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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

Phthaloyl-L-isoleucine

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Phthaloyl-L-isoleucine

Cas:29588-88-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

PHT-ILE-OH CAS:29588-88-3

Cas:29588-88-3

Min.Order:1 Kilogram

FOB Price: $30.0 / 40.0

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Phthaloyl-L-isoleucine

Cas:29588-88-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Pht-Ile cas no.29588-88-3 0.98

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery

Top purity PHT-ILE-OH

Cas:29588-88-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Phthaloyl-L-isoleucine

Cas:29588-88-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

29588-88-3 CAS NO.29588-88-3

Cas:29588-88-3

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

N-Phthaloyl-L-isoleucine

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Research Peptide Biotechnology Co., Ltd.

High purity, high success rate, short cycle and moderate priceAppearance:White powder solid Storage:Negative 20 degrees Celsius Package:5mg, 10mg 100mg, 1gram Application:Applied to various scientific research

PHT-ILE-OH

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

PHT-ILE-OH

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Phthaloyl-L-isoleucine Application:Organic Chemicals

Phthaloyl-L-isoleucine

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Ocean Chemical Co., Ltd.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support

Phthaloyl-L-isoleucine

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

factory?direct?sale Application:Fine chemical intermediates, used as the main raw material for the synthesis of various pesticides, medicines, surfactants, polymer monomers, and antifungal agents

Phthaloyl-L-isoleucine

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

PHT-ILE-OH

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

29588-88-3

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Phthaloyl-L-isoleucineAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Phthaloyl-L-isoleucine

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Other

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

PHT-ILE-OH

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

HENAN SUNLAKE ENTERPRISE CORPORATION

PHT-ILE-OH Basic information Product Name:

PHT-ILE-OH

Cas:29588-88-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Changzhou Pesan Chemical Co.,Ltd

Strong R&D strength and team We have a R&D team with around 30 R&D personnel.All of our employees have chemical backgrounds and have worked in the chemical industry for many years.Our laboratory can synthesize target products with wei

pht-ile-oh 29588-88-3

Cas:29588-88-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 99999.0

Type:Other

inquiry

Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

29588-88-3 CAS NO.29588-88-3

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Sichuan Jiayinglai Technology Co,Ltd (Enlai Biotech)

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

PHT-ILE-OH

Cas:29588-88-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hanhong Scientific Co.,Ltd.

factory,reasonable price Appearance:detailed see specifications Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:pharmaceutical intermediates Transportation:by courier,air or sea Port:c

Phthaloyl-L-isoleucine29588-88-3

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Apeptide Co., Ltd.

Apeptide is a famous-peptide manufacturer in China,We supply high quality peptides(Custom Peptides\Amino acids\API pepitdes and so on )with the best competitive price and short lead time.,Please check our website: www.apeptides.com/en/Appearance:pow

Phthaloyl-L-isoleucine

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

coolpharm Ltd

Cool Pharm Ltd, found in 8139,is a high-tech enterprise which provides customer synthesis service for domestic and international pharmaceutical companies according to international standards. Our business includes research , development, process opti

(2S,3S)-2-(1,3-Dioxoisoindolin-2-yl)-3-methylpentanoic acid

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Other

inquiry

Wuxi Morality Chemical Co., Ltd

Do best quality products, erect the morality model Application:please email us, thanks

PHT-ILE-OH

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Other

inquiry

Finetech Industry Limited

High Quality Best Price Storage:Store in dry, dark and ventilated place Application:Chemical Synthesis Intermediate

FT-0698183

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

NovaChemistry

high purity Application:Drug intermediates Materials intermediates and active molecules

PHT-ILE-OH

Cas:29588-88-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

phthalic anhydride
85-44-9

phthalic anhydride

L-isoleucine
73-32-5

L-isoleucine

N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

Conditions
ConditionsYield
at 135℃;100%
at 140℃; for 0.166667h;99%
With triethylamine Inert atmosphere;98%
benzyl (2S,3S)-3-methyl-2-phthalimido-pentanoate
42406-41-7

benzyl (2S,3S)-3-methyl-2-phthalimido-pentanoate

N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol99%
L-isoleucine hydrochloride
17694-98-3

