As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceutical intermed
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inquiryhigh quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/698.html Product Name (2-Butyl-5-
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryName: 2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran Synonyms: 2-N-Butyl-3-(4-Hydroxybenzoyl)-5-Nitrobenzofuran CAS:141645-16-1 MF: C19H17NO5 Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
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inquiry(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone CAS:141645-16-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, sp
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryProduct Name: (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone Synonyms: (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone;2-Butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran;2-butyl-3-[(4-Methoxyphenyl)carbonyl]-6-nitro-1-benzofur
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryProName:Manufacturer high quality (2-Butyl-5-n... CasNo:141645-16-1 Molecular Formula:C19H17NO5 Appearance:White crystalline powder Application:pharmaceutical intermediate DeliveryTime:Within 7 days after payment received PackAge:1kg/foil bag
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
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inquiry2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuranAppearance:White powder Storage:In Shade Package:according to customers' requirements Application:chemical research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect
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inquiry(2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Stage #1: (2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone With aluminum (III) chloride In chlorobenzene at 85℃; for 4h; Stage #2: With water In chlorobenzene at 35 - 60℃; | 92% |
Stage #1: (2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone With aluminum (III) chloride In chlorobenzene at 75℃; for 2h; Stage #2: With water In chlorobenzene at 5 - 65℃; for 0.5h; | 92% |
In aluminium chloride; ice-water; 1,1-dichloroethane | 90.1% |
4-hydroxybenzoyl chloride
2-(n-butyl)-5-nitrobenzofuran
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
With tin(IV) chloride In dichloromethane at 0 - 20℃; for 2.5h; Friedel-Crafts Acylation; | 88% |
1-(4-hydroxy-phenyl)-heptane-1,3-dione 3-[O-(4-nitro-phenyl)-oxime]
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
With formic acid; trifluoroacetic acid at 45℃; for 5h; Product distribution / selectivity; Inert atmosphere; | 87% |
With formic acid; trifluoroacetic acid at 45℃; for 5h; Product distribution / selectivity; Inert atmosphere; | 87% |
With formic acid; trifluoroacetic acid at 45℃; for 5h; Product distribution / selectivity; Inert atmosphere; | 87% |
With acetic acid at 115℃; for 3h; Product distribution / selectivity; Industry scale; | 78% |
4-hydroxy-benzoic acid
2-(n-butyl)-5-nitrobenzofuran
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Stage #1: 4-hydroxy-benzoic acid; 2-(n-butyl)-5-nitrobenzofuran With Methyltrichlorosilane; iron(III) chloride In chlorobenzene at 20 - 40℃; for 3.45 - 5h; Stage #2: With ethanol In chlorobenzene at 0 - 30℃; for 0.45 - 0.5h; Product distribution / selectivity; | 81.6% |
Stage #1: 4-hydroxy-benzoic acid; 2-(n-butyl)-5-nitrobenzofuran With dimethylsilicon dichloride; iron(II) chloride In chlorobenzene at 23 - 50℃; for 5h; Stage #2: With ethanol In chlorobenzene at 20℃; Product distribution / selectivity; | 76% |
Stage #1: 4-hydroxy-benzoic acid; 2-(n-butyl)-5-nitrobenzofuran With tetrachlorosilane; iron(III) chloride In chlorobenzene at 23 - 50℃; for 5h; Stage #2: With ethanol In chlorobenzene at 20℃; Product distribution / selectivity; | 75% |
Stage #1: 4-hydroxy-benzoic acid; 2-(n-butyl)-5-nitrobenzofuran With Methyltrichlorosilane; bismuth(lll) trifluoromethanesulfonate In chlorobenzene at 23 - 60℃; for 15h; Stage #2: With ethanol In chlorobenzene at 20℃; Product distribution / selectivity; | 10% |
With trichlorophosphate; zinc(II) chloride at 23 - 60℃; for 15h; Product distribution / selectivity; | 1% |
1-(4-hydroxy-phenyl)-heptane-1,3-dione
p-nitrophenoxyamine
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
With acetic acid at 70 - 100℃; for 25h; Product distribution / selectivity; | 80% |
In acetic acid at 70 - 100℃; for 25h; Product distribution / selectivity; | 80% |
With acetic acid at 70 - 100℃; for 17h; Product distribution / selectivity; | 80% |
