Phthaloyl-L-isoleucine supplier

Name
PHT-ILE-OH
EINECS
CAS No. 29588-88-3
Article Data17
CAS DataBase
Density 1.311
Solubility
Melting Point 123-125℃
Formula C14H15NO4
Boiling Point
Molecular Weight 261.277
Flash Point
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms N-Phthaloyl-L-isoleucine;PHTHALYL-L-ISOLEUCINE;N-phthalimide l-isoleucine;PHTHALOYL-L-ISOLEUCINE;Pht-i-LeuOH;Pht-lle-OH;
PSA 74.68000
LogP 1.71980

Synthetic route

: 85-44-9
phthalic anhydride

: 73-32-5
L-isoleucine

: 29588-88-3
N-phthaloyl-L-isoleucine

Conditions

Conditions	Yield
at 135℃;	100%
at 140℃; for 0.166667h;	99%
With triethylamine Inert atmosphere;	98%

: 42406-41-7
benzyl (2S,3S)-3-methyl-2-phthalimido-pentanoate

: 29588-88-3
N-phthaloyl-L-isoleucine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol	99%

: 17694-98-3
L-isoleucine hydrochloride

: 438470-19-0
methyl 2-((succinimidooxyl)carbonyl)benzoate

: 29588-88-3
N-phthaloyl-L-isoleucine

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃; for 4h;	81%

: 73-32-5
L-isoleucine

: 22509-74-6
N-ethoxycarbonylphthalimide

: 29588-88-3
N-phthaloyl-L-isoleucine

Conditions

Conditions	Yield
With sodium carbonate In water	40%
Stage #1: L-isoleucine; N-ethoxycarbonylphthalimide With sodium carbonate In water at 20℃; for 3h; Stage #2: With hydrogenchloride In water at 0℃; pH=1-2;
With sodium carbonate In water at 20℃; for 5h;

: 4376-18-5
Monomethyl phthalate

diethyl-<β chloride ethyl>-amine: diethyl-<β chloride ethyl>-amine

: 29588-88-3
N-phthaloyl-L-isoleucine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 98 percent / DCC / 1,2-dimethoxy-ethane / 6 h / 0 °C 2: 81 percent / aq. K2CO3 / acetonitrile / 4 h / 20 °C View Scheme

: 4376-18-5
Monomethyl phthalate

alkali: alkali

: 29588-88-3
N-phthaloyl-L-isoleucine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) thionyl chloride, DMF, 3.) triethylamine / 1.) reflux, 1 h, 2.) benzene, 3.) THF, 0 deg C, 2 h 2: 99 percent / H2 / 10percent Pd/C / ethanol View Scheme
Multi-step reaction with 3 steps 1: 1.) thionyl chloride, DMF, 3.) triethylamine / 1.) reflux, 1 h, 2.) benzene, 3.) THF, 0 deg C, 2 h 2: 88 percent / Bu4NBr, 5percent NaOH / CH2Cl2; H2O / 1.17 h 3: 99 percent / H2 / 10percent Pd/C / ethanol View Scheme

: 157919-58-9
benzyl (2S,3S)-N-<2-(methoxycarbonyl)-benzoyl>-2-amino-3-methyl-pentanoate

: 29588-88-3
N-phthaloyl-L-isoleucine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 88 percent / Bu4NBr, 5percent NaOH / CH2Cl2; H2O / 1.17 h 2: 99 percent / H2 / 10percent Pd/C / ethanol View Scheme

: 67-56-1
methanol

: 29588-88-3
N-phthaloyl-L-isoleucine

: 137649-35-5
(2S,3S)-N-phthaloylisoleucine methyl ester

Conditions

Conditions	Yield
With hydrogenchloride at 10℃; for 4h;	99%
With hydrogenchloride at 10℃;	98%

: 29588-88-3
N-phthaloyl-L-isoleucine

: 126926-31-6
(2S,3S)-2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanoyl chloride

Conditions

Conditions	Yield
With thionyl chloride for 1h; Ambient temperature;	94%
With thionyl chloride In dichloromethane for 5h; Heating;	88%
With thionyl chloride In toluene Reflux; Schlenk technique;

: rhodium(II) acetate dimer

: 29588-88-3
N-phthaloyl-L-isoleucine

: 141-78-6
ethyl acetate

: tetrakis[N-phthaloyl-(S)-iso-leucinate]bis(ethyl acetate)

Conditions

Conditions	Yield
Stage #1: rhodium(II) acetate dimer; N-phthaloyl-L-isoleucine In chlorobenzene for 3h; Inert atmosphere; Reflux; Stage #2: ethyl acetate In hexane Inert atmosphere;	83%

