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HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. It is made obtainable from us at the most reasonable rate. Our Service: 1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical are

Silodosin Intermediate 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate CAS 160969-03-9

Cas:160969-03-9

Min.Order:1 Kilogram

FOB Price: $4.8 / 5.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

Cas:160969-03-9

Min.Order:1 Gram

FOB Price: $34.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate CAS No.:160969-03-9 Name: 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate Molecular Structure Molecular Formula: C11H13F3O5S Molecular

High purity 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate CAS No.:160969-03-9

Cas:160969-03-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

Cas:160969-03-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

Cas:160969-03-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-[2-(2,2,2-Trifluoroethoxy)-phenoxy]-ethyl methanesulfonate

Cas:160969-03-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei Vanz Pharm Co.,Ltd

1. Direct manufacturer 2. Stock available 3. Stable and fine quality 4. Premium service Appearance:white powder Storage:rm Package:bag/bottle/drum Application:intermediate for Silodosin Transportation:common transporta

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

Cas:160969-03-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate Basic information Product Name: 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate Synonyms: 2-[2-(2,2,2-Trifluoroethox

160969-03-9

Cas:160969-03-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate CAS160969-03-9

Cas:160969-03-9

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Discount priceCAS 160969-03-9 with competitive price

Cas:160969-03-9

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate/ LIDE PHARMA- Factory supply / Best price

Cas:160969-03-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate CAS NO160969-03-9

Cas:160969-03-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA

160969-03-9 cas 99% 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

Cas:160969-03-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate CAS:160969-03-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, sp

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate CAS:160969-03-9

Cas:160969-03-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethanol,2-[2-(2,2,2-trifluoroethoxy)phenoxy]-, 1-methanesulfonate

Cas:160969-03-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

2-(2-(2,2,2-Trifluoroethoxy)phenoxy)ethyl methanesulfonate cas:160969-03-9

Cas:160969-03-9

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ethanol,2-[2-(2,2,2-trifluoroethoxy)phenoxy]-, 1-methanesulfonate

Cas:160969-03-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-[2-(2,2,2-Trifluoroethoxy)Phenoxy]Ethyl Methanesulfonate

Cas:160969-03-9

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

Cas:160969-03-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate [160969-03-9]

Cas:160969-03-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-[2-(2,2,2-Trifluoroethoxy)Phenoxy]Ethyl Methanesulfonate

Cas:160969-03-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate/High quality/Best price

Cas:160969-03-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

Cas:160969-03-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

Cas:160969-03-9

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Ethanol,2-[2-(2,2,2-trifluoroethoxy)phenoxy]-, 1-Methanesulfonate

Cas:160969-03-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethylmethanesulfonate

Cas:160969-03-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Siwei Development Group Ltd.

Product name: 2-[2-(2,2,2-Trifluoroethoxy)Phenoxy]-Ethanol,1-Methanesulfonate CAS No.:160969-03-9 Molecule Formula:C11H13F3O5S Molecule Weight:314.28 Purity: 99.0% Package: 25kg/drum Description:White to light-yellow crystalline powder

Best Quality 2-[2-(2,2,2-Trifluoroethoxy)Phenoxy]-Ethanol,1-Methanesulfonate

Cas:160969-03-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

Cas:160969-03-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

160969-03-9 CAS NO.160969-03-9

Cas:160969-03-9

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Synthetic route

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethanol
160969-02-8

2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethanol

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 4h; Reflux;92.5%
With triethylamine In dichloromethane at 0℃; for 0.25h;
With triethylamine In dichloromethane; water
With triethylamine In dichloromethane at 20℃; for 1h; Cooling with ice;
2-(2-hydroxy-phenoxy)-ethanol
4792-78-3

2-(2-hydroxy-phenoxy)-ethanol

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 3.8 g / K2CO3 / dimethylformamide / 18 h / 100 °C
2: Et3N / CH2Cl2 / 0.25 h / 0 °C
View Scheme
benzene-1,2-diol
120-80-9

benzene-1,2-diol

n-pentadecanoic acid

n-pentadecanoic acid

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 25.8 g / n-BuN4Br / 3.5 h / 180 °C
2: 3.8 g / K2CO3 / dimethylformamide / 18 h / 100 °C
3: Et3N / CH2Cl2 / 0.25 h / 0 °C
View Scheme
ethyl bromoacetate
105-36-2

ethyl bromoacetate

2-O-(2,2,2-trifluoroethyl)catechol
160968-99-0

2-O-(2,2,2-trifluoroethyl)catechol

A

ethyl 2-(2,2,2-trifluoroethoxy)phenoxyacetate
160969-01-7

ethyl 2-(2,2,2-trifluoroethoxy)phenoxyacetate

B

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Conditions
ConditionsYield
With potassium carbonate In ethyl acetate; N,N-dimethyl-formamide
2-methoxy-phenol
90-05-1