With hydrogen bromide; acetic acid at 20℃; for 1h; |
1-(4-hydroxyphenyl)heptane-1,3-dione-3-[O-(4-nitrophenyl)oxime]
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
With acetic acid at 115℃; for 3h; Product distribution / selectivity; | 78% |
4-acetoxyiodobenzene
carbon monoxide
2-(hex-1-yn-1-yl)-4-nitrophenyl acetate
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate at 55℃; for 24h; Sealed tube; | 76% |
2-(2-pentanoyloxy-5-nitrophenyl)-1-(4-methoxyphenyl)-ethanone
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Stage #1: 2-(2-pentanoyloxy-5-nitrophenyl)-1-(4-methoxyphenyl)-ethanone With tributyl-amine In xylene for 8h; Molecular sieve; Reflux; Stage #2: With hydrogenchloride; tributyl-amine at 200℃; for 4h; Stage #3: With water In tert-butyl methyl ether at 20℃; | 65% |
1-(4-benzyloxyphenyl)-heptane-1,3-dione
p-nitrophenoxyamine
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
With hydrogen bromide; acetic acid at 20℃; for 6h; Product distribution / selectivity; | 59% |
(2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone
2-n-butyl-5-nitro-3-(2'-methoxy)-acetophenonebenzofuran
A
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
B
2-(n-butyl)-3-(2-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Stage #1: (2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone; 2-n-butyl-5-nitro-3-(2'-methoxy)-acetophenonebenzofuran; aluminum (III) chloride In chlorobenzene at 60℃; for 7h; Stage #2: With water In chlorobenzene at 60℃; |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium tert-butylate / Isobutyronitrile / 2 h / 0 - 95 °C 2: water / hydrogenchloride / Isobutyronitrile / 0.25 h / 0 °C 3: dichloromethane / 16 h / 20 °C 4: trifluoroacetic acid; formic acid / 5 h / 45 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydride / 1,4-dioxane; mineral oil / 3 h / 70 °C / Inert atmosphere 1.2: 0.5 h / 60 °C 2.1: dichloromethane / 16 h / 20 °C 3.1: trifluoroacetic acid; formic acid / 5 h / 45 °C / Inert atmosphere View Scheme |
4-Hydroxyacetophenone
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sulfuric acid / tetrahydrofuran / 1.75 h / 0 °C 2: potassium tert-butylate / Isobutyronitrile / 2 h / 0 - 95 °C 3: water / hydrogenchloride / Isobutyronitrile / 0.25 h / 0 °C 4: dichloromethane / 16 h / 20 °C 5: trifluoroacetic acid; formic acid / 5 h / 45 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: sulfuric acid / tetrahydrofuran / 1.75 h / 0 °C 2.1: sodium hydride / 1,4-dioxane; mineral oil / 3 h / 70 °C / Inert atmosphere 2.2: 0.5 h / 60 °C 3.1: dichloromethane / 16 h / 20 °C 4.1: trifluoroacetic acid; formic acid / 5 h / 45 °C / Inert atmosphere View Scheme |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: water / hydrogenchloride / Isobutyronitrile / 0.25 h / 0 °C 2: dichloromethane / 16 h / 20 °C 3: trifluoroacetic acid; formic acid / 5 h / 45 °C / Inert atmosphere View Scheme |
1-(4-hydroxy-phenyl)-heptane-1,3-dione
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dichloromethane / 16 h / 20 °C 2: trifluoroacetic acid; formic acid / 5 h / 45 °C / Inert atmosphere View Scheme |
4-methoxy-benzoyl chloride
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride / dichloromethane / 4 h / 25 °C 2.1: aluminum (III) chloride / chlorobenzene / 4 h / 85 °C 2.2: 35 - 60 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride / chlorobenzene / 2 h / 25 °C / Reflux 2.1: aluminum (III) chloride / chlorobenzene / 2 h / 75 °C 2.2: 0.5 h / 5 - 65 °C View Scheme | |
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane 2: aluminum (III) chloride / chlorobenzene View Scheme | |
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride / dichloromethane / 22 h / 25 - 30 °C / Large scale 2.1: aluminum (III) chloride / 40 h / Reflux; Large scale 2.2: 15 °C / Large scale View Scheme |
2-(n-butyl)-5-nitrobenzofuran
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride / dichloromethane / 4 h / 25 °C 2.1: aluminum (III) chloride / chlorobenzene / 4 h / 85 °C 2.2: 35 - 60 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride / chlorobenzene / 2 h / 25 °C / Reflux 2.1: aluminum (III) chloride / chlorobenzene / 2 h / 75 °C 2.2: 0.5 h / 5 - 65 °C View Scheme | |
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane 2: aluminum (III) chloride / chlorobenzene View Scheme | |
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride / dichloromethane / 22 h / 25 - 30 °C / Large scale 2.1: aluminum (III) chloride / 40 h / Reflux; Large scale 2.2: 15 °C / Large scale View Scheme | |
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere 2: aluminum (III) chloride / chlorobenzene / 2 h / 80 °C / Inert atmosphere View Scheme |
