Name: Mereletinib Alias: N-[2-[[2-(dimethylamino) ethyl] methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indole-3-yl) -2-pyrimidinyl] amino] phenyl]-2-acrylamide; AZD-9291; AZD9291; AZD9291; free base; AZD9291; Ostinib; Oxitin
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inquiryItems Specifications Results Appearance off-white crystalline powder Conforms Identification
LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White crystalline powder Storage:Refrigerator Package:50g/bot
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inquiryOsimertinib CAS No.:1421373-65-0 Name: Osimertinib Molecular Structure: Molecular Formula: C28H33N7O2 Molecular Weight: 499.61 CAS Registry Number: 1421373-65-0 Appearance:d
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryDayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Near 20 years DayangChem has provided dif
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inquirychengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct Name AZD-9291 Synonyms AZD9291, >=98%;AZD9291 (free base);Osimertinib (AZD-9291);ZAD9291;AZD9291, Osimertinib;AZD9291 Base;Osimertinib Base;N-(2-{[2-(Dimethylamino)ethyl](methyl)amino}-4-meth
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Beluga chemical professional supply High Quality AZD-9291 CAS 1421373-65-0 Why choose Beluga chemical 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabili
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By Se
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:1421373-65-0
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inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:1421373-65-0
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
N‑2‑[[2‑(dimethylamino)ethyl]methylamino]‑4‑methoxy‑5‑[[4‑(1‑methyl‑1H‑indole-3-yl)-2-pyrimidinyl]amino]aniline
acrylic acid
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
In isopropyl alcohol at 35℃; for 4h; Temperature; Time; Solvent; Molecular sieve; Microwave irradiation; | 97.9% |
In isopropyl alcohol at 35℃; for 4h; Solvent; Temperature; Molecular sieve; Microwave irradiation; | 97.9% |
In ethanol; Petroleum ether at 55 - 60℃; for 8h; Time; Reflux; Molecular sieve; | 95.3% |
Stage #1: acrylic acid With lithium carbonate; methanesulfonyl chloride In acetonitrile at 10℃; for 1.5h; Stage #2: N‑2‑[[2‑(dimethylamino)ethyl]methylamino]‑4‑methoxy‑5‑[[4‑(1‑methyl‑1H‑indole-3-yl)-2-pyrimidinyl]amino]aniline In acetonitrile at 0℃; Reagent/catalyst; Solvent; Temperature; | 92.2% |
N‑2‑[[2‑(dimethylamino)ethyl]methylamino]‑4‑methoxy‑5‑[[4‑(1‑methyl‑1H‑indole-3-yl)-2-pyrimidinyl]amino]aniline
acryloyl chloride
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
With sodium carbonate In N,N-dimethyl-formamide at -5℃; for 2h; Temperature; Solvent; | 95.5% |
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 40℃; for 12h; Solvent; Reagent/catalyst; Temperature; | 88% |
With triethylamine In ethyl acetate at 5 - 10℃; Inert atmosphere; | 86.37% |
N‑2‑[[2‑(dimethylamino)ethyl]methylamino]‑4‑methoxy‑5‑[[4‑(1‑methyl‑1H‑indole-3-yl)-2-pyrimidinyl]amino]aniline
2-chloropropionyl chloride
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Stage #1: N‑2‑[[2‑(dimethylamino)ethyl]methylamino]‑4‑methoxy‑5‑[[4‑(1‑methyl‑1H‑indole-3-yl)-2-pyrimidinyl]amino]aniline; 2-chloropropionyl chloride With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; water at 0 - 20℃; for 0.25h; Stage #2: With sodium hydroxide In tetrahydrofuran; water at 65℃; for 10h; | 94% |
Stage #1: N‑2‑[[2‑(dimethylamino)ethyl]methylamino]‑4‑methoxy‑5‑[[4‑(1‑methyl‑1H‑indole-3-yl)-2-pyrimidinyl]amino]aniline; 2-chloropropionyl chloride In tetrahydrofuran; water at 20℃; for 0.25h; Stage #2: With sodium hydroxide In tetrahydrofuran; water at 65℃; for 10h; | 94% |
Stage #1: N‑2‑[[2‑(dimethylamino)ethyl]methylamino]‑4‑methoxy‑5‑[[4‑(1‑methyl‑1H‑indole-3-yl)-2-pyrimidinyl]amino]aniline; 2-chloropropionyl chloride In tetrahydrofuran at 0 - 20℃; for 0.25h; Stage #2: With sodium hydroxide In tetrahydrofuran at 65℃; for 10h; | 94% |
Stage #1: N‑2‑[[2‑(dimethylamino)ethyl]methylamino]‑4‑methoxy‑5‑[[4‑(1‑methyl‑1H‑indole-3-yl)-2-pyrimidinyl]amino]aniline; 2-chloropropionyl chloride In tetrahydrofuran; water at 0 - 28℃; for 1h; Stage #2: With sodium hydroxide In tetrahydrofuran; water for 8h; Reflux; | 79.6% |
