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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

4-Bromo-2-fluoroanisole Manufacturer/High quality/Best price/In stock

Cas:2357-52-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Bromo-2-Fluoroanisole

Cas:2357-52-0

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: 4-Bromo-2-fluoroanisole Synonyms: 4-Bromo-2-fluoro-1-methoxybenzene;Benzene, 4-bromo-2-fluoro-1-methoxy-;1-BROMO-3-FLUORO-4-METHOXYBENZENE;2-FLUORO-4-BROMOANISOLE;4-BROMO-2-FLUOROANISOLE;4-Bromo-2-Fluoromethoxybenzene;4-Bromo-2

2357-52-0 4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:1 Gram

FOB Price: $8900.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 2357-52-0 with fast shipping

Cas:2357-52-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Bromo-2-fluoroanisole 2357-52-0

Cas:2357-52-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Qingdao Beluga Import and Export Co., LTD

4-Bromo-2-fluoroanisole CAS:2357-52-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in

4-Bromo-2-fluoroanisole CAS:2357-52-0

Cas:2357-52-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

cas 2357-52-0 4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:2357-52-0

Cas:2357-52-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Bromo-2-Fluoroanisole

Cas:2357-52-0

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

4-bromo-2-fluoro-1-methoxybenzene

Cas:2357-52-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 4-Bromo-2-Fluoroanisole CAS No.:2357-52-0 Molecule Formula:C7H6BrFO Molecule Weight:205.03 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING I

High Quality 4-Bromo-2-Fluoroanisole on stock

Cas:2357-52-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

4-Bromo-2-fluoroanisole Basic information Product Name: 4-Bromo-2-fluoroanisole Synonyms: 4-Bromo-2-fluoro-1-methoxybenzene;Benzene, 4-bromo-2-fluoro-1-methoxy-;1-BROMO-3-FLUORO-4-METHOXYBENZENE;2-FLUORO-4-BROMOANISOLE;4-BROMO-2-FLUOROANISOLE;

4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Changzhou Anchor Biological Technology Co., Ltd.

Our company is engaged in customizing the benzene ring and pyridine derivative organic intermediates, and the quantity is flexible according to customer's needs. It mainly provides high-quality intermediates for domestic and foreign pharmaceutical an

4-Bromo-2-fluoroanisole Manufacturer/High quality/Best price/In stock CAS NO.2357-52-0

Cas:2357-52-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Bromo-2-fluoroanisole cas no. 2357-52-0 98%

Cas:2357-52-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:Shanghai, Qingdao Port

4-Bromo-2-fluoroanisole 104-92-7

Cas:2357-52-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

4-Bromo-2-fluoroanisole

Cas:2357-52-0

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

1-fluoro-2-methoxybenzene
321-28-8

1-fluoro-2-methoxybenzene

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Conditions
ConditionsYield
With N-Bromosuccinimide at 20℃; for 0.5h; regioselective reaction;96%
With sodium bicarbonate; bromine; sodium hydrogensulfite In chloroform; water94%
With bromine In chloroform for 3h; Ambient temperature;92%
4-bromo-2-fluorophenol
2105-94-4

4-bromo-2-fluorophenol

methyl iodide
74-88-4

methyl iodide

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;70%
With potassium carbonate In acetone at 0 - 60℃; for 48h;
With potassium carbonate In acetone at 0 - 60℃; for 48h;
With potassium carbonate In acetone at 0 - 60℃; for 48h;
methanol
67-56-1

methanol

1-bromo-3,4-difluorobenzene
348-61-8

1-bromo-3,4-difluorobenzene

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 2,2,2-trifluoroethanol; 1,2-dichloro-ethane at 40℃; for 48h; Irradiation;64%
3-fluoro-4-methoxyaniline
366-99-4

3-fluoro-4-methoxyaniline

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Conditions
ConditionsYield
With sulfuric acid; sodium nitrite Behandeln des Reaktionsgemisches mit Kupfer(I)-bromid und wss. Bromwasserstoffsaeure;
5-bromo-2-methoxy-benzenediazonium; tetrafluoroborate

5-bromo-2-methoxy-benzenediazonium; tetrafluoroborate

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Conditions
ConditionsYield
beim Erhitzen;
5-bromo-2-methoxy-benzenediazonium-(1)-tetrafluoroborate

