CAS No.16648-44-5,Benzeneacetic acid, a-acetyl-, methyl ester Suppliers

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Synthetic route

: 79-20-9
acetic acid methyl ester

: 101-41-7
benzeneacetic acid methyl ester

: 16648-44-5
methyl α-acetylphenylacetate

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at -78 - 45℃; for 13h; Inert atmosphere;	51%
With potassium tert-butylate 1.) -78 deg C, 2 h, 2.) r.t., 18 h; reflux,1 h;	39%

: 108-24-7
acetic anhydride

: 101-41-7
benzeneacetic acid methyl ester

: 16648-44-5
methyl α-acetylphenylacetate

Conditions

Conditions	Yield
Stage #1: benzeneacetic acid methyl ester With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.333333h; Stage #2: acetic anhydride In tetrahydrofuran at -78 - 0℃;	50%

: 67-56-1
methanol

: 2009-96-3
2-diazo-1-phenylbutane-1,3-dione

A: 32742-19-1, 116782-25-3, 29540-54-3
methyl 2-benzoylpropionate

B: 614-27-7
methyl 3-oxo-3-phenylpropionate

C: 16648-44-5
methyl α-acetylphenylacetate

D: 112370-88-4
2-Methoxy-3-oxo-3-phenylpropionsaeuremethylester

Conditions

Conditions	Yield
In 1,4-dioxane at 10℃; Product distribution; Mechanism; Irradiation; also thermolysis at 80 deg C, other 2-diazo-1,3-dicarbonyl compounds;	A 23.9 % Chromat. B n/a C 12.5 % Chromat. D 27.2 % Chromat.

...Expand

: 75-36-5
acetyl chloride

: 101-41-7
benzeneacetic acid methyl ester

: 16648-44-5
methyl α-acetylphenylacetate

Conditions

Conditions	Yield
Stage #1: benzeneacetic acid methyl ester With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane In tetrahydrofuran; hexane at -78℃; for 0.166667h; Stage #2: acetyl chloride In tetrahydrofuran; hexane at -78 - 20℃;	1.5 g

: 16648-44-5
methyl α-acetylphenylacetate

: 98-59-9
p-toluenesulfonyl chloride

: C18H18O5S

Conditions

Conditions	Yield
With 1-methyl-1H-imidazole; triethylamine In N,N-dimethyl-formamide at 0 - 25℃; for 2h; stereoselective reaction;	94%

: 16648-44-5
methyl α-acetylphenylacetate

: 98-59-9
p-toluenesulfonyl chloride

: C18H18O5S

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; lithium chloride In acetonitrile at 0 - 25℃; for 2h; stereoselective reaction;	93%

: 16648-44-5
methyl α-acetylphenylacetate

: 3-phenyl-4-(piperidin-1-yl)-1H-pyrazol-5-amine

: 5-methyl-2,6-diphenyl-3-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Conditions

Conditions	Yield
With acetic acid for 0.5h; Reflux; Inert atmosphere;	88%

: 16648-44-5
methyl α-acetylphenylacetate

: 2524-64-3
chlorophosphoric acid diphenyl ester

: (Z)-methyl 2-phenyl-3-(diphenoxyphosphoryloxy)but-2-enoate

Conditions

Conditions	Yield
With 1-methyl-1H-imidazole; N-ethyl-N,N-diisopropylamine; lithium chloride at 0 - 5℃; for 1h; Inert atmosphere; stereoselective reaction;	86%

: 16648-44-5
methyl α-acetylphenylacetate

: 2524-64-3
chlorophosphoric acid diphenyl ester

: (E)-methyl 2-phenyl-3-(diphenoxyphosphoryloxy)but-2-enoate

Conditions

Conditions	Yield
With 1-methyl-1H-imidazole; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 0 - 5℃; for 1h; Inert atmosphere; stereoselective reaction;	74%

: 16648-44-5
methyl α-acetylphenylacetate

: 4187-87-5
1-Phenyl-2-propyn-1-ol

: 3-oxo-2-phenylbutyric acid 1-phenylprop-2-ynyl ester

Conditions

Conditions	Yield
In toluene at 20℃; for 122h; Reflux; Inert atmosphere;	68%

: 59488-94-7
2-bromo-4-methyl-2H-furan-5-one

: 16648-44-5
methyl α-acetylphenylacetate

: 2-(4-Methyl-5-oxo-2,5-dihydro-furan-2-yl)-3-oxo-2-phenyl-butyric acid methyl ester

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide for 15h; Ambient temperature;	65%

: 16648-44-5
methyl α-acetylphenylacetate

: 108-98-5
thiophenol

: methyl 3-oxo-2-phenyl-2-(phenylthio)butanoate

Conditions

Conditions	Yield
With oxygen; potassium iodide; sodium hydroxide In acetonitrile at 80℃; under 760.051 Torr; for 18h; Green chemistry;	61%

: 1425864-74-9
3-amino-1-phenylpyrazin-2(1H)-one

: 16648-44-5
methyl α-acetylphenylacetate

: 1425865-18-4
C20H15N3O2

Conditions

Conditions	Yield
With methanesulfonic acid In acetonitrile at 180℃; for 0.5h; Conrad-Limpach Synthesis; Microwave irradiation;	60%

: 16648-44-5
methyl α-acetylphenylacetate

: 64754-67-2
3-methyl-4-phenyl-1H-pyrazol-5-ol

Conditions

Conditions	Yield
With ethanol; hydrazine hydrate for 4h; Reflux;	55%

: 16648-44-5
methyl α-acetylphenylacetate

: 94-36-0
dibenzoyl peroxide

: C18H16O5

Conditions

Conditions	Yield
With 2,6-di-tert-butyl-4-methyl-phenol; CHF3O3S*C10H24N2 In chloroform at 20℃; Schlenk technique; Inert atmosphere; enantioselective reaction;	40%

