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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Cephalothin Manufacturer/High quality/Best price/In stock

Cas:153-61-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Cephalotin Acid supplier in China

Cas:153-61-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Cefalotin

Cas:153-61-7

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Cephalothin (base and/or unspecified salts)

Cas:153-61-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

TIANFUCHEM--153-61-7---C16H16N2O6S2

Cas:153-61-7

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 153-61-7 with best quality

Cas:153-61-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Qingdao Beluga Import and Export Co., LTD

Cephalothin CAS:153-61-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Cephalothin CAS:153-61-7

Cas:153-61-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c

Cephalothin

Cas:153-61-7

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Cephalotin acid

Cas:153-61-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

afine-CEFALOTHIN ACID

Cas:153-61-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

Cephalothin CAS 153-61-7

Cas:153-61-7

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

BEST PRICE/Cephalothin CAS NO.153-61-7

Cas:153-61-7

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Cephalothin

Cas:153-61-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Cephalothin 100g

Cas:153-61-7

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Cephalotin Acid

Cas:153-61-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

BOC Sciences

BOC Sciences is committed to supplying cost-effective products and services. We provide Cefalonium Impurity A. A first generation cephalosporin antibiotic with a wide range antibacterial activity. It is effective against gram-positive and gram-nega

Cefalonium Impurity A

Cas:153-61-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Cephalothin

Cas:153-61-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

Cephalothin

Cas:153-61-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

TIANFU-CHEM (6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acidAppearance:white powder Storage:room temperature Package:200KG Application:Industrial Grade Transportation:By sea , by ai

Hangzhou Huarong Pharm Co., Ltd.

High qualityAppearance:White powder Storage:Room temperature Package:Aluminum bag Application:Used in producing API Transportation:By air Port:Beijing

Cephalotin

Cas:153-61-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

CEPHALOTHIN CAS No.153-61-7

Cas:153-61-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

2-thienylacetic acid chloride
39098-97-0

2-thienylacetic acid chloride

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
Stage #1: 7-Aminocephalosporanic acid With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane at 25 - 30℃; Inert atmosphere;
Stage #2: 2-thienylacetic acid chloride In dichloromethane at 10℃; for 1h; Temperature; Solvent; Reagent/catalyst; Inert atmosphere;
92%
With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile Inert atmosphere;85%
With tetrabutylammomium bromide; sodium hydrogencarbonate In dichloromethane; water at -5 - 0℃; Temperature;
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 30℃; for 2h; Time; Reagent/catalyst; Green chemistry;85%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

1-methanesulfonyloxy-1,2,3-benzotriazole
54769-22-1

1-methanesulfonyloxy-1,2,3-benzotriazole

3-acetoxymethyl-7-aminoceph-3-em-4-carboxylic acid

3-acetoxymethyl-7-aminoceph-3-em-4-carboxylic acid

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
With sodium acetate; acetic acid; triethylamine In dichloromethane70%
3-(trimethylsiloxy)-8-oxo-7-(2-(2-thienyl) acetamido)-5-thiazabicyclo [4.2.0]Carboxylic acid
80927-95-3

3-(trimethylsiloxy)-8-oxo-7-(2-(2-thienyl) acetamido)-5-thiazabicyclo [4.2.0]Carboxylic acid

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
With water; hydrogen cation Yield given;
2,2,2-trichloroethyl (6R,7R)-3-acetoxymethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate
5317-29-3

2,2,2-trichloroethyl (6R,7R)-3-acetoxymethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
With Deacidite FF ion-exchange resin; zinc(II) chloride; zinc 1.) formic acid, RT, 5 h; Multistep reaction;
acetic acid
64-19-7

acetic acid

5-Methylene-2-[propylcarbamoyl-(2-thiophen-2-yl-acetylamino)-methyl]-5,6-dihydro-2H-[1,3]thiazine-4-carboxylic acid

5-Methylene-2-[propylcarbamoyl-(2-thiophen-2-yl-acetylamino)-methyl]-5,6-dihydro-2H-[1,3]thiazine-4-carboxylic acid

