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Shanghai Hope Chem Co., Ltd

Our Advantages: Our products are manufactured in GMP factory Most products can provide DMF files for customer review Professional logistics team to provide fast and best services for customer Please contact with us freely for getting det

Dabrafenib

Cas:1195765-45-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide

Cas:1195765-45-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

DABRAFENIB

Cas:1195765-45-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White to slight colour silid Off white solid Purity by HPLC (% area)

High purity Various Specifications Dabrafenib CAS:1195765-45-7

Cas:1195765-45-7

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

GIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, GIHI CHEMICALS is your best choice. pls contact with us freely for getting detailed prod

Best price 1195765-45-7 Dabrafenib

Cas:1195765-45-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Dabrafenib Cas1195765-45-7 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to slight colour solid Storage:N/M Package:1kg/bag with foil bag;25kg/dru

Manufacturer supply Dabrafenib Cas1195765-45-7 with high purity

Cas:1195765-45-7

Min.Order:1 Kilogram

FOB Price: $15000.0 / 16000.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Dabrafenib 1195765-45-7 GMP Manufacturer

Cas:1195765-45-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Dabrafenib

Cas:1195765-45-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Dabrafenib The alias:dabrafenib mesylate CAS NO:1195765-45-7 Molecular formula:C24H24F3N5O5S3 Molecular weight:615.66800 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage

Dabrafenib/CAS:1195765-45-7/Raw material supply

Cas:1195765-45-7

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 1195765-45-7 with competitive price

Cas:1195765-45-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Dabrafenib Base CAS NO 1195765-45-7

Cas:1195765-45-7

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Qingdao Beluga Import and Export Co., LTD

Dabrafenib CAS:1195765-45-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Dabrafenib CAS:1195765-45-7

Cas:1195765-45-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

GSK2118436

Cas:1195765-45-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Dabrafenib

Cas:1195765-45-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

API name:dabrafenib Certificates: GMP, DMF CAS No.: 1195765-45-7 Chemical name: Dabrafenib;N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide;Dabrafenibfreebase(GSK2118436A);Dabraf

dabrafenib 1195765-45-7

Cas:1195765-45-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

high purity Dabrafenib Base

Cas:1195765-45-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Debrafenib 1195765-45-7

Cas:1195765-45-7

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Dabrafenib

Cas:1195765-45-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity Various Specifications Dabrafenib

Cas:1195765-45-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

GSK2118436Appearance:White or Almost White crystalline powder Storage:Store in refrigerator Package:according to customers' requirements Application:Steroids injection For Body building Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by s

GSK2118436

Cas:1195765-45-7

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum;200kg/drum as per your request Application:Used as Pharmaceutical Intermedia

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, in

Dabrafenib

Cas:1195765-45-7

Min.Order:1 Kilogram

FOB Price: $150.0 / 200.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Dabrafenib USP/EP/BP

Cas:1195765-45-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Synthetic route

N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1 ,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
1195768-23-0

N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1 ,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
With ammonium hydroxide In water at 20 - 103℃; Product distribution / selectivity; sealed tube;88%
With ammonium hydroxide at 98 - 103℃; for 2h; Sealed tube;88%
With ammonium hydroxide at 20 - 103℃; Reagent/catalyst; Autoclave;88%
2,6-difluorobenzene-1-sulfonamide
60230-37-7

2,6-difluorobenzene-1-sulfonamide

4-(4-(3-bromo-2-fluorophenyl)-2-(tert-butyl)thiazol-5-yl)pyrimidin-2-amine

4-(4-(3-bromo-2-fluorophenyl)-2-(tert-butyl)thiazol-5-yl)pyrimidin-2-amine

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N,N,N',N'-tetramethylguanidine In dimethyl sulfoxide at 55℃; for 40h; Inert atmosphere; Glovebox; Irradiation;57%
2,6-difluorobenzene-1-sulfonyl chloride
60230-36-6