L-isoleucine hydrochloride

methyl 2-((succinimidooxyl)carbonyl)benzoate
438470-19-0

methyl 2-((succinimidooxyl)carbonyl)benzoate

N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃; for 4h;81%
L-isoleucine
73-32-5

L-isoleucine

N-ethoxycarbonylphthalimide
22509-74-6

N-ethoxycarbonylphthalimide

N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

Conditions
ConditionsYield
With sodium carbonate In water40%
Stage #1: L-isoleucine; N-ethoxycarbonylphthalimide With sodium carbonate In water at 20℃; for 3h;
Stage #2: With hydrogenchloride In water at 0℃; pH=1-2;
With sodium carbonate In water at 20℃; for 5h;
Monomethyl phthalate
4376-18-5

Monomethyl phthalate

diethyl-<β chloride ethyl>-amine

diethyl-<β chloride ethyl>-amine

N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / DCC / 1,2-dimethoxy-ethane / 6 h / 0 °C
2: 81 percent / aq. K2CO3 / acetonitrile / 4 h / 20 °C
View Scheme
Monomethyl phthalate
4376-18-5

Monomethyl phthalate

alkali

alkali

N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) thionyl chloride, DMF, 3.) triethylamine / 1.) reflux, 1 h, 2.) benzene, 3.) THF, 0 deg C, 2 h
2: 99 percent / H2 / 10percent Pd/C / ethanol
View Scheme
Multi-step reaction with 3 steps
1: 1.) thionyl chloride, DMF, 3.) triethylamine / 1.) reflux, 1 h, 2.) benzene, 3.) THF, 0 deg C, 2 h
2: 88 percent / Bu4NBr, 5percent NaOH / CH2Cl2; H2O / 1.17 h
3: 99 percent / H2 / 10percent Pd/C / ethanol
View Scheme
benzyl (2S,3S)-N-<2-(methoxycarbonyl)-benzoyl>-2-amino-3-methyl-pentanoate
157919-58-9

benzyl (2S,3S)-N-<2-(methoxycarbonyl)-benzoyl>-2-amino-3-methyl-pentanoate

N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 88 percent / Bu4NBr, 5percent NaOH / CH2Cl2; H2O / 1.17 h
2: 99 percent / H2 / 10percent Pd/C / ethanol
View Scheme
methanol
67-56-1

methanol

N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

(2S,3S)-N-phthaloylisoleucine methyl ester
137649-35-5

(2S,3S)-N-phthaloylisoleucine methyl ester

Conditions
ConditionsYield
With hydrogenchloride at 10℃; for 4h;99%
With hydrogenchloride at 10℃;98%
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

(2S,3S)-2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanoyl chloride
126926-31-6

(2S,3S)-2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanoyl chloride

Conditions
ConditionsYield
With thionyl chloride for 1h; Ambient temperature;94%
With thionyl chloride In dichloromethane for 5h; Heating;88%
With thionyl chloride In toluene Reflux; Schlenk technique;
rhodium(II) acetate dimer

rhodium(II) acetate dimer

N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

ethyl acetate
141-78-6

ethyl acetate

tetrakis[N-phthaloyl-(S)-iso-leucinate]bis(ethyl acetate)

tetrakis[N-phthaloyl-(S)-iso-leucinate]bis(ethyl acetate)

Conditions
ConditionsYield
Stage #1: rhodium(II) acetate dimer; N-phthaloyl-L-isoleucine In chlorobenzene for 3h; Inert atmosphere; Reflux;
Stage #2: ethyl acetate In hexane Inert atmosphere;
83%
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

1-(4-tert-butylbenzyl)piperazine
956-61-6

1-(4-tert-butylbenzyl)piperazine

2-((2S,3S)-1-(4-(4-(tert-butyl)benzyl)piperazin-1-yl)-3-methyl-1-oxopentan-2-yl) isoindoline-1,3-dione

2-((2S,3S)-1-(4-(4-(tert-butyl)benzyl)piperazin-1-yl)-3-methyl-1-oxopentan-2-yl) isoindoline-1,3-dione

Conditions
ConditionsYield
Stage #1: N-phthaloyl-L-isoleucine With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; for 0.25h;
Stage #2: With benzotriazol-1-ol In dichloromethane at 0℃; for 0.25h;
Stage #3: 1-(4-tert-butylbenzyl)piperazine In dichloromethane at 20℃; for 24h;
80%
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

