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Henan Allgreen Chemical Co.,Ltd

he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:Whit

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Cas:170491-63-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

1-BOC-(2-HYDROXYMETHYL)PYRROLIDINE

Cas:170491-63-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER CAS 170491-63-1

Cas:170491-63-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 170491-63-1 with best quality

Cas:170491-63-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-Pyrrolidinecarboxylicacid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester 170491-63-1

Cas:170491-63-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER CAS:170491-63-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER CAS:170491-63-1

Cas:170491-63-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-Pyrrolidinecarboxylicacid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester

Cas:170491-63-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Pyrrolidinecarboxylicacid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester

Cas:170491-63-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Boc-DL-Prolinol

Cas:170491-63-1

Min.Order:1 Gram

FOB Price: $99.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1-Pyrrolidinecarboxylicacid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester

Cas:170491-63-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-(hydroxymethyl)-1-Pyrrolidinecarboxylic acid 1,1-dimethylethyl ester

Cas:170491-63-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate

Cas:170491-63-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Basic information Product Name: 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Synonyms: AKOS 92835;2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Cas:170491-63-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

170491-63-1 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Cas:170491-63-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

1-Boc-(2-Hydroxymethyl)pyrrolidine

Cas:170491-63-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Cas:170491-63-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

170491-63-1 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Cas:170491-63-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

170491-63-1 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Cas:170491-63-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis:

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Cas:170491-63-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate

Cas:170491-63-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

170491-63-1 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Cas:170491-63-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

1-Pyrrolidinecarboxylicacid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester

Cas:170491-63-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER cas no. 170491-63-1 98%

Cas:170491-63-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Sibian Chemical Technology Co., Ltd

The process is mature and can be mass produced to 100 kg, with good quality and purity up to 99%.The product has a large stock and can be supplied stably. Package:bottle Application:Drug R&D Transportation:Sealed drying(25℃) Port:ShangHai

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Cas:170491-63-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Research Peptide Biotechnology Co., Ltd.

High purity, high success rate, short cycle and moderate priceAppearance:White powder solid Storage:Negative 20 degrees Celsius Package:5mg, 10mg 100mg, 1gram Application:Applied to various scientific research

1-Pyrrolidinecarboxylicacid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester

Cas:170491-63-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

1-Pyrrolidinecarboxylicacid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester

Cas:170491-63-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

1-Pyrrolidinecarboxylicacid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester

Cas:170491-63-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Cas:170491-63-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

1-Pyrrolidinecarboxylicacid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester

Cas:170491-63-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Cas:170491-63-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

2-hydroxymethylpyrrolidine
498-63-5

2-hydroxymethylpyrrolidine

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

Conditions
ConditionsYield
In dichloromethane at 20℃; for 16h;98%
With triethylamine In dichloromethane for 1h;94%
With triethylamine In dichloromethane at 20℃;90%
tert-butyl 2-(((4-methoxybenzyl)oxy)methyl)pyrrolidine-1-carboxylate

tert-butyl 2-(((4-methoxybenzyl)oxy)methyl)pyrrolidine-1-carboxylate

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

Conditions
ConditionsYield
With 4,4'-bipyridine; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone In toluene at 80℃; under 3000.3 Torr; for 18h; Autoclave; Green chemistry;88%
With ammonium peroxydisulfate; 9-(2-mesityl)-10-methylacridinium perchlorate In dichloromethane; water at 20 - 30℃; for 3h; Irradiation; Green chemistry;85%
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile
58632-95-4

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

2-hydroxymethylpyrrolidine
498-63-5

2-hydroxymethylpyrrolidine

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water for 2h; Ambient temperature;75%
N-(tert-butoxycarbonyl)pyrrolidine-2-carboxaldehyde
59378-82-4

N-(tert-butoxycarbonyl)pyrrolidine-2-carboxaldehyde

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 0℃; Inert atmosphere; Schlenk technique;53%
With sodium tetrahydroborate
chlorobromomethane
74-97-5

chlorobromomethane

tert-butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolidine-1-carboxylate

tert-butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolidine-1-carboxylate