2-methoxy-phenol

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C / Sealed vessel
2: ethanethiol; aluminum (III) chloride / dichloromethane / 4 h / 0 - 20 °C
3: potassium carbonate / acetonitrile / 66 h / 90 - 100 °C
4: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice
View Scheme
benzene-1,2-diol
120-80-9

benzene-1,2-diol

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 110 °C / Sealed vessel
2: potassium carbonate / acetonitrile / 66 h / 90 - 100 °C
3: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / acetonitrile / 24 h / 110 - 120 °C
2: potassium carbonate / N,N-dimethyl-formamide / 120 °C
3: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice
View Scheme
1-methoxy-2-(2,2,2-trifluoroethoxy)benzene
106854-74-4

1-methoxy-2-(2,2,2-trifluoroethoxy)benzene

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanethiol; aluminum (III) chloride / dichloromethane / 4 h / 0 - 20 °C
2: potassium carbonate / acetonitrile / 66 h / 90 - 100 °C
3: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice
View Scheme
2-O-(2,2,2-trifluoroethyl)catechol
160968-99-0

2-O-(2,2,2-trifluoroethyl)catechol

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / acetonitrile / 66 h / 90 - 100 °C
2: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice
View Scheme
salicylaldehyde
90-02-8

salicylaldehyde

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl acetamide / 7 h / 110 °C / Inert atmosphere
2: sodium hydroxide; dihydrogen peroxide / 2 h / 20 - 30 °C / Inert atmosphere
3: potassium carbonate / 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide / 16 h / 160 °C / Inert atmosphere
4: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Reflux
View Scheme
2-(2-hydroxyethoxy)benzaldehyde
22042-72-4

2-(2-hydroxyethoxy)benzaldehyde

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; dihydrogen peroxide / 2 h / 20 - 30 °C / Inert atmosphere
2: potassium carbonate / 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide / 16 h / 160 °C / Inert atmosphere
3: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Reflux
View Scheme
N-[(2R)-1-[1-(3-benzoyloxypropyl)-7-cyanoindoline-5-yl]propan-2-yl]-2-nitrobenzenesulfonamide

N-[(2R)-1-[1-(3-benzoyloxypropyl)-7-cyanoindoline-5-yl]propan-2-yl]-2-nitrobenzenesulfonamide

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

N-[(2R)-1-[1-(3-benzoyloxypropyl)-7-cyanoindoline-5-yl]propan-2-yl]-N-[2-[2-[2,2,2]-trifluoroethoxy]phenoxyethyl]-2-nitrobenzenesulfonamide

N-[(2R)-1-[1-(3-benzoyloxypropyl)-7-cyanoindoline-5-yl]propan-2-yl]-N-[2-[2-[2,2,2]-trifluoroethoxy]phenoxyethyl]-2-nitrobenzenesulfonamide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 10h; Temperature;97.3%
1-acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile
175837-01-1

1-acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile
175837-07-7

1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 16h; Inert atmosphere; Reflux;93%
With sodium hydrogencarbonate In ethanol; water
C18H25N3O2

C18H25N3O2

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

C28H34F3N3O4

C28H34F3N3O4

Conditions
ConditionsYield
With lithium carbonate In ethanol; tert-butyl alcohol at 50 - 90℃; for 40h; Inert atmosphere;92.7%
(R)-5-(2-aminopropyl)-1-(3-hydroxypropyl)indoline-7-carbonitrile
1401991-17-0

(R)-5-(2-aminopropyl)-1-(3-hydroxypropyl)indoline-7-carbonitrile

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carbonitrile
885340-13-6

1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carbonitrile

Conditions
ConditionsYield
With sodium carbonate In acetonitrile Reflux;91%
C17H23N3O2

C17H23N3O2

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

C27H32F3N3O4

C27H32F3N3O4

Conditions
ConditionsYield
With potassium carbonate In ethanol; tert-butyl alcohol at 50 - 80℃; for 32h; Inert atmosphere;90.1%
5-[(2R)-2-aminopropyl]-2,3-dihydro-1-[3-(benzoyloxy)propyl]-1H-indole-7-carbonitrile
239463-72-0

