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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone Manufacturer/High quality/Best price/In stock

Cas:141645-16-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceutical intermed

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2-Butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Cas:141645-16-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-butyl-3-(4-hydroxybenzoyl)-5-nitro-benzofuran

Cas:141645-16-1

Min.Order:1

Negotiable

Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2-Butyl-3- (4-Hydroxybenzoyl) -5-Nitrobenzofuran

Cas:141645-16-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone

Cas:141645-16-1

Min.Order:0

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(2-Butyl-5-nitro-3-benzofuranyl)-(4-hydroxyphenyl)-methanone

Cas:141645-16-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/698.html Product Name (2-Butyl-5-

(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone

Cas:141645-16-1

Min.Order:1 Gram

FOB Price: $42.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

CAS 141645-16-1 (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone

Cas:141645-16-1

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

(2-Butyl-5-nitrobenzofuran-3-yl) (4-hydroxyphenyl) Methanone CAS 141645-16-1

Cas:141645-16-1

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 141645-16-1 with competitive price

Cas:141645-16-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

(2-butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone 141645-16-1 supplier

Cas:141645-16-1

Min.Order:10 Kilogram

FOB Price: $100.0 / 120.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone/ LIDE PHARMA- Factory supply / Best price

Cas:141645-16-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Name: 2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran Synonyms: 2-N-Butyl-3-(4-Hydroxybenzoyl)-5-Nitrobenzofuran CAS:141645-16-1 MF: C19H17NO5 Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum

2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Cas:141645-16-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone 141645-16-1

Cas:141645-16-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate, (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone CAS:141645-16-1

Cas:141645-16-1

Min.Order:1 Kilogram

FOB Price: $56.0 / 59.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone CAS:141645-16-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, sp

(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone CAS:141645-16-1

Cas:141645-16-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone

Cas:141645-16-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone

Cas:141645-16-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone Synonyms: (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone;2-Butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran;2-butyl-3-[(4-Methoxyphenyl)carbonyl]-6-nitro-1-benzofur

(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone Manufactory best quality

Cas:141645-16-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-N-Butyl-3-(4-Hydroxybenzoyl)-5-Nitrobenzofuran

Cas:141645-16-1

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone

Cas:141645-16-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

2-(n-Butyl)-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Cas:141645-16-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone

Cas:141645-16-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Saiwante (shanghai) New Material Technology Co., Ltd.

ProName:Manufacturer high quality (2-Butyl-5-n... CasNo:141645-16-1 Molecular Formula:C19H17NO5 Appearance:White crystalline powder Application:pharmaceutical intermediate DeliveryTime:Within 7 days after payment received PackAge:1kg/foil bag

Manufacturer high quality (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone Cas 141645-16-1

Cas:141645-16-1

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Cas:141645-16-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)Methanone

Cas:141645-16-1

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2-Butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Cas:141645-16-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(2-butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone

Cas:141645-16-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuranAppearance:White powder Storage:In Shade Package:according to customers' requirements Application:chemical research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect

2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Cas:141645-16-1

Min.Order:1 Gram

Negotiable

Type:Other

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Synthetic route

(2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone
141627-42-1

(2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Stage #1: (2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone With aluminum (III) chloride In chlorobenzene at 85℃; for 4h;
Stage #2: With water In chlorobenzene at 35 - 60℃;
92%
Stage #1: (2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone With aluminum (III) chloride In chlorobenzene at 75℃; for 2h;
Stage #2: With water In chlorobenzene at 5 - 65℃; for 0.5h;
92%
In aluminium chloride; ice-water; 1,1-dichloroethane90.1%
4-hydroxybenzoyl chloride
28141-24-4

4-hydroxybenzoyl chloride

2-(n-butyl)-5-nitrobenzofuran
133238-87-6

2-(n-butyl)-5-nitrobenzofuran

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
With tin(IV) chloride In dichloromethane at 0 - 20℃; for 2.5h; Friedel-Crafts Acylation;88%
1-(4-hydroxy-phenyl)-heptane-1,3-dione 3-[O-(4-nitro-phenyl)-oxime]
1253293-38-7

1-(4-hydroxy-phenyl)-heptane-1,3-dione 3-[O-(4-nitro-phenyl)-oxime]