A

propylamine
107-10-8

propylamine

B

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
With potassium chloride In water at 30℃; Equilibrium constant;
2-thienylacetic acid chloride
39098-97-0

2-thienylacetic acid chloride

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / ethylene oxide / CH2Cl2 / 0.07 h
2: 68 percent / acetic acid / dimethylformamide / 3 h / 22 °C
3: 65 percent / potassium iodide, acetyl chloride / acetic acid / 0.17 h / 20 °C
4: 1.) Zn, ZnCl2; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, RT, 5 h
View Scheme
Multi-step reaction with 5 steps
1: 1.) phosphorus oxychloride; 2.) dimethylacetamide / 1.) MeOH, 45-55 deg C; 2.) CH2Cl2, 0-5 deg C, 45 min
2: 66 percent / sodium iodide / acetone / 1.5 h
3: 50 percent / acetic acid / dimethylformamide / 3 h / 22 °C
4: 65 percent / potassium iodide, acetyl chloride / acetic acid / 0.17 h / 20 °C
5: 1.) Zn, ZnCl2; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, RT, 5 h
View Scheme
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 46.3 percent / N,N'-dicyclohexylcarbodiimide / CH2Cl2 / 1 h / 20 °C
2: 66 percent / sodium iodide / acetone / 1.5 h
3: 50 percent / acetic acid / dimethylformamide / 3 h / 22 °C
4: 65 percent / potassium iodide, acetyl chloride / acetic acid / 0.17 h / 20 °C
5: 1.) Zn, ZnCl2; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, RT, 5 h
View Scheme
2,2,2-trichloroethyl (1S,6R,7R)-3-chloromethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide
85904-87-6

2,2,2-trichloroethyl (1S,6R,7R)-3-chloromethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 66 percent / sodium iodide / acetone / 1.5 h
2: 50 percent / acetic acid / dimethylformamide / 3 h / 22 °C
3: 65 percent / potassium iodide, acetyl chloride / acetic acid / 0.17 h / 20 °C
4: 1.) Zn, ZnCl2; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, RT, 5 h
View Scheme
2,2,2-trichloroethyl (1S,6R,7R)-3-bromomethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide
33492-83-0

2,2,2-trichloroethyl (1S,6R,7R)-3-bromomethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 68 percent / acetic acid / dimethylformamide / 3 h / 22 °C
2: 65 percent / potassium iodide, acetyl chloride / acetic acid / 0.17 h / 20 °C
3: 1.) Zn, ZnCl2; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, RT, 5 h
View Scheme
2,2,2-trichloroethyl (1S,6R,7R)-3-iodomethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide
33465-64-4

2,2,2-trichloroethyl (1S,6R,7R)-3-iodomethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 50 percent / acetic acid / dimethylformamide / 3 h / 22 °C
2: 65 percent / potassium iodide, acetyl chloride / acetic acid / 0.17 h / 20 °C
3: 1.) Zn, ZnCl2; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, RT, 5 h
View Scheme
2,2,2-trichloroethyl (1S,6R,7R)-3-acetoxymethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide
33492-84-1

2,2,2-trichloroethyl (1S,6R,7R)-3-acetoxymethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 65 percent / potassium iodide, acetyl chloride / acetic acid / 0.17 h / 20 °C
2: 1.) Zn, ZnCl2; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, RT, 5 h
View Scheme
2,2,2-trichloroethyl (1S,6R,7R)-7-amino-3-bromomethylceph-3-em-4-carboxylate 1-oxide hydrobromide
85904-86-5

2,2,2-trichloroethyl (1S,6R,7R)-7-amino-3-bromomethylceph-3-em-4-carboxylate 1-oxide hydrobromide

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / ethylene oxide / CH2Cl2 / 0.07 h
2: 68 percent / acetic acid / dimethylformamide / 3 h / 22 °C
3: 65 percent / potassium iodide, acetyl chloride / acetic acid / 0.17 h / 20 °C
4: 1.) Zn, ZnCl2; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, RT, 5 h
View Scheme
2,2,2-trichloroethyl (1S,6R,7R)-7-amino-3-chloromethylceph-3-em-4-carboxylate 1-oxide
85904-84-3