2,6-difluorobenzene-1-sulfonyl chloride

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyridine / dichloromethane / 15 - 25 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 3 °C
3.1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C
3.2: 2.5 h / 10 - 75 °C
4.1: ammonium hydroxide / water / 20 - 103 °C / sealed tube
View Scheme
Multi-step reaction with 4 steps
1.1: pyridine / dichloromethane / 15 - 25 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 3 °C
3.1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C
3.2: 2.5 h / 10 - 75 °C
4.1: ammonium hydroxide / 2 h / 98 - 103 °C / Sealed tube
View Scheme
Multi-step reaction with 5 steps
1: pyridine / dichloromethane / 15 - 25 °C
2: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 3 °C
3: N-Bromosuccinimide / dichloromethane / 10 - 20 °C
4: ethyl acetate; N,N-dimethyl acetamide / 10 - 75 °C
5: ammonium hydroxide / 20 - 103 °C / Autoclave
View Scheme
methyl 3-amino-2-fluoro-benzoate
1195768-18-3

methyl 3-amino-2-fluoro-benzoate

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyridine / dichloromethane / 15 - 25 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 3 °C
3.1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C
3.2: 2.5 h / 10 - 75 °C
4.1: ammonium hydroxide / water / 20 - 103 °C / sealed tube
View Scheme
Multi-step reaction with 6 steps
1: pyridine / dichloromethane / 20 °C
2: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Cooling with ice
3: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C
4: N,N-dimethyl acetamide / 20 - 60 °C
5: N,N-dimethyl acetamide / 60 - 80 °C
6: ammonia / methanol / 24 h / 90 °C / Sealed tube
View Scheme
Multi-step reaction with 4 steps
1.1: pyridine / dichloromethane / 15 - 25 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 3 °C
3.1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C
3.2: 2.5 h / 10 - 75 °C
4.1: ammonium hydroxide / 2 h / 98 - 103 °C / Sealed tube
View Scheme
3-(2,6-difluorobenzenesulfonamido)-2-fluorobenzoic acid methyl ester
1195768-19-4

3-(2,6-difluorobenzenesulfonamido)-2-fluorobenzoic acid methyl ester

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 3 °C
2.1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C
2.2: 2.5 h / 10 - 75 °C
3.1: ammonium hydroxide / water / 20 - 103 °C / sealed tube
View Scheme
Multi-step reaction with 5 steps
1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Cooling with ice
2: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C
3: N,N-dimethyl acetamide / 20 - 60 °C
4: N,N-dimethyl acetamide / 60 - 80 °C
5: ammonia / methanol / 24 h / 90 °C / Sealed tube
View Scheme
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 3 °C
2.1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C
2.2: 2.5 h / 10 - 75 °C
3.1: ammonium hydroxide / 2 h / 98 - 103 °C / Sealed tube
View Scheme
methyl 3-((tert-butoxycarbonyl)amino)-2-fluorobenzoate
1042055-86-6

methyl 3-((tert-butoxycarbonyl)amino)-2-fluorobenzoate

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
2: pyridine / dichloromethane / 20 °C
3: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Cooling with ice
4: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C
5: N,N-dimethyl acetamide / 20 - 60 °C
6: N,N-dimethyl acetamide / 60 - 80 °C
7: ammonia / methanol / 24 h / 90 °C / Sealed tube
View Scheme
N-(3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
1195768-20-7

N-(3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C
2: N,N-dimethyl acetamide / 20 - 60 °C
3: N,N-dimethyl acetamide / 60 - 80 °C
4: ammonia / methanol / 24 h / 90 °C / Sealed tube
View Scheme
Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C
1.2: 2.5 h / 10 - 75 °C
2.1: ammonium hydroxide / 2 h / 98 - 103 °C / Sealed tube
View Scheme
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / dichloromethane / 10 - 20 °C
2: ethyl acetate; N,N-dimethyl acetamide / 10 - 75 °C
3: ammonium hydroxide / 20 - 103 °C / Autoclave
View Scheme
N-(3-(2-bromo-2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

N-(3-(2-bromo-2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N,N-dimethyl acetamide / 20 - 60 °C
2: N,N-dimethyl acetamide / 60 - 80 °C
3: ammonia / methanol / 24 h / 90 °C / Sealed tube
View Scheme
Multi-step reaction with 2 steps
1: ethyl acetate; N,N-dimethyl acetamide / 10 - 75 °C
2: ammonium hydroxide / 20 - 103 °C / Autoclave
View Scheme
2-fluoro-3-bromobenzoic acid methyl ester
206551-41-9