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
With formic acid; trifluoroacetic acid at 45℃; for 5h; Product distribution / selectivity; Inert atmosphere;87%
With formic acid; trifluoroacetic acid at 45℃; for 5h; Product distribution / selectivity; Inert atmosphere;87%
With formic acid; trifluoroacetic acid at 45℃; for 5h; Product distribution / selectivity; Inert atmosphere;87%
With acetic acid at 115℃; for 3h; Product distribution / selectivity; Industry scale;78%
4-hydroxy-benzoic acid
99-96-7

4-hydroxy-benzoic acid

2-(n-butyl)-5-nitrobenzofuran
133238-87-6

2-(n-butyl)-5-nitrobenzofuran

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Stage #1: 4-hydroxy-benzoic acid; 2-(n-butyl)-5-nitrobenzofuran With Methyltrichlorosilane; iron(III) chloride In chlorobenzene at 20 - 40℃; for 3.45 - 5h;
Stage #2: With ethanol In chlorobenzene at 0 - 30℃; for 0.45 - 0.5h; Product distribution / selectivity;
81.6%
Stage #1: 4-hydroxy-benzoic acid; 2-(n-butyl)-5-nitrobenzofuran With dimethylsilicon dichloride; iron(II) chloride In chlorobenzene at 23 - 50℃; for 5h;
Stage #2: With ethanol In chlorobenzene at 20℃; Product distribution / selectivity;
76%
Stage #1: 4-hydroxy-benzoic acid; 2-(n-butyl)-5-nitrobenzofuran With tetrachlorosilane; iron(III) chloride In chlorobenzene at 23 - 50℃; for 5h;
Stage #2: With ethanol In chlorobenzene at 20℃; Product distribution / selectivity;
75%
Stage #1: 4-hydroxy-benzoic acid; 2-(n-butyl)-5-nitrobenzofuran With Methyltrichlorosilane; bismuth(lll) trifluoromethanesulfonate In chlorobenzene at 23 - 60℃; for 15h;
Stage #2: With ethanol In chlorobenzene at 20℃; Product distribution / selectivity;
10%
With trichlorophosphate; zinc(II) chloride at 23 - 60℃; for 15h; Product distribution / selectivity;1%
1-(4-hydroxy-phenyl)-heptane-1,3-dione
1137261-89-2

1-(4-hydroxy-phenyl)-heptane-1,3-dione

p-nitrophenoxyamine
33543-55-4

p-nitrophenoxyamine

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
With acetic acid at 70 - 100℃; for 25h; Product distribution / selectivity;80%
In acetic acid at 70 - 100℃; for 25h; Product distribution / selectivity;80%
With acetic acid at 70 - 100℃; for 17h; Product distribution / selectivity;80%
With hydrogen bromide; acetic acid at 20℃; for 1h;
1-(4-hydroxyphenyl)heptane-1,3-dione-3-[O-(4-nitrophenyl)oxime]
1137261-95-0

1-(4-hydroxyphenyl)heptane-1,3-dione-3-[O-(4-nitrophenyl)oxime]

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
With acetic acid at 115℃; for 3h; Product distribution / selectivity;78%
4-acetoxyiodobenzene
33527-94-5

4-acetoxyiodobenzene

carbon monoxide
201230-82-2

carbon monoxide

2-(hex-1-yn-1-yl)-4-nitrophenyl acetate
1636167-45-7

2-(hex-1-yn-1-yl)-4-nitrophenyl acetate

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate at 55℃; for 24h; Sealed tube;76%
2-(2-pentanoyloxy-5-nitrophenyl)-1-(4-methoxyphenyl)-ethanone
1256921-45-5

2-(2-pentanoyloxy-5-nitrophenyl)-1-(4-methoxyphenyl)-ethanone

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Stage #1: 2-(2-pentanoyloxy-5-nitrophenyl)-1-(4-methoxyphenyl)-ethanone With tributyl-amine In xylene for 8h; Molecular sieve; Reflux;
Stage #2: With hydrogenchloride; tributyl-amine at 200℃; for 4h;
Stage #3: With water In tert-butyl methyl ether at 20℃;
65%
1-(4-benzyloxyphenyl)-heptane-1,3-dione
1137261-88-1