Stage #1: N‑2‑[[2‑(dimethylamino)ethyl]methylamino]‑4‑methoxy‑5‑[[4‑(1‑methyl‑1H‑indole-3-yl)-2-pyrimidinyl]amino]aniline; 2-chloropropionyl chloride In water; acetone at -3 - 30℃; for 1.5h; Stage #2: With triethylamine In water; acetone at 25 - 60℃; | 77.14% |
3-chloro-N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propanamide
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 80℃; for 6h; | 94% |
With sodium hydroxide In tetrahydrofuran; water at 65℃; for 10h; | 94% |
Stage #1: 3-chloro-N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propanamide With triethylamine In acetonitrile at 80℃; for 6h; Stage #2: With water at 20℃; for 12h; | 94% |
2-chloro-4-(1'-methyl-1H-indol-3-yl)pyrimidine
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In 2-methyl-propan-1-ol at 55℃; for 5h; | 93% |
With toluene-4-sulfonic acid In butan-1-ol at 40℃; for 2.5h; | 92% |
With potassium carbonate In N,N-dimethyl-formamide at 20 - 80℃; for 7h; Reagent/catalyst; Time; | 75.5% |
(2E)-3-(dimethylamino)-1-(1-methyl-1H-indol-3-yl)-2-propen-1-one
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
With sodium hydroxide In butan-1-ol at 90 - 105℃; | 91% |
N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine
acrylic acid
acryloyl chloride
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Stage #1: N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 20 - 50℃; Stage #2: acrylic acid; acryloyl chloride With N-ethyl-N,N-diisopropylamine at 20℃; | 72.1% |
acrylic acid anhydride
N‑2‑[[2‑(dimethylamino)ethyl]methylamino]‑4‑methoxy‑5‑[[4‑(1‑methyl‑1H‑indole-3-yl)-2-pyrimidinyl]amino]aniline
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 5℃; for 2h; | 62% |
N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine
acrylic acid
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Stage #1: N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine With 5%-palladium/activated carbon; hydrogen In tetrahydrofuran at 20℃; for 2h; Stage #2: acrylic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine at 20℃; for 4h; Inert atmosphere; | 61% |
4-fluoro-2-methoxy-5-nitro-phenylamine
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 3.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 4.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 4.2: 10 h / 65 °C View Scheme | |
Multi-step reaction with 4 steps 1: toluene-4-sulfonic acid / 2.5 h / 105 °C 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 3: iron; ammonium chloride / water; ethanol / 2 h / Reflux 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice View Scheme | |
Multi-step reaction with 5 steps 1: toluene-4-sulfonic acid / 2.5 h / 105 °C 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 3: iron; ammonium chloride / water; ethanol / 2 h / Reflux 4: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 5: triethylamine / acetonitrile / 6 h / 80 °C View Scheme |
N‑2‑[[2‑(dimethylamino)ethyl]methylamino]‑4‑methoxy‑5‑[[4‑(1‑methyl‑1H‑indole-3-yl)-2-pyrimidinyl]amino]aniline
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 2: triethylamine / acetonitrile / 6 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: tetrahydrofuran; water / 0.25 h / 20 °C 2: sodium hydroxide / tetrahydrofuran; water / 10 h / 65 °C View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / tetrahydrofuran; water / 0 - 30 °C / Large scale 2: triethylamine / acetonitrile / 80 °C / Large scale View Scheme |
N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 2.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 2.2: 10 h / 65 °C View Scheme | |
Multi-step reaction with 2 steps 1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice View Scheme | |
Multi-step reaction with 3 steps 1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 2: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 3: triethylamine / acetonitrile / 6 h / 80 °C View Scheme |
N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indole-3-yl)-pyrimidine-2-amine
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 2.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 3.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 3.2: 10 h / 65 °C View Scheme | |
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 2: iron; ammonium chloride / water; ethanol / 2 h / Reflux 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice View Scheme | |
Multi-step reaction with 4 steps 1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 2: iron; ammonium chloride / water; ethanol / 2 h / Reflux 3: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 4: triethylamine / acetonitrile / 6 h / 80 °C View Scheme |
