Product Name

  • Name

    4-Bromo-2-fluoroanisole

  • EINECS 219-096-2
  • CAS No. 2357-52-0
  • Article Data19
  • CAS DataBase
  • Density 1.531 g/cm3
  • Solubility insoluble in water
  • Melting Point 16 °C
  • Formula C7H6BrFO
  • Boiling Point 215.1 °C at 760 mmHg
  • Molecular Weight 205.026
  • Flash Point 98.3 °C
  • Transport Information
  • Appearance clear very slightly yellow liquid
  • Safety 26-36-24/25
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 2357-52-0 (4-Bromo-2-fluoroanisole)
  • Hazard Symbols IrritantXi
  • Synonyms 2-Fluoro-4-Bromo anisole;1-bromo-3-fluoro-4-methoxybenzene;2-fluoro-4-bromoanisole;2-Fluoro-4-bromo anisol;4-bromo-2-fluoro-1-methoxy-benzene;
  • PSA 9.23000
  • LogP 2.59680

Synthetic route

1-fluoro-2-methoxybenzene
321-28-8

1-fluoro-2-methoxybenzene

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Conditions
ConditionsYield
With N-Bromosuccinimide at 20℃; for 0.5h; regioselective reaction;96%
With sodium bicarbonate; bromine; sodium hydrogensulfite In chloroform; water94%
With bromine In chloroform for 3h; Ambient temperature;92%
4-bromo-2-fluorophenol
2105-94-4

4-bromo-2-fluorophenol

methyl iodide
74-88-4

methyl iodide

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;70%
With potassium carbonate In acetone at 0 - 60℃; for 48h;
With potassium carbonate In acetone at 0 - 60℃; for 48h;
With potassium carbonate In acetone at 0 - 60℃; for 48h;
methanol
67-56-1

methanol

1-bromo-3,4-difluorobenzene
348-61-8

1-bromo-3,4-difluorobenzene

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 2,2,2-trifluoroethanol; 1,2-dichloro-ethane at 40℃; for 48h; Irradiation;64%
3-fluoro-4-methoxyaniline
366-99-4

3-fluoro-4-methoxyaniline

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Conditions
ConditionsYield
With sulfuric acid; sodium nitrite Behandeln des Reaktionsgemisches mit Kupfer(I)-bromid und wss. Bromwasserstoffsaeure;
5-bromo-2-methoxy-benzenediazonium; tetrafluoroborate

5-bromo-2-methoxy-benzenediazonium; tetrafluoroborate

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Conditions
ConditionsYield
beim Erhitzen;
5-bromo-2-methoxy-benzenediazonium-(1)-tetrafluoroborate

5-bromo-2-methoxy-benzenediazonium-(1)-tetrafluoroborate

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

A

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

B

5-bromo-1,3-difluoro-2-methoxy-benzene
104197-14-0

5-bromo-1,3-difluoro-2-methoxy-benzene

Conditions
ConditionsYield
With formic acid; fluorine at 10℃; for 1.75h; Fluorination; Title compound not separated from byproducts;A 43 % Spectr.
B 15 % Spectr.
bromobenzene
108-86-1

bromobenzene

(iso-C4 H9)2 AlH

(iso-C4 H9)2 AlH

Cl2 Pd(PPh3)2

Cl2 Pd(PPh3)2

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Conditions
ConditionsYield
With magnesium In tetrahydrofuran; hexane; nitrogen
...Expand
2-fluorophenol
367-12-4

2-fluorophenol

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / tetrahydrofuran / 1 h / 50 °C
2: N-Bromosuccinimide / acetonitrile / 3 h / 70 °C
View Scheme
ethyl 3,3-dicyano-2-methylprop-2-enoate
24878-26-0

ethyl 3,3-dicyano-2-methylprop-2-enoate

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

ethyl 3,3-dicyano-2-(3-fluoro-4-methoxyphenyl)-2-methylpropanoate

ethyl 3,3-dicyano-2-(3-fluoro-4-methoxyphenyl)-2-methylpropanoate

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With iodine; magnesium; lithium chloride In ethylene dibromide at 20℃; for 1h; Inert atmosphere;
Stage #2: ethyl 3,3-dicyano-2-methylprop-2-enoate In benzene at -40℃; for 0.5h; Inert atmosphere; regioselective reaction;		95%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