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

Conditions
ConditionsYield
Stage #1: chlorobromomethane; tert-butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolidine-1-carboxylate With n-butyllithium In diethyl ether; hexane at -78 - 20℃;
Stage #2: In chloroform at 70℃; for 20h;
Stage #3: With dihydrogen peroxide; sodium hydroxide In tetrahydrofuran; water at 0℃; for 2h;
52%
carbon monoxide
201230-82-2

carbon monoxide

N-(tert-butoxycarbonyl)-2,3-dihydropyrrole
73286-71-2

N-(tert-butoxycarbonyl)-2,3-dihydropyrrole

A

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

B

tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate
114214-69-6

tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 2-(dicyclohexylphosphanyl)-1-(2-methoxyphenyl)-1H-imidazole; hydrogen In toluene at 160℃; under 37503.8 Torr; for 24h; Autoclave; Inert atmosphere; Overall yield = 43 %Chromat.; regioselective reaction;A n/a
B 47%
rac-1-(tert-butyl) 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate
861657-91-2

rac-1-(tert-butyl) 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

Conditions
ConditionsYield
Stage #1: rac-1-(tert-butyl) 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate With dimethylsulfide borane complex In tetrahydrofuran for 1h; Heating / reflux;
Stage #2: With methanol In tetrahydrofuran at 20℃;
N-tert-butoxycarbonyl-proline
15761-39-4

N-tert-butoxycarbonyl-proline

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

Conditions
ConditionsYield
With dimethylsulfide borane complex In tetrahydrofuran at 20℃; for 14h;
With borane-THF
Multi-step reaction with 3 steps
1: dichloromethane / 1 h / 0 °C / Schlenk technique; Inert atmosphere
2: diisobutylaluminium hydride / dichloromethane / 0.75 h / -78 °C / Schlenk technique; Inert atmosphere
3: sodium tetrahydroborate / methanol / 0 °C / Inert atmosphere; Schlenk technique
View Scheme
With dimethylsulfide borane complex In tetrahydrofuran at 0℃;
D-prolinol
68832-13-3

D-prolinol

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

Conditions
ConditionsYield
In tetrahydrofuran; chloroform40.6 g (81%)
(S)-1-Pyrrolidin-2-yl-methanol
23356-96-9

(S)-1-Pyrrolidin-2-yl-methanol

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

1-(tert-butoxycarbonyl)-L-proline
15761-39-4

1-(tert-butoxycarbonyl)-L-proline

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

Conditions
ConditionsYield
With diborane In tetrahydrofuran
rac-Pro-OH
609-36-9

rac-Pro-OH

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: thionyl chloride / methanol / 0 - 20 °C
1.2: 0 - 60 °C
2.1: triethylamine / dichloromethane / 3 h / 20 °C
View Scheme
2-(pyrrolidin-2-yl)acetic acid
56879-46-0

2-(pyrrolidin-2-yl)acetic acid

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

Conditions
ConditionsYield
Stage #1: 2-(pyrrolidin-2-yl)acetic acid; di-tert-butyl dicarbonate In ethanol at 45℃; for 0.166667h;
Stage #2: With borane-THF In tetrahydrofuran at 0 - 20℃; for 3h;
2-(Imidazole-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

2-(Imidazole-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diisobutylaluminium hydride / dichloromethane / 0.75 h / -78 °C / Schlenk technique; Inert atmosphere
2: sodium tetrahydroborate / methanol / 0 °C / Inert atmosphere; Schlenk technique
View Scheme
tert-butyl pyrrolidine-1-carboxylate
86953-79-9

tert-butyl pyrrolidine-1-carboxylate

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sec.-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / 3 h / -78 °C
1.2: 1 h / -78 °C
2.1: n-butyllithium / diethyl ether; hexane / -78 - 20 °C
2.2: 20 h / 70 °C
2.3: 2 h / 0 °C
View Scheme
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

N-(tert-butoxycarbonyl)pyrrolidine-2-carboxaldehyde
59378-82-4

N-(tert-butoxycarbonyl)pyrrolidine-2-carboxaldehyde

Conditions
ConditionsYield
With pyridine-SO3 complex; dimethyl sulfoxide; triethylamine In dichloromethane at 0℃; for 1h; Parikh-Doering oxidation;98%
98%
With Dess-Martin periodane In dichloromethane at 20℃; for 12h; Inert atmosphere;87%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