2,2,2-trichloroethyl (1S,6R,7R)-7-amino-3-chloromethylceph-3-em-4-carboxylate 1-oxide

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 46.3 percent / N,N'-dicyclohexylcarbodiimide / CH2Cl2 / 1 h / 20 °C
2: 66 percent / sodium iodide / acetone / 1.5 h
3: 50 percent / acetic acid / dimethylformamide / 3 h / 22 °C
4: 65 percent / potassium iodide, acetyl chloride / acetic acid / 0.17 h / 20 °C
5: 1.) Zn, ZnCl2; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, RT, 5 h
View Scheme
2,2,2-trichloroethyl (1S,6R,7R)-3-bromomethyl-7-formamidoceph-3-em-4-carboxylate 1-oxide
33465-56-4

2,2,2-trichloroethyl (1S,6R,7R)-3-bromomethyl-7-formamidoceph-3-em-4-carboxylate 1-oxide

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.) phosphorus oxychloride; 2.) dimethylacetamide / 1.) MeOH, 45-55 deg C; 2.) CH2Cl2, 0-5 deg C, 45 min
2: 66 percent / sodium iodide / acetone / 1.5 h
3: 50 percent / acetic acid / dimethylformamide / 3 h / 22 °C
4: 65 percent / potassium iodide, acetyl chloride / acetic acid / 0.17 h / 20 °C
5: 1.) Zn, ZnCl2; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, RT, 5 h
View Scheme
Multi-step reaction with 4 steps
1: 1.) phosphorus oxychloride; 2.) dimethylacetamide / 1.) MeOH, 45-55 deg C; 2.) CH2Cl2, 0-5 deg C, 45 min
2: 68 percent / acetic acid / dimethylformamide / 3 h / 22 °C
3: 65 percent / potassium iodide, acetyl chloride / acetic acid / 0.17 h / 20 °C
4: 1.) Zn, ZnCl2; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, RT, 5 h
View Scheme
Multi-step reaction with 5 steps
1: 98 percent / phosphorus tribromide / methanol; diethyl ether / 1.17 h / 0 - 10 °C
2: 92 percent / ethylene oxide / CH2Cl2 / 0.07 h
3: 68 percent / acetic acid / dimethylformamide / 3 h / 22 °C
4: 65 percent / potassium iodide, acetyl chloride / acetic acid / 0.17 h / 20 °C
5: 1.) Zn, ZnCl2; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, RT, 5 h
View Scheme
Multi-step reaction with 6 steps
1: 46.2 percent / conc. hydrochloric acid / tetrahydrofuran / 30 h / 6 °C
2: 46.3 percent / N,N'-dicyclohexylcarbodiimide / CH2Cl2 / 1 h / 20 °C
3: 66 percent / sodium iodide / acetone / 1.5 h
4: 50 percent / acetic acid / dimethylformamide / 3 h / 22 °C
5: 65 percent / potassium iodide, acetyl chloride / acetic acid / 0.17 h / 20 °C
6: 1.) Zn, ZnCl2; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, RT, 5 h
View Scheme
p-methoxybenzyl 7β-(2-thienylacetamido)-3-(acetoxymethyl)-3-cephem-4-carboxylate
52646-45-4

p-methoxybenzyl 7β-(2-thienylacetamido)-3-(acetoxymethyl)-3-cephem-4-carboxylate

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CH2Cl2 / 0.25 h / 20 °C
2: H2O, H(1+)
View Scheme
(6R,7R)-3-Acetoxymethyl-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methyl-benzyl ester
80927-93-1

(6R,7R)-3-Acetoxymethyl-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methyl-benzyl ester

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CDCl3 / 0.25 h / 20 °C
2: H2O, H(1+)
View Scheme
(6R,7R)-3-Acetoxymethyl-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2-methyl-benzyl ester
80927-92-0