1-(4-benzyloxyphenyl)-heptane-1,3-dione

p-nitrophenoxyamine
33543-55-4

p-nitrophenoxyamine

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
With hydrogen bromide; acetic acid at 20℃; for 6h; Product distribution / selectivity;59%
(2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone
141627-42-1

(2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone

2-n-butyl-5-nitro-3-(2'-methoxy)-acetophenonebenzofuran
856758-04-8

2-n-butyl-5-nitro-3-(2'-methoxy)-acetophenonebenzofuran

A

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

B

2-(n-butyl)-3-(2-hydroxybenzoyl)-5-nitrobenzofuran
856758-05-9

2-(n-butyl)-3-(2-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Stage #1: (2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone; 2-n-butyl-5-nitro-3-(2'-methoxy)-acetophenonebenzofuran; aluminum (III) chloride In chlorobenzene at 60℃; for 7h;
Stage #2: With water In chlorobenzene at 60℃;
1-[4-(1-ethoxy-ethoxy)-phenyl]-ethanone

1-[4-(1-ethoxy-ethoxy)-phenyl]-ethanone

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium tert-butylate / Isobutyronitrile / 2 h / 0 - 95 °C
2: water / hydrogenchloride / Isobutyronitrile / 0.25 h / 0 °C
3: dichloromethane / 16 h / 20 °C
4: trifluoroacetic acid; formic acid / 5 h / 45 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / 1,4-dioxane; mineral oil / 3 h / 70 °C / Inert atmosphere
1.2: 0.5 h / 60 °C
2.1: dichloromethane / 16 h / 20 °C
3.1: trifluoroacetic acid; formic acid / 5 h / 45 °C / Inert atmosphere
View Scheme
4-Hydroxyacetophenone
99-93-4

4-Hydroxyacetophenone

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sulfuric acid / tetrahydrofuran / 1.75 h / 0 °C
2: potassium tert-butylate / Isobutyronitrile / 2 h / 0 - 95 °C
3: water / hydrogenchloride / Isobutyronitrile / 0.25 h / 0 °C
4: dichloromethane / 16 h / 20 °C
5: trifluoroacetic acid; formic acid / 5 h / 45 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: sulfuric acid / tetrahydrofuran / 1.75 h / 0 °C
2.1: sodium hydride / 1,4-dioxane; mineral oil / 3 h / 70 °C / Inert atmosphere
2.2: 0.5 h / 60 °C
3.1: dichloromethane / 16 h / 20 °C
4.1: trifluoroacetic acid; formic acid / 5 h / 45 °C / Inert atmosphere
View Scheme
C17H24O4

C17H24O4

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water / hydrogenchloride / Isobutyronitrile / 0.25 h / 0 °C
2: dichloromethane / 16 h / 20 °C
3: trifluoroacetic acid; formic acid / 5 h / 45 °C / Inert atmosphere
View Scheme
1-(4-hydroxy-phenyl)-heptane-1,3-dione
1137261-89-2

1-(4-hydroxy-phenyl)-heptane-1,3-dione

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloromethane / 16 h / 20 °C
2: trifluoroacetic acid; formic acid / 5 h / 45 °C / Inert atmosphere
View Scheme
4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / dichloromethane / 4 h / 25 °C
2.1: aluminum (III) chloride / chlorobenzene / 4 h / 85 °C
2.2: 35 - 60 °C
View Scheme
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / chlorobenzene / 2 h / 25 °C / Reflux
2.1: aluminum (III) chloride / chlorobenzene / 2 h / 75 °C
2.2: 0.5 h / 5 - 65 °C
View Scheme
Multi-step reaction with 2 steps
1: aluminum (III) chloride / dichloromethane
2: aluminum (III) chloride / chlorobenzene
View Scheme
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / dichloromethane / 22 h / 25 - 30 °C / Large scale
2.1: aluminum (III) chloride / 40 h / Reflux; Large scale
2.2: 15 °C / Large scale
View Scheme
2-(n-butyl)-5-nitrobenzofuran
133238-87-6

