CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD. founded in 1984, engages in pharmaceutical research, development, production, process design and technical consultation of synthetic pharmaceutical products. The organizati
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inquiryName AZD-9291 mesylate Synonyms N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate (
Name: Methylsulfonate AZD9291 Alias: Miritibu Mesylate; Miritini Mesylate; AZD9291 Mesylate; AZD9291 (Mesylate); Meritini Mesylate; Meritini Mesylate English Name: AZD-9291 (Mesylate) English alias: Osimertinib mesylate; N-
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryGIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, GIHI CHEMICALS is your best choice. pls contact with us freely for getting detailed prod
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inquirySpecification: Product name: AZD-9291(Mesylate) CAS No.: 1421373-66-1 Assay: 99%min Molecular Formula:
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inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
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inquiryUnique advantages for AZD-9291 (Mesylate) Cas1421373-66-1 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Yellow powder Storage:Be kept airtight,dry and in cool place Package:1
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inquiryOsimertinib mesylate CAS No.:1421373-66-1 Name: Osimertinib mesylate Synonyms: N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate
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inquiryHigh quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryOsimertinib mesylate Basic information Product Name: Osimertinib mesylate Synonyms: AZD-9291 (Mesylate);N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfona
LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryAppearance:Light yellow to yellow crystalline powder Storage:R.T Package:100G/Bottle, 500G/Bottle, 1KG/Bottle or at customers reqirement. Application:Antitumor drugs Transportation:Express/Sea/Air Port:Any port in China
Cas:1421373-66-1
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:1421373-66-1
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inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:1421373-66-1
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inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
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inquiryBeluga chemical professional supply AZD-9291 Mesylate CAS 1421373-66-1 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and expo
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryAZD-9291 mesylate/Osimertinib CAS: 1421373-66-1 Specification product name: azd-9291(mesylate) cas no.: 1421373-66-1 assay: 99%min molecular formula: c28h33n7o2.ch4o3s molecular weight:
Cas:1421373-66-1
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
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inquiryOsimertinib mesylate cas 1421373-66-1 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality c
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquirymethanesulfonic acid
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Stage #1: [N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide] With pyrographite In acetone at 25 - 55℃; Stage #2: methanesulfonic acid at 25 - 55℃; | 96.73% |
With N-ethyl-N,N-diisopropylamine In ethanol; ethyl acetate at 70℃; for 1.5h; | 94% |
In water; acetone at 50℃; for 1.5h; Inert atmosphere; | 94% |
4-fluoro-2-methoxy-5-nitro-phenylamine
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 3.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 4.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 4.2: 10 h / 65 °C 5.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 5 steps 1: toluene-4-sulfonic acid / 2.5 h / 105 °C 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 3: iron; ammonium chloride / water; ethanol / 2 h / Reflux 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice 5: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 6 steps 1: toluene-4-sulfonic acid / 2.5 h / 105 °C 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 3: iron; ammonium chloride / water; ethanol / 2 h / Reflux 4: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 5: triethylamine / acetonitrile / 6 h / 80 °C 6: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme |
N‑2‑[[2‑(dimethylamino)ethyl]methylamino]‑4‑methoxy‑5‑[[4‑(1‑methyl‑1H‑indole-3-yl)-2-pyrimidinyl]amino]aniline
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 1.2: 10 h / 65 °C 2.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice 2: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 2: triethylamine / acetonitrile / 6 h / 80 °C 3: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme |
