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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Isosorbide-2-Acetate supplier in China

Cas:13042-39-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

1,4:3,6-Dianhydro-D-glucitol 2-acetate

Cas:13042-39-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Competitve Price in stockCAS 13042-39-2 with fast shipping

Cas:13042-39-2

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: Isosorbide-2-acetate Synonyms: 2-O-acetyl-1,4:3,6-dianhydrohexitol CAS: 13042-39-2 MF: C8H12O5 Appearance: White powder Storage:Store in cool and dry place, away from sun light. Package:25KG/Drum Application:Pharmaceutical Intermediates Tra

Isosorbide-2-acetate

Cas:13042-39-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,4:3,6-Dianhydro-D-glucitol 2-acetate 13042-39-2

Cas:13042-39-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

1,4:3,6-Dianhydro-D-glucitol 2-acetate CAS:13042-39-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high q

1,4:3,6-Dianhydro-D-glucitol 2-acetate CAS:13042-39-2

Cas:13042-39-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,4:3,6-Dianhydro-D-glucitol 2-acetate

Cas:13042-39-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1,4:3,6-Dianhydro-D-glucitol 2-acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1,4:3,6-Dianhydro-D-glucitol 2-acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Isosorbide-2-Acetate

Cas:13042-39-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply Isosorbide-2-acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company

TIANFU-CHEM - 1,4:3,6-Dianhydro-D-glucitol 2-acetate

Cas:13042-39-2

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

1,4:3,6-Dianhydro-D-glucitol 2-acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Isosorbide-2-acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Isosorbide-2-acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Other

inquiry

Lonwin Chemical Group Limited

Shanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is

Best price Isosorbide-2-Acetate 13042-39-2

Cas:13042-39-2

Min.Order:100 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Isosorbide 2-acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

1,4:3,6-Dianhydro-D-glucitol 2-acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

1,4:3,6-Dianhydro-D-glucitol 2-acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Isosorbide-2-Acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

1,4:3,6-Dianhydro-D-glucitol 2-acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

1,4:3,6-Dianhydro-D-glucitol 2-acetateAppearance:white to brown low melting crystalline solid Storage:2-8, cold storage, to avoid light storage. Package:1g;5g;10g;25g;50g;100g;500g;1KG;5KG,25kg,50kg or as customers request Application:13042-39-2 Tran

1,4:3,6-Dianhydro-D-glucitol 2-acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

Isosorbide-2-acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

1,4:3,6-Dianhydro-D-glucitol 2-acetate CAS No.13042-39-2

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white to light yellow crystal powder Storage:Room temperature with sealed well Package:according to the clients requirement Appl

Isosorbide-2-acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

1,4:3,6-Dianhydro-D-glucitol 2-acetate cas 13042-39-2Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

1,4:3,6-Dianhydro-D-glucitol 2-acetate cas 13042-39-2

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

Isosorbide-2-acetate 13042-39-2

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shenzhen Foris Technology Co. LTD

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

Isosorbide-2-acetate 13042-39-2

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1,4:3,6-Dianhydro-D-glucitol 2-acetate

Cas:13042-39-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

2-(2-methylcyclohexylidene)propanedinitrile

Cas:13042-39-2

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate
13042-38-1

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

Conditions
ConditionsYield
In acetone for 288h; Ambient temperature; lipase from Pseudomonas sp. (SAM II);91%
With Novozym 435; sodium hydrogencarbonate In aq. phosphate buffer at 50℃; for 12h; pH=6; Catalytic behavior; Reagent/catalyst; Temperature; Large scale; Enzymatic reaction; regioselective reaction;91.3%
With sodium hydroxide; lipase In tetrahydrofuran89%
n-heptan1ol
111-70-6

n-heptan1ol

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate
13042-38-1

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

Conditions
ConditionsYield
In acetone91%
acetic anhydride
108-24-7

acetic anhydride

Isosorbide
652-67-5

Isosorbide

A

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

B

(6S,3R,3aR,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl acetate
65940-93-4