2-(n-butyl)-5-nitrobenzofuran

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / dichloromethane / 4 h / 25 °C
2.1: aluminum (III) chloride / chlorobenzene / 4 h / 85 °C
2.2: 35 - 60 °C
View Scheme
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / chlorobenzene / 2 h / 25 °C / Reflux
2.1: aluminum (III) chloride / chlorobenzene / 2 h / 75 °C
2.2: 0.5 h / 5 - 65 °C
View Scheme
Multi-step reaction with 2 steps
1: aluminum (III) chloride / dichloromethane
2: aluminum (III) chloride / chlorobenzene
View Scheme
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / dichloromethane / 22 h / 25 - 30 °C / Large scale
2.1: aluminum (III) chloride / 40 h / Reflux; Large scale
2.2: 15 °C / Large scale
View Scheme
Multi-step reaction with 2 steps
1: aluminum (III) chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere
2: aluminum (III) chloride / chlorobenzene / 2 h / 80 °C / Inert atmosphere
View Scheme
4-nitro-phenol
100-02-7

4-nitro-phenol

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: triethylamine / dichloromethane / 1 h / 0 - 5 °C / Inert atmosphere
2: aluminum (III) chloride / nitrobenzene / 5 h / 140 °C
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 2 h / 25 - 30 °C
4: bromine / dichloromethane / 1 h / 25 - 30 °C
5: aluminum (III) chloride / dichloromethane / 15 - 20 °C
6: triethylamine / dichloromethane / 2 h / 25 - 30 °C
7: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C
8: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C
9: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C
10: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C
View Scheme
Multi-step reaction with 5 steps
1: hydrogenchloride / water / 38 h / 40 - 55 °C / Large scale
2: 1,2-dichloro-ethane / 65 - 75 °C / Large scale
3: sodium hydrogencarbonate / 1,2-dichloro-ethane / 55 - 60 °C / Large scale
4: aluminum (III) chloride / 1,2-dichloro-ethane / 35 - 40 °C / Large scale
5: aluminum (III) chloride / chlorobenzene / 65 - 70 °C / Large scale
View Scheme
2-butyl-5-nitrobenzofuran-3(2H)-one

2-butyl-5-nitrobenzofuran-3(2H)-one

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C
2: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C
3: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C
4: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C
View Scheme
2-butyl-5-nitro-2,3-dihydrobenzofuran-3-ol

2-butyl-5-nitro-2,3-dihydrobenzofuran-3-ol

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C
2: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C
3: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C
View Scheme
p-nitrophenyl hexanoate
956-75-2

p-nitrophenyl hexanoate

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: aluminum (III) chloride / nitrobenzene / 5 h / 140 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 2 h / 25 - 30 °C
3: bromine / dichloromethane / 1 h / 25 - 30 °C
4: aluminum (III) chloride / dichloromethane / 15 - 20 °C
5: triethylamine / dichloromethane / 2 h / 25 - 30 °C
6: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C
7: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C
8: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C
9: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C
View Scheme
1-(2-hydroxy-5-nitrophenyl)hexan-1-one
1393093-65-6

1-(2-hydroxy-5-nitrophenyl)hexan-1-one

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 2 h / 25 - 30 °C
2: bromine / dichloromethane / 1 h / 25 - 30 °C
3: aluminum (III) chloride / dichloromethane / 15 - 20 °C
4: triethylamine / dichloromethane / 2 h / 25 - 30 °C
5: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C
6: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C
7: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C
8: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C
View Scheme
1-(2-methoxy-5-nitrophenyl)hexan-1-one
1393093-66-7

1-(2-methoxy-5-nitrophenyl)hexan-1-one

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: bromine / dichloromethane / 1 h / 25 - 30 °C
2: aluminum (III) chloride / dichloromethane / 15 - 20 °C
3: triethylamine / dichloromethane / 2 h / 25 - 30 °C
4: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C
5: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C
6: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C
7: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C
View Scheme
2-bromo-1-(2-methoxy-5-nitrophenyl)hexan-1-one
1393093-67-8

2-bromo-1-(2-methoxy-5-nitrophenyl)hexan-1-one

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: aluminum (III) chloride / dichloromethane / 15 - 20 °C
2: triethylamine / dichloromethane / 2 h / 25 - 30 °C
3: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C
4: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C
5: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C
6: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C
View Scheme
2-bromo-1-(2-hydroxy-5-nitrophenyl)hexan-1-one
1393093-68-9

