy)thiochroman-6-ylethynyl]nicotinic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C 2: 5 h / 130 °C 3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C 4: triethylamine / dichloromethane / 18 h / 0 - 20 °C View Scheme |
tazarotene
A
(R)-6-[4,4-dimethyl-2-(pyridine-3-carbonyloxy)thiochroman-6-ylethynyl]nicotinic acid ethyl ester
B
(S)-6-[4,4-dimethyl-2-(pyridine-3-carbonyloxy)thiochroman-6-ylethynyl]nicotinic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C 2: 5 h / 130 °C 3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C 4: triethylamine / dichloromethane / 18 h / 0 - 20 °C 5: OJH column / ethanol / Resolution of racemate View Scheme |
tazarotene
ethyl 6-((4,4-dimethyl-2-oxothiochroman-6-yl)ethynyl)nicotinate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C 2: 5 h / 130 °C 3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C 4: Dess-Martin periodane / dichloromethane / 1 h / 20 °C View Scheme |
tazarotene
6-(2-acetoxy-4,4-dimethylthiochroman-6-ylethynyl)nicotinic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C 2: 5 h / 130 °C View Scheme |
tazarotene
6-((2-hydroxy-4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C 2.1: 5 h / 130 °C 3.1: potassium hydroxide; water / ethanol / 18.5 h / 20 °C 3.2: pH ~ 5 View Scheme |
tazarotene
6-((4,4-dimethyl-2-oxothiochroman-6-yl)ethynyl)nicotinic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C 2.1: 5 h / 130 °C 3.1: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C 4.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C 5.1: potassium hydroxide; water / ethanol / 18 h / 20 °C 5.2: pH ~ 5 View Scheme |
tazarotene
C29H37NO5SSi
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C 2: 5 h / 130 °C 3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C 4: triethylamine / dichloromethane / 17 h / 20 °C / Inert atmosphere View Scheme |
tazarotene
6-[2-(2-hydroxy-acetoxy)-4,4-dimethyl-thiochroman-6-ylethynyl]-nicotinic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C 2: 5 h / 130 °C 3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C 4: triethylamine / dichloromethane / 17 h / 20 °C / Inert atmosphere 5: water; tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1 h / 20 °C View Scheme |
tazarotene
ethyl 6-[(2-hydroxy-4,4-dimethyl-3,4-dihydro-2-thiochromen-6-yl)ethynyl]pyridine-3-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C 2: 5 h / 130 °C 3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C View Scheme |
tazarotene
6-(2-(2-benzoyloxy-4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C 2: 5 h / 130 °C 3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C 4: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere View Scheme |
tazarotene
A
(R)-6-(2-(2-benzoyloxy-4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid ethyl ester
B
(S)-6-(2-(2-benzoyloxy-4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium periodate / water; methanol / 18.5 h / 10 - 20 °C 2: 5 h / 130 °C 3: sodium ethanolate; water / tetrahydrofuran / 12 h / 75 °C 4: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere 5: chiral ADH column / isopropyl alcohol; water / Resolution of racemate View Scheme |
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