(6S,3R,3aR,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl acetate

C

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate
13042-38-1

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate

Conditions
ConditionsYield
at 120 - 140℃; for 1h; Yields of byproduct given;A 90%
B n/a
C n/a
With pyridine at 20℃; for 24h; Product distribution; other acylating agents;
isosorbide 2-acetate-5-mononitrate
39813-48-4

isosorbide 2-acetate-5-mononitrate

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethyl acetate for 24h;90%
acetyl chloride
75-36-5

acetyl chloride

Isosorbide
652-67-5

Isosorbide

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

Conditions
ConditionsYield
Stage #1: Isosorbide With methylmagnesium chloride In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: acetyl chloride In tetrahydrofuran at 0℃; for 2h; Reagent/catalyst; Temperature;
78%
acetic anhydride
108-24-7

acetic anhydride

Isosorbide
652-67-5

Isosorbide

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

Conditions
ConditionsYield
at 120 - 140℃; for 1h;70%
With potassium hydroxide 1.) 120-140 deg C, 1 h, 2.) reflux; Yield given. Multistep reaction;
acetic acid
64-19-7

acetic acid

Isosorbide
652-67-5

Isosorbide

A

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

B

(6S,3R,3aR,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl acetate
65940-93-4

(6S,3R,3aR,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl acetate

C

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate
13042-38-1

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate

Conditions
ConditionsYield
Stage #1: acetic acid; Isosorbide In dichloromethane at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 3h; Inert atmosphere;
A 64%
B n/a
C n/a
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h;A 60%
B n/a
C n/a
hydrogenchloride In 1,4-dioxane at 20 - 160℃; for 0.366667h; Microwave irradiation;
D-sorbitol
50-70-4

D-sorbitol

acetic acid
64-19-7

acetic acid

A

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

B

(6S,3R,3aR,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl acetate
65940-93-4

(6S,3R,3aR,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl acetate

C

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate
13042-38-1

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate

Conditions
ConditionsYield
With phosphotungstic acid In toluene at 170℃; for 6h; Temperature; Solvent; Reagent/catalyst; Inert atmosphere; Sealed tube; Overall yield = 83 percent;A 13%
B 9%
C 61%
acetic anhydride
108-24-7

acetic anhydride

Isosorbide
652-67-5

Isosorbide

A

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

B

(6S,3R,3aR,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl acetate
65940-93-4

(6S,3R,3aR,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl acetate

Conditions
ConditionsYield
at 120℃; for 1h;A 13.5%
B 22.5%
With scandium tris(trifluoromethanesulfonate) at 20℃; for 0.166667h; Reagent/catalyst; Overall yield = 54%;A n/a
B n/a
D-sorbitol
50-70-4

D-sorbitol

ethyl acetate
141-78-6

ethyl acetate

A

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

B

Isosorbide
652-67-5

Isosorbide

Conditions
ConditionsYield
With calcium sulfate In 1,4-dioxane at 78 - 84℃; for 120h; Heating;A 21%
B n/a
acetic acid
64-19-7

acetic acid

Isosorbide
652-67-5

Isosorbide

A

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

B

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate
13042-38-1

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 2.5h; Ambient temperature;A 68 % Chromat.
B 12 % Chromat.
vinyl acetate
108-05-4

vinyl acetate

Isosorbide
652-67-5

Isosorbide

A

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

B

(6S,3R,3aR,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl acetate
65940-93-4

(6S,3R,3aR,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl acetate

Conditions
ConditionsYield
With Candida antarctica B In chloroform for 120h; Product distribution; Further Variations:; Reagents; Acetylation;
potassium hydrogensulfate
7646-93-7

potassium hydrogensulfate

Isosorbide
652-67-5

Isosorbide

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

Conditions
ConditionsYield
In diethyl ether; diethylene glycol dimethyl ether; water; acetic acid; toluene
Isosorbide
652-67-5

Isosorbide

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

Conditions
ConditionsYield
With sodium acetate; acetic anhydride
Multi-step reaction with 2 steps
1: Amberlite® IR-120 / 2 h / 80 °C
2: methylmagnesium chloride / tetrahydrofuran / 8 h / Reflux
View Scheme
D-sorbitol
50-70-4

D-sorbitol

acetic acid
64-19-7

acetic acid

A

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

B

(6S,3R,3aR,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl acetate
65940-93-4

(6S,3R,3aR,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl acetate

C

Isosorbide
652-67-5

Isosorbide

D

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate
13042-38-1

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate

Conditions
ConditionsYield
Amberlyst 35 resin at 85℃;
acetic acid
64-19-7

acetic acid

Isosorbide
652-67-5

Isosorbide

A

D-sorbitol
50-70-4

D-sorbitol

B

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

C

(6S,3R,3aR,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl acetate
65940-93-4