2-chloro-4-(1'-methyl-1H-indol-3-yl)pyrimidine
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 3.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 4.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 4.2: 10 h / 65 °C View Scheme | |
Multi-step reaction with 4 steps 1: toluene-4-sulfonic acid / 2.5 h / 105 °C 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 3: iron; ammonium chloride / water; ethanol / 2 h / Reflux 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice View Scheme | |
Multi-step reaction with 5 steps 1: toluene-4-sulfonic acid / 2.5 h / 105 °C 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 3: iron; ammonium chloride / water; ethanol / 2 h / Reflux 4: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 5: triethylamine / acetonitrile / 6 h / 80 °C View Scheme |
3-(2-chloro-pyrimidin-4-yl)-1H-indole
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C 1.2: 3 h / 0 °C 2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 5.2: 10 h / 65 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C 1.2: 3 h / 0 °C 2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice View Scheme | |
Multi-step reaction with 6 steps 1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C 1.2: 3 h / 0 °C 2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5.1: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 6.1: triethylamine / acetonitrile / 6 h / 80 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 1.2: 3 h / 0 °C / Inert atmosphere 2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C / Inert atmosphere 3.1: N-ethyl-N,N-diisopropylamine / 2,2,2-trifluoroethanol / 1 h / 140 °C / Inert atmosphere 4.1: ammonium chloride; iron / ethanol; water / 2 h / 100 °C / Inert atmosphere 5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere View Scheme |
indole
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: methylmagnesium bromide / diethyl ether; 1,2-dichloro-ethane / 0.42 h / 0 °C / Inert atmosphere 1.2: 16 h / 0 - 20 °C / Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C 2.2: 3 h / 0 °C 3.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 5.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 6.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 6.2: 10 h / 65 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: methylmagnesium bromide / diethyl ether; 1,2-dichloro-ethane / 0.42 h / 0 °C / Inert atmosphere 1.2: 16 h / 0 - 20 °C / Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C 2.2: 3 h / 0 °C 3.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 5.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice View Scheme | |
Multi-step reaction with 7 steps 1.1: methylmagnesium bromide / diethyl ether; 1,2-dichloro-ethane / 0.42 h / 0 °C / Inert atmosphere 1.2: 16 h / 0 - 20 °C / Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C 2.2: 3 h / 0 °C 3.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 5.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 6.1: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 7.1: triethylamine / acetonitrile / 6 h / 80 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: methylmagnesium bromide / diethyl ether; 1,2-dichloro-ethane / 0.25 h / 0 °C / Inert atmosphere 1.2: 16 h / 0 °C / Inert atmosphere; Heating 2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 2.2: 3 h / 0 °C / Inert atmosphere 3.1: toluene-4-sulfonic acid / 2.5 h / 105 °C / Inert atmosphere 4.1: N-ethyl-N,N-diisopropylamine / 2,2,2-trifluoroethanol / 1 h / 140 °C / Inert atmosphere 5.1: ammonium chloride; iron / ethanol; water / 2 h / 100 °C / Inert atmosphere 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere View Scheme |
4-fluoro-2-methoxyaniline
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sulfuric acid; potassium nitrate / 15 °C / Cooling with ice 2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 5.2: 10 h / 65 °C View Scheme | |
Multi-step reaction with 5 steps 1: sulfuric acid; potassium nitrate / 15 °C / Cooling with ice 2: toluene-4-sulfonic acid / 2.5 h / 105 °C 3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice View Scheme | |
Multi-step reaction with 6 steps 1: sulfuric acid; potassium nitrate / 15 °C / Cooling with ice 2: toluene-4-sulfonic acid / 2.5 h / 105 °C 3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 6: triethylamine / acetonitrile / 6 h / 80 °C View Scheme |
1-methylindole