5-[(2R)-2-aminopropyl]-2,3-dihydro-1-[3-(benzoyloxy)propyl]-1H-indole-7-carbonitrile

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile
885340-11-4

2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate; potassium iodide In water at 80℃; for 6h;88%
With sodium carbonate In ethanol; tert-butyl alcohol at 50 - 90℃; for 34h; Time; Inert atmosphere;87.1%
With sodium carbonate In ethanol; tert-butyl alcohol at 50 - 90℃; for 42h;54%
Stage #1: 5-[(2R)-2-aminopropyl]-2,3-dihydro-1-[3-(benzoyloxy)propyl]-1H-indole-7-carbonitrile With sodium carbonate In tert-butyl alcohol for 0.166667h; Large scale;
Stage #2: 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene In tert-butyl alcohol at 81℃; Large scale;
4.6 kg
3-{7-cyano-5-[(2R)-2-aminopropyl]-2,3-dihydro-1H-indol-1-yl}propyl benzoate monotartarate

3-{7-cyano-5-[(2R)-2-aminopropyl]-2,3-dihydro-1H-indol-1-yl}propyl benzoate monotartarate

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile
885340-11-4

2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile

Conditions
ConditionsYield
With sodium phosphate; potassium iodide In water at 70℃; for 16h; Reagent/catalyst; Temperature;88%
5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt
239463-85-5

5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile
885340-11-4

2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile

Conditions
ConditionsYield
Stage #1: 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt With potassium carbonate In water; ethyl acetate at 20℃; for 1h;
Stage #2: 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene With tetrabutylammomium bromide; sodium carbonate In acetonitrile at 75 - 85℃; for 30h; Reagent/catalyst; Solvent;
85%
Stage #1: 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt With potassium carbonate In water; ethyl acetate at 20℃; for 1h;
Stage #2: 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene With sodium carbonate In isopropyl alcohol at 80℃; Product distribution / selectivity;
Stage #1: 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt With potassium carbonate In N,N-dimethyl acetamide; acetonitrile at 80℃; for 0.5h;
Stage #2: 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene With potassium iodide at 80℃; for 10h;
Stage #1: 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt With potassium carbonate In N,N-dimethyl acetamide; acetonitrile at 80℃; for 0.5h;
Stage #2: 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene With potassium iodide In N,N-dimethyl acetamide; acetonitrile at 80℃; for 10h;
Stage #1: 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt With potassium carbonate In water; ethyl acetate for 2h; Reflux;
Stage #2: 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene With sodium carbonate In toluene Reflux;
3-7-cyano-5-(R)-2-(R)-1-phenylethylaminopropyl-1-H-indolylpropyl-4-fluorobenzoate L-tartaric acid salt

3-7-cyano-5-(R)-2-(R)-1-phenylethylaminopropyl-1-H-indolylpropyl-4-fluorobenzoate L-tartaric acid salt

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

3-(7-cyano-5-((R)-2-(((R)-1-phenylethyl)(2-(2-(trifluoroethoxy)phenoxy)ethyl)amino)propyl)1-H-indolyl)propyl 4-fluorobenzoate

3-(7-cyano-5-((R)-2-(((R)-1-phenylethyl)(2-(2-(trifluoroethoxy)phenoxy)ethyl)amino)propyl)1-H-indolyl)propyl 4-fluorobenzoate

Conditions
ConditionsYield
Stage #1: 3-7-cyano-5-(R)-2-(R)-1-phenylethylaminopropyl-1-H-indolylpropyl-4-fluorobenzoate L-tartaric acid salt With sodium carbonate In methanol pH=9 - 10;
Stage #2: 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene With tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 120℃; for 30h; Reagent/catalyst; Solvent;
83.2%
5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt
239463-85-5

5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt

oxalic acid
144-62-7

oxalic acid

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

1-(3-hydroxypropyl)-5-(2R)-2-{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}aminopropyl-2,3-dihydro-1H-indole-7-carbonitrile oxalic acid

1-(3-hydroxypropyl)-5-(2R)-2-{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}aminopropyl-2,3-dihydro-1H-indole-7-carbonitrile oxalic acid