(6R,7R)-3-Acetoxymethyl-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2-methyl-benzyl ester

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CDCl3 / 0.25 h / 20 °C
2: H2O, H(1+)
View Scheme
(6R)-3-acetoxymethyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
35607-83-1

(6R)-3-acetoxymethyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CH2Cl2 / 0.25 h / 20 °C
2: H2O, H(1+)
View Scheme
2-thienylacetic acid chloride
39098-97-0

2-thienylacetic acid chloride

2-diethylamino-1,3,2-dioxaphospholane
3741-34-2

2-diethylamino-1,3,2-dioxaphospholane

3-acetoxymethyl-7-aminoceph-3-em-4-carboxylic acid

3-acetoxymethyl-7-aminoceph-3-em-4-carboxylic acid

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
With sodium hydroxide; chloro-trimethyl-silane In water; ethyl acetate; acetonitrile
2-thienylacetic acid chloride
39098-97-0

2-thienylacetic acid chloride

2-chloro-[1,3,2]dioxaborolane
1192-03-6

2-chloro-[1,3,2]dioxaborolane

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
With sodium hydrogencarbonate; triethylamine In dichloromethane; water; acetone
methyl 2-thiopheneacetate
19432-68-9

methyl 2-thiopheneacetate

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
With ammonium hydroxide; penicillin G amidase In water at 20℃; pH=6.5 - 7; Enzymatic reaction;
2-thiopheneacetyl N-hydroxysuccinimide ester
93799-48-5

2-thiopheneacetyl N-hydroxysuccinimide ester

7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

cephalothin
153-61-7

cephalothin

Conditions
ConditionsYield
In 1,2-dimethoxyethane at 15 - 25℃; for 1h; Solvent; Temperature; Concentration; Irradiation;154 g
pyrographite
7440-44-0

pyrographite

thiophenol
108-98-5

thiophenol

1,2-dichloro-ethane
107-06-2

1,2-dichloro-ethane

cephalothin
153-61-7

cephalothin

3-((PHENYLTHIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

3-((PHENYLTHIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

Conditions
ConditionsYield
With sodium hydrogencarbonate In methanol; ethanol; Isopropyl acetate; water; ethyl acetate19.4%
cephalothin
153-61-7

cephalothin

sodium cephalothin
58-71-9

sodium cephalothin

Conditions
ConditionsYield
With sodium 2-ethylhexanoic acid In acetone26%
2,2,2-trichloroethyl glycinate*HBr
40126-72-5

2,2,2-trichloroethyl glycinate*HBr

cephalothin
153-61-7

cephalothin

{[(6R,7R)-3-Acetoxymethyl-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-acetic acid 2,2,2-trichloro-ethyl ester
113322-14-8

{[(6R,7R)-3-Acetoxymethyl-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-acetic acid 2,2,2-trichloro-ethyl ester

Conditions
ConditionsYield
With triethylamine; diisopropyl-carbodiimide In dichloromethane28%
H2N-TrpOTce
113322-02-4

H2N-TrpOTce

cephalothin
153-61-7

cephalothin

(S)-2-{[(6R,7R)-3-Acetoxymethyl-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-3-(1H-indol-3-yl)-propionic acid 2,2,2-trichloro-ethyl ester
113322-16-0

(S)-2-{[(6R,7R)-3-Acetoxymethyl-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-3-(1H-indol-3-yl)-propionic acid 2,2,2-trichloro-ethyl ester

Conditions
ConditionsYield
With methyl(diethylamino)acetylene In dichloromethane31%
1-methyl-5-mercaptotetrazole
13183-79-4

1-methyl-5-mercaptotetrazole

cephalothin
153-61-7

cephalothin

3-(((1H-TETRAZOL-5-YL)THIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

3-(((1H-TETRAZOL-5-YL)THIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

Conditions
ConditionsYield
In acetic acid31%
2-mercapto-5-methyl-1,3,4-thiadiazole
29490-19-5