: 16648-44-5
methyl α-acetylphenylacetate

: 100-63-0
phenylhydrazine

: 3-methyl-1,4-diphenyl-1H-pyrazol-5-ol

Conditions

Conditions	Yield
With ethanol at 70℃; for 4h;	23%

: 59488-94-7
2-bromo-4-methyl-2H-furan-5-one

: 16648-44-5
methyl α-acetylphenylacetate

A: 2-(4-Methyl-5-oxo-2,5-dihydro-furan-2-yl)-3-oxo-2-phenyl-butyric acid methyl ester

B: (Z)-3-(4-Methyl-5-oxo-2,5-dihydro-furan-2-yloxy)-2-phenyl-but-2-enoic acid methyl ester

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium tert-butylate In toluene for 15h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 16648-44-5
methyl α-acetylphenylacetate

: (E)-3-(4-Methyl-5-oxo-2,5-dihydro-furan-2-yloxy)-2-phenyl-but-2-enoic acid methyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: KOBu-t, 18-crown-6 / toluene / 15 h / Ambient temperature 2: benzophenone / acetone / 0.5 h / Irradiation View Scheme

: 16648-44-5
methyl α-acetylphenylacetate

: 42443-37-8
(E)-methyl 2,3-diphenyl-2-butenoate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-methyl-1H-imidazole; triethylamine / N,N-dimethyl-formamide / 2 h / 0 - 25 °C 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 2 h / 80 - 85 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1.1: 1-methyl-1H-imidazole; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 0 - 5 °C / Inert atmosphere 2.1: zinc(II) chloride / tetrahydrofuran; acetonitrile / 0.5 h / 0 - 5 °C / Inert atmosphere 2.2: 2 h / 0 - 65 °C / Inert atmosphere View Scheme

: 16648-44-5
methyl α-acetylphenylacetate

: 42443-38-9
α carbomethoxy β methyl stilbene cis

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N,N,N,N,-tetramethylethylenediamine; lithium chloride / acetonitrile / 2 h / 0 - 25 °C 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 2 h / 80 - 85 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1.1: lithium chloride; 1-methyl-1H-imidazole; N-ethyl-N,N-diisopropylamine / 1 h / 0 - 5 °C / Inert atmosphere 2.1: zinc(II) chloride / tetrahydrofuran; acetonitrile / 0.5 h / 0 - 5 °C / Inert atmosphere 2.2: 2 h / 0 - 65 °C / Inert atmosphere View Scheme

: 16648-44-5
methyl α-acetylphenylacetate

: C18H18O2

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-methyl-1H-imidazole; triethylamine / N,N-dimethyl-formamide / 2 h / 0 - 25 °C 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 2 h / 80 - 85 °C / Inert atmosphere View Scheme

: 16648-44-5
methyl α-acetylphenylacetate

: C18H18O2

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N,N,N,N,-tetramethylethylenediamine; lithium chloride / acetonitrile / 2 h / 0 - 25 °C 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 2 h / 80 - 85 °C / Inert atmosphere View Scheme

: 16648-44-5
methyl α-acetylphenylacetate

: (E)-3-(4-Methoxy-phenyl)-2-phenyl-but-2-enoic acid methyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-methyl-1H-imidazole; triethylamine / N,N-dimethyl-formamide / 2 h / 0 - 25 °C 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 2 h / 80 - 85 °C / Inert atmosphere View Scheme

: 16648-44-5
methyl α-acetylphenylacetate

: (Z)-3-(4-Methoxy-phenyl)-2-phenyl-but-2-enoic acid methyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N,N,N,N,-tetramethylethylenediamine; lithium chloride / acetonitrile / 2 h / 0 - 25 °C 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 2 h / 80 - 85 °C / Inert atmosphere View Scheme

: 16648-44-5
methyl α-acetylphenylacetate

A: C17H15ClO2

B: C17H15ClO2

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-methyl-1H-imidazole; triethylamine / N,N-dimethyl-formamide / 2 h / 0 - 25 °C 2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / isopropyl alcohol; water / 4 h / 60 °C / Inert atmosphere View Scheme

: 16648-44-5
methyl α-acetylphenylacetate

A: C17H15ClO2

B: C23H19ClO2

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-methyl-1H-imidazole; triethylamine / N,N-dimethyl-formamide / 2 h / 0 - 25 °C 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 2 h / 80 - 85 °C / Inert atmosphere View Scheme

: 16648-44-5
methyl α-acetylphenylacetate

: C17H15ClO2

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N,N,N,N,-tetramethylethylenediamine; lithium chloride / acetonitrile / 2 h / 0 - 25 °C 2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / isopropyl alcohol; water / 1 h / 60 °C / Inert atmosphere View Scheme

: 16648-44-5
methyl α-acetylphenylacetate

: C15H14O3

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-methyl-1H-imidazole; triethylamine / N,N-dimethyl-formamide / 2 h / 0 - 25 °C 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 2 h / 80 - 85 °C / Inert atmosphere View Scheme

: 16648-44-5
methyl α-acetylphenylacetate

: C15H14O3

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N,N,N,N,-tetramethylethylenediamine; lithium chloride / acetonitrile / 2 h / 0 - 25 °C 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 2 h / 80 - 85 °C / Inert atmosphere View Scheme

: 16648-44-5
methyl α-acetylphenylacetate

: C15H14O2S

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-methyl-1H-imidazole; triethylamine / N,N-dimethyl-formamide / 2 h / 0 - 25 °C 2: N-ethyl-N,N-diisopropylamine; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 2 h / 80 - 85 °C / Inert atmosphere View Scheme

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