2-fluoro-3-bromobenzoic acid methyl ester

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 90 °C / Sealed tube; Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3: pyridine / dichloromethane / 20 °C
4: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Cooling with ice
5: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C
6: N,N-dimethyl acetamide / 20 - 60 °C
7: N,N-dimethyl acetamide / 60 - 80 °C
8: ammonia / methanol / 24 h / 90 °C / Sealed tube
View Scheme
Multi-step reaction with 4 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C
2.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C
2.2: 2 h / 120 °C
3.1: ammonium hydroxide / 1,4-dioxane / 24 h / 90 °C / Sealed tube
4.1: (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N,N,N',N'-tetramethylguanidine / dimethyl sulfoxide / 40 h / 55 °C / Inert atmosphere; Glovebox; Irradiation
View Scheme
3-bromo-2-fluorobenzoic acid
161957-56-8

3-bromo-2-fluorobenzoic acid

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: sulfuric acid / 1 h / Reflux
2: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 90 °C / Sealed tube; Inert atmosphere
3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
4: pyridine / dichloromethane / 20 °C
5: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Cooling with ice
6: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C
7: N,N-dimethyl acetamide / 20 - 60 °C
8: N,N-dimethyl acetamide / 60 - 80 °C
9: ammonia / methanol / 24 h / 90 °C / Sealed tube
View Scheme
C23H19BrClF3N4O2S2

C23H19BrClF3N4O2S2

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl acetamide / 60 - 80 °C
2: ammonia / methanol / 24 h / 90 °C / Sealed tube
View Scheme
1-(3-bromo-2-fluorophenyl)-2-(2-chloropyrimidin-4-yl)ethan-1-one

1-(3-bromo-2-fluorophenyl)-2-(2-chloropyrimidin-4-yl)ethan-1-one

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C
1.2: 2 h / 120 °C
2.1: ammonium hydroxide / 1,4-dioxane / 24 h / 90 °C / Sealed tube
3.1: (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N,N,N',N'-tetramethylguanidine / dimethyl sulfoxide / 40 h / 55 °C / Inert atmosphere; Glovebox; Irradiation
View Scheme
2-chloro-4-methylpyrimidine
13036-57-2

2-chloro-4-methylpyrimidine

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C
2.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C
2.2: 2 h / 120 °C
3.1: ammonium hydroxide / 1,4-dioxane / 24 h / 90 °C / Sealed tube
4.1: (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N,N,N',N'-tetramethylguanidine / dimethyl sulfoxide / 40 h / 55 °C / Inert atmosphere; Glovebox; Irradiation
View Scheme
C26H24F3N5O3S2

C26H24F3N5O3S2

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
With hydrogenchloride In water for 8h; Reflux; Green chemistry;31.89 g
C7H10ClNS

C7H10ClNS

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / 6 h / 43 °C / Green chemistry
2: sodium hydroxide / butan-1-ol / 100 °C / Green chemistry
3: aluminum (III) chloride / Green chemistry
4: sodium hydroxide / 0 - 5 °C / Green chemistry
5: hydrogenchloride / water / 8 h / Reflux; Green chemistry
View Scheme
C12H17ClN2OS

C12H17ClN2OS

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide / butan-1-ol / 100 °C / Green chemistry
2: aluminum (III) chloride / Green chemistry
3: sodium hydroxide / 0 - 5 °C / Green chemistry
4: hydrogenchloride / water / 8 h / Reflux; Green chemistry
View Scheme
C14H17ClN4OS

