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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 6-Ethynyl-4,4-Dimethylthiochroman;4,4-Dimethyl-6-Ethynylthiochroman supplier in China

Cas:118292-06-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

6-Ethynyl-4,4-dimethylthiochroman CAS No.:118292-06-1 Name: 6-Ethynyl-4,4-dimethylthiochroman Synonyms: 4,4-Dimethyl-6-ethynylthiochroman; 6-Ethynyl-3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyr

High purity 6-Ethynyl-4,4-dimethylthiochroman CAS No.:118292-06-1

Cas:118292-06-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

6-Ethynyl-4,4-dimethylthiochroman

Cas:118292-06-1

Min.Order:1 Gram

FOB Price: $6.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6-Ethynyl-4,4-dimethyl-thiochroman

Cas:118292-06-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/227.html Product Name : 6-Ethynyl-4,4-dimethylthiochroman CAS No. 118292-06-1

6-Ethynyl-4,4-dimethylthiochroman

Cas:118292-06-1

Min.Order:1 Gram

FOB Price: $43.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

6-Ethynyl-4,4-Dimethyl-Thiochroman

Cas:118292-06-1

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

6-Ethynyl-4,4-dimethylthiochroman 118292-06-1

Cas:118292-06-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 118292-06-1 with best quality

Cas:118292-06-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2H-1-Benzothiopyran,6-ethynyl-3,4-dihydro-4,4-dimethyl- 118292-06-1

Cas:118292-06-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

6-Ethynyl-4,4-dimethylthiochroman CAS:118292-06-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali

6-Ethynyl-4,4-dimethylthiochroman CAS:118292-06-1

Cas:118292-06-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2H-1-Benzothiopyran,6-ethynyl-3,4-dihydro-4,4-dimethyl-

Cas:118292-06-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2H-1-Benzothiopyran,6-ethynyl-3,4-dihydro-4,4-dimethyl-

Cas:118292-06-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

6-Ethynyl-4,4-Dimethylthiochroman;4,4-Dimethyl-6-Ethynylthiochroman

Cas:118292-06-1

Min.Order:0

Negotiable

Type:Manufacturers

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

6-Ethynyl-4,4-dimethylthiochroman

Cas:118292-06-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

6-Ethynyl-4,4-dimethylthiochroman

Cas:118292-06-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

6-Ethynyl-4,4-dimethylthiochroman

Cas:118292-06-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

advantage: 1. The best price, satisfactory quality; 2. customers have the right to choose the delivery of parcels (EMS, DHL, FedEx, UPS); 3. customers have the right to choose from the recent effective packaging methods of their products packaging

Best price/In stock 6-Ethynyl-4,4-dimethylthiochroman 118292-06-1

Cas:118292-06-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2H-1-Benzothiopyran,6-ethynyl-3,4-dihydro-4,4-dimethyl-

Cas:118292-06-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

6-Ethynyl-4,4-dimethylthiochroman

Cas:118292-06-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 6-Ethynyl-4,4-Dimethylthiochroman;4,4-Dimethyl-6-Ethynylthiochroman

Cas:118292-06-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Siwei Development Group Ltd.

Product name: 4,4-Dimethyl-6-Ethynylthiochroman CAS No.:118292-06-1 Molecule Formula:C13H14S Molecule Weight:202.32 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

High Quality 4,4-Dimethyl-6-Ethynylthiochroman

Cas:118292-06-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

6-Ethynyl-4,4-dimethylthiochroman

Cas:118292-06-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

6-Ethynyl-4,4-dimethylthiochroman

Cas:118292-06-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

6-Ethynyl-4,4-dimethylthiochroman

Cas:118292-06-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

6-Ethynyl-4,4-dimethylthiochroman

Cas:118292-06-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Intermediate of Tazarotene

Cas:118292-06-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

6-Ethynyl-4,4-dimethylthiochroman cas no. 118292-06-1 98%

Cas:118292-06-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

6-Ethynyl-4,4-Dimethyl-Thiochroman

Cas:118292-06-1

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

6-(1,1-dichloroethyl)-4,4-dimethylthiochroman
1187617-88-4

6-(1,1-dichloroethyl)-4,4-dimethylthiochroman

(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -5 - 35℃; Product distribution / selectivity;90%
3-[4,4-dimethylthiochroman-6-yl]-3-chloro-2-propene-1-al