4-nitro-phenol
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: triethylamine / dichloromethane / 1 h / 0 - 5 °C / Inert atmosphere 2: aluminum (III) chloride / nitrobenzene / 5 h / 140 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 2 h / 25 - 30 °C 4: bromine / dichloromethane / 1 h / 25 - 30 °C 5: aluminum (III) chloride / dichloromethane / 15 - 20 °C 6: triethylamine / dichloromethane / 2 h / 25 - 30 °C 7: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 8: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 9: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C 10: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme | |
Multi-step reaction with 5 steps 1: hydrogenchloride / water / 38 h / 40 - 55 °C / Large scale 2: 1,2-dichloro-ethane / 65 - 75 °C / Large scale 3: sodium hydrogencarbonate / 1,2-dichloro-ethane / 55 - 60 °C / Large scale 4: aluminum (III) chloride / 1,2-dichloro-ethane / 35 - 40 °C / Large scale 5: aluminum (III) chloride / chlorobenzene / 65 - 70 °C / Large scale View Scheme |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 2: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 3: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C 4: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 2: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C 3: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme |
p-nitrophenyl hexanoate
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: aluminum (III) chloride / nitrobenzene / 5 h / 140 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 2 h / 25 - 30 °C 3: bromine / dichloromethane / 1 h / 25 - 30 °C 4: aluminum (III) chloride / dichloromethane / 15 - 20 °C 5: triethylamine / dichloromethane / 2 h / 25 - 30 °C 6: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 7: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 8: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C 9: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme |
1-(2-hydroxy-5-nitrophenyl)hexan-1-one
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 2 h / 25 - 30 °C 2: bromine / dichloromethane / 1 h / 25 - 30 °C 3: aluminum (III) chloride / dichloromethane / 15 - 20 °C 4: triethylamine / dichloromethane / 2 h / 25 - 30 °C 5: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 6: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 7: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C 8: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme |
1-(2-methoxy-5-nitrophenyl)hexan-1-one
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: bromine / dichloromethane / 1 h / 25 - 30 °C 2: aluminum (III) chloride / dichloromethane / 15 - 20 °C 3: triethylamine / dichloromethane / 2 h / 25 - 30 °C 4: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 5: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 6: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C 7: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme |
2-bromo-1-(2-methoxy-5-nitrophenyl)hexan-1-one
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: aluminum (III) chloride / dichloromethane / 15 - 20 °C 2: triethylamine / dichloromethane / 2 h / 25 - 30 °C 3: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 4: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 5: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C 6: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme |
2-bromo-1-(2-hydroxy-5-nitrophenyl)hexan-1-one
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 2 h / 25 - 30 °C 2: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 3: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 4: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C 5: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme |
Hexanoyl chloride
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: triethylamine / dichloromethane / 1 h / 0 - 5 °C / Inert atmosphere 2: aluminum (III) chloride / nitrobenzene / 5 h / 140 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 2 h / 25 - 30 °C 4: bromine / dichloromethane / 1 h / 25 - 30 °C 5: aluminum (III) chloride / dichloromethane / 15 - 20 °C 6: triethylamine / dichloromethane / 2 h / 25 - 30 °C 7: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C 8: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C 9: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C 10: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C View Scheme |
2-iodo-4-nitrophenyl acetate
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / tetrahydrofuran / 5.5 h / 20 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 24 h / 55 °C / Sealed tube View Scheme |
