Our Advantages: Our products are manufactured in GMP factory Most products can provide DMF files for customer review Professional logistics team to provide fast and best services for customer Please contact with us freely for getting det
Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:1195765-45-7
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryItems Standard Result Appearance White to slight colour silid Off white solid Purity by HPLC (% area)
Cas:1195765-45-7
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inquiryGIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, GIHI CHEMICALS is your best choice. pls contact with us freely for getting detailed prod
Cas:1195765-45-7
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inquiryUnique advantages for Dabrafenib Cas1195765-45-7 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to slight colour solid Storage:N/M Package:1kg/bag with foil bag;25kg/dru
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:1195765-45-7
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Dabrafenib The alias:dabrafenib mesylate CAS NO:1195765-45-7 Molecular formula:C24H24F3N5O5S3 Molecular weight:615.66800 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage
Cas:1195765-45-7
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inquiryOur company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o
Cas:1195765-45-7
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:1195765-45-7
Min.Order:1 Kilogram
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Cas:1195765-45-7
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:1195765-45-7
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:1195765-45-7
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Type:Trading Company
inquiryDabrafenib CAS:1195765-45-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:1195765-45-7
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
API name:dabrafenib Certificates: GMP, DMF CAS No.: 1195765-45-7 Chemical name: Dabrafenib;N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide;Dabrafenibfreebase(GSK2118436A);Dabraf
Cas:1195765-45-7
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:1195765-45-7
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Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:1195765-45-7
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:1195765-45-7
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:1195765-45-7
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryGSK2118436Appearance:White or Almost White crystalline powder Storage:Store in refrigerator Package:according to customers' requirements Application:Steroids injection For Body building Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by s
Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum;200kg/drum as per your request Application:Used as Pharmaceutical Intermedia
Cas:1195765-45-7
Min.Order:1 Kilogram
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Type:Trading Company
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, in
Cas:1195765-45-7
Min.Order:1 Kilogram
FOB Price: $150.0 / 200.0
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:1195765-45-7
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Cas:1195765-45-7
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:1195765-45-7
Min.Order:1 Milligram
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Type:Trading Company
inquiryN-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1 ,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
dabrafenib
Conditions | Yield |
---|---|
With ammonium hydroxide In water at 20 - 103℃; Product distribution / selectivity; sealed tube; | 88% |
With ammonium hydroxide at 98 - 103℃; for 2h; Sealed tube; | 88% |
With ammonium hydroxide at 20 - 103℃; Reagent/catalyst; Autoclave; | 88% |
2,6-difluorobenzene-1-sulfonamide
dabrafenib
Conditions | Yield |
---|---|
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N,N,N',N'-tetramethylguanidine In dimethyl sulfoxide at 55℃; for 40h; Inert atmosphere; Glovebox; Irradiation; | 57% |
2,6-difluorobenzene-1-sulfonyl chloride
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: pyridine / dichloromethane / 15 - 25 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 3 °C 3.1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C 3.2: 2.5 h / 10 - 75 °C 4.1: ammonium hydroxide / water / 20 - 103 °C / sealed tube View Scheme | |