5-bromo-2-methoxy-benzenediazonium-(1)-tetrafluoroborate

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

A

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

B

5-bromo-1,3-difluoro-2-methoxy-benzene
104197-14-0

5-bromo-1,3-difluoro-2-methoxy-benzene

Conditions
ConditionsYield
With formic acid; fluorine at 10℃; for 1.75h; Fluorination; Title compound not separated from byproducts;A 43 % Spectr.
B 15 % Spectr.
bromobenzene
108-86-1

bromobenzene

(iso-C4 H9)2 AlH

(iso-C4 H9)2 AlH

Cl2 Pd(PPh3)2

Cl2 Pd(PPh3)2

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Conditions
ConditionsYield
With magnesium In tetrahydrofuran; hexane; nitrogen
2-fluorophenol
367-12-4

2-fluorophenol

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / tetrahydrofuran / 1 h / 50 °C
2: N-Bromosuccinimide / acetonitrile / 3 h / 70 °C
View Scheme
ethyl 3,3-dicyano-2-methylprop-2-enoate
24878-26-0

ethyl 3,3-dicyano-2-methylprop-2-enoate

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

ethyl 3,3-dicyano-2-(3-fluoro-4-methoxyphenyl)-2-methylpropanoate

ethyl 3,3-dicyano-2-(3-fluoro-4-methoxyphenyl)-2-methylpropanoate

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With iodine; magnesium; lithium chloride In ethylene dibromide at 20℃; for 1h; Inert atmosphere;
Stage #2: ethyl 3,3-dicyano-2-methylprop-2-enoate In benzene at -40℃; for 0.5h; Inert atmosphere; regioselective reaction;
95%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

2-(3-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
754226-34-1

2-(3-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Conditions
ConditionsYield
With 10H-phenothiazine; caesium carbonate In acetonitrile for 24h; Irradiation; Sealed tube; Inert atmosphere;95%
With meso-tetra(p-tolyl)porphinato-palladium(II); potassium acetate In 1,4-dioxane at 110℃; for 8h; Miyaura Borylation Reaction; chemoselective reaction;70%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 80℃; for 3h; Inert atmosphere;
2-amino-N-(4-fluorophenyl)nicotinamide
949559-59-5

2-amino-N-(4-fluorophenyl)nicotinamide

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

2-(3-fluoro-4-methoxyphenylamino)-N-(4-fluorophenyl)nicotinamide
949559-60-8

2-(3-fluoro-4-methoxyphenylamino)-N-(4-fluorophenyl)nicotinamide

Conditions
ConditionsYield
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 90℃; for 48h;93%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

phenylboronic acid
98-80-6

phenylboronic acid

3-fluoro-4-methoxy-biphenyl
106291-23-0

3-fluoro-4-methoxy-biphenyl

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 90℃; for 16h;93%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

magnesium
7439-95-4

magnesium

lithium chloride

lithium chloride

zinc(II) chloride
7646-85-7

zinc(II) chloride

C7H6ClFOZn*MgCl2*LiCl

C7H6ClFOZn*MgCl2*LiCl

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide; magnesium; lithium chloride In tetrahydrofuran at 20℃; Inert atmosphere; Schlenk technique;
Stage #2: zinc(II) chloride In tetrahydrofuran at 0 - 20℃; for 0.25h; Inert atmosphere; Schlenk technique;
92%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

copper(l) cyanide

copper(l) cyanide

3-fluoro-4-methoxybenzonitrile
331-62-4

3-fluoro-4-methoxybenzonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 120℃;91%
styrene
292638-84-7

styrene

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

E-1-(phenyl)-2-(3'-fluoro-4'-methoxyphenyl)ethene

E-1-(phenyl)-2-(3'-fluoro-4'-methoxyphenyl)ethene

Conditions
ConditionsYield
With potassium carbonate In water; dimethyl sulfoxide at 90℃; for 10h; Heck Reaction; Green chemistry;91%
2-(3,4,5-trimethoxyphenyl)-4-tert.-butyldimethylsilyoxy-cyclopent-2-en-1-one
631900-75-9

