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CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD. founded in 1984, engages in pharmaceutical research, development, production, process design and technical consultation of synthetic pharmaceutical products. The organizati

AZD-9291 (Mesylate) 1421373-66-1 high purity 99%min stock

Cas:1421373-66-1

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Name AZD-9291 mesylate Synonyms N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate (

AZD-9291 mesylate

Cas:1421373-66-1

Min.Order:10 Gram

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Hubei DiBo chemical co., LTD

Name: Methylsulfonate AZD9291 Alias: Miritibu Mesylate; Miritini Mesylate; AZD9291 Mesylate; AZD9291 (Mesylate); Meritini Mesylate; Meritini Mesylate English Name: AZD-9291 (Mesylate) English alias: Osimertinib mesylate; N-

AZD9291 Mesylate /Osimertinib mesylate/Mereletinib Manufacturer

Cas:1421373-66-1

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Mereletinib mesylate

Cas:1421373-66-1

Min.Order:1 Kilogram

FOB Price: $3.0

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GIHI CHEMICALS CO.,LIMITED

GIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, GIHI CHEMICALS is your best choice. pls contact with us freely for getting detailed prod

Oleoylethanolamine(OEA 99%) factory

Cas:1421373-66-1

Min.Order:1 Kilogram

FOB Price: $3.0

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Kono Chem Co.,Ltd

Specification: Product name: AZD-9291(Mesylate) CAS No.: 1421373-66-1 Assay: 99%min Molecular Formula:

CAS:1421373-66-1 AZD-9291 (Mesylate)

Cas:1421373-66-1

Min.Order:1 Kilogram

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Osimertinib mesylate 1421373-66-1 API

Cas:1421373-66-1

Min.Order:1 Metric Ton

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for AZD-9291 (Mesylate) Cas1421373-66-1 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Yellow powder Storage:Be kept airtight,dry and in cool place Package:1

High purity AZD-9291 (Mesylate) Cas1421373-66-1 with fast delivery

Cas:1421373-66-1

Min.Order:1 Kilogram

FOB Price: $5000.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Osimertinib mesylate CAS No.:1421373-66-1 Name: Osimertinib mesylate Synonyms: N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate

High purity Osimertinib mesylate CAS No.:1421373-66-1

Cas:1421373-66-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

Osimertinib mesylate

Cas:1421373-66-1

Min.Order:1 Kilogram

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Osimertinib mesylate

Cas:1421373-66-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

AZD-9291 mesylate

Cas:1421373-66-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

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Ality Chemical Corporation

Osimertinib mesylate Basic information Product Name: Osimertinib mesylate Synonyms: AZD-9291 (Mesylate);N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfona

Factory Supply AZD-9291 mesylate

Cas:1421373-66-1

Min.Order:1 Gram

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

AZD-9291 (Mesylate)

Cas:1421373-66-1

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

CAS 1421373-66-1 Osimertinib mesylate

Cas:1421373-66-1

Min.Order:1 Kilogram

FOB Price: $1000.0

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Anti-Cancer Pharmaceutical Intermediate Raw Material CAS 1421373-66-1 Osimertinib Mesylate Powder

Cas:1421373-66-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 1421373-66-1 with competitive price

Cas:1421373-66-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:Light yellow to yellow crystalline powder Storage:R.T Package:100G/Bottle, 500G/Bottle, 1KG/Bottle or at customers reqirement. Application:Antitumor drugs Transportation:Express/Sea/Air Port:Any port in China

AZD9291 Osimertinib mesylate cas 1421373-66-1

Cas:1421373-66-1

Min.Order:100 Gram

FOB Price: $3.5 / 4.2

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 1421373-66-1 Osimertinib mesylate with best price

Cas:1421373-66-1

Min.Order:10 Gram

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Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

factory supply Mesylate-AZD9291 Osimertinib Mesylate//CAS 1421373-66-1, High Purity.