3-[4,4-dimethylthiochroman-6-yl]-3-chloro-2-propene-1-al

(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane; water at 80 - 90℃; for 2h; Vilsmeier Hack reaction;87.68%
With sodium hydroxide In 1,4-dioxane; water at 80 - 90℃; for 2h;87.68%
With sodium hydroxide In 1,4-dioxane; water at 80 - 90℃; for 2h;87.68%
4,4-dimethyl-6-ethynylthiochromane S-oxide
864841-55-4

4,4-dimethyl-6-ethynylthiochromane S-oxide

(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

Conditions
ConditionsYield
With N,N-dimethyl-formamide; phosphorus trichloride at -20℃; for 1h;85%
With phosphorus trichloride In N,N-dimethyl-formamide at -20℃; for 1h;85%
C13H18N2S

C13H18N2S

(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

Conditions
ConditionsYield
Stage #1: C13H18N2S With iodine; triethylamine In tetrahydrofuran at 20℃; for 2h;
Stage #2: With potassium hydroxide In ethanol for 8h; Heating / reflux;
conc. hydrogen chloride

conc. hydrogen chloride

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl methyl ketone
88579-23-1

3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl methyl ketone

(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

Conditions
ConditionsYield
With n-butyllithium; diisopropylamine; lithium diisopropyl amide In tetrahydrofuran; hexane; water; ethyl acetate
With n-butyllithium; diisopropylamine; lithium diisopropyl amide In tetrahydrofuran; hexane; water; ethyl acetate
2,2-dibromo-1-(4,4-dimethylthiochroman-6-yl)ethylene

2,2-dibromo-1-(4,4-dimethylthiochroman-6-yl)ethylene

(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane
diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl methyl ketone
88579-23-1

3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl methyl ketone

(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

Conditions
ConditionsYield
With n-butyllithium; diisopropylamine; lithium diisopropyl amide In tetrahydrofuran; hexane
With n-butyllithium; diisopropylamine; lithium diisopropyl amide In tetrahydrofuran; hexane
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

ethyl 4-iodo-3-nitrobenzoate
57362-77-3

ethyl 4-iodo-3-nitrobenzoate

ethyl 3-nitro-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoate

ethyl 3-nitro-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 70℃; for 8h; Inert atmosphere;97%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

ethyl 2-chloro-4-iodobenzoate

ethyl 2-chloro-4-iodobenzoate

ethyl 2-chloro-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoate

ethyl 2-chloro-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 80℃; for 8h; Inert atmosphere;95%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

2-(4-bromophenyl)-1H-benzimidazole
2622-74-4

2-(4-bromophenyl)-1H-benzimidazole

C26H22N2S
1038865-98-3

C26H22N2S

Conditions
ConditionsYield
With copper(l) iodide; triethylamine; triphenylphosphine; palladium dichloride In dimethyl sulfoxide at 90℃; Sonogashira coupling;90%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

ethyl 2-fluoro-4-iodobenzoate
205750-82-9

ethyl 2-fluoro-4-iodobenzoate

ethyl 2-fluoro-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoate

ethyl 2-fluoro-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 80℃; for 6h; Inert atmosphere;86%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

2-amino-4-iodobenzoic acid
20776-54-9

2-amino-4-iodobenzoic acid

2-amino-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoic acid

2-amino-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoic acid

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 75℃; for 12h; Inert atmosphere;85%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

triethyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane
745783-97-5

triethyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane

(Z)-(2-(4,4-dimethylthiochroman-6-yl)-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)triethylsilane

(Z)-(2-(4,4-dimethylthiochroman-6-yl)-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)triethylsilane

Conditions
ConditionsYield
With potassium hexamethylsilazane at 70℃; for 12h; stereoselective reaction;84%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

ethyl 2,3-difluoro-4-iodobenzoate

ethyl 2,3-difluoro-4-iodobenzoate

ethyl 2,3-difluoro-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoate

ethyl 2,3-difluoro-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 75℃; for 8h; Inert atmosphere;82%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