2-(3,4,5-trimethoxyphenyl)-4-tert.-butyldimethylsilyoxy-cyclopent-2-en-1-one

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

magnesium
7439-95-4

magnesium

C27H37FO6Si

C27H37FO6Si

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide; magnesium In tetrahydrofuran at 20℃; for 2h; Argon atmosphere;
Stage #2: 2-(3,4,5-trimethoxyphenyl)-4-tert.-butyldimethylsilyoxy-cyclopent-2-en-1-one In tetrahydrofuran at 0 - 20℃; for 3h; Argon atmosphere;
90%
Stage #1: 3-fluoro-4-methoxyphenyl bromide; magnesium In tetrahydrofuran at 20℃; for 2h;
Stage #2: 2-(3,4,5-trimethoxyphenyl)-4-tert.-butyldimethylsilyoxy-cyclopent-2-en-1-one In tetrahydrofuran at 0 - 20℃; for 3h;
90%
n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

C11H15FO

C11H15FO

Conditions
ConditionsYield
In tetrahydrofuran at 25℃; for 16h; Inert atmosphere;90%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

(4S)-4-isobutyl-2-trifluoromethyl-oxazolidine
671818-85-2

(4S)-4-isobutyl-2-trifluoromethyl-oxazolidine

(1S,2S)-4-methyl-2-[2,2,2-trifluoro-1-(3-fluoro-4-methoxyphenyl)-ethylamino]-pentan-1-ol

(1S,2S)-4-methyl-2-[2,2,2-trifluoro-1-(3-fluoro-4-methoxyphenyl)-ethylamino]-pentan-1-ol

Conditions
ConditionsYield
Stage #1: (4S)-4-isobutyl-2-trifluoromethyl-oxazolidine With chloro-trimethyl-silane; lithium hexamethyldisilazane In tetrahydrofuran; toluene at 0 - 20℃; for 1.5h;
Stage #2: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran; hexane; toluene at -78℃; for 2h;
Stage #3: With hydrogenchloride In tetrahydrofuran; hexane; toluene at -78 - 20℃; for 0.5h;
89%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

(2E)-3-[4-[[tert-butyldimethylsilyl]oxy]-3-methoxyphenyl]acrylaldehyde
290820-47-2

(2E)-3-[4-[[tert-butyldimethylsilyl]oxy]-3-methoxyphenyl]acrylaldehyde

(2E)-3-[(4-tert-butyldimethylsiloxy)-3-methoxyphenyl]-1-(3-fluoro-4-methoxyphenyl)prop-2-en-1-ol

(2E)-3-[(4-tert-butyldimethylsiloxy)-3-methoxyphenyl]-1-(3-fluoro-4-methoxyphenyl)prop-2-en-1-ol

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With magnesium In tetrahydrofuran at -78 - 20℃;
Stage #2: (2E)-3-[4-[[tert-butyldimethylsilyl]oxy]-3-methoxyphenyl]acrylaldehyde In tetrahydrofuran at -78℃; for 0.833333h; Grignard reaction; Further stages.;
88%
(R)-benzyl (3,8,8,9,9-pentamethyl-4-oxo-2,7-dioxa-3-aza-8-siladecan-5-yl)carbamate
160349-51-9

(R)-benzyl (3,8,8,9,9-pentamethyl-4-oxo-2,7-dioxa-3-aza-8-siladecan-5-yl)carbamate

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

C24H32FNO5Si

C24H32FNO5Si

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: (R)-benzyl 3,8,8,9,9-pentamethyl-4-oxo-2,7-dioxa-3-aza-8-siladecane-5-ylcarbamate In tetrahydrofuran at -60℃; for 0.0833333h; Inert atmosphere;
86%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

(2R,3R,4R)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-3,4-dihydro-2H-pyrrole 1-oxide
537030-19-6

(2R,3R,4R)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-3,4-dihydro-2H-pyrrole 1-oxide

C33H34FNO5

C33H34FNO5

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With iodine; magnesium In tetrahydrofuran at 50℃; for 0.5h; Inert atmosphere;
Stage #2: (2R,3R,4R)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-3,4-dihydro-2H-pyrrole 1-oxide In tetrahydrofuran; ethylene dibromide at 0℃; for 0.0833333h; Grignard Reaction; Inert atmosphere;
86%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