Multi-step reaction with 4 steps 1.1: pyridine / dichloromethane / 15 - 25 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 3 °C 3.1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C 3.2: 2.5 h / 10 - 75 °C 4.1: ammonium hydroxide / 2 h / 98 - 103 °C / Sealed tube View Scheme | |
Multi-step reaction with 5 steps 1: pyridine / dichloromethane / 15 - 25 °C 2: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 3 °C 3: N-Bromosuccinimide / dichloromethane / 10 - 20 °C 4: ethyl acetate; N,N-dimethyl acetamide / 10 - 75 °C 5: ammonium hydroxide / 20 - 103 °C / Autoclave View Scheme |
methyl 3-amino-2-fluoro-benzoate
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: pyridine / dichloromethane / 15 - 25 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 3 °C 3.1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C 3.2: 2.5 h / 10 - 75 °C 4.1: ammonium hydroxide / water / 20 - 103 °C / sealed tube View Scheme | |
Multi-step reaction with 6 steps 1: pyridine / dichloromethane / 20 °C 2: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Cooling with ice 3: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C 4: N,N-dimethyl acetamide / 20 - 60 °C 5: N,N-dimethyl acetamide / 60 - 80 °C 6: ammonia / methanol / 24 h / 90 °C / Sealed tube View Scheme | |
Multi-step reaction with 4 steps 1.1: pyridine / dichloromethane / 15 - 25 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 3 °C 3.1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C 3.2: 2.5 h / 10 - 75 °C 4.1: ammonium hydroxide / 2 h / 98 - 103 °C / Sealed tube View Scheme |
3-(2,6-difluorobenzenesulfonamido)-2-fluorobenzoic acid methyl ester
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 3 °C 2.1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C 2.2: 2.5 h / 10 - 75 °C 3.1: ammonium hydroxide / water / 20 - 103 °C / sealed tube View Scheme | |
Multi-step reaction with 5 steps 1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Cooling with ice 2: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C 3: N,N-dimethyl acetamide / 20 - 60 °C 4: N,N-dimethyl acetamide / 60 - 80 °C 5: ammonia / methanol / 24 h / 90 °C / Sealed tube View Scheme | |
Multi-step reaction with 3 steps 1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 3 °C 2.1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C 2.2: 2.5 h / 10 - 75 °C 3.1: ammonium hydroxide / 2 h / 98 - 103 °C / Sealed tube View Scheme |
methyl 3-((tert-butoxycarbonyl)amino)-2-fluorobenzoate
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 2: pyridine / dichloromethane / 20 °C 3: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Cooling with ice 4: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C 5: N,N-dimethyl acetamide / 20 - 60 °C 6: N,N-dimethyl acetamide / 60 - 80 °C 7: ammonia / methanol / 24 h / 90 °C / Sealed tube View Scheme |
N-(3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C 2: N,N-dimethyl acetamide / 20 - 60 °C 3: N,N-dimethyl acetamide / 60 - 80 °C 4: ammonia / methanol / 24 h / 90 °C / Sealed tube View Scheme | |
Multi-step reaction with 2 steps 1.1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C 1.2: 2.5 h / 10 - 75 °C 2.1: ammonium hydroxide / 2 h / 98 - 103 °C / Sealed tube View Scheme | |
Multi-step reaction with 3 steps 1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C 2: ethyl acetate; N,N-dimethyl acetamide / 10 - 75 °C 3: ammonium hydroxide / 20 - 103 °C / Autoclave View Scheme |
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N,N-dimethyl acetamide / 20 - 60 °C 2: N,N-dimethyl acetamide / 60 - 80 °C 3: ammonia / methanol / 24 h / 90 °C / Sealed tube View Scheme | |
Multi-step reaction with 2 steps 1: ethyl acetate; N,N-dimethyl acetamide / 10 - 75 °C 2: ammonium hydroxide / 20 - 103 °C / Autoclave View Scheme |
2-fluoro-3-bromobenzoic acid methyl ester
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 90 °C / Sealed tube; Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 3: pyridine / dichloromethane / 20 °C 4: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Cooling with ice 5: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C 6: N,N-dimethyl acetamide / 20 - 60 °C 7: N,N-dimethyl acetamide / 60 - 80 °C 8: ammonia / methanol / 24 h / 90 °C / Sealed tube View Scheme | |
Multi-step reaction with 4 steps 1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C 2.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C 2.2: 2 h / 120 °C 3.1: ammonium hydroxide / 1,4-dioxane / 24 h / 90 °C / Sealed tube 4.1: (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N,N,N',N'-tetramethylguanidine / dimethyl sulfoxide / 40 h / 55 °C / Inert atmosphere; Glovebox; Irradiation View Scheme |