1,3-dioxoisoindolin-2-yl 2-methyl-2-phenylpropanoate

1,3-dioxoisoindolin-2-yl 2-methyl-2-phenylpropanoate

tert-butyl 2-{[(2-phenylpropan-2-yl)oxy]methyl}pyrrolidine-1-carboxylate

tert-butyl 2-{[(2-phenylpropan-2-yl)oxy]methyl}pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With lithium tetrafluoroborate; 12-phenyl-12H-benzo[b]phenothiazine In acetonitrile at 0.4℃; for 24h; Irradiation; Inert atmosphere;96%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

benzoyl chloride
98-88-4

benzoyl chloride

tert-butyl 2-((benzoyloxy)methyl)pyrrolidine-1-carboxylate

tert-butyl 2-((benzoyloxy)methyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 6h;95%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

diethyl ethylidenemalonate
1462-12-0

diethyl ethylidenemalonate

(±)-diethyl 2-(1-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)ethyl)malonate

(±)-diethyl 2-(1-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)ethyl)malonate

Conditions
ConditionsYield
With cerium(III) bromide; tetrabutylammomium bromide In acetonitrile at 20℃; for 48h; Irradiation; Sealed tube; Inert atmosphere;95%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

4-bromo-1,1'-biphenyl
92-66-0

4-bromo-1,1'-biphenyl

tert-butyl 2-([1,1'-biphenyl]-4-yl)pyrrolidine-1-carboxylate

tert-butyl 2-([1,1'-biphenyl]-4-yl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; C12H20N2NiO4(2+)*2Cl(1-); C16H23O2(1-)*K(1+); sodium phosphate In dimethyl sulfoxide; acetonitrile at 20℃; for 36h; Catalytic behavior; Reagent/catalyst; Solvent; Glovebox; Sealed tube; Irradiation;93%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

1-fluoro-2-nitro-4-trifluoromethyl-benzene
367-86-2

1-fluoro-2-nitro-4-trifluoromethyl-benzene

C17H21F3N2O5
862873-90-3

C17H21F3N2O5

Conditions
ConditionsYield
With caesium carbonate In DMF (N,N-dimethyl-formamide) at 50℃; for 3h;92%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

2,6-dinitrobenzonitrile
35213-00-4

2,6-dinitrobenzonitrile

(R)-tert-butyl 2-((2-cyano-3-nitrophenoxy)methyl)pyrrolidine-1-carboxylate

(R)-tert-butyl 2-((2-cyano-3-nitrophenoxy)methyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
89%
87%
oxalyl dichloride
79-37-8

oxalyl dichloride

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

N-(tert-butoxycarbonyl)pyrrolidine-2-carboxaldehyde
59378-82-4

N-(tert-butoxycarbonyl)pyrrolidine-2-carboxaldehyde

Conditions
ConditionsYield
In hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate84%
With triethylamine In dichloromethane; water; dimethyl sulfoxide; ethyl acetate14.2 g (95%)
1-bromo-3-chlorobenzene
108-37-2

1-bromo-3-chlorobenzene

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

tert-butyl 2-(3-chlorophenyl)pyrrolidine-1-carboxylate

tert-butyl 2-(3-chlorophenyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; C12H20N2NiO4(2+)*2Cl(1-); C16H23O2(1-)*K(1+); sodium phosphate In dimethyl sulfoxide; acetonitrile at 20℃; for 36h; Glovebox; Sealed tube; Irradiation;82%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

5-(5-bromo-6-fluoro-2,3-dihydro-1H-isoindol-2-yl)-4-(trifluoromethyl)-2-[[2-(trimethylsilyl)ethoxy]methyl]-2,3-dihydropyridazin-3-one