2-bromo-1-(2-hydroxy-5-nitrophenyl)hexan-1-one

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 2 h / 25 - 30 °C
2: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C
3: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C
4: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C
5: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C
View Scheme
Hexanoyl chloride
142-61-0

Hexanoyl chloride

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: triethylamine / dichloromethane / 1 h / 0 - 5 °C / Inert atmosphere
2: aluminum (III) chloride / nitrobenzene / 5 h / 140 °C
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 2 h / 25 - 30 °C
4: bromine / dichloromethane / 1 h / 25 - 30 °C
5: aluminum (III) chloride / dichloromethane / 15 - 20 °C
6: triethylamine / dichloromethane / 2 h / 25 - 30 °C
7: sodium tetrahydroborate / methanol / 0.5 h / 0 - 5 °C
8: hydrogenchloride / methanol; water / 5 h / 90 - 95 °C
9: aluminum (III) chloride / dichloromethane / 5.08 h / 0 - 30 °C
10: aluminum (III) chloride / chlorobenzene / 5.17 h / 20 - 80 °C
View Scheme
2-iodo-4-nitrophenyl acetate
504421-91-4

2-iodo-4-nitrophenyl acetate

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / tetrahydrofuran / 5.5 h / 20 °C / Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 24 h / 55 °C / Sealed tube
View Scheme
2-iodo-4-nitrophenol
89487-91-2

2-iodo-4-nitrophenol

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / tetrahydrofuran; dichloromethane / 4 h / 0 - 20 °C
2: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / tetrahydrofuran / 5.5 h / 20 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 24 h / 55 °C / Sealed tube
View Scheme
4-Iodophenol
540-38-5

4-Iodophenol

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dmap; triethylamine / dichloromethane / 1.5 h / 20 °C
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 24 h / 55 °C / Sealed tube
View Scheme
Koshlands reagent I
772-33-8

Koshlands reagent I

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triphenylphosphine / dichloromethane / 1 h / Reflux
1.2: 3 h / Reflux
2.1: tin(IV) chloride / dichloromethane / 2.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triphenylphosphine / dichloromethane / 1 h / 40 °C / Inert atmosphere
1.2: 3 h / 110 °C / Inert atmosphere
2.1: aluminum (III) chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere
3.1: aluminum (III) chloride / chlorobenzene / 2 h / 80 °C / Inert atmosphere
View Scheme
n-valeryl chloride
638-29-9

n-valeryl chloride

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triphenylphosphine / dichloromethane / 1 h / Reflux
1.2: 3 h / Reflux
2.1: tin(IV) chloride / dichloromethane / 2.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triphenylphosphine / dichloromethane / 1 h / 40 °C / Inert atmosphere
1.2: 3 h / 110 °C / Inert atmosphere
2.1: aluminum (III) chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere
3.1: aluminum (III) chloride / chlorobenzene / 2 h / 80 °C / Inert atmosphere
View Scheme
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyl-methanesulfonate
1448297-26-4

4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyl-methanesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 12.5h; Reflux;100%
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

1,2-Epoxy-3-bromopropane
3132-64-7

1,2-Epoxy-3-bromopropane

(2-butyl-5-nitro-1-benzofuran-3-yl)[4-(oxiran-2-yl-methoxy)phenyl]methanone

(2-butyl-5-nitro-1-benzofuran-3-yl)[4-(oxiran-2-yl-methoxy)phenyl]methanone

Conditions
ConditionsYield
With sodium hydroxide In isopropyl alcohol for 1.5h; Reflux;100%
Stage #1: 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran With sodium hydroxide In isopropyl alcohol at 20℃; for 0.166667h;
Stage #2: 1,2-Epoxy-3-bromopropane In isopropyl alcohol for 1.5h; Reflux;
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

dibutyl-(3-chloro-propyl)-amine
36421-15-5

dibutyl-(3-chloro-propyl)-amine

(2-butyl-5-nitrobenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone
141645-23-0

(2-butyl-5-nitrobenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone

Conditions
ConditionsYield
Stage #1: 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran With potassium carbonate In toluene at 25 - 110℃; for 0.5h; Large scale;
Stage #2: dibutyl-(3-chloro-propyl)-amine In toluene Temperature; Solvent; Reflux; Large scale;
99.5%
Stage #1: 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran With potassium carbonate In acetonitrile for 0.5h;
Stage #2: dibutyl-(3-chloro-propyl)-amine In acetonitrile Reflux;
91%
Stage #1: 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran With potassium carbonate In acetonitrile for 0.5h; Reflux;
Stage #2: dibutyl-(3-chloro-propyl)-amine In acetonitrile Reflux;
91%
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