2-(3-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
754226-34-1

2-(3-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Conditions
ConditionsYield
With 10H-phenothiazine; caesium carbonate In acetonitrile for 24h; Irradiation; Sealed tube; Inert atmosphere;95%
With meso-tetra(p-tolyl)porphinato-palladium(II); potassium acetate In 1,4-dioxane at 110℃; for 8h; Miyaura Borylation Reaction; chemoselective reaction;70%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 80℃; for 3h; Inert atmosphere;
2-amino-N-(4-fluorophenyl)nicotinamide
949559-59-5

2-amino-N-(4-fluorophenyl)nicotinamide

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

2-(3-fluoro-4-methoxyphenylamino)-N-(4-fluorophenyl)nicotinamide
949559-60-8

2-(3-fluoro-4-methoxyphenylamino)-N-(4-fluorophenyl)nicotinamide

Conditions
ConditionsYield
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 90℃; for 48h;93%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

phenylboronic acid
98-80-6

phenylboronic acid

3-fluoro-4-methoxy-biphenyl
106291-23-0

3-fluoro-4-methoxy-biphenyl

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 90℃; for 16h;93%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

magnesium
7439-95-4

magnesium

lithium chloride

lithium chloride

zinc(II) chloride
7646-85-7

zinc(II) chloride

C7H6ClFOZn*MgCl2*LiCl

C7H6ClFOZn*MgCl2*LiCl

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide; magnesium; lithium chloride In tetrahydrofuran at 20℃; Inert atmosphere; Schlenk technique;
Stage #2: zinc(II) chloride In tetrahydrofuran at 0 - 20℃; for 0.25h; Inert atmosphere; Schlenk technique;		92%
...Expand
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

copper(l) cyanide

copper(l) cyanide

3-fluoro-4-methoxybenzonitrile
331-62-4

3-fluoro-4-methoxybenzonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 120℃;91%
styrene
292638-84-7

styrene

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

E-1-(phenyl)-2-(3'-fluoro-4'-methoxyphenyl)ethene

E-1-(phenyl)-2-(3'-fluoro-4'-methoxyphenyl)ethene

Conditions
ConditionsYield
With potassium carbonate In water; dimethyl sulfoxide at 90℃; for 10h; Heck Reaction; Green chemistry;91%
2-(3,4,5-trimethoxyphenyl)-4-tert.-butyldimethylsilyoxy-cyclopent-2-en-1-one
631900-75-9

2-(3,4,5-trimethoxyphenyl)-4-tert.-butyldimethylsilyoxy-cyclopent-2-en-1-one

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

magnesium
7439-95-4

magnesium

C27H37FO6Si

C27H37FO6Si

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide; magnesium In tetrahydrofuran at 20℃; for 2h; Argon atmosphere;
Stage #2: 2-(3,4,5-trimethoxyphenyl)-4-tert.-butyldimethylsilyoxy-cyclopent-2-en-1-one In tetrahydrofuran at 0 - 20℃; for 3h; Argon atmosphere;		90%
Stage #1: 3-fluoro-4-methoxyphenyl bromide; magnesium In tetrahydrofuran at 20℃; for 2h;
Stage #2: 2-(3,4,5-trimethoxyphenyl)-4-tert.-butyldimethylsilyoxy-cyclopent-2-en-1-one In tetrahydrofuran at 0 - 20℃; for 3h;		90%
...Expand
n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

C11H15FO

C11H15FO

Conditions
ConditionsYield
In tetrahydrofuran at 25℃; for 16h; Inert atmosphere;90%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

(4S)-4-isobutyl-2-trifluoromethyl-oxazolidine
671818-85-2

(4S)-4-isobutyl-2-trifluoromethyl-oxazolidine

(1S,2S)-4-methyl-2-[2,2,2-trifluoro-1-(3-fluoro-4-methoxyphenyl)-ethylamino]-pentan-1-ol

(1S,2S)-4-methyl-2-[2,2,2-trifluoro-1-(3-fluoro-4-methoxyphenyl)-ethylamino]-pentan-1-ol

Conditions
ConditionsYield
Stage #1: (4S)-4-isobutyl-2-trifluoromethyl-oxazolidine With chloro-trimethyl-silane; lithium hexamethyldisilazane In tetrahydrofuran; toluene at 0 - 20℃; for 1.5h;
Stage #2: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran; hexane; toluene at -78℃; for 2h;
Stage #3: With hydrogenchloride In tetrahydrofuran; hexane; toluene at -78 - 20℃; for 0.5h;		89%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