5-(5-bromo-6-fluoro-2,3-dihydro-1H-isoindol-2-yl)-4-(trifluoromethyl)-2-[[2-(trimethylsilyl)ethoxy]methyl]-2,3-dihydropyridazin-3-one

tert-butyl 2-[([6-fluoro-2-[6-oxo-5-(trifluoromethyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1,6-dihydropyridazin-4-yl]-2,3-dihydro-1H-isoindol-5-yl]oxy)methyl]pyrrolidine-1-carboxylate

tert-butyl 2-[([6-fluoro-2-[6-oxo-5-(trifluoromethyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1,6-dihydropyridazin-4-yl]-2,3-dihydro-1H-isoindol-5-yl]oxy)methyl]pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); di-tert-butyl (2’,4’,6’-triisopropyl-3,6-dimethoxy-[1,1‘-biphenyl]-2-yl)phosphine; caesium carbonate In toluene at 90℃; for 5h; Inert atmosphere;81%
bromochlorobenzene
106-39-8

bromochlorobenzene

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

tert-butyl 2-(4-chlorophenyl)pyrrolidine-1-carboxylate

tert-butyl 2-(4-chlorophenyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; C12H20N2NiO4(2+)*2Cl(1-); C16H23O2(1-)*K(1+); sodium phosphate In dimethyl sulfoxide; acetonitrile at 20℃; for 36h; Glovebox; Sealed tube; Irradiation;80%
3-(1,3-dioxolan-2-yl)-phenylbromide
17789-14-9

3-(1,3-dioxolan-2-yl)-phenylbromide

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

tert-butyl 2-(3-(1,3-dioxolan-2-yl)phenyl)pyrrolidine-1-carboxylate

tert-butyl 2-(3-(1,3-dioxolan-2-yl)phenyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; C12H20N2NiO4(2+)*2Cl(1-); C16H23O2(1-)*K(1+); sodium phosphate In dimethyl sulfoxide; acetonitrile at 20℃; for 36h; Glovebox; Sealed tube; Irradiation;80%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

1-bromo-4-tert-butylbenzene
3972-65-4

1-bromo-4-tert-butylbenzene

tert-butyl 2-(4-(tert-butyl)phenyl)pyrrolidine-1-carboxylate

tert-butyl 2-(4-(tert-butyl)phenyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; C12H20N2NiO4(2+)*2Cl(1-); C16H23O2(1-)*K(1+); sodium phosphate In dimethyl sulfoxide; acetonitrile at 20℃; for 36h; Glovebox; Sealed tube; Irradiation;79%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

NIDA 41057
502486-92-2

NIDA 41057

2-{4-[2-(2,4-dichloro-phenyl)-4-methyl-5-(piperidin-1-ylcarbamoyl)-2H-pyrazol-3-yl]-phenoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester
501426-63-7

2-{4-[2-(2,4-dichloro-phenyl)-4-methyl-5-(piperidin-1-ylcarbamoyl)-2H-pyrazol-3-yl]-phenoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With diethylazodicarboxylate; triethylphosphine In tetrahydrofuran for 16h; Mitsunobu coupling;78%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

1-bromo-4-(trifluoromethoxy)benzene
407-14-7

1-bromo-4-(trifluoromethoxy)benzene

tert-butyl 2-(4-(trifluoromethoxy)phenyl)pyrrolidine-1-carboxylate

tert-butyl 2-(4-(trifluoromethoxy)phenyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; C12H20N2NiO4(2+)*2Cl(1-); C16H23O2(1-)*K(1+); sodium phosphate In dimethyl sulfoxide; acetonitrile at 20℃; for 36h; Glovebox; Sealed tube; Irradiation;76%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

p-bromophenylboronic acid pinacol ester
68716-49-4

p-bromophenylboronic acid pinacol ester

2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]pyrrolidine-1-carboxylic acid tert-butyl ester

2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]pyrrolidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; C12H20N2NiO4(2+)*2Cl(1-); C16H23O2(1-)*K(1+); sodium phosphate In dimethyl sulfoxide; acetonitrile at 20℃; for 36h; Glovebox; Sealed tube; Irradiation;76%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine
137736-63-1

2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine

tert-butyl 2-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)pyrrolidine-1-carboxylate

tert-butyl 2-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; C12H20N2NiO4(2+)*2Cl(1-); C16H23O2(1-)*K(1+); sodium phosphate In dimethyl sulfoxide; acetonitrile at 20℃; for 36h; Glovebox; Sealed tube; Irradiation;76%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