1,3-chlorobromopropane
109-70-6

1,3-chlorobromopropane

(4-(3-chloropropoxy)phenyl)(2-butyl-5-nitrobenzofuran-3-yl)methanone
1310430-03-5

(4-(3-chloropropoxy)phenyl)(2-butyl-5-nitrobenzofuran-3-yl)methanone

Conditions
ConditionsYield
With potassium carbonate In butanone at 81 - 82℃; for 4h;99.1%
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 20h;88.8%
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

(2-butyl-5-nitro-1-benzofuran-3-yl)[4-(3,3-diethoxypropoxy)phenyl]methanone
1420181-01-6

(2-butyl-5-nitro-1-benzofuran-3-yl)[4-(3,3-diethoxypropoxy)phenyl]methanone

Conditions
ConditionsYield
With potassium carbonate; sodium iodide for 6h; Reflux;99%
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

acrylonitrile
107-13-1

acrylonitrile

(5-nitro-2-butylbenzofuran-3-yl)-[4-(2-cyanoethoxy)phenyl]methanone
1401355-76-7

(5-nitro-2-butylbenzofuran-3-yl)-[4-(2-cyanoethoxy)phenyl]methanone

Conditions
ConditionsYield
With N-benzyl-trimethylammonium hydroxide at 80 - 85℃; for 48h;94.2%
With N-benzyl-trimethylammonium hydroxide at 80 - 85℃; for 48h;94.2%
With N-benzyl-trimethylammonium hydroxide at 80 - 85℃; for 48h;94.2%
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

1-chloro 3-di-n-butylamino propane
90050-13-8

1-chloro 3-di-n-butylamino propane

2-n-butyl 3-[4-(3-di-n-butylamino-propoxy)benzoyl] 5-nitro benzofuran
141671-42-3

2-n-butyl 3-[4-(3-di-n-butylamino-propoxy)benzoyl] 5-nitro benzofuran

Conditions
ConditionsYield
With sodium hydroxide; potassium carbonate In diethyl ether; butanone88.76%
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyltrifluoromethanesulfonate
1448297-17-3

4-[(2-butyl-5-nitro-1-benzofuran-3-yl)carbonyl]phenyltrifluoromethanesulfonate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 3.16667h; Inert atmosphere;87%
With triethylamine In dichloromethane at 20℃; for 5.5h; Reflux;
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

(5-amino-2-butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone
1278585-68-4

(5-amino-2-butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; under 3750.38 Torr; for 6h;78.3%
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

1-chloro-3-hydroxypropane
627-30-5

1-chloro-3-hydroxypropane

3-{ 4-[(2-butyl-5-nitro-1-benzofuran-3-yl) carbonyl]phenoxy}propan-1-ol
1310430-11-5

3-{ 4-[(2-butyl-5-nitro-1-benzofuran-3-yl) carbonyl]phenoxy}propan-1-ol

Conditions
ConditionsYield
Stage #1: 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran With tetrabutylammomium bromide; potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 50℃; for 0.5h;
Stage #2: 1-chloro-3-hydroxypropane In N,N-dimethyl-formamide at 80 - 85℃;
69%
With tetrabutylammomium bromide; potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 80 - 85℃;69%
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

1,3-dibromo-propane
109-64-8

1,3-dibromo-propane

[4-(3-bromo-propoxy)-phenyl]-(2-butyl-5-nitro-benzofuran-3-yl)-methanone
141645-38-7

[4-(3-bromo-propoxy)-phenyl]-(2-butyl-5-nitro-benzofuran-3-yl)-methanone

Conditions
ConditionsYield
With sodium hydroxide In neat (no solvent) for 5h; Reagent/catalyst; Solvent; Reflux;64%
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

[2H6]-1,3-dibromopropane
120404-22-0

[2H6]-1,3-dibromopropane

[4-(3-bromo-[2H6]-propoxy)-phenyl]-(2-butyl-5-nitrobenzofuran-3-yl)-methanone
1542232-34-7