Conditions
ConditionsYield
Stage #1: 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt With potassium carbonate In N,N-dimethyl acetamide; acetonitrile at 80℃; for 0.5h;
Stage #2: 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene With potassium iodide In N,N-dimethyl acetamide; acetonitrile at 80℃; for 10h;
Stage #3: oxalic acid at 50℃; for 0.5h; Solvent;
82%
5-[(2S)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-7-cyano-1H-indole tartrate

5-[(2S)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-7-cyano-1H-indole tartrate

oxalic acid
144-62-7

oxalic acid

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

1-[3-(benzoyloxy)propyl]-2,3-dihydro-5-[(2S)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile oxalate

1-[3-(benzoyloxy)propyl]-2,3-dihydro-5-[(2S)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile oxalate

Conditions
ConditionsYield
Stage #1: 5-[(2S)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-7-cyano-1H-indole tartrate; 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene With potassium carbonate; potassium iodide In acetonitrile at 80 - 85℃;
Stage #2: oxalic acid for 0.5h; Reflux;
81.44%
5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt
239463-85-5

5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt

succinic acid
110-15-6

succinic acid

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

1-(3-hydroxypropyl)-5-(2R)-2-{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}aminopropyl-2,3-dihydro-1H-indole-7-carbonitrile succinic acid

1-(3-hydroxypropyl)-5-(2R)-2-{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}aminopropyl-2,3-dihydro-1H-indole-7-carbonitrile succinic acid

Conditions
ConditionsYield
Stage #1: 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt With potassium carbonate In N,N-dimethyl acetamide; acetonitrile at 80℃; for 0.5h;
Stage #2: 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene With potassium iodide In N,N-dimethyl acetamide; acetonitrile at 80℃; for 10h;
Stage #3: succinic acid at 50℃; for 0.5h;
81%
5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt
239463-85-5

5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

1-(3-hydroxypropyl)-5-(2R)-2-{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}aminopropyl-2,3-dihydro-1H-indole-7-carbonitrile fumaric acid

1-(3-hydroxypropyl)-5-(2R)-2-{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}aminopropyl-2,3-dihydro-1H-indole-7-carbonitrile fumaric acid

Conditions
ConditionsYield
Stage #1: 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt With potassium carbonate In N,N-dimethyl acetamide; acetonitrile at 80℃; for 0.5h;
Stage #2: 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene With potassium iodide In N,N-dimethyl acetamide; acetonitrile at 80℃; for 10h;
Stage #3: (2E)-but-2-enedioic acid at 50℃; for 0.5h;
81%
5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt
239463-85-5

5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt

L-Tartaric acid
87-69-4

L-Tartaric acid

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

3-(7-cyano-5-[(2R)-2-(2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino)propyl]-2,3-dihydro-1H-indol-1-yl)propylbenzoate (2R,3R)-tartrate salt

3-(7-cyano-5-[(2R)-2-(2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino)propyl]-2,3-dihydro-1H-indol-1-yl)propylbenzoate (2R,3R)-tartrate salt

Conditions
ConditionsYield
Stage #1: 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt; 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene With sodium carbonate In acetonitrile for 24h; Reflux;
Stage #2: L-Tartaric acid In ethanol at 20℃; for 5h;
79.3%
Stage #1: 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt With potassium carbonate In acetic acid butyl ester; water at 45℃;
Stage #2: 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene In acetic acid butyl ester; water for 18h; Reflux;
Stage #3: L-Tartaric acid In acetic acid butyl ester at 80℃;
4.6 g
3-(7-cyano-5-((R)-2-((R)-1-phenylethylamino)propyl) 1-H-indolyl)propyl alcohol

3-(7-cyano-5-((R)-2-((R)-1-phenylethylamino)propyl) 1-H-indolyl)propyl alcohol

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

3-(7-cyano-5-((R)-2-(((R)-1-phenylethyl)(2-(2-(trifluoroethoxy)phenoxy)ethyl)amino)propyl)-1-H-indolyl)propyl alcohol

3-(7-cyano-5-((R)-2-(((R)-1-phenylethyl)(2-(2-(trifluoroethoxy)phenoxy)ethyl)amino)propyl)-1-H-indolyl)propyl alcohol

Conditions
ConditionsYield
With tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 120℃; for 40h;75.2%
α-ketoglutaric acid
328-50-7

α-ketoglutaric acid

3-{7-cyano-5-[(2R)-2-aminopropyl]-2,3-dihydro-1H-indol-1-yl}propyl benzoate monotartarate