(2E)-3-[4-[[tert-butyldimethylsilyl]oxy]-3-methoxyphenyl]acrylaldehyde
290820-47-2

(2E)-3-[4-[[tert-butyldimethylsilyl]oxy]-3-methoxyphenyl]acrylaldehyde

(2E)-3-[(4-tert-butyldimethylsiloxy)-3-methoxyphenyl]-1-(3-fluoro-4-methoxyphenyl)prop-2-en-1-ol

(2E)-3-[(4-tert-butyldimethylsiloxy)-3-methoxyphenyl]-1-(3-fluoro-4-methoxyphenyl)prop-2-en-1-ol

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With magnesium In tetrahydrofuran at -78 - 20℃;
Stage #2: (2E)-3-[4-[[tert-butyldimethylsilyl]oxy]-3-methoxyphenyl]acrylaldehyde In tetrahydrofuran at -78℃; for 0.833333h; Grignard reaction; Further stages.;		88%
(R)-benzyl (3,8,8,9,9-pentamethyl-4-oxo-2,7-dioxa-3-aza-8-siladecan-5-yl)carbamate
160349-51-9

(R)-benzyl (3,8,8,9,9-pentamethyl-4-oxo-2,7-dioxa-3-aza-8-siladecan-5-yl)carbamate

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

C24H32FNO5Si

C24H32FNO5Si

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: (R)-benzyl 3,8,8,9,9-pentamethyl-4-oxo-2,7-dioxa-3-aza-8-siladecane-5-ylcarbamate In tetrahydrofuran at -60℃; for 0.0833333h; Inert atmosphere;		86%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

(2R,3R,4R)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-3,4-dihydro-2H-pyrrole 1-oxide
537030-19-6

(2R,3R,4R)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-3,4-dihydro-2H-pyrrole 1-oxide

C33H34FNO5

C33H34FNO5

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With iodine; magnesium In tetrahydrofuran at 50℃; for 0.5h; Inert atmosphere;
Stage #2: (2R,3R,4R)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-3,4-dihydro-2H-pyrrole 1-oxide In tetrahydrofuran; ethylene dibromide at 0℃; for 0.0833333h; Grignard Reaction; Inert atmosphere;		86%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

3-fluoro-4-methoxy-phenylboronic acid
149507-26-6

3-fluoro-4-methoxy-phenylboronic acid

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1.16667h;
Stage #2: With Triisopropyl borate In tetrahydrofuran; hexane at -78 - 20℃;		85.2%
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: With Triisopropyl borate In tetrahydrofuran at -78 - 0℃;
Stage #3: With hydrogenchloride In tetrahydrofuran; water at 0℃; for 0.5h;		64%
(S)-N'-(2-methoxycyclohexylidene)-4-methylbenzenesulfonohydrazide
1254223-87-4

(S)-N'-(2-methoxycyclohexylidene)-4-methylbenzenesulfonohydrazide

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

2-fluoro-1-methoxy-4-[(S)-6-methoxycyclohex-1-enyl]benzene
1254223-91-0

2-fluoro-1-methoxy-4-[(S)-6-methoxycyclohex-1-enyl]benzene

Conditions
ConditionsYield
Stage #1: (S)-N'-(2-methoxycyclohexylidene)-4-methylbenzenesulfonohydrazide With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos In 1,4-dioxane for 0.0166667h; Inert atmosphere;
Stage #2: 3-fluoro-4-methoxyphenyl bromide In 1,4-dioxane at 110℃; for 4h; Inert atmosphere; optical yield given as %ee; regioselective reaction;		83%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

2-dibenzylaminopropionic acid methyl ester
112302-87-1

2-dibenzylaminopropionic acid methyl ester

methyl 2-(dibenzylamino)-3-(3-fluoro-4-methoxyphenyl)propanoate
1433460-23-1

methyl 2-(dibenzylamino)-3-(3-fluoro-4-methoxyphenyl)propanoate

Conditions
ConditionsYield
Stage #1: 2-dibenzylaminopropionic acid methyl ester With lithium dicyclohexylamide In toluene at 0℃; for 0.25h; Inert atmosphere;
Stage #2: 3-fluoro-4-methoxyphenyl bromide With bis(3,5,3′,5′-dimethoxydibenzylideneacetone)palladium(0); 2-(2-(dicyclohexylphosphino)-1H-imidazol-1-yl)-N,N-dimethylaniline In toluene at 70℃; for 16h; Inert atmosphere; regioselective reaction;		82%
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