Cas:1421373-66-1

Min.Order:1 Kilogram

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

Topsale AZD-9291 (Mesylate) with lower price

Cas:1421373-66-1

Min.Order:25 Kilogram

FOB Price: $1.0

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

AZD-9291 (Mesylate) 99%

Cas:1421373-66-1

Min.Order:1 Kilogram

FOB Price: $86.0 / 99.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply AZD-9291 Mesylate CAS 1421373-66-1 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and expo

AZD-9291 Mesylate CAS 1421373-66-1

Cas:1421373-66-1

Min.Order:1 Gram

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Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

AZD-9291 (Mesylate)

Cas:1421373-66-1

Min.Order:1 Kilogram

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Lonwin Chemical Group Limited

AZD-9291 mesylate/Osimertinib CAS: 1421373-66-1 Specification product name: azd-9291(mesylate) cas no.: 1421373-66-1 assay: 99%min molecular formula: c28h33n7o2.ch4o3s molecular weight:

Factory supply AZD-9291 mesylate/Osimertinib

Cas:1421373-66-1

Min.Order:1 Kilogram

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Type:Other

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

AZD-9291 (Mesylate)

Cas:1421373-66-1

Min.Order:0

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

AZD-9291 (Mesylate) 1421373-66-1

Cas:1421373-66-1

Min.Order:0 Metric Ton

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Osimertinib mesylate 1421373-66-1

Cas:1421373-66-1

Min.Order:100 Milligram

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Type:Lab/Research institutions

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Hefei Zhaobo Technology Co., Ltd.

Osimertinib mesylate cas 1421373-66-1 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality c

Osimertinib mesylate cas 1421373-66-1

Cas:1421373-66-1

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

OSIMERTINIB MESYLATE

Cas:1421373-66-1

Min.Order:1 Gram

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Type:Lab/Research institutions

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Synthetic route

methanesulfonic acid
75-75-2

methanesulfonic acid

[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
1421373-65-0

[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Stage #1: [N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide] With pyrographite In acetone at 25 - 55℃;
Stage #2: methanesulfonic acid at 25 - 55℃;
96.73%
With N-ethyl-N,N-diisopropylamine In ethanol; ethyl acetate at 70℃; for 1.5h;94%
In water; acetone at 50℃; for 1.5h; Inert atmosphere;94%
4-fluoro-2-methoxy-5-nitro-phenylamine
1075705-01-9

4-fluoro-2-methoxy-5-nitro-phenylamine

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / 2.5 h / 105 °C
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
3.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux
4.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C
4.2: 10 h / 65 °C
5.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 5 steps
1: toluene-4-sulfonic acid / 2.5 h / 105 °C
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
3: iron; ammonium chloride / water; ethanol / 2 h / Reflux
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice
5: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 6 steps
1: toluene-4-sulfonic acid / 2.5 h / 105 °C
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
3: iron; ammonium chloride / water; ethanol / 2 h / Reflux
4: potassium carbonate / acetone / 0.5 h / -50 - -20 °C
5: triethylamine / acetonitrile / 6 h / 80 °C
6: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
N‑2‑[[2‑(dimethylamino)ethyl]methylamino]‑4‑methoxy‑5‑[[4‑(1‑methyl‑1H‑indole-3-yl)-2-pyrimidinyl]amino]aniline
1421372-66-8

N‑2‑[[2‑(dimethylamino)ethyl]methylamino]‑4‑methoxy‑5‑[[4‑(1‑methyl‑1H‑indole-3-yl)-2-pyrimidinyl]amino]aniline

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C
1.2: 10 h / 65 °C
2.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice
2: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / acetone / 0.5 h / -50 - -20 °C
2: triethylamine / acetonitrile / 6 h / 80 °C
3: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine
1421372-67-9