2-iodo-4-nitrophenol
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / tetrahydrofuran; dichloromethane / 4 h / 0 - 20 °C 2: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / tetrahydrofuran / 5.5 h / 20 °C / Inert atmosphere 3: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 24 h / 55 °C / Sealed tube View Scheme |
4-Iodophenol
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dmap; triethylamine / dichloromethane / 1.5 h / 20 °C 2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 24 h / 55 °C / Sealed tube View Scheme |
Koshlands reagent I
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triphenylphosphine / dichloromethane / 1 h / Reflux 1.2: 3 h / Reflux 2.1: tin(IV) chloride / dichloromethane / 2.5 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: triphenylphosphine / dichloromethane / 1 h / 40 °C / Inert atmosphere 1.2: 3 h / 110 °C / Inert atmosphere 2.1: aluminum (III) chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere 3.1: aluminum (III) chloride / chlorobenzene / 2 h / 80 °C / Inert atmosphere View Scheme |
n-valeryl chloride
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triphenylphosphine / dichloromethane / 1 h / Reflux 1.2: 3 h / Reflux 2.1: tin(IV) chloride / dichloromethane / 2.5 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: triphenylphosphine / dichloromethane / 1 h / 40 °C / Inert atmosphere 1.2: 3 h / 110 °C / Inert atmosphere 2.1: aluminum (III) chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere 3.1: aluminum (III) chloride / chlorobenzene / 2 h / 80 °C / Inert atmosphere View Scheme |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
methanesulfonyl chloride
4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyl-methanesulfonate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 12.5h; Reflux; | 100% |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
1,2-Epoxy-3-bromopropane
Conditions | Yield |
---|---|
With sodium hydroxide In isopropyl alcohol for 1.5h; Reflux; | 100% |
Stage #1: 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran With sodium hydroxide In isopropyl alcohol at 20℃; for 0.166667h; Stage #2: 1,2-Epoxy-3-bromopropane In isopropyl alcohol for 1.5h; Reflux; |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
dibutyl-(3-chloro-propyl)-amine
(2-butyl-5-nitrobenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone
Conditions | Yield |
---|---|
Stage #1: 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran With potassium carbonate In toluene at 25 - 110℃; for 0.5h; Large scale; Stage #2: dibutyl-(3-chloro-propyl)-amine In toluene Temperature; Solvent; Reflux; Large scale; | 99.5% |
Stage #1: 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran With potassium carbonate In acetonitrile for 0.5h; Stage #2: dibutyl-(3-chloro-propyl)-amine In acetonitrile Reflux; | 91% |
Stage #1: 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran With potassium carbonate In acetonitrile for 0.5h; Reflux; Stage #2: dibutyl-(3-chloro-propyl)-amine In acetonitrile Reflux; | 91% |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
1,3-chlorobromopropane
(4-(3-chloropropoxy)phenyl)(2-butyl-5-nitrobenzofuran-3-yl)methanone
Conditions | Yield |
---|---|
With potassium carbonate In butanone at 81 - 82℃; for 4h; | 99.1% |
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 20h; | 88.8% |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
3-chloro-1,1-diethoxy-propane
(2-butyl-5-nitro-1-benzofuran-3-yl)[4-(3,3-diethoxypropoxy)phenyl]methanone
Conditions | Yield |
---|---|
With potassium carbonate; sodium iodide for 6h; Reflux; | 99% |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
acrylonitrile
(5-nitro-2-butylbenzofuran-3-yl)-[4-(2-cyanoethoxy)phenyl]methanone
Conditions | Yield |
---|---|
With N-benzyl-trimethylammonium hydroxide at 80 - 85℃; for 48h; | 94.2% |
With N-benzyl-trimethylammonium hydroxide at 80 - 85℃; for 48h; | 94.2% |
With N-benzyl-trimethylammonium hydroxide at 80 - 85℃; for 48h; | 94.2% |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
1-chloro 3-di-n-butylamino propane
2-n-butyl 3-[4-(3-di-n-butylamino-propoxy)benzoyl] 5-nitro benzofuran
Conditions | Yield |
---|---|
With sodium hydroxide; potassium carbonate In diethyl ether; butanone | 88.76% |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
trifluoromethylsulfonic anhydride
4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyltrifluoromethanesulfonate
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0 - 20℃; for 3.16667h; Inert atmosphere; | 87% |