3-fluoro-4-methoxy-phenylboronic acid
149507-26-6

3-fluoro-4-methoxy-phenylboronic acid

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1.16667h;
Stage #2: With Triisopropyl borate In tetrahydrofuran; hexane at -78 - 20℃;
85.2%
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: With Triisopropyl borate In tetrahydrofuran at -78 - 0℃;
Stage #3: With hydrogenchloride In tetrahydrofuran; water at 0℃; for 0.5h;
64%
(S)-N'-(2-methoxycyclohexylidene)-4-methylbenzenesulfonohydrazide
1254223-87-4

(S)-N'-(2-methoxycyclohexylidene)-4-methylbenzenesulfonohydrazide

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

2-fluoro-1-methoxy-4-[(S)-6-methoxycyclohex-1-enyl]benzene
1254223-91-0

2-fluoro-1-methoxy-4-[(S)-6-methoxycyclohex-1-enyl]benzene

Conditions
ConditionsYield
Stage #1: (S)-N'-(2-methoxycyclohexylidene)-4-methylbenzenesulfonohydrazide With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos In 1,4-dioxane for 0.0166667h; Inert atmosphere;
Stage #2: 3-fluoro-4-methoxyphenyl bromide In 1,4-dioxane at 110℃; for 4h; Inert atmosphere; optical yield given as %ee; regioselective reaction;
83%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

2-dibenzylaminopropionic acid methyl ester
112302-87-1

2-dibenzylaminopropionic acid methyl ester

methyl 2-(dibenzylamino)-3-(3-fluoro-4-methoxyphenyl)propanoate
1433460-23-1

methyl 2-(dibenzylamino)-3-(3-fluoro-4-methoxyphenyl)propanoate

Conditions
ConditionsYield
Stage #1: 2-dibenzylaminopropionic acid methyl ester With lithium dicyclohexylamide In toluene at 0℃; for 0.25h; Inert atmosphere;
Stage #2: 3-fluoro-4-methoxyphenyl bromide With bis(3,5,3′,5′-dimethoxydibenzylideneacetone)palladium(0); 2-(2-(dicyclohexylphosphino)-1H-imidazol-1-yl)-N,N-dimethylaniline In toluene at 70℃; for 16h; Inert atmosphere; regioselective reaction;
82%
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

C16H14FNO

C16H14FNO

Conditions
ConditionsYield
With copper(l) iodide; caesium carbonate In N,N-dimethyl-formamide at 180℃; for 0.75h; Ullmann Condensation; Microwave irradiation;81%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

6-bromo-2-fluoro-3-methoxybenzaldehyde
853792-27-5

6-bromo-2-fluoro-3-methoxybenzaldehyde

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - 0℃; for 0.666667h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78 - 20℃; for 1h;
80%
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium; diisopropylamine In tetrahydrofuran at -70 - 0℃; for 2h; Inert atmosphere;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -70℃; for 2h;
67.4%
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - 0℃; for 0.5h; Inert atmosphere;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78 - 20℃; for 1h;
58%
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Cooling with acetone-dry ice;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78 - 20℃; for 1h; Inert atmosphere;
58%
diisopropyl 2-(butylimino)malonate

diisopropyl 2-(butylimino)malonate

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

diisopropyl 2-(butyl(3-fluoro-4-methoxyphenyl)amino)malonate

diisopropyl 2-(butyl(3-fluoro-4-methoxyphenyl)amino)malonate

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With magnesium; ethylene dibromide In tetrahydrofuran at -78 - 20℃; Inert atmosphere;
Stage #2: diisopropyl 2-(butylimino)malonate In tetrahydrofuran at -78℃; for 1.01667h; Inert atmosphere;
80%
copper (1) chloride

copper (1) chloride

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

phenol
108-95-2

phenol

A

butylcarbamic acid 2-fluoro-4-phenoxyphenyl ester

butylcarbamic acid 2-fluoro-4-phenoxyphenyl ester

B

3-fluoro-4-methoxydiphenyl ether
85983-50-2

3-fluoro-4-methoxydiphenyl ether

Conditions
ConditionsYield
With potassium hydroxide In water; tolueneA n/a
B 79%
copper (1) chloride

copper (1) chloride

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

phenol
108-95-2

phenol

A

4-[[(Hexylamino)carbonyl]oxy]-1-piperidinecarboxylic acid 2-fluoro-4-phenoxyphenyl ester