N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 2.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 2.2: 10 h / 65 °C 3.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 3 steps 1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice 3: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 4 steps 1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 2: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 3: triethylamine / acetonitrile / 6 h / 80 °C 4: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme |
N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indole-3-yl)-pyrimidine-2-amine
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 2.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 3.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 3.2: 10 h / 65 °C 4.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 4 steps 1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 2: iron; ammonium chloride / water; ethanol / 2 h / Reflux 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice 4: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 5 steps 1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 2: iron; ammonium chloride / water; ethanol / 2 h / Reflux 3: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 4: triethylamine / acetonitrile / 6 h / 80 °C 5: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme |
2-chloro-4-(1'-methyl-1H-indol-3-yl)pyrimidine
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 3.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 4.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 4.2: 10 h / 65 °C 5.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 5 steps 1: toluene-4-sulfonic acid / 2.5 h / 105 °C 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 3: iron; ammonium chloride / water; ethanol / 2 h / Reflux 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice 5: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 6 steps 1: toluene-4-sulfonic acid / 2.5 h / 105 °C 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 3: iron; ammonium chloride / water; ethanol / 2 h / Reflux 4: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 5: triethylamine / acetonitrile / 6 h / 80 °C 6: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme |
3-(2-chloro-pyrimidin-4-yl)-1H-indole
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C 1.2: 3 h / 0 °C 2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 5.2: 10 h / 65 °C 6.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C 1.2: 3 h / 0 °C 2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice 6.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C 1.2: 3 h / 0 °C 2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5.1: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 6.1: triethylamine / acetonitrile / 6 h / 80 °C 7.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 1.2: 3 h / 0 °C / Inert atmosphere 2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C / Inert atmosphere 3.1: N-ethyl-N,N-diisopropylamine / 2,2,2-trifluoroethanol / 1 h / 140 °C / Inert atmosphere 4.1: ammonium chloride; iron / ethanol; water / 2 h / 100 °C / Inert atmosphere 5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere 6.1: water; acetone / 1.5 h / 50 °C / Inert atmosphere View Scheme |
3-chloro-N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propanamide
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / acetonitrile / 6 h / 80 °C 2: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide / tetrahydrofuran; water / 10 h / 65 °C 2: water; ethanol / 1.5 h / 70 °C View Scheme |
indole
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: methylmagnesium bromide / diethyl ether; 1,2-dichloro-ethane / 0.42 h / 0 °C / Inert atmosphere 1.2: 16 h / 0 - 20 °C / Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C 2.2: 3 h / 0 °C 3.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 5.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice 7.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: methylmagnesium bromide / diethyl ether; 1,2-dichloro-ethane / 0.42 h / 0 °C / Inert atmosphere 1.2: 16 h / 0 - 20 °C / Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C 2.2: 3 h / 0 °C 3.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 5.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 6.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 6.2: 10 h / 65 °C 7.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 8 steps 1.1: methylmagnesium bromide / diethyl ether; 1,2-dichloro-ethane / 0.42 h / 0 °C / Inert atmosphere 1.2: 16 h / 0 - 20 °C / Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C 2.2: 3 h / 0 °C 3.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 5.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 6.1: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 7.1: triethylamine / acetonitrile / 6 h / 80 °C 8.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: methylmagnesium bromide / diethyl ether; 1,2-dichloro-ethane / 0.25 h / 0 °C / Inert atmosphere 1.2: 16 h / 0 °C / Inert atmosphere; Heating 2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 2.2: 3 h / 0 °C / Inert atmosphere 3.1: toluene-4-sulfonic acid / 2.5 h / 105 °C / Inert atmosphere 4.1: N-ethyl-N,N-diisopropylamine / 2,2,2-trifluoroethanol / 1 h / 140 °C / Inert atmosphere 5.1: ammonium chloride; iron / ethanol; water / 2 h / 100 °C / Inert atmosphere 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere 7.1: water; acetone / 1.5 h / 50 °C / Inert atmosphere View Scheme |