3-bromo-2-fluorobenzoic acid
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: sulfuric acid / 1 h / Reflux 2: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 90 °C / Sealed tube; Inert atmosphere 3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 4: pyridine / dichloromethane / 20 °C 5: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Cooling with ice 6: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C 7: N,N-dimethyl acetamide / 20 - 60 °C 8: N,N-dimethyl acetamide / 60 - 80 °C 9: ammonia / methanol / 24 h / 90 °C / Sealed tube View Scheme |
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl acetamide / 60 - 80 °C 2: ammonia / methanol / 24 h / 90 °C / Sealed tube View Scheme |
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C 1.2: 2 h / 120 °C 2.1: ammonium hydroxide / 1,4-dioxane / 24 h / 90 °C / Sealed tube 3.1: (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N,N,N',N'-tetramethylguanidine / dimethyl sulfoxide / 40 h / 55 °C / Inert atmosphere; Glovebox; Irradiation View Scheme |
2-chloro-4-methylpyrimidine
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C 2.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C 2.2: 2 h / 120 °C 3.1: ammonium hydroxide / 1,4-dioxane / 24 h / 90 °C / Sealed tube 4.1: (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N,N,N',N'-tetramethylguanidine / dimethyl sulfoxide / 40 h / 55 °C / Inert atmosphere; Glovebox; Irradiation View Scheme |
dabrafenib
Conditions | Yield |
---|---|
With hydrogenchloride In water for 8h; Reflux; Green chemistry; | 31.89 g |
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: triethylamine / 6 h / 43 °C / Green chemistry 2: sodium hydroxide / butan-1-ol / 100 °C / Green chemistry 3: aluminum (III) chloride / Green chemistry 4: sodium hydroxide / 0 - 5 °C / Green chemistry 5: hydrogenchloride / water / 8 h / Reflux; Green chemistry View Scheme |
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydroxide / butan-1-ol / 100 °C / Green chemistry 2: aluminum (III) chloride / Green chemistry 3: sodium hydroxide / 0 - 5 °C / Green chemistry 4: hydrogenchloride / water / 8 h / Reflux; Green chemistry View Scheme |
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aluminum (III) chloride / Green chemistry 2: sodium hydroxide / 0 - 5 °C / Green chemistry 3: hydrogenchloride / water / 8 h / Reflux; Green chemistry View Scheme |
methanesulfonic acid
dabrafenib
N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonic acid
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; for 3h; | 87% |
In water; acetonitrile at 20 - 60℃; Product distribution / selectivity; | 85.1% |
In water; acetonitrile at 20 - 60℃; Solvent; | 85.1% |
methanesulfonic acid
dabrafenib
Conditions | Yield |
---|---|
In water; acetonitrile at 50 - 60℃; Solvent; Temperature; Time; | 85.1% |
dabrafenib
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 0.6h; Solvent; UV-irradiation; | 37% |
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In dichloromethane at 40℃; |
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.5 h / 20 °C 2: N,N,N′,N′-tetramethyl-N″-tert-butylguanidine / tetrahydrofuran / 4 h / 65 °C View Scheme |
dabrafenib
4-[4-(3-amino-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.5 h / 20 °C 2: N,N,N′,N′-tetramethyl-N″-tert-butylguanidine / tetrahydrofuran / 4 h / 65 °C 3: hydroxylamine / tetrahydrofuran; water / 0.5 h / 20 °C View Scheme |
dabrafenib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.5 h / 20 °C 2: N,N,N′,N′-tetramethyl-N″-tert-butylguanidine / tetrahydrofuran / 4 h / 65 °C 3: hydroxylamine / tetrahydrofuran; water / 0.5 h / 20 °C 4: pyridine / tetrahydrofuran; water / 1 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
With Hexamethylphosphorous triamide In tetrahydrofuran at 20℃; for 0.5h; chemoselective reaction; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.5 h / 20 °C 2: N,N,N′,N′-tetramethyl-N″-tert-butylguanidine / tetrahydrofuran / 4 h / 65 °C View Scheme |
Conditions | Yield |
---|---|
In acetonitrile for 0.166667h; Milling; |
Conditions | Yield |
---|---|
In acetonitrile for 0.166667h; Milling; |
Conditions | Yield |
---|---|
In acetonitrile for 0.166667h; Milling; |
Conditions | Yield |
---|---|
In acetonitrile for 0.166667h; Milling; |
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