N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux
2.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C
2.2: 10 h / 65 °C
3.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 3 steps
1: iron; ammonium chloride / water; ethanol / 2 h / Reflux
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice
3: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 4 steps
1: iron; ammonium chloride / water; ethanol / 2 h / Reflux
2: potassium carbonate / acetone / 0.5 h / -50 - -20 °C
3: triethylamine / acetonitrile / 6 h / 80 °C
4: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indole-3-yl)-pyrimidine-2-amine
1421372-94-2

N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indole-3-yl)-pyrimidine-2-amine

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
2.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux
3.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C
3.2: 10 h / 65 °C
4.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
2: iron; ammonium chloride / water; ethanol / 2 h / Reflux
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice
4: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
2: iron; ammonium chloride / water; ethanol / 2 h / Reflux
3: potassium carbonate / acetone / 0.5 h / -50 - -20 °C
4: triethylamine / acetonitrile / 6 h / 80 °C
5: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
2-chloro-4-(1'-methyl-1H-indol-3-yl)pyrimidine
1032452-86-0

2-chloro-4-(1'-methyl-1H-indol-3-yl)pyrimidine

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / 2.5 h / 105 °C
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
3.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux
4.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C
4.2: 10 h / 65 °C
5.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 5 steps
1: toluene-4-sulfonic acid / 2.5 h / 105 °C
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
3: iron; ammonium chloride / water; ethanol / 2 h / Reflux
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice
5: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 6 steps
1: toluene-4-sulfonic acid / 2.5 h / 105 °C
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
3: iron; ammonium chloride / water; ethanol / 2 h / Reflux
4: potassium carbonate / acetone / 0.5 h / -50 - -20 °C
5: triethylamine / acetonitrile / 6 h / 80 °C
6: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
3-(2-chloro-pyrimidin-4-yl)-1H-indole
945016-63-7

3-(2-chloro-pyrimidin-4-yl)-1H-indole

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
1.2: 3 h / 0 °C
2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux
5.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C
5.2: 10 h / 65 °C
6.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
1.2: 3 h / 0 °C
2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice
6.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 7 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
1.2: 3 h / 0 °C
2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux
5.1: potassium carbonate / acetone / 0.5 h / -50 - -20 °C
6.1: triethylamine / acetonitrile / 6 h / 80 °C
7.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 3 h / 0 °C / Inert atmosphere
2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / 2,2,2-trifluoroethanol / 1 h / 140 °C / Inert atmosphere
4.1: ammonium chloride; iron / ethanol; water / 2 h / 100 °C / Inert atmosphere
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere
6.1: water; acetone / 1.5 h / 50 °C / Inert atmosphere
View Scheme
3-chloro-N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propanamide
1421373-36-5

3-chloro-N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propanamide

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / acetonitrile / 6 h / 80 °C
2: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / tetrahydrofuran; water / 10 h / 65 °C
2: water; ethanol / 1.5 h / 70 °C
View Scheme
indole
120-72-9

indole

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: methylmagnesium bromide / diethyl ether; 1,2-dichloro-ethane / 0.42 h / 0 °C / Inert atmosphere
1.2: 16 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
2.2: 3 h / 0 °C
3.1: toluene-4-sulfonic acid / 2.5 h / 105 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
5.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice
7.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 7 steps
1.1: methylmagnesium bromide / diethyl ether; 1,2-dichloro-ethane / 0.42 h / 0 °C / Inert atmosphere
1.2: 16 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
2.2: 3 h / 0 °C
3.1: toluene-4-sulfonic acid / 2.5 h / 105 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
5.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux
6.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C
6.2: 10 h / 65 °C
7.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 8 steps
1.1: methylmagnesium bromide / diethyl ether; 1,2-dichloro-ethane / 0.42 h / 0 °C / Inert atmosphere
1.2: 16 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
2.2: 3 h / 0 °C
3.1: toluene-4-sulfonic acid / 2.5 h / 105 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
5.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux
6.1: potassium carbonate / acetone / 0.5 h / -50 - -20 °C
7.1: triethylamine / acetonitrile / 6 h / 80 °C
8.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 7 steps
1.1: methylmagnesium bromide / diethyl ether; 1,2-dichloro-ethane / 0.25 h / 0 °C / Inert atmosphere
1.2: 16 h / 0 °C / Inert atmosphere; Heating
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2.2: 3 h / 0 °C / Inert atmosphere
3.1: toluene-4-sulfonic acid / 2.5 h / 105 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / 2,2,2-trifluoroethanol / 1 h / 140 °C / Inert atmosphere
5.1: ammonium chloride; iron / ethanol; water / 2 h / 100 °C / Inert atmosphere
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere
7.1: water; acetone / 1.5 h / 50 °C / Inert atmosphere
View Scheme
4-fluoro-2-methoxyaniline
450-91-9