4-iodo-2-methoxybenzoic acid-methyl ester
148490-97-5

4-iodo-2-methoxybenzoic acid-methyl ester

C22H22O3S

C22H22O3S

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; isopropylamine In N,N-dimethyl-formamide at 20℃; for 8h; Inert atmosphere;82%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

ethyl 2-hydroxy-4-iodobenzoate
730977-57-8

ethyl 2-hydroxy-4-iodobenzoate

ethyl 4-((4,4-dimethylthiochroman-6-yl)ethynyl)-2-hydroxybenzoate

ethyl 4-((4,4-dimethylthiochroman-6-yl)ethynyl)-2-hydroxybenzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; isopropylamine In N,N-dimethyl-formamide at 20℃; for 8h; Inert atmosphere;82%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

6-chloro-3-pyridinecarboxylic acid ethyl ester
49608-01-7

6-chloro-3-pyridinecarboxylic acid ethyl ester

6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl] nicotinic acid ethyl ester hydrochloride

6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl] nicotinic acid ethyl ester hydrochloride

Conditions
ConditionsYield
Stage #1: (4,4-dimethylthiochroman-6-yl)acetylene; 6-chloro-3-pyridinecarboxylic acid ethyl ester With copper(l) iodide; triethanolamine; bis-triphenylphosphine-palladium(II) chloride In dimethyl sulfoxide at 20 - 98℃; for 3h;
Stage #2: With hydrogenchloride In ethyl acetate at 20℃; for 2.25h;
81%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

methyl 4-iodosalicylate
18179-39-0

methyl 4-iodosalicylate

methyl 4-((4,4-dimethylthiochroman-6-yl)ethynyl)-2-hydroxybenzoate

methyl 4-((4,4-dimethylthiochroman-6-yl)ethynyl)-2-hydroxybenzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; isopropylamine In N,N-dimethyl-formamide at 20℃; for 8h; Inert atmosphere;81%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

C10H11IO3

C10H11IO3

C23H24O3S

C23H24O3S

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; isopropylamine In N,N-dimethyl-formamide at 20℃; for 8h; Inert atmosphere;77%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

methyl 3-acetamido-4-iodobenzoate
51411-83-7

methyl 3-acetamido-4-iodobenzoate

methyl 3-acetamido-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoate

methyl 3-acetamido-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 70℃; for 8h; Inert atmosphere;76%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

N,N-dimethyl-aniline
121-69-7

N,N-dimethyl-aniline

N-(3-(4,4-dimethylthiochroman-6-yl)prop-2-yn-1-yl)-N-methylaniline

N-(3-(4,4-dimethylthiochroman-6-yl)prop-2-yn-1-yl)-N-methylaniline

Conditions
ConditionsYield
With tert.-butylhydroperoxide; copper(I) bromide In decane at 100℃; for 3.25h; Inert atmosphere;76%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

methyl 4-iodo-3-methoxybenzoate
35387-92-9

methyl 4-iodo-3-methoxybenzoate

C22H22O3S

C22H22O3S

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; isopropylamine In N,N-dimethyl-formamide at 20℃; for 8h; Inert atmosphere;75%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

(3-bromo-3, 3-difluoroprop-1-yn-1-yl)triisopropylsilane
257887-58-4

(3-bromo-3, 3-difluoroprop-1-yn-1-yl)triisopropylsilane

C25H34F2SSi

C25H34F2SSi

Conditions
ConditionsYield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; caesium carbonate; tris-(o-tolyl)phosphine In toluene at 100℃; for 24h;74%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

ethyl 2-chloropyrimidine-5-carboxylate
89793-12-4

ethyl 2-chloropyrimidine-5-carboxylate

ethyl 2-((4,4-dimethylthiochroman-6-yl)ethynyl)pyrimidin-5-carboxylate

ethyl 2-((4,4-dimethylthiochroman-6-yl)ethynyl)pyrimidin-5-carboxylate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 75℃; for 22h; Inert atmosphere;73%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide for 22h; Inert atmosphere;73%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