With triethylamine In dichloromethane at 20℃; for 5.5h; Reflux; |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
(5-amino-2-butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; under 3750.38 Torr; for 6h; | 78.3% |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
1-chloro-3-hydroxypropane
3-{ 4-[(2-butyl-5-nitro-1-benzofuran-3-yl) carbonyl]phenoxy}propan-1-ol
Conditions | Yield |
---|---|
Stage #1: 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran With tetrabutylammomium bromide; potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 50℃; for 0.5h; Stage #2: 1-chloro-3-hydroxypropane In N,N-dimethyl-formamide at 80 - 85℃; | 69% |
With tetrabutylammomium bromide; potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 80 - 85℃; | 69% |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
1,3-dibromo-propane
[4-(3-bromo-propoxy)-phenyl]-(2-butyl-5-nitro-benzofuran-3-yl)-methanone
Conditions | Yield |
---|---|
With sodium hydroxide In neat (no solvent) for 5h; Reagent/catalyst; Solvent; Reflux; | 64% |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
[2H6]-1,3-dibromopropane
[4-(3-bromo-[2H6]-propoxy)-phenyl]-(2-butyl-5-nitrobenzofuran-3-yl)-methanone
Conditions | Yield |
---|---|
With sodium hydroxide In water for 8h; Solvent; Reagent/catalyst; Reflux; | 62% |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
ethylene dibromide
3-[4-(2-bromoethoxy)benzoyl] 2-n-butyl 5-nitro benzofuran
Conditions | Yield |
---|---|
With potassium carbonate In butanone | 56% |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
β-Propiolactone
3-[4-(2-butyl-5-nitro-benzofuran-3-carbonyl)phenoxy]-propionic acid
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at 20℃; Inert atmosphere; Reflux; | 37% |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
With bromine |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
dronedarone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium carbonate / butanone / 4 h / 81 - 82 °C 2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 50 °C / 3750.38 Torr 3: pyridine / dichloromethane / 15 °C 4: sodium iodide / butanone / 16 h View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium carbonate / butanone / 0.5 h / 20 °C 1.2: 12 h / 78 - 82 °C 2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 25 - 35 °C 3.1: triethylamine / dichloromethane / 0.5 h / 20 °C 3.2: 1.5 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / acetonitrile / 0.5 h 1.2: Reflux 2.1: hydrogen / Raney nickel / methanol / 45 - 50 °C / 3677.86 Torr 3.1: tetramethlyammonium chloride / toluene / Reflux 4.1: sodium hydroxide / 1 h / 0 - 5 °C View Scheme |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium carbonate / butanone / 4 h / 81 - 82 °C 2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 50 °C / 3750.38 Torr 3: pyridine / dichloromethane / 15 °C 4: sodium iodide / butanone / 16 h 5: hydrogenchloride / isopropyl alcohol; water / 5 h / 0 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate; potassium iodide; tetrabutylammomium bromide / N,N-dimethyl-formamide / 0.5 h / 50 °C 1.2: 80 - 85 °C 2.1: hydrogen / palladium 10% on activated carbon / water; methanol / 40 °C / 3000.3 Torr / Autoclave 3.1: pyridine / dichloromethane / 24 h / 10 - 20 °C 4.1: acetonitrile / Reflux 4.2: 2 h / 40 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 25 °C 2.1: palladium 10% on activated carbon; ammonium formate / isopropyl alcohol / 0.5 h / 50 °C 3.1: sodium hydrogencarbonate / dichloromethane / 6 h / 35 °C 4.1: N,N-dimethyl-formamide / 4 h / 125 °C 4.2: 2 h / 25 °C View Scheme |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
(4-(3-chloropropoxy)phenyl)(5-amino-2-butylbenzofuran-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / butanone / 4 h / 81 - 82 °C 2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 50 °C / 3750.38 Torr View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 25 °C 2: palladium 10% on activated carbon; ammonium formate / isopropyl alcohol / 0.5 h / 50 °C View Scheme |
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
N-(2-butyl-3-(4-(3-chloropropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / butanone / 4 h / 81 - 82 °C 2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 50 °C / 3750.38 Torr 3: pyridine / dichloromethane / 15 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 25 °C 2: palladium 10% on activated carbon; ammonium formate / isopropyl alcohol / 0.5 h / 50 °C 3: sodium hydrogencarbonate / dichloromethane / 6 h / 35 °C View Scheme |
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