2-mercapto-5-methyl-1,3,4-thiadiazole

cephalothin
153-61-7

cephalothin

3-(((5-METHYL-1,3,4-THIADIAZOL-2-YL)THIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

3-(((5-METHYL-1,3,4-THIADIAZOL-2-YL)THIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

Conditions
ConditionsYield
In acetonitrile33.9%
N-(2-hydroxyethyl)nicotinamide
6265-73-2

N-(2-hydroxyethyl)nicotinamide

cephalothin
153-61-7

cephalothin

A

2-<(3-pyridinylcarbonyl)amino>ethyl 7-(2-thienylacetamido)cephalosporante Δ2

2-<(3-pyridinylcarbonyl)amino>ethyl 7-(2-thienylacetamido)cephalosporante Δ2

B

2-<(3-pyridinylcarbonyl)amino>ethyl 7-(2-thienylacetamido)cephalosporante Δ3
154777-98-7

2-<(3-pyridinylcarbonyl)amino>ethyl 7-(2-thienylacetamido)cephalosporante Δ3

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide at 20 - 25℃; for 20h;A 17.9%
B 35.9%
1-(carboxymethyl)-1-H-tetrazole-5-thiol

1-(carboxymethyl)-1-H-tetrazole-5-thiol

cephalothin
153-61-7

cephalothin

3-(((1-(CARBOXYMETHYL)-1H-TETRAZOL-5-YL)THIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

3-(((1-(CARBOXYMETHYL)-1H-TETRAZOL-5-YL)THIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

Conditions
ConditionsYield
In hexane; ethyl acetate; acetonitrile38%
Octanethiol
111-88-6

Octanethiol

cephalothin
153-61-7

cephalothin

N-((6R,7R)-3-((octylthio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)-2-(thiophen-2-yl)acetamide

N-((6R,7R)-3-((octylthio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)-2-(thiophen-2-yl)acetamide

Conditions
ConditionsYield
With 6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diyl)bis(oxy)]bis(di-benzo[d,f][1,3,2]dioxaphosphepin); bis(dibenzylideneacetone)-palladium(0) In acetonitrile at 60℃; for 5h; Tsuji-Trost Allylation; Schlenk technique; regioselective reaction;39%
vinyldiazomethane
2032-04-4

vinyldiazomethane

acetonitrile
75-05-8

acetonitrile

cephalothin
153-61-7

cephalothin

A

allyl 7β-(2-(thien-2-yl)acetamido)-3-(acetoxymethyl)-3-cephem-4-carboxylate
104949-45-3

allyl 7β-(2-(thien-2-yl)acetamido)-3-(acetoxymethyl)-3-cephem-4-carboxylate

B

C21H23N3O6S2

C21H23N3O6S2

Conditions
ConditionsYield
In diethyl etherA 40%
B 36%
para-thiocresol
106-45-6

para-thiocresol

cephalothin
153-61-7

cephalothin

(6R,7R)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-3-((p-tolylthio)methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-3-((p-tolylthio)methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With 6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diyl)bis(oxy)]bis(di-benzo[d,f][1,3,2]dioxaphosphepin); bis(dibenzylideneacetone)-palladium(0) In acetonitrile at 40℃; for 7h; Tsuji-Trost Allylation; Schlenk technique; regioselective reaction;41%
pyrographite
7440-44-0

pyrographite

1-methyl-5-mercaptotetrazole
13183-79-4

1-methyl-5-mercaptotetrazole

cephalothin
153-61-7

cephalothin

3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-7-(2-(2-thienyl)acetamido)-3-cephem-4-carboxylic acid

3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-7-(2-(2-thienyl)acetamido)-3-cephem-4-carboxylic acid

Conditions
ConditionsYield
With methanesulfonic acid; sodium hydrogencarbonate In water; ethyl acetate; butanone41.6%
5-mercapto-3-methyl-1,2,4-oxadiazole

5-mercapto-3-methyl-1,2,4-oxadiazole

cephalothin
153-61-7

cephalothin

3-(((3-METHYL-1,2,4-OXADIAZOL-5-YL)THIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