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: iron(III) chloride / 1,2-dimethoxyethane / 60 °C 2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5.1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0.25 h / 0 - 20 °C 5.2: 10 h / 65 °C View Scheme | |
Multi-step reaction with 5 steps 1: iron(III) chloride / 1,2-dimethoxyethane / 60 °C 2: toluene-4-sulfonic acid / 2.5 h / 105 °C 3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / Cooling with ice View Scheme | |
Multi-step reaction with 6 steps 1: iron(III) chloride / 1,2-dimethoxyethane / 60 °C 2: toluene-4-sulfonic acid / 2.5 h / 105 °C 3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 85 °C 4: iron; ammonium chloride / water; ethanol / 2 h / Reflux 5: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 6: triethylamine / acetonitrile / 6 h / 80 °C View Scheme |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 2 h / 60 °C 2: palladium on activated charcoal; hydrogen / methanol / 20 °C 3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 °C 4: hydrogenchloride; methanol / 20 h / 20 °C 5: toluene-4-sulfonic acid / butan-1-ol / 2.5 h / 40 °C View Scheme | |
Multi-step reaction with 4 steps 1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 2 h / 45 °C / Inert atmosphere 2: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C 3: hydrogenchloride / 1,4-dioxane; water / 10 h / 0 - 20 °C / Inert atmosphere 4: toluene-4-sulfonic acid / 2-methyl-propan-1-ol / 5 h / 55 °C View Scheme |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: palladium on activated charcoal; hydrogen / methanol / 20 °C 2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 °C 3: hydrogenchloride; methanol / 20 h / 20 °C 4: toluene-4-sulfonic acid / butan-1-ol / 2.5 h / 40 °C View Scheme | |
Multi-step reaction with 3 steps 1: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C 2: hydrogenchloride / 1,4-dioxane; water / 10 h / 0 - 20 °C / Inert atmosphere 3: toluene-4-sulfonic acid / 2-methyl-propan-1-ol / 5 h / 55 °C View Scheme |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 °C 2: hydrogenchloride; methanol / 20 h / 20 °C 3: toluene-4-sulfonic acid / butan-1-ol / 2.5 h / 40 °C View Scheme |
4-fluoro-2-methoxy-1-nitrobenzene
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: palladium on activated charcoal; hydrogen / 20 °C 2: nitric acid; sulfuric acid / 0 - 5 °C 3: dichloromethane 4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 2 h / 60 °C 5: palladium on activated charcoal; hydrogen / methanol / 20 °C 6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 °C 7: hydrogenchloride; methanol / 20 h / 20 °C 8: toluene-4-sulfonic acid / butan-1-ol / 2.5 h / 40 °C View Scheme | |
Multi-step reaction with 7 steps 1: hydrogen / methanol / 12 h / 20 °C / 1140.08 Torr 2: potassium nitrate; sulfuric acid / 2 h / 5 - 20 °C 3: hydrogenchloride / ethanol; water / 24 h / Reflux 4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 100 °C 5: butan-1-ol / 24 h / 135 °C 6: hydrogen / tetrahydrofuran / 12 h / 20 °C / 2280.15 Torr 7: N-ethyl-N,N-diisopropylamine / chloroform / 2 h / 5 - 15 °C View Scheme | |
Multi-step reaction with 7 steps 1: hydrogen / methanol / 12 h / 15 - 26 °C / 836.06 Torr 2: sulfuric acid; potassium nitrate / 2 h / 0 - 25 °C 3: hydrogenchloride / ethanol; water / 24.5 h / 2280.15 Torr / Reflux 4: N,N-dimethyl acetamide / 12 h / 90 °C 5: butan-1-ol / 24 h / 135 °C 6: hydrogen / tetrahydrofuran / 12 h / 25 °C / 2280.15 Torr 7: N-ethyl-N,N-diisopropylamine / chloroform / 2 h / 5 - 15 °C View Scheme |
2-fluoro-4-(methoxy)aniline
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Cooling with ice 2: N,N-dimethyl acetamide / 20 - 95 °C 3: sulfuric acid; potassium nitrate / 12 h / 5 - 20 °C 4: hydrogen; palladium 10% on activated carbon / ethanol / 20 °C 5: hydrogenchloride / water; butan-1-ol / 80 - 90 °C 6: sodium hydroxide / butan-1-ol / 90 - 105 °C View Scheme |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: N,N-dimethyl acetamide / 20 - 95 °C 2: sulfuric acid; potassium nitrate / 12 h / 5 - 20 °C 3: hydrogen; palladium 10% on activated carbon / ethanol / 20 °C 4: hydrogenchloride / water; butan-1-ol / 80 - 90 °C 5: sodium hydroxide / butan-1-ol / 90 - 105 °C View Scheme |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid; potassium nitrate / 12 h / 5 - 20 °C 2: hydrogen; palladium 10% on activated carbon / ethanol / 20 °C 3: hydrogenchloride / water; butan-1-ol / 80 - 90 °C 4: sodium hydroxide / butan-1-ol / 90 - 105 °C View Scheme |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogen; palladium 10% on activated carbon / ethanol / 20 °C 2: hydrogenchloride / water; butan-1-ol / 80 - 90 °C 3: sodium hydroxide / butan-1-ol / 90 - 105 °C View Scheme |