C16H30N2OSi

C16H30N2OSi

C30H43N3O4Si

C30H43N3O4Si

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;79%
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

diphenyl diselenide
1666-13-3

diphenyl diselenide

2,2'-dipyridyl disulfide bis-N-oxide
3696-28-4

2,2'-dipyridyl disulfide bis-N-oxide

(1SR,2S)-2-methyl-1-phenylseleno-1-phthalimido-butane

(1SR,2S)-2-methyl-1-phenylseleno-1-phthalimido-butane

Conditions
ConditionsYield
With tributylphosphine In tetrahydrofuran at 16℃; for 0.0833333h; Irradiation;78%
2-aminoethylpyridine
42088-91-5

2-aminoethylpyridine

N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

C21H23N3O3

C21H23N3O3

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;73%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

ethanol
64-17-5

ethanol

ethyl 2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanoate
1423187-78-3

ethyl 2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanoate

Conditions
ConditionsYield
With sulfuric acid at 60℃; for 4h;72.46%
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

2-(pyridin-2-yl)isopropyl amine
52568-28-2

2-(pyridin-2-yl)isopropyl amine

C22H25N3O3

C22H25N3O3

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;71%
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

1-(4-bromobenzyl)piperazine
91345-62-9

1-(4-bromobenzyl)piperazine

2-((2S,3S)-1-(4-(4-bromobenzyl)piperazin-1-yl)-3-methyl-1-oxopentan-2-yl)isoindoline-1,3-dione

2-((2S,3S)-1-(4-(4-bromobenzyl)piperazin-1-yl)-3-methyl-1-oxopentan-2-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
Stage #1: N-phthaloyl-L-isoleucine With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; for 0.25h;
Stage #2: With benzotriazol-1-ol In dichloromethane at 0℃; for 0.25h;
Stage #3: 1-(4-bromobenzyl)piperazine In dichloromethane at 20℃; for 24h;
69%
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

1-(4-fluorophenylmethyl)piperazine
70931-28-1

1-(4-fluorophenylmethyl)piperazine

2-((2S,3S)-1-(4-(4-fluorobenzyl)piperazin-1-yl)-3-methyl-1-oxopentan-2-yl)isoindoline-1,3-dione

2-((2S,3S)-1-(4-(4-fluorobenzyl)piperazin-1-yl)-3-methyl-1-oxopentan-2-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
Stage #1: N-phthaloyl-L-isoleucine With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; for 0.25h;
Stage #2: With benzotriazol-1-ol In dichloromethane at 0℃; for 0.25h;
Stage #3: 1-(4-fluorophenylmethyl)piperazine In dichloromethane at 20℃; for 24h;
69%
4-(phenethyl)piperazine
5321-49-3

4-(phenethyl)piperazine

N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

2-((2S,3S)-3-methyl-1-oxo-1-(4-phenethylpiperazin-1-yl)pentan-2-yl)isoindoline-1,3-dione

2-((2S,3S)-3-methyl-1-oxo-1-(4-phenethylpiperazin-1-yl)pentan-2-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
Stage #1: N-phthaloyl-L-isoleucine With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; for 0.25h;
Stage #2: With benzotriazol-1-ol In dichloromethane at 0℃; for 0.25h;
Stage #3: 4-(phenethyl)piperazine In dichloromethane at 20℃; for 24h;
67%
(2-aminomethylpyridine)
3731-51-9

(2-aminomethylpyridine)

N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

C20H21N3O3

C20H21N3O3

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;60%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

1-(4-trifluoromethylbenzyl)piperazine
107890-32-4

1-(4-trifluoromethylbenzyl)piperazine

2-((2S,3S)-3-methyl-1-oxo-1-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)pentan-2-yl)isoindoline-1,3-dione

2-((2S,3S)-3-methyl-1-oxo-1-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)pentan-2-yl)isoindoline-1,3-dione

Conditions
ConditionsYield
Stage #1: N-phthaloyl-L-isoleucine With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; for 0.25h;
Stage #2: With benzotriazol-1-ol In dichloromethane at 0℃; for 0.25h;
Stage #3: 1-(4-trifluoromethylbenzyl)piperazine In dichloromethane at 20℃; for 24h;
59%
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