C16H14FNO

C16H14FNO

Conditions
ConditionsYield
With copper(l) iodide; caesium carbonate In N,N-dimethyl-formamide at 180℃; for 0.75h; Ullmann Condensation; Microwave irradiation;81%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

6-bromo-2-fluoro-3-methoxybenzaldehyde
853792-27-5

6-bromo-2-fluoro-3-methoxybenzaldehyde

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - 0℃; for 0.666667h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78 - 20℃; for 1h;		80%
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium; diisopropylamine In tetrahydrofuran at -70 - 0℃; for 2h; Inert atmosphere;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -70℃; for 2h;		67.4%
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - 0℃; for 0.5h; Inert atmosphere;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78 - 20℃; for 1h;		58%
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Cooling with acetone-dry ice;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78 - 20℃; for 1h; Inert atmosphere;		58%
diisopropyl 2-(butylimino)malonate

diisopropyl 2-(butylimino)malonate

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

diisopropyl 2-(butyl(3-fluoro-4-methoxyphenyl)amino)malonate

diisopropyl 2-(butyl(3-fluoro-4-methoxyphenyl)amino)malonate

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With magnesium; ethylene dibromide In tetrahydrofuran at -78 - 20℃; Inert atmosphere;
Stage #2: diisopropyl 2-(butylimino)malonate In tetrahydrofuran at -78℃; for 1.01667h; Inert atmosphere;		80%
copper (1) chloride

copper (1) chloride

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

phenol
108-95-2

phenol

A

butylcarbamic acid 2-fluoro-4-phenoxyphenyl ester

butylcarbamic acid 2-fluoro-4-phenoxyphenyl ester

B

3-fluoro-4-methoxydiphenyl ether
85983-50-2

3-fluoro-4-methoxydiphenyl ether

Conditions
ConditionsYield
With potassium hydroxide In water; tolueneA n/a
B 79%
...Expand
copper (1) chloride

copper (1) chloride

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

phenol
108-95-2

phenol

A

4-[[(Hexylamino)carbonyl]oxy]-1-piperidinecarboxylic acid 2-fluoro-4-phenoxyphenyl ester

4-[[(Hexylamino)carbonyl]oxy]-1-piperidinecarboxylic acid 2-fluoro-4-phenoxyphenyl ester

B

3-fluoro-4-methoxydiphenyl ether
85983-50-2

3-fluoro-4-methoxydiphenyl ether

Conditions
ConditionsYield
With potassium hydroxide In water; tolueneA n/a
B 79%
...Expand
4-methyl-N′-(1-(3,4,5-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide
1170045-84-7

4-methyl-N′-(1-(3,4,5-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

5-(1-(3-fluoro-4-methoxyphenyl)vinyl)-1,2,3-trimethoxybenzene
1070195-79-7

5-(1-(3-fluoro-4-methoxyphenyl)vinyl)-1,2,3-trimethoxybenzene

Conditions
ConditionsYield
Stage #1: 4-methyl-N′-(1-(3,4,5-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide With dichloro bis(acetonitrile) palladium(II) In 1,4-dioxane at 20℃; for 0.0333333h;
Stage #2: In 1,4-dioxane for 0.0333333h; Alkaline conditions;
Stage #3: 3-fluoro-4-methoxyphenyl bromide In 1,4-dioxane at 100℃; for 3h; Sealed tube;		78%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

cyclohexanone
108-94-1

cyclohexanone

1-(3-fluoro-4-methoxyphenyl)cyclohexan-1-ol

1-(3-fluoro-4-methoxyphenyl)cyclohexan-1-ol

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -78℃;
Stage #2: cyclohexanone In tetrahydrofuran; hexane at -78℃;		78%
3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

Diethyl carbonate
105-58-8

Diethyl carbonate

tris(3-fluoro-4-methoxyphenyl)carbinol
271241-68-0

tris(3-fluoro-4-methoxyphenyl)carbinol

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran at -78℃; for 0.25h; Metallation;
Stage #2: Diethyl carbonate In tetrahydrofuran at -78 - 0℃; for 1h; Substitution; Further stages.;		75%
(E)-4-methyl-N'-(1-(2,4,6-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide
1417652-26-6