3-(((3-METHYL-1,2,4-OXADIAZOL-5-YL)THIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

Conditions
ConditionsYield
With sodium chloride; sodium hydrogencarbonate In 1,1,2-trichloroethane; ethyl acetate48%
5-[(tetrazol-1-yl)methyl]-1,3,4-thiadiazole-2-thiol
202116-96-9

5-[(tetrazol-1-yl)methyl]-1,3,4-thiadiazole-2-thiol

cephalothin
153-61-7

cephalothin

7-{[(thiophen-2-yl)acetyl]amino}-3-{[5-[(tetrazol-1-yl)methyl]-1,3,4-thiadiazol-2-ylthio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-{[(thiophen-2-yl)acetyl]amino}-3-{[5-[(tetrazol-1-yl)methyl]-1,3,4-thiadiazol-2-ylthio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In acetic acid for 0.025h; Condensation; microwave irradiation;51%
5-[(quinolin-8-yloxy)methyl]-1,3,4-thiadiazole-2-thiol
239468-65-6

5-[(quinolin-8-yloxy)methyl]-1,3,4-thiadiazole-2-thiol

cephalothin
153-61-7

cephalothin

7-{[(thiophen-2-yl)acetyl]amino}-3-{[5-[(quinolin-8-yloxy)methyl]-1,3,4-thiadiazol-2-ylthio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-{[(thiophen-2-yl)acetyl]amino}-3-{[5-[(quinolin-8-yloxy)methyl]-1,3,4-thiadiazol-2-ylthio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In acetic acid for 0.0166667h; Condensation; microwave irradiation;53%
5-[(5-methyl-1,3,4-thiadiazol-2-ylthio)methyl]-1,3,4-thiadiazole-2-thiol
202116-95-8

5-[(5-methyl-1,3,4-thiadiazol-2-ylthio)methyl]-1,3,4-thiadiazole-2-thiol

cephalothin
153-61-7

cephalothin

7-{[(thiophen-2-yl)acetyl]amino}-3-{[5-[(5-methyl-1,3,4-thiadiazol-2-ylthio)methyl]-1,3,4-thiadiazol-2-ylthio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-{[(thiophen-2-yl)acetyl]amino}-3-{[5-[(5-methyl-1,3,4-thiadiazol-2-ylthio)methyl]-1,3,4-thiadiazol-2-ylthio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In acetic acid for 0.0166667h; Condensation; microwave irradiation;54%
H2N-OTroc-TyrOTce
113351-77-2

H2N-OTroc-TyrOTce

cephalothin
153-61-7

cephalothin

(S)-2-{[(6R,7R)-3-Acetoxymethyl-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-3-[4-(2,2,2-trichloro-ethoxycarbonyloxy)-phenyl]-propionic acid 2,2,2-trichloro-ethyl ester
113322-17-1

(S)-2-{[(6R,7R)-3-Acetoxymethyl-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbonyl]-amino}-3-[4-(2,2,2-trichloro-ethoxycarbonyloxy)-phenyl]-propionic acid 2,2,2-trichloro-ethyl ester

Conditions
ConditionsYield
With methyl(diethylamino)acetylene In dichloromethane55%
sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

1-methyl-5-mercaptotetrazole
13183-79-4

1-methyl-5-mercaptotetrazole

cephalothin
153-61-7

cephalothin

3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-7-(2-(2-thienyl)acetamido)-3-cephem-4-carboxylic acid

3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-7-(2-(2-thienyl)acetamido)-3-cephem-4-carboxylic acid

Conditions
ConditionsYield
In diethyl ether; nitromethane; ethyl acetate56.2%
4-Fluorothiophenol
371-42-6