(2S,3S)-2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanamide
329686-65-9

(2S,3S)-2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanamide

Conditions
ConditionsYield
With 1H-imidazole In tetrahydrofuran at 60℃; for 4h;56.39%
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

(Z)-N'-(4-chlorobenzylidene)-2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanehydrazide
1637438-74-4

(Z)-N'-(4-chlorobenzylidene)-2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanehydrazide

Conditions
ConditionsYield
In ethanol for 4h; Reflux;55.54%
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

3,4-dichlorobenzaldehyde
6287-38-3

3,4-dichlorobenzaldehyde

C21H19Cl2N3O3

C21H19Cl2N3O3

Conditions
ConditionsYield
In ethanol for 4h; Reflux;50.02%
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

(Z)-2-(1,3-dioxoisoindolin-2-yl)-N'-(4-methoxybenzylidene)-3-methylpentanehydrazide
1637437-24-1

(Z)-2-(1,3-dioxoisoindolin-2-yl)-N'-(4-methoxybenzylidene)-3-methylpentanehydrazide

Conditions
ConditionsYield
In ethanol for 4h; Reflux;48.75%
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

benzaldehyde
100-52-7

benzaldehyde

(Z)-N'-benzylidene-2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanehydrazide

(Z)-N'-benzylidene-2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanehydrazide

Conditions
ConditionsYield
In ethanol for 4h; Reflux;42.84%
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

hydrogen ethyl malonate
1071-46-1

hydrogen ethyl malonate

ethyl (5S)-5-methyl-3-oxo-4-phthalimidoheptanoate

ethyl (5S)-5-methyl-3-oxo-4-phthalimidoheptanoate

Conditions
ConditionsYield
Stage #1: N-phthaloyl-L-isoleucine With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 16h; Inert atmosphere;
Stage #2: hydrogen ethyl malonate With triethylamine; magnesium chloride In tetrahydrofuran at 0 - 20℃; for 4.5h; Inert atmosphere;
14%
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

isobutyl chloroformate
543-27-1

isobutyl chloroformate

C19H23NO6

C19H23NO6

Conditions
ConditionsYield
With 4-methyl-morpholine In tetrahydrofuran at -20℃; for 0.166667h;
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

Ethyl 3-sec-butyl-2,5-dioxo-2,3-dihydro-5H-pyrrolo<1,2-a>isoindole-1-carboxylate

Ethyl 3-sec-butyl-2,5-dioxo-2,3-dihydro-5H-pyrrolo<1,2-a>isoindole-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / SOCl2 / 1 h / Ambient temperature
2: 76 percent / tetrahydrofuran / 4 h / Heating
3: 0 h / 500 °C / 0 - 0.01 Torr
View Scheme
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

(4S,5S)-4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-5-methyl-3-oxo-2-(triphenyl-λ5-phosphanylidene)-heptanoic acid ethyl ester
175913-71-0

(4S,5S)-4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-5-methyl-3-oxo-2-(triphenyl-λ5-phosphanylidene)-heptanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 94 percent / SOCl2 / 1 h / Ambient temperature
2: 76 percent / tetrahydrofuran / 4 h / Heating
View Scheme
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

(2S,3S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-pentanoic acid 2-thioxo-2H-pyridin-1-yl ester
157919-38-5

(2S,3S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-pentanoic acid 2-thioxo-2H-pyridin-1-yl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NMM / tetrahydrofuran / 0.17 h / -20 °C
2: Et3N, DMAP / tetrahydrofuran / 0.5 h
View Scheme
N-phthaloyl-L-isoleucine
29588-88-3

N-phthaloyl-L-isoleucine

(1SR,2S)-1-deutero-2-methyl-1-phthalimido-butane

(1SR,2S)-1-deutero-2-methyl-1-phthalimido-butane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NMM / tetrahydrofuran / 0.17 h / -20 °C
2: Et3N, DMAP / tetrahydrofuran / 0.5 h
3: 34 percent / tetrahydrofuran / 0.08 h / 16 °C / Irradiation
4: 79 percent / Bu3SnD, AIBN / benzene / 2 h / 80 °C
View Scheme

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