(E)-4-methyl-N'-(1-(2,4,6-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

2-(1-(3-fluoro-4-methoxyphenyl)vinyl)-1,3,5-trimethoxybenzene
1417652-41-5

2-(1-(3-fluoro-4-methoxyphenyl)vinyl)-1,3,5-trimethoxybenzene

Conditions
ConditionsYield
With dichloro bis(acetonitrile) palladium(II); sodium t-butanolate; XPhos In fluorobenzene at 100℃; for 1h; Sealed tube;74%
styrene
292638-84-7

styrene

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

C15H15FO

C15H15FO

Conditions
ConditionsYield
With (1,2-dimethoxyethane)dichloronickel(II); sodium t-butanolate In benzene at 25℃; for 14h; regioselective reaction;73%
2-methyl-2-phenylmalononitrile
86164-70-7

2-methyl-2-phenylmalononitrile

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

3-fluoro-4-methoxybenzonitrile
331-62-4

3-fluoro-4-methoxybenzonitrile

Conditions
ConditionsYield
With C10H8Br2N2Ni*(x)H2O; zinc In N,N-dimethyl acetamide at 80℃; for 16h; Inert atmosphere; Sealed tube;73%
ethylthioacetic acid methyl ester
2432-51-1

ethylthioacetic acid methyl ester

carbon monoxide
201230-82-2

carbon monoxide

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

C9H9FOS2

C9H9FOS2

Conditions
ConditionsYield
With potassium tert-butylate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; palladium dichloride In 5,5-dimethyl-1,3-cyclohexadiene at 130℃; under 15001.5 Torr; for 16h;73%
...Expand
carbon dioxide
124-38-9

carbon dioxide

3-fluoro-4-methoxyphenyl bromide
2357-52-0

3-fluoro-4-methoxyphenyl bromide

3-fluoro-p-anisic acid
403-20-3

3-fluoro-p-anisic acid

Conditions
ConditionsYield
Stage #1: 3-fluoro-4-methoxyphenyl bromide With magnesium; lithium chloride In tetrahydrofuran for 2h; Reflux;
Stage #2: carbon dioxide In tetrahydrofuran at -70 - 20℃;
Stage #3: With hydrogenchloride In tetrahydrofuran; water pH=0;		72.4%

4-Bromo-2-fluoroanisole Chemical Properties

The molecular structure of 4-Bromo-2-fluoroanisole (CAS NO.2357-52-0):

IUPAC Name: 4-Bromo-2-fluoro-1-methoxybenzene 
Molecular Weight: 205.024343 g/mol
Molecular Formula: C7H6BrFO 
Density: 1.531 g/cm3 
Melting Point: 16 °C
Boiling Point: 215.1 °C at 760 mmHg 
Flash Point: 98.3 °C
Index of Refraction: 1.518
Molar Refractivity: 40.61 cm3
Molar Volume: 133.8 cm3
Surface Tension: 33.3 dyne/cm 
Enthalpy of Vaporization: 43.3 kJ/mol
Vapour Pressure: 0.22 mmHg at 25 °C 
Water Solubility: insoluble
XLogP3-AA: 2.7
H-Bond Acceptor: 2
Rotatable Bond Count: 1
Exact Mass: 203.958606
MonoIsotopic Mass: 203.958606
Topological Polar Surface Area: 9.2
Heavy Atom Count: 10
Canonical SMILES: COC1=C(C=C(C=C1)Br)F
InChI: InChI=1S/C7H6BrFO/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,1H3
InChIKey: DWNXGZBXFDNKOR-UHFFFAOYSA-N
EINECS: 219-096-2
Product Categories: Other fluorin-contained compounds; Fluorobenzene Series; Aromatic Halides (substituted); AnisoleSeries; Anisole; Miscellaneous; Anisoles, Alkyloxy Compounds & Phenylacetates; Bromine Compounds; Fluorine Compounds; Benzenes

4-Bromo-2-fluoroanisole Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT

4-Bromo-2-fluoroanisole Specification

 4-Bromo-2-fluoroanisole (CAS NO.2357-52-0) is also named as 4-Brom-2-fluor-1-methoxybenzol ; 4-Bromo-2-fluoro-1-methoxybenzene ; 4-Bromo-2-fluorophenyl methyl ether ; Benzene, 4-bromo-2-fluoro-1-methoxy- . 4-Bromo-2-fluoroanisole (CAS NO.2357-52-0) is clear very slightly yellow liquid.

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