4-[[(Hexylamino)carbonyl]oxy]-1-piperidinecarboxylic acid 2-fluoro-4-phenoxyphenyl ester

B

3-fluoro-4-methoxydiphenyl ether
85983-50-2

3-fluoro-4-methoxydiphenyl ether

Conditions
ConditionsYield
With potassium hydroxide In water; tolueneA n/a
B 79%
4-methyl-N′-(1-(3,4,5-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide
1170045-84-7

4-methyl-N′-(1-(3,4,5-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

5-(1-(3-fluoro-4-methoxyphenyl)vinyl)-1,2,3-trimethoxybenzene
1070195-79-7

5-(1-(3-fluoro-4-methoxyphenyl)vinyl)-1,2,3-trimethoxybenzene

Conditions
ConditionsYield
Stage #1: 4-methyl-N′-(1-(3,4,5-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide With dichloro bis(acetonitrile) palladium(II) In 1,4-dioxane at 20℃; for 0.0333333h;
Stage #2: In 1,4-dioxane for 0.0333333h; Alkaline conditions;
Stage #3: 3-fluoro-4-methoxyphenyl bromide In 1,4-dioxane at 100℃; for 3h; Sealed tube;
78%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

cyclohexanone
108-94-1

cyclohexanone

1-(3-fluoro-4-methoxyphenyl)cyclohexan-1-ol

1-(3-fluoro-4-methoxyphenyl)cyclohexan-1-ol

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -78℃;
Stage #2: cyclohexanone In tetrahydrofuran; hexane at -78℃;
78%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Diethyl carbonate
105-58-8

Diethyl carbonate

tris(3-fluoro-4-methoxyphenyl)carbinol
271241-68-0

tris(3-fluoro-4-methoxyphenyl)carbinol

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran at -78℃; for 0.25h; Metallation;
Stage #2: Diethyl carbonate In tetrahydrofuran at -78 - 0℃; for 1h; Substitution; Further stages.;
75%
(E)-4-methyl-N'-(1-(2,4,6-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide
1417652-26-6

(E)-4-methyl-N'-(1-(2,4,6-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

2-(1-(3-fluoro-4-methoxyphenyl)vinyl)-1,3,5-trimethoxybenzene
1417652-41-5

2-(1-(3-fluoro-4-methoxyphenyl)vinyl)-1,3,5-trimethoxybenzene

Conditions
ConditionsYield
With dichloro bis(acetonitrile) palladium(II); sodium t-butanolate; XPhos In fluorobenzene at 100℃; for 1h; Sealed tube;74%
styrene
292638-84-7

styrene

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

C15H15FO

C15H15FO

Conditions
ConditionsYield
With (1,2-dimethoxyethane)dichloronickel(II); sodium t-butanolate In benzene at 25℃; for 14h; regioselective reaction;73%
2-methyl-2-phenylmalononitrile
86164-70-7

2-methyl-2-phenylmalononitrile

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

3-fluoro-4-methoxybenzonitrile
331-62-4

3-fluoro-4-methoxybenzonitrile

Conditions
ConditionsYield
With C10H8Br2N2Ni*(x)H2O; zinc In N,N-dimethyl acetamide at 80℃; for 16h; Inert atmosphere; Sealed tube;73%
ethylthioacetic acid methyl ester
2432-51-1

ethylthioacetic acid methyl ester

carbon monoxide
201230-82-2

carbon monoxide

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

C9H9FOS2

C9H9FOS2

Conditions
ConditionsYield
With potassium tert-butylate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; palladium dichloride In 5,5-dimethyl-1,3-cyclohexadiene at 130℃; under 15001.5 Torr; for 16h;73%
carbon dioxide
124-38-9

carbon dioxide

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

3-fluoro-p-anisic acid
403-20-3

3-fluoro-p-anisic acid

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With magnesium; lithium chloride In tetrahydrofuran for 2h; Reflux;
Stage #2: carbon dioxide In tetrahydrofuran at -70 - 20℃;
Stage #3: With hydrogenchloride In tetrahydrofuran; water pH=0;
72.4%

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