C14H17ClN4OS

dabrafenib
1195765-45-7

dabrafenib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aluminum (III) chloride / Green chemistry
2: sodium hydroxide / 0 - 5 °C / Green chemistry
3: hydrogenchloride / water / 8 h / Reflux; Green chemistry
View Scheme
methanesulfonic acid
75-75-2

methanesulfonic acid

dabrafenib
1195765-45-7

dabrafenib

N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonic acid
1195768-06-9

N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonic acid

Conditions
ConditionsYield
In isopropyl alcohol at 20℃; for 3h;87%
In water; acetonitrile at 20 - 60℃; Product distribution / selectivity;85.1%
In water; acetonitrile at 20 - 60℃; Solvent;85.1%
methanesulfonic acid
75-75-2

methanesulfonic acid

dabrafenib
1195765-45-7

dabrafenib

N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonate

N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonate

Conditions
ConditionsYield
In water; acetonitrile at 50 - 60℃; Solvent; Temperature; Time;85.1%
dabrafenib
1195765-45-7

dabrafenib

N-(5-amino-2-(tert-butyl)-11-fluorobenzo[f]thiazolo[4,5-h]-quinazolin-10-yl)-2,6-difluorobenzenesulfonamide

N-(5-amino-2-(tert-butyl)-11-fluorobenzo[f]thiazolo[4,5-h]-quinazolin-10-yl)-2,6-difluorobenzenesulfonamide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 0.6h; Solvent; UV-irradiation;37%
dabrafenib
1195765-45-7

dabrafenib

levulinic acid
123-76-2

levulinic acid

C28H26F3N5O4S2

C28H26F3N5O4S2

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 40℃;
dabrafenib
1195765-45-7

dabrafenib

C6H4F2O2S

C6H4F2O2S

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.5 h / 20 °C
2: N,N,N′,N′-tetramethyl-N″-tert-butylguanidine / tetrahydrofuran / 4 h / 65 °C
View Scheme
dabrafenib
1195765-45-7

dabrafenib

4-[4-(3-amino-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinamine
1195769-01-7

4-[4-(3-amino-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.5 h / 20 °C
2: N,N,N′,N′-tetramethyl-N″-tert-butylguanidine / tetrahydrofuran / 4 h / 65 °C
3: hydroxylamine / tetrahydrofuran; water / 0.5 h / 20 °C
View Scheme
dabrafenib
1195765-45-7

dabrafenib

N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)benzamide

N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.5 h / 20 °C
2: N,N,N′,N′-tetramethyl-N″-tert-butylguanidine / tetrahydrofuran / 4 h / 65 °C
3: hydroxylamine / tetrahydrofuran; water / 0.5 h / 20 °C
4: pyridine / tetrahydrofuran; water / 1 h / 20 °C
View Scheme
phenylglyoxylic acid ethyl ester
1603-79-8

phenylglyoxylic acid ethyl ester

dabrafenib
1195765-45-7

dabrafenib

C33H30F3N5O4S2

C33H30F3N5O4S2

Conditions
ConditionsYield
With Hexamethylphosphorous triamide In tetrahydrofuran at 20℃; for 0.5h; chemoselective reaction;
phenylglyoxylic acid ethyl ester
1603-79-8

phenylglyoxylic acid ethyl ester

dabrafenib
1195765-45-7

dabrafenib

C27H26FN5O2S

C27H26FN5O2S

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.5 h / 20 °C
2: N,N,N′,N′-tetramethyl-N″-tert-butylguanidine / tetrahydrofuran / 4 h / 65 °C
View Scheme
dabrafenib
1195765-45-7

dabrafenib

saccharin
81-07-2

saccharin

C23H20F3N5O2S2*C7H5NO3S

C23H20F3N5O2S2*C7H5NO3S

Conditions
ConditionsYield
In acetonitrile for 0.166667h; Milling;
dabrafenib
1195765-45-7

dabrafenib

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

C23H20F3N5O2S2*0.5C4H4O4

C23H20F3N5O2S2*0.5C4H4O4

Conditions
ConditionsYield
In acetonitrile for 0.166667h; Milling;
succinic acid
110-15-6

succinic acid

dabrafenib
1195765-45-7

dabrafenib

C23H20F3N5O2S2*0.5C4H6O4

C23H20F3N5O2S2*0.5C4H6O4

Conditions
ConditionsYield
In acetonitrile for 0.166667h; Milling;
Adipic acid
124-04-9

Adipic acid

dabrafenib
1195765-45-7

dabrafenib

C23H20F3N5O2S2*0.5C6H10O4

C23H20F3N5O2S2*0.5C6H10O4

Conditions
ConditionsYield
In acetonitrile for 0.166667h; Milling;

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