(6S,3R,3aR,6aR)-6-hydroxy-hexahydrofuro[3,2-b]furan-3-yl acetate

D

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate
13042-38-1

[(3S,3aR,6R,6aR)-6-acetoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] acetate

Conditions
ConditionsYield
Amberlyst 35 resin at 85℃;
acetic acid
64-19-7

acetic acid

Isosorbide
652-67-5

Isosorbide

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

Conditions
ConditionsYield
Stage #1: acetic acid; Isosorbide With toluene-4-sulfonic acid In toluene Heating;
Stage #2: With potassium hydroxide under 0.1 Torr;
Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; dmap / dichloromethane / 3 h
2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 24 h
View Scheme
D-sorbitol
50-70-4

D-sorbitol

acetic anhydride
108-24-7

acetic anhydride

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

Conditions
ConditionsYield
With phosphotungstic acid; acetic acid at 150℃; for 12h; Reagent/catalyst; Temperature; Inert atmosphere; Sealed tube;
isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

(1R,4S,5R,8R)-4-acetoxy-8-benzenesulfonyloxy-2,6-dioxabicyclo<3.3.0>octane

(1R,4S,5R,8R)-4-acetoxy-8-benzenesulfonyloxy-2,6-dioxabicyclo<3.3.0>octane

Conditions
ConditionsYield
With pyridine at 0℃;96%
isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

2(5)-O-acetyl-5(2)-chloro-5(2)-deoxy-1,4:3,6-dianhydro-L-iditol
73952-86-0

2(5)-O-acetyl-5(2)-chloro-5(2)-deoxy-1,4:3,6-dianhydro-L-iditol

Conditions
ConditionsYield
With pyridine; thionyl chloride at 0 - 100℃;96%
Multi-step reaction with 2 steps
1: 83 percent
2: 73 percent / pyridine hydrochloride / pyridine / 48 h / Heating
View Scheme
isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

3-(bromomethyl)-2-oxido-4-phenyl-1,2,5-oxadiazole
169614-78-2

3-(bromomethyl)-2-oxido-4-phenyl-1,2,5-oxadiazole

(2-O-acetyl-1,4:3,6-dianhydro-5-O-[(2-oxido-4-phenyl-1,2,5-oxadiazol-3-yl)methyl]-D-glucitol)

(2-O-acetyl-1,4:3,6-dianhydro-5-O-[(2-oxido-4-phenyl-1,2,5-oxadiazol-3-yl)methyl]-D-glucitol)

Conditions
ConditionsYield
With silver(l) oxide In dichloromethane for 72h; Reflux; Darkness;96%
isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

allyl bromide
106-95-6

allyl bromide

2-O-acetyl-5-O-allyl-1,4:3,6-dianhydro-D-glucitol
162306-05-0

2-O-acetyl-5-O-allyl-1,4:3,6-dianhydro-D-glucitol

Conditions
ConditionsYield
With calcium sulfate; silver(l) oxide for 48h; Ambient temperature;93%
With calcium sulfate; silver(l) oxide at 20℃; for 48h;
isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

methyl iodide
74-88-4

methyl iodide

2-O-acetyl-1,4:3,6-dianhydro-5-O-methyl-D-glucitol
162306-07-2

2-O-acetyl-1,4:3,6-dianhydro-5-O-methyl-D-glucitol

Conditions
ConditionsYield
With calcium sulfate; silver(l) oxide for 48h; Ambient temperature;92%
With calcium sulfate; silver(l) oxide at 20℃; for 48h;92%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

(3S,6R)-6-(((trifluoromethyl)sulfonyl)oxy)hexahydrofuro[3,2-b]furan-3-yl acetate

(3S,6R)-6-(((trifluoromethyl)sulfonyl)oxy)hexahydrofuro[3,2-b]furan-3-yl acetate

Conditions
ConditionsYield
With pyridine In dichloromethane at -10 - 0℃; for 4h; Inert atmosphere;90.1%
isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

(3S,3aR,6R,6aS)-6-{[(4-methylphenyl)sulfonyl]oxy}hexahydrofuro[3,2-b]furan-3-yl acetate
111443-17-5

(3S,3aR,6R,6aS)-6-{[(4-methylphenyl)sulfonyl]oxy}hexahydrofuro[3,2-b]furan-3-yl acetate