4-fluoro-2-methoxyaniline

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sulfuric acid; potassium nitrate / 15 °C / Cooling with ice
2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux
5.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C
5.2: 10 h / 65 °C
6.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 6 steps
1: sulfuric acid; potassium nitrate / 15 °C / Cooling with ice
2: toluene-4-sulfonic acid / 2.5 h / 105 °C
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
4: iron; ammonium chloride / water; ethanol / 2 h / Reflux
5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice
6: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 7 steps
1: sulfuric acid; potassium nitrate / 15 °C / Cooling with ice
2: toluene-4-sulfonic acid / 2.5 h / 105 °C
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
4: iron; ammonium chloride / water; ethanol / 2 h / Reflux
5: potassium carbonate / acetone / 0.5 h / -50 - -20 °C
6: triethylamine / acetonitrile / 6 h / 80 °C
7: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
1-methylindole
603-76-9

1-methylindole

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: iron(III) chloride / 1,2-dimethoxyethane / 60 °C
2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux
5.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C
5.2: 10 h / 65 °C
6.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 6 steps
1: iron(III) chloride / 1,2-dimethoxyethane / 60 °C
2: toluene-4-sulfonic acid / 2.5 h / 105 °C
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
4: iron; ammonium chloride / water; ethanol / 2 h / Reflux
5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice
6: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 7 steps
1: iron(III) chloride / 1,2-dimethoxyethane / 60 °C
2: toluene-4-sulfonic acid / 2.5 h / 105 °C
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C
4: iron; ammonium chloride / water; ethanol / 2 h / Reflux
5: potassium carbonate / acetone / 0.5 h / -50 - -20 °C
6: triethylamine / acetonitrile / 6 h / 80 °C
7: N-ethyl-N,N-diisopropylamine / ethyl acetate; ethanol / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 6 steps
1.1: aluminum (III) chloride / 1,2-dimethoxyethane / 0.08 h / 20 °C / Inert atmosphere
1.2: 2 h / 80 °C / Inert atmosphere
2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / 2,2,2-trifluoroethanol / 1 h / 140 °C / Inert atmosphere
4.1: ammonium chloride; iron / ethanol; water / 2 h / 100 °C / Inert atmosphere
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere
6.1: water; acetone / 1.5 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1: cobalt(II) chloride; thionyl chloride / acetonitrile / 4 h / 60 °C
2: toluene-4-sulfonic acid / acetonitrile / 12 h / 85 °C
3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 2 h / 85 °C
4: ammonium chloride; cobalt(II) sulphate heptahydrate; hydrazine hydrate / ethanol; water / 8 h / 85 °C
5: sodium carbonate / N,N-dimethyl-formamide / 2 h / -5 °C
6: ethanol; isopropyl alcohol / 12 h / 45 °C
View Scheme
2-(4-fluoro-2-methoxy-5-nitrophenylamino)pyrimidin-4(3H)-one

2-(4-fluoro-2-methoxy-5-nitrophenylamino)pyrimidin-4(3H)-one

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium methylate / toluene / 12 h / 100 °C
2: hydrogen / ethanol / 5 h / 20 °C / 3750.38 Torr
3: trichlorophosphate / tetrahydrofuran / 12 h / 35 °C
4: potassium hydride / 1,2-dichloro-ethane / 8 h / 50 °C
5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 40 °C
6: dichloromethane / 4 h / 20 °C
View Scheme
2-(4-(N-(2-(dimethylamino)ethyl)-N-methylamino)-2-methoxy-5-nitrophenylamino) pyrimidine-4(3H)-one