4-fluoro-2-methoxyaniline
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sulfuric acid; potassium nitrate / 15 °C / Cooling with ice 2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 5.2: 10 h / 65 °C 6.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 6 steps 1: sulfuric acid; potassium nitrate / 15 °C / Cooling with ice 2: toluene-4-sulfonic acid / 2.5 h / 105 °C 3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice 6: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 7 steps 1: sulfuric acid; potassium nitrate / 15 °C / Cooling with ice 2: toluene-4-sulfonic acid / 2.5 h / 105 °C 3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 6: triethylamine / acetonitrile / 6 h / 80 °C 7: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme |
1-methylindole
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: iron(III) chloride / 1,2-dimethoxyethane / 60 °C 2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 5.2: 10 h / 65 °C 6.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 6 steps 1: iron(III) chloride / 1,2-dimethoxyethane / 60 °C 2: toluene-4-sulfonic acid / 2.5 h / 105 °C 3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice 6: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 7 steps 1: iron(III) chloride / 1,2-dimethoxyethane / 60 °C 2: toluene-4-sulfonic acid / 2.5 h / 105 °C 3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 6: triethylamine / acetonitrile / 6 h / 80 °C 7: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: aluminum (III) chloride / 1,2-dimethoxyethane / 0.08 h / 20 °C / Inert atmosphere 1.2: 2 h / 80 °C / Inert atmosphere 2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C / Inert atmosphere 3.1: N-ethyl-N,N-diisopropylamine / 2,2,2-trifluoroethanol / 1 h / 140 °C / Inert atmosphere 4.1: ammonium chloride; iron / ethanol; water / 2 h / 100 °C / Inert atmosphere 5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere 6.1: water; acetone / 1.5 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 6 steps 1: cobalt(II) chloride; thionyl chloride / acetonitrile / 4 h / 60 °C 2: toluene-4-sulfonic acid / acetonitrile / 12 h / 85 °C 3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 2 h / 85 °C 4: ammonium chloride; cobalt(II) sulphate heptahydrate; hydrazine hydrate / ethanol; water / 8 h / 85 °C 5: sodium carbonate / N,N-dimethyl-formamide / 2 h / -5 °C 6: ethanol; isopropyl alcohol / 12 h / 45 °C View Scheme |
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: sodium methylate / toluene / 12 h / 100 °C 2: hydrogen / ethanol / 5 h / 20 °C / 3750.38 Torr 3: trichlorophosphate / tetrahydrofuran / 12 h / 35 °C 4: potassium hydride / 1,2-dichloro-ethane / 8 h / 50 °C 5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 40 °C 6: dichloromethane / 4 h / 20 °C View Scheme |
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrogen / ethanol / 5 h / 20 °C / 3750.38 Torr 2: trichlorophosphate / tetrahydrofuran / 12 h / 35 °C 3: potassium hydride / 1,2-dichloro-ethane / 8 h / 50 °C 4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 40 °C 5: dichloromethane / 4 h / 20 °C View Scheme |
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: trichlorophosphate / tetrahydrofuran / 12 h / 35 °C 2: potassium hydride / 1,2-dichloro-ethane / 8 h / 50 °C 3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 40 °C 4: dichloromethane / 4 h / 20 °C View Scheme |
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium hydride / 1,2-dichloro-ethane / 8 h / 50 °C 2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 40 °C 3: dichloromethane / 4 h / 20 °C View Scheme |
3-(2-aminopyrimidin-4-yl)-1-methyl-1H-indole
methanesulfonic acid
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Stage #1: 3-(2-aminopyrimidin-4-yl)-1-methyl-1H-indole; 1-methoxy-2-nitro-5-[(N-(dimethylamino)ethyl)-Ν-methylamino]-4-cinnamamide With diammonium sulfide In isopropyl alcohol Stage #2: methanesulfonic acid | 18.5 g |
4-Chloro-3-nitroaniline
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium iodide / 55 °C / Alkaline conditions 2: bromine; iron; acetic acid 3: Alkaline conditions 4: diammonium sulfide / isopropyl alcohol View Scheme |
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: bromine; iron; acetic acid 2: Alkaline conditions 3: diammonium sulfide / isopropyl alcohol View Scheme |
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Alkaline conditions 2: diammonium sulfide / isopropyl alcohol View Scheme |
methanesulfonic acid
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
In ethanol; water at 60℃; for 14.75h; |
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