3-{7-cyano-5-[(2R)-2-aminopropyl]-2,3-dihydro-1H-indol-1-yl}propyl benzoate monotartarate

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

3-{7-cyano-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indol-1-yl}propyl benzoate 2-oxoglutaric acid salt

3-{7-cyano-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indol-1-yl}propyl benzoate 2-oxoglutaric acid salt

Conditions
ConditionsYield
Stage #1: 3-{7-cyano-5-[(2R)-2-aminopropyl]-2,3-dihydro-1H-indol-1-yl}propyl benzoate monotartarate With potassium carbonate In water; ethyl acetate
Stage #2: 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene With sodium carbonate; 3-ethyl-1-methyl-1H-imidazol-3-ium bromide In isopropyl alcohol for 22h; Reflux;
Stage #3: α-ketoglutaric acid In acetone at 20℃; for 2h; Solvent;
75%
2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile
885340-11-4

2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile

oxalic acid
144-62-7

oxalic acid

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

1-(3-hydroxypropyl)-5-(2R)-2-{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}aminopropyl-2,3-dihydro-1H-indole-7-carbonitrile oxalic acid

1-(3-hydroxypropyl)-5-(2R)-2-{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}aminopropyl-2,3-dihydro-1H-indole-7-carbonitrile oxalic acid

Conditions
ConditionsYield
Stage #1: 2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile With potassium carbonate In water; ethyl acetate for 1h;
Stage #2: 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene With sodium carbonate In isopropyl alcohol at 80℃; for 50h;
Stage #3: oxalic acid In isopropyl alcohol for 6h;
60.2%
(R)-5-(2-aminopropyl)-1-(3-hydroxypropyl)indoline-7-carboxamide

(R)-5-(2-aminopropyl)-1-(3-hydroxypropyl)indoline-7-carboxamide

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

silodosin
160970-54-7

silodosin

Conditions
ConditionsYield
With potassium carbonate In tert-butyl alcohol60%
1-acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile
175837-01-1

1-acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrile

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

5-(2-((2-(2-(2,2,2-Trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile
1427272-01-2

5-(2-((2-(2-(2,2,2-Trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 16h; Inert atmosphere; Reflux;52%
4-amino-1-benzylpiperidine
50541-93-0

4-amino-1-benzylpiperidine

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

(1-Benzyl-piperidin-4-yl)-{2-[2-(2,2,2-trifluoro-ethoxy)-phenoxy]-ethyl}-amine

(1-Benzyl-piperidin-4-yl)-{2-[2-(2,2,2-trifluoro-ethoxy)-phenoxy]-ethyl}-amine

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 18h; Heating;
1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Piperidin-4-yl-{2-[2-(2,2,2-trifluoro-ethoxy)-phenoxy]-ethyl}-amine

Piperidin-4-yl-{2-[2-(2,2,2-trifluoro-ethoxy)-phenoxy]-ethyl}-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: K2CO3 / acetonitrile / 18 h / Heating
2: H2 / 10percent Pd/C Degussa type E101 / methanol / 4 h / 760 Torr
View Scheme
1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

4-{2-[2-(2,2,2-Trifluoro-ethoxy)-phenoxy]-ethylamino}-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carboxylic acid dimethylamide

4-{2-[2-(2,2,2-Trifluoro-ethoxy)-phenoxy]-ethylamino}-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carboxylic acid dimethylamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: K2CO3 / acetonitrile / 18 h / Heating
2: H2 / 10percent Pd/C Degussa type E101 / methanol / 4 h / 760 Torr
3: K2CO3 / xylene / 6 h / 140 °C
View Scheme
1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

[2-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]-{2-[2-(2,2,2-trifluoroethyloxy)phenoxy]ethyl}amine hydrochloride

[2-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]-{2-[2-(2,2,2-trifluoroethyloxy)phenoxy]ethyl}amine hydrochloride

5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt
239463-85-5

5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene
160969-03-9

1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene

A

2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile
885340-11-4

2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile

B

C40H41F6N3O7

C40H41F6N3O7

Conditions
ConditionsYield
Stage #1: 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt With potassium carbonate In water; ethyl acetate at 20℃; for 2h;
Stage #2: 1-(2-methanesulfonyloxyethoxy)-2-(2,2,2-trifluoroethoxy)benzene With sodium carbonate In tert-butyl alcohol for 24h; Heating / reflux;

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