2-(4-(N-(2-(dimethylamino)ethyl)-N-methylamino)-2-methoxy-5-nitrophenylamino) pyrimidine-4(3H)-one

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogen / ethanol / 5 h / 20 °C / 3750.38 Torr
2: trichlorophosphate / tetrahydrofuran / 12 h / 35 °C
3: potassium hydride / 1,2-dichloro-ethane / 8 h / 50 °C
4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 40 °C
5: dichloromethane / 4 h / 20 °C
View Scheme
2-(4-(N-(2-(dimethylamino)ethyl)-N-methylamino)-2-methoxy-5-aminophenylamino)pyrimidine-4(3H)-one

2-(4-(N-(2-(dimethylamino)ethyl)-N-methylamino)-2-methoxy-5-aminophenylamino)pyrimidine-4(3H)-one

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: trichlorophosphate / tetrahydrofuran / 12 h / 35 °C
2: potassium hydride / 1,2-dichloro-ethane / 8 h / 50 °C
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 40 °C
4: dichloromethane / 4 h / 20 °C
View Scheme
2-(4-(N-(2-(dimethylamino)ethyl)-N-methylamino)-2-methoxy-5-aminophenylamino)-4-chloropyrimidine

2-(4-(N-(2-(dimethylamino)ethyl)-N-methylamino)-2-methoxy-5-aminophenylamino)-4-chloropyrimidine

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium hydride / 1,2-dichloro-ethane / 8 h / 50 °C
2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 40 °C
3: dichloromethane / 4 h / 20 °C
View Scheme
3-(2-aminopyrimidin-4-yl)-1-methyl-1H-indole
199865-36-6

3-(2-aminopyrimidin-4-yl)-1-methyl-1H-indole

methanesulfonic acid
75-75-2

methanesulfonic acid

1-methoxy-2-nitro-5-[(N-(dimethylamino)ethyl)-Ν-methylamino]-4-cinnamamide

1-methoxy-2-nitro-5-[(N-(dimethylamino)ethyl)-Ν-methylamino]-4-cinnamamide

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Stage #1: 3-(2-aminopyrimidin-4-yl)-1-methyl-1H-indole; 1-methoxy-2-nitro-5-[(N-(dimethylamino)ethyl)-Ν-methylamino]-4-cinnamamide With diammonium sulfide In isopropyl alcohol
Stage #2: methanesulfonic acid
18.5 g
4-Chloro-3-nitroaniline
635-22-3

4-Chloro-3-nitroaniline

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium iodide / 55 °C / Alkaline conditions
2: bromine; iron; acetic acid
3: Alkaline conditions
4: diammonium sulfide / isopropyl alcohol
View Scheme
N-(4-methoxy-3-nitrophenyl) acrylamide

N-(4-methoxy-3-nitrophenyl) acrylamide

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: bromine; iron; acetic acid
2: Alkaline conditions
3: diammonium sulfide / isopropyl alcohol
View Scheme
1-methoxy-2-nitro-4-acrylamido-5-bromobenzene

1-methoxy-2-nitro-4-acrylamido-5-bromobenzene

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Alkaline conditions
2: diammonium sulfide / isopropyl alcohol
View Scheme
methanesulfonic acid
75-75-2

methanesulfonic acid

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
1421373-66-1

N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate

N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methyl-indol-3-yl)pyrimidine 2-yl]amino}phenyl)prop-2-enamide dimesylate

N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methyl-indol-3-yl)pyrimidine 2-yl]amino}phenyl)prop-2-enamide dimesylate

Conditions
ConditionsYield
In ethanol; water at 60℃; for 14.75h;

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