[4-(3-bromo-[2H6]-propoxy)-phenyl]-(2-butyl-5-nitrobenzofuran-3-yl)-methanone

Conditions
ConditionsYield
With sodium hydroxide In water for 8h; Solvent; Reagent/catalyst; Reflux;62%
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

ethylene dibromide
106-93-4

ethylene dibromide

3-[4-(2-bromoethoxy)benzoyl] 2-n-butyl 5-nitro benzofuran
141645-36-5

3-[4-(2-bromoethoxy)benzoyl] 2-n-butyl 5-nitro benzofuran

Conditions
ConditionsYield
With potassium carbonate In butanone56%
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

β-Propiolactone
57-57-8

β-Propiolactone

3-[4-(2-butyl-5-nitro-benzofuran-3-carbonyl)phenoxy]-propionic acid
1542232-29-0

3-[4-(2-butyl-5-nitro-benzofuran-3-carbonyl)phenoxy]-propionic acid

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 20℃; Inert atmosphere; Reflux;37%
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

2-n-butyl-3-(3,5-dibromo-4-hydroxybenzoyl)5-nitrobenzofuran

2-n-butyl-3-(3,5-dibromo-4-hydroxybenzoyl)5-nitrobenzofuran

Conditions
ConditionsYield
With bromine
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

dronedarone
141626-36-0

dronedarone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / butanone / 4 h / 81 - 82 °C
2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 50 °C / 3750.38 Torr
3: pyridine / dichloromethane / 15 °C
4: sodium iodide / butanone / 16 h
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / butanone / 0.5 h / 20 °C
1.2: 12 h / 78 - 82 °C
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 25 - 35 °C
3.1: triethylamine / dichloromethane / 0.5 h / 20 °C
3.2: 1.5 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 0.5 h
1.2: Reflux
2.1: hydrogen / Raney nickel / methanol / 45 - 50 °C / 3677.86 Torr
3.1: tetramethlyammonium chloride / toluene / Reflux
4.1: sodium hydroxide / 1 h / 0 - 5 °C
View Scheme
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

dronedarone hydrochloride

dronedarone hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium carbonate / butanone / 4 h / 81 - 82 °C
2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 50 °C / 3750.38 Torr
3: pyridine / dichloromethane / 15 °C
4: sodium iodide / butanone / 16 h
5: hydrogenchloride / isopropyl alcohol; water / 5 h / 0 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate; potassium iodide; tetrabutylammomium bromide / N,N-dimethyl-formamide / 0.5 h / 50 °C
1.2: 80 - 85 °C
2.1: hydrogen / palladium 10% on activated carbon / water; methanol / 40 °C / 3000.3 Torr / Autoclave
3.1: pyridine / dichloromethane / 24 h / 10 - 20 °C
4.1: acetonitrile / Reflux
4.2: 2 h / 40 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 25 °C
2.1: palladium 10% on activated carbon; ammonium formate / isopropyl alcohol / 0.5 h / 50 °C
3.1: sodium hydrogencarbonate / dichloromethane / 6 h / 35 °C
4.1: N,N-dimethyl-formamide / 4 h / 125 °C
4.2: 2 h / 25 °C
View Scheme
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

(4-(3-chloropropoxy)phenyl)(5-amino-2-butylbenzofuran-3-yl)methanone
1309476-89-8

(4-(3-chloropropoxy)phenyl)(5-amino-2-butylbenzofuran-3-yl)methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / butanone / 4 h / 81 - 82 °C
2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 50 °C / 3750.38 Torr
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 25 °C
2: palladium 10% on activated carbon; ammonium formate / isopropyl alcohol / 0.5 h / 50 °C
View Scheme
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

N-(2-butyl-3-(4-(3-chloropropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide
1310430-05-7

N-(2-butyl-3-(4-(3-chloropropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / butanone / 4 h / 81 - 82 °C
2: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 50 °C / 3750.38 Torr
3: pyridine / dichloromethane / 15 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 25 °C
2: palladium 10% on activated carbon; ammonium formate / isopropyl alcohol / 0.5 h / 50 °C
3: sodium hydrogencarbonate / dichloromethane / 6 h / 35 °C
View Scheme
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