...Expand

: 29588-88-3
N-phthaloyl-L-isoleucine

: 956-61-6
1-(4-tert-butylbenzyl)piperazine

: 2-((2S,3S)-1-(4-(4-(tert-butyl)benzyl)piperazin-1-yl)-3-methyl-1-oxopentan-2-yl) isoindoline-1,3-dione

Conditions

Conditions	Yield
Stage #1: N-phthaloyl-L-isoleucine With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; for 0.25h; Stage #2: With benzotriazol-1-ol In dichloromethane at 0℃; for 0.25h; Stage #3: 1-(4-tert-butylbenzyl)piperazine In dichloromethane at 20℃; for 24h;	80%

: 29588-88-3
N-phthaloyl-L-isoleucine

: C16H30N2OSi

: C30H43N3O4Si

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	79%

: 29588-88-3
N-phthaloyl-L-isoleucine

: 1666-13-3
diphenyl diselenide

: 3696-28-4
2,2'-dipyridyl disulfide bis-N-oxide

: (1SR,2S)-2-methyl-1-phenylseleno-1-phthalimido-butane

Conditions

Conditions	Yield
With tributylphosphine In tetrahydrofuran at 16℃; for 0.0833333h; Irradiation;	78%

...Expand

: 42088-91-5
2-aminoethylpyridine

: 29588-88-3
N-phthaloyl-L-isoleucine

: C21H23N3O3

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	73%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;

: 29588-88-3
N-phthaloyl-L-isoleucine

: 64-17-5
ethanol

: 1423187-78-3
ethyl 2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanoate

Conditions

Conditions	Yield
With sulfuric acid at 60℃; for 4h;	72.46%

: 29588-88-3
N-phthaloyl-L-isoleucine

: 52568-28-2
2-(pyridin-2-yl)isopropyl amine

: C22H25N3O3

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	71%

: 29588-88-3
N-phthaloyl-L-isoleucine

: 91345-62-9
1-(4-bromobenzyl)piperazine

: 2-((2S,3S)-1-(4-(4-bromobenzyl)piperazin-1-yl)-3-methyl-1-oxopentan-2-yl)isoindoline-1,3-dione

Conditions

Conditions	Yield
Stage #1: N-phthaloyl-L-isoleucine With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; for 0.25h; Stage #2: With benzotriazol-1-ol In dichloromethane at 0℃; for 0.25h; Stage #3: 1-(4-bromobenzyl)piperazine In dichloromethane at 20℃; for 24h;	69%

: 29588-88-3
N-phthaloyl-L-isoleucine

: 70931-28-1
1-(4-fluorophenylmethyl)piperazine

: 2-((2S,3S)-1-(4-(4-fluorobenzyl)piperazin-1-yl)-3-methyl-1-oxopentan-2-yl)isoindoline-1,3-dione

Conditions

Conditions	Yield
Stage #1: N-phthaloyl-L-isoleucine With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; for 0.25h; Stage #2: With benzotriazol-1-ol In dichloromethane at 0℃; for 0.25h; Stage #3: 1-(4-fluorophenylmethyl)piperazine In dichloromethane at 20℃; for 24h;	69%

: 5321-49-3
4-(phenethyl)piperazine

: 29588-88-3
N-phthaloyl-L-isoleucine

: 2-((2S,3S)-3-methyl-1-oxo-1-(4-phenethylpiperazin-1-yl)pentan-2-yl)isoindoline-1,3-dione

Conditions

Conditions	Yield
Stage #1: N-phthaloyl-L-isoleucine With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; for 0.25h; Stage #2: With benzotriazol-1-ol In dichloromethane at 0℃; for 0.25h; Stage #3: 4-(phenethyl)piperazine In dichloromethane at 20℃; for 24h;	67%

: 3731-51-9
(2-aminomethylpyridine)

: 29588-88-3
N-phthaloyl-L-isoleucine

: C20H21N3O3

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	60%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;

: 29588-88-3
N-phthaloyl-L-isoleucine

: 107890-32-4
1-(4-trifluoromethylbenzyl)piperazine

: 2-((2S,3S)-3-methyl-1-oxo-1-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)pentan-2-yl)isoindoline-1,3-dione

Conditions

Conditions	Yield
Stage #1: N-phthaloyl-L-isoleucine With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; for 0.25h; Stage #2: With benzotriazol-1-ol In dichloromethane at 0℃; for 0.25h; Stage #3: 1-(4-trifluoromethylbenzyl)piperazine In dichloromethane at 20℃; for 24h;	59%