N,N',N'-trimethylenediamine
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 6 h / 85 °C 2.1: iron; ammonium chloride / ethanol; water / 2 h / Reflux 3.1: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 3.2: 4 h / 20 °C 4.1: 5%-palladium/activated carbon; hydrogen / methanol / 12 h / 20 °C / 3800.26 Torr 5.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 20 - 80 °C View Scheme | |
Multi-step reaction with 4 steps 1: potassium carbonate / acetonitrile / 80 °C / Inert atmosphere 2: p-toluenesulfonic acid monohydrate / isopropyl alcohol / Reflux 3: hydrogen / ethyl acetate / 40 °C / 15001.5 Torr / Autoclave 4: triethylamine / ethyl acetate / 5 - 10 °C / Inert atmosphere View Scheme |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 6 h / 85 °C 2.1: iron; ammonium chloride / ethanol; water / 2 h / Reflux 3.1: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 3.2: 4 h / 20 °C 4.1: 5%-palladium/activated carbon; hydrogen / methanol / 12 h / 20 °C / 3800.26 Torr 5.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 20 - 80 °C View Scheme |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: iron; ammonium chloride / ethanol; water / 2 h / Reflux 2.1: potassium carbonate / acetone / 0.5 h / -50 - -20 °C 2.2: 4 h / 20 °C 3.1: 5%-palladium/activated carbon; hydrogen / methanol / 12 h / 20 °C / 3800.26 Torr 4.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 20 - 80 °C View Scheme |
methanesulfonic acid
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate
Conditions | Yield |
---|---|
Stage #1: [N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide] With pyrographite In acetone at 25 - 55℃; Stage #2: methanesulfonic acid at 25 - 55℃; | 96.73% |
With N-ethyl-N,N-diisopropylamine In ethanol; ethyl acetate at 70℃; for 1.5h; | 94% |
In water; acetone at 50℃; for 1.5h; Inert atmosphere; | 94% |
methanesulfonic acid
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
In ethanol; ethyl acetate for 2h; Time; Reflux; | 94.6% |
malonic acid
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
In water; acetone at 20℃; for 0.5h; | 86% |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0℃; for 0.5h; | 85% |
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 0.5h; |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
With sulfuric acid In water; acetone at 20℃; for 0.5h; | 84% |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
(2E)-but-2-enedioic acid
Conditions | Yield |
---|---|
In water; acetone at 20℃; for 0.5h; | 84% |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
citric acid
Conditions | Yield |
---|---|
In water; acetone at 20℃; for 0.5h; Solvent; | 81% |
LACTIC ACID
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
In water; acetone at 20℃; for 0.5h; | 81% |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
maleic acid
Conditions | Yield |
---|---|
In water; acetone at 20℃; for 0.5h; | 81% |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
1-bromo-3-propanol
Conditions | Yield |
---|---|
Stage #1: [N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide] With potassium carbonate In acetonitrile for 0.5h; Stage #2: 1-bromo-3-propanol In acetonitrile for 12h; Reflux; | 78.9% |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
tartaric acid
Conditions | Yield |
---|---|
In water; acetone at 20℃; for 0.5h; Solvent; Concentration; | 77% |
gluconic acid
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
In water; acetone at 20℃; for 0.5h; | 77% |
succinic acid
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
Conditions | Yield |
---|---|
In water; acetone at 20℃; for 0.5h; | 76% |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
dimethyl amine
Conditions | Yield |
---|---|
In ethanol at 20℃; for 0.5h; | 73.38% |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
toluene-4-sulfonic acid
Conditions | Yield |
---|---|
In water; acetone at 20℃; for 0.5h; | 60% |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
acetic acid
Conditions | Yield |
---|---|
In water; acetone at 20℃; for 0.5h; Solvent; | 52% |
[N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide]
acrylic acid
Conditions | Yield |
---|---|
In water at 40℃; for 2h; | 23% |
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