4-Fluorothiophenol

cephalothin
153-61-7

cephalothin

(6R,7R)-3-(((4-fluorophenyl)thio)methyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-3-(((4-fluorophenyl)thio)methyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With 6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diyl)bis(oxy)]bis(di-benzo[d,f][1,3,2]dioxaphosphepin); bis(dibenzylideneacetone)-palladium(0) In acetonitrile at 40℃; for 7h; Tsuji-Trost Allylation; Schlenk technique; regioselective reaction;58%
5-[(4-methylquinolin-2-yloxy)methyl]-1,3,4-thiadiazole-2-thiol
239468-67-8

5-[(4-methylquinolin-2-yloxy)methyl]-1,3,4-thiadiazole-2-thiol

cephalothin
153-61-7

cephalothin

7-{[(thiophen-2-yl)acetyl]amino}-3-{[5-[(4-methylquinolin-2-yloxy)methyl]-1,3,4-thiadiazol-2-ylthio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-{[(thiophen-2-yl)acetyl]amino}-3-{[5-[(4-methylquinolin-2-yloxy)methyl]-1,3,4-thiadiazol-2-ylthio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In acetic acid for 0.0333333h; Condensation; microwave irradiation;59%
thioacetic acid
507-09-5

thioacetic acid

cephalothin
153-61-7

cephalothin

(6R,7R)-3-(acetylthiomethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
23958-17-0

(6R,7R)-3-(acetylthiomethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate60%
2-mercapto-5-methyl-1,3,4-thiadiazole
29490-19-5

2-mercapto-5-methyl-1,3,4-thiadiazole

cephalothin
153-61-7

cephalothin

7β-(thiophen-2-acetamido)-3-<(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl>-ceph-3-em-4-carboxylic acid
26970-95-6

7β-(thiophen-2-acetamido)-3-<(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl>-ceph-3-em-4-carboxylic acid

Conditions
ConditionsYield
With phosphate buffer pH 6.4; sodium hydrogencarbonate at 60℃; for 5h;62%
With phosphate buffer; sodium carbonate at 55 - 60℃; for 6h;
3-methyl-5-mercapto-1,2,4-thiadiazole
36988-21-3

3-methyl-5-mercapto-1,2,4-thiadiazole

cephalothin
153-61-7

cephalothin

3-(((3-METHYL-1,2,4-THIADIAZOL-5-YL)THIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

3-(((3-METHYL-1,2,4-THIADIAZOL-5-YL)THIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

Conditions
ConditionsYield
In ethyl acetate; 1,2-dichloro-ethane65%
2-sulfanylpyrimidine
131242-36-9

2-sulfanylpyrimidine

cephalothin
153-61-7

cephalothin

3-(((2-PYRIMIDINYL)THIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

3-(((2-PYRIMIDINYL)THIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

Conditions
ConditionsYield
With sodium acetate In acetic acid70.5%
In acetonitrile
N-cyclohexyl-cyclohexanamine
101-83-7

N-cyclohexyl-cyclohexanamine

1-methyl-5-mercaptotetrazole
13183-79-4

1-methyl-5-mercaptotetrazole

cephalothin
153-61-7

cephalothin

3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-7-(2-(2-thienyl)acetamido)-3-cephem-4-carboxylic acid

3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-7-(2-(2-thienyl)acetamido)-3-cephem-4-carboxylic acid

Conditions
ConditionsYield
In ethanol; acetonitrile71%
In ethanol; propiononitrile39%
In ethanol; acetonitrile
In ethanol; 1,2-dichloro-ethane
3-mercapto-4-methyl-5-oxo-6-hydroxy-4,5-dihydro-1,2,4-triazine
21094-62-2

3-mercapto-4-methyl-5-oxo-6-hydroxy-4,5-dihydro-1,2,4-triazine

cephalothin
153-61-7

cephalothin

3-(((4,5-DIHYDRO-6-HYDROXY-4-METHYL-5-OXO-1,2,4-TRIAZIN-3-YL)THIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

3-(((4,5-DIHYDRO-6-HYDROXY-4-METHYL-5-OXO-1,2,4-TRIAZIN-3-YL)THIO)METHYL)-7-(2-(2-THIENYL)ACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACID

Conditions
ConditionsYield
In acetonitrile72.6%

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