: 29588-88-3
N-phthaloyl-L-isoleucine

: 329686-65-9
(2S,3S)-2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanamide

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran at 60℃; for 4h;	56.39%

: 29588-88-3
N-phthaloyl-L-isoleucine

: 104-88-1
4-chlorobenzaldehyde

: 1637438-74-4
(Z)-N'-(4-chlorobenzylidene)-2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanehydrazide

Conditions

Conditions	Yield
In ethanol for 4h; Reflux;	55.54%

: 29588-88-3
N-phthaloyl-L-isoleucine

: 6287-38-3
3,4-dichlorobenzaldehyde

: C21H19Cl2N3O3

Conditions

Conditions	Yield
In ethanol for 4h; Reflux;	50.02%

: 29588-88-3
N-phthaloyl-L-isoleucine

: 123-11-5
4-methoxy-benzaldehyde

: 1637437-24-1
(Z)-2-(1,3-dioxoisoindolin-2-yl)-N'-(4-methoxybenzylidene)-3-methylpentanehydrazide

Conditions

Conditions	Yield
In ethanol for 4h; Reflux;	48.75%

: 29588-88-3
N-phthaloyl-L-isoleucine

: 100-52-7
benzaldehyde

: (Z)-N'-benzylidene-2-(1,3-dioxoisoindolin-2-yl)-3-methylpentanehydrazide

Conditions

Conditions	Yield
In ethanol for 4h; Reflux;	42.84%

: 29588-88-3
N-phthaloyl-L-isoleucine

: 1071-46-1
hydrogen ethyl malonate

: ethyl (5S)-5-methyl-3-oxo-4-phthalimidoheptanoate

Conditions

Conditions	Yield
Stage #1: N-phthaloyl-L-isoleucine With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 16h; Inert atmosphere; Stage #2: hydrogen ethyl malonate With triethylamine; magnesium chloride In tetrahydrofuran at 0 - 20℃; for 4.5h; Inert atmosphere;	14%

: 29588-88-3
N-phthaloyl-L-isoleucine

: 543-27-1
isobutyl chloroformate

: C19H23NO6

Conditions

Conditions	Yield
With 4-methyl-morpholine In tetrahydrofuran at -20℃; for 0.166667h;

: 29588-88-3
N-phthaloyl-L-isoleucine

: Ethyl 3-sec-butyl-2,5-dioxo-2,3-dihydro-5H-pyrrolo<1,2-a>isoindole-1-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 94 percent / SOCl2 / 1 h / Ambient temperature 2: 76 percent / tetrahydrofuran / 4 h / Heating 3: 0 h / 500 °C / 0 - 0.01 Torr View Scheme

: 29588-88-3
N-phthaloyl-L-isoleucine

: 175913-71-0
(4S,5S)-4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-5-methyl-3-oxo-2-(triphenyl-λ5-phosphanylidene)-heptanoic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 94 percent / SOCl2 / 1 h / Ambient temperature 2: 76 percent / tetrahydrofuran / 4 h / Heating View Scheme

: 29588-88-3
N-phthaloyl-L-isoleucine

: 157919-38-5
(2S,3S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-pentanoic acid 2-thioxo-2H-pyridin-1-yl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NMM / tetrahydrofuran / 0.17 h / -20 °C 2: Et3N, DMAP / tetrahydrofuran / 0.5 h View Scheme

: 29588-88-3
N-phthaloyl-L-isoleucine

: (1SR,2S)-1-deutero-2-methyl-1-phthalimido-butane

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: NMM / tetrahydrofuran / 0.17 h / -20 °C 2: Et3N, DMAP / tetrahydrofuran / 0.5 h 3: 34 percent / tetrahydrofuran / 0.08 h / 16 °C / Irradiation 4: 79 percent / Bu3SnD, AIBN / benzene / 2 h / 80 °C View Scheme

Phthaloyl-L-isoleucine Chemical Properties

Molecular Structure of Phthaloyl-L-isoleucine (CAS NO.29588-88-3):

Product Name: Phthaloyl-L-isoleucine
Empirical Formula: C₁₄H₁₅NO₄
Molecular Weight: 261.27
CAS: 29588-88-3
Storage temp: Store at 0°C

Phthaloyl-L-isoleucine Specification

Phthaloyl-L-isoleucine , with CAS number of 29588-88-3, can be called Pht-Ile-OH ; Phthalyl-L-Isoleucine .

Product Name

PHT-ILE-OH

Synthetic route

Phthaloyl-L-isoleucine Chemical Properties

Phthaloyl-L-isoleucine Specification

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