4,4-dimethyl-6-ethynylthiochromane S-oxide
864841-55-4

4,4-dimethyl-6-ethynylthiochromane S-oxide

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 3h;72%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

trifluoroacetaldehyde N-triftosylhydrazone

trifluoroacetaldehyde N-triftosylhydrazone

5-(4,4-dimethylthiochroman-6-yl)-3-(trifluoromethyl)-1H-pyrazole

5-(4,4-dimethylthiochroman-6-yl)-3-(trifluoromethyl)-1H-pyrazole

Conditions
ConditionsYield
With potassium hydroxide In 1,4-dioxane at 100℃; for 10h; Schlenk technique; Glovebox; Inert atmosphere;72%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

ethyl 5-bromopyrazine-2-carboxylate
36070-83-4

ethyl 5-bromopyrazine-2-carboxylate

ethyl 5-((4,4-dimethylthiochroman-6-yl)ethynyl)pyrazin-2-carboxylate

ethyl 5-((4,4-dimethylthiochroman-6-yl)ethynyl)pyrazin-2-carboxylate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 80℃; for 8h; Inert atmosphere;71.5%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

methyl 3-hydroxy-4-iodobenzoate
157942-12-6

methyl 3-hydroxy-4-iodobenzoate

methyl 4-((4,4-dimethylthiochroman-6-yl)ethynyl)-3-hydroxybenzoate

methyl 4-((4,4-dimethylthiochroman-6-yl)ethynyl)-3-hydroxybenzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; isopropylamine In N,N-dimethyl-formamide at 20℃; for 8h; Inert atmosphere;71%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

ethyl 3-fluoro-4-iodobenzoate
1027513-43-4

ethyl 3-fluoro-4-iodobenzoate

ethyl 3-fluoro-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoate

ethyl 3-fluoro-4-((4,4-dimethylthiochroman-6-yl)ethynyl)benzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 70℃; for 8h; Inert atmosphere;68%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

5-chloropyrimidine-2-carbonitrile
38275-56-8

5-chloropyrimidine-2-carbonitrile

2-cyano-5-((4,4-dimethylthiochroman-6-yl)ethynyl)pyrimidine

2-cyano-5-((4,4-dimethylthiochroman-6-yl)ethynyl)pyrimidine

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 50℃; for 22h; Inert atmosphere;65%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

6-chloro-3-pyridinecarboxylic acid ethyl ester
49608-01-7

6-chloro-3-pyridinecarboxylic acid ethyl ester

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
Stage #1: 6-chloro-3-pyridinecarboxylic acid ethyl ester With potassium carbonate; triphenylphosphine; 5%-palladium/activated carbon In toluene at 45 - 50℃;
Stage #2: (4,4-dimethylthiochroman-6-yl)acetylene; copper(l) iodide In toluene at 45 - 115℃; Product distribution / selectivity;
60%
Stage #1: 6-chloro-3-pyridinecarboxylic acid ethyl ester With palladium on activated charcoal; potassium carbonate; sodium sulfate; triphenylphosphine In toluene at 50 - 55℃; for 2h; Sonogashira Cross-Coupling; Inert atmosphere;
Stage #2: (4,4-dimethylthiochroman-6-yl)acetylene With copper(l) iodide In toluene at 105 - 115℃;
9 g
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

2-(trimethylsilyl)phenyl trifluoromethanesulfonate
88284-48-4

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

6-((2-iodophenyl)ethynyl)-4,4-dimethylthiochromane

6-((2-iodophenyl)ethynyl)-4,4-dimethylthiochromane

Conditions
ConditionsYield
With N-iodo-succinimide; chloro[1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene]copper(I); caesium carbonate; cesium fluoride In acetonitrile at 60℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube;54%
(4,4-dimethylthiochroman-6-yl)acetylene
118292-06-1

(4,4-dimethylthiochroman-6-yl)acetylene

tazarotene
118292-40-3

tazarotene

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine In tetrahydrofuran for 5h; Product distribution / selectivity; Heating / reflux;
With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine In tetrahydrofuran at 25 - 30℃; for 24h; Product distribution / selectivity;

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