Conditions
ConditionsYield
With pyridine at 20℃; for 8h;86%
isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

isosorbide 2-acetate-5-mononitrate
39813-48-4

isosorbide 2-acetate-5-mononitrate

Conditions
ConditionsYield
With nitric acid; acetic anhydride In dichloromethane; water85%
With nitric acid; acetic anhydride at 0℃;
With nitric acid; acetic acid
With nitric acid; acetic anhydride at 20℃; for 2h; Temperature; Inert atmosphere; Sealed tube;28 %Chromat.
benzyl bromide
100-39-0

benzyl bromide

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

2-O-acetyl-1,4:3,6-dianhydro-5-O-benzyl-D-glucitol
162426-81-5

2-O-acetyl-1,4:3,6-dianhydro-5-O-benzyl-D-glucitol

Conditions
ConditionsYield
With calcium sulfate; silver(l) oxide for 48h; Ambient temperature;85%
With sodium hydride In tetrahydrofuran at 25 - 60℃; for 5h;
(3-(bromomethyl)-4-(4-nitrophenyl)-2-oxido-1,2,5-oxadiazole)

(3-(bromomethyl)-4-(4-nitrophenyl)-2-oxido-1,2,5-oxadiazole)

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

(1,4:3,6-dianhydro-5-O-[4-(4-nitrophenyl)-2-oxido-1,2,5-oxadiazol-3-yl]methyl-D-glucitol)

(1,4:3,6-dianhydro-5-O-[4-(4-nitrophenyl)-2-oxido-1,2,5-oxadiazol-3-yl]methyl-D-glucitol)

Conditions
ConditionsYield
With silver(l) oxide In dichloromethane for 72h; Reflux; Darkness;85%
isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

2-O-acetyl-1,4:3,6-dianhydro-5-O-(methylsulfonyl)-D-glucitol
73938-79-1, 73952-87-1, 134237-15-3

2-O-acetyl-1,4:3,6-dianhydro-5-O-(methylsulfonyl)-D-glucitol

Conditions
ConditionsYield
83%
1-iodo-butane
542-69-8

1-iodo-butane

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

2-O-acetyl-1,4:3,6-dianhydro-5-O-butyl-D-glucitol
162306-06-1

2-O-acetyl-1,4:3,6-dianhydro-5-O-butyl-D-glucitol

Conditions
ConditionsYield
With calcium sulfate; silver(l) oxide In tetrahydrofuran Heating;80%
isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

1,4-3,6-dianhydro-5-keto-D-glucitol-2-acetate

1,4-3,6-dianhydro-5-keto-D-glucitol-2-acetate

Conditions
ConditionsYield
With dipyridinium dichromate; acetic anhydride In dichloromethane at 50℃; for 4h;64%
pyridine-3-carbonyl chloride hydrochloride
20260-53-1

pyridine-3-carbonyl chloride hydrochloride

isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

isosorbide 2-acetate-5-nicotinate

isosorbide 2-acetate-5-nicotinate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane for 24h;64%
isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
572-09-8

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

2-O-acetyl-5-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)isosorbide

2-O-acetyl-5-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)isosorbide

Conditions
ConditionsYield
With silver(l) oxide In dichloromethane at 20℃; for 36h;53%
isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

1-bromo-2,3,4-tri-O-acetyl-α-D-xylopyranose
3068-31-3

1-bromo-2,3,4-tri-O-acetyl-α-D-xylopyranose

2-O-acetyl-5-O-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)isosorbide

2-O-acetyl-5-O-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)isosorbide

Conditions
ConditionsYield
With silver(l) oxide In dichloromethane at 20℃; for 36h;48%
isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside
3068-32-4

1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside

2-O-acetyl-5-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)isosorbide

2-O-acetyl-5-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)isosorbide

Conditions
ConditionsYield
With silver(l) oxide In dichloromethane at 20℃;34%
isosorbide 2-acetate
13042-39-2

isosorbide 2-acetate

(3S,3aR,6R,6aR)-3-(allyloxy)-6-methoxy-hexahydrofuro[3,2-b]furan
936828-56-7

(3S,3aR,6R,6aR)-3-(allyloxy)-6-methoxy-hexahydrofuro[3,2-b]furan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / Ag2O; CaSO4 / 48 h / 20 °C
2: 86 percent / KOH / ethanol / 0.5 h / 50 °C
3: 98 percent / Ag2O; CaSO4 / 48 h / 20 °C
View Scheme

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