C5H11NO4S
1262775-24-5

C5H11NO4S

Conditions
ConditionsYield
With chlorosulfonic acid In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;75%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

N-(tert-butoxycarbonyl)-2,3-dihydropyrrole
73286-71-2

N-(tert-butoxycarbonyl)-2,3-dihydropyrrole

Conditions
ConditionsYield
With methoxy(cyclooctadiene)rhodium(I) dimer; N,N-Dimethylacrylamide; 3-Methoxybenzoic acid; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 90℃; for 24h; Inert atmosphere; Glovebox; Sealed tube; chemoselective reaction;75%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

tert-butyl pyrrolidine-1-carboxylate
86953-79-9

tert-butyl pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; 1,2-bis(2,4,6-triisopropylphenyl)disulfane; tetrabutyl-ammonium chloride In acetonitrile for 24h; Irradiation; Inert atmosphere;75%
1-(4-bromophenyl)-1H-pyrrole
5044-39-3

1-(4-bromophenyl)-1H-pyrrole

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

tert-butyl 2-(4-(1H-pyrrol-1-yl)phenyl)pyrrolidine-1-carboxylate

tert-butyl 2-(4-(1H-pyrrol-1-yl)phenyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; C12H20N2NiO4(2+)*2Cl(1-); C16H23O2(1-)*K(1+); sodium phosphate In dimethyl sulfoxide; acetonitrile at 20℃; for 36h; Glovebox; Sealed tube; Irradiation;75%
bromobenzene
108-86-1

bromobenzene

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

(±)-tert-butyl-2-phenylpyrrolidine-1-carboxylate
154874-88-1

(±)-tert-butyl-2-phenylpyrrolidine-1-carboxylate

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; C12H20N2NiO4(2+)*2Cl(1-); C16H23O2(1-)*K(1+); sodium phosphate In dimethyl sulfoxide; acetonitrile at 20℃; for 36h; Glovebox; Sealed tube; Irradiation;74%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

tert-butyl 2-(4-fluorophenyl)pyrrolidine-1-carboxylate
1243198-94-8

tert-butyl 2-(4-fluorophenyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; C12H20N2NiO4(2+)*2Cl(1-); C16H23O2(1-)*K(1+); sodium phosphate In dimethyl sulfoxide; acetonitrile at 20℃; for 36h; Glovebox; Sealed tube; Irradiation;74%
N-Boc-prolinol
170491-63-1

N-Boc-prolinol

1-bromo-4-(trimethylsilyl)benzene
6999-03-7

1-bromo-4-(trimethylsilyl)benzene

tert-butyl 2-(4-(trimethylsilyl)phenyl)pyrrolidine-1-carboxylate

tert-butyl 2-(4-(trimethylsilyl)phenyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; C12H20N2NiO4(2+)*2Cl(1-); C16H23O2(1-)*K(1+); sodium phosphate In dimethyl sulfoxide; acetonitrile at 20℃; for 36h; Glovebox; Sealed tube; Irradiation;74%
3-Bromopyridine
626-55-1

3-Bromopyridine

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

2-pyridin-3-ylpyrrolidine-1-carboxylic acid tert-butyl ester
1076199-53-5

2-pyridin-3-ylpyrrolidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; C12H20N2NiO4(2+)*2Cl(1-); C16H23O2(1-)*K(1+); sodium phosphate In dimethyl sulfoxide; acetonitrile at 20℃; for 36h; Glovebox; Sealed tube; Irradiation;71%
1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

N-Boc-prolinol
170491-63-1

N-Boc-prolinol

(±)-tert-butyl-2-(4-methoxyphenyl)pyrrolidine-1-carboxylate

(±)-tert-butyl-2-(4-methoxyphenyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With cerium(III) chloride; 9,10-diphenylanthracene; C12H20N2NiO4(2+)*2Cl(1-); C16H23O2(1-)*K(1+); sodium phosphate In dimethyl sulfoxide; acetonitrile at 20℃; for 36h; Glovebox; Sealed tube; Irradiation;67%

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