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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for t

High purity 6-Methylnicotinic acid 98% TOP1 supplier in China

Cas:3222-47-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

High purity 6-Methylnicotinic acid 98% TOP1 supplier in China CAS NO.3222-47-7

Cas:3222-47-7

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to light yellow crystalline powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum

6-Methylpyridine-3-carboxylic acid Cas 3222-47-7

Cas:3222-47-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 6-Methylnicotinic Acid

Cas:3222-47-7

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% 6-Methylnicotinic acid 3222-47-7 Producer

Cas:3222-47-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6-Methylnicotinic acid

Cas:3222-47-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1529.html Product Name 6-Methylnicotinic acid CAS No. 3222-47-7

6-Methylnicotinic acid

Cas:3222-47-7

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: 6-Methylpyridine-3-carboxylic acid Synonyms: RARECHEM AL BO 0418;TIMTEC-BB SBB006666;6-METHYLNICOTINIC ACID;6-METHYLPYRIDINE-3-CARBOXYLIC ACID;6-Methylnicotinicacid,99%;6-Methylnicotinic;6-METHYL-3-PYRIDINECARBOXYLIC ACID

3222-47-7 6-Methylpyridine-3-carboxylic acid

Cas:3222-47-7

Min.Order:1 Gram

FOB Price: $8900.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

6-Methylpyridine-3-Carboxylic Acid CAS 3222-47-7

Cas:3222-47-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 3222-47-7 with best quality

Cas:3222-47-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High purity 6-Methylnicotinic acid 98% TOP1 supplier in China CAS NO.3222-47-7

Cas:3222-47-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

6-Methylnicotinic acid 3222-47-7

Cas:3222-47-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Qingdao Beluga Import and Export Co., LTD

Empagliflozin CAS:864070-44-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia

6-Methylpyridine-3-carboxylic acid CAS:3222-47-7

Cas:3222-47-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

6-Methylnicotinic acid

Cas:3222-47-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:3222-47-7

Cas:3222-47-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 6-Methylpyridine-3-carboxylic acid Synonyms: 2-Methylpyridine-5-carboxylic acid;6-Methylnicotinic acid, 99% 1GR;6-Methylnicotic acid;3-Pyridinecarboxylic acid, 6-methyl-;6-Methylpyridine-3-carboxylic acid 99%;5-Carboxy-2-methylpyri

6-Methylpyridine-3-carboxylic acid high purity best quality

Cas:3222-47-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

6-Methylnicotinic Acid

Cas:3222-47-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality, moderate price & quick delivery Appearance:slight yellow powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:according to the clients requirements Application:Pharmaceutical intermediates

6-Methylpyridine-3-carboxylic acid

Cas:3222-47-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

6-Methyl-nicotinic acid

Cas:3222-47-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

6-methylpyridine-3-carboxylic acid

Cas:3222-47-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

6-Methylpyridine-3-carboxylic acid

Cas:3222-47-7

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

6-Methylpyridine-3-carboxylic acid

Cas:3222-47-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 6-Methylnicotinic Acid

Cas:3222-47-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

High purity 6-Methylnicotinic acid 98% TOP1 supplier in China CAS NO.3222-47-7

Cas:3222-47-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

6-Methylpyridine-3-carboxylic acid

Cas:3222-47-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

6-Methylnicotinic acid Manufacturer/High quality/Best price/In stock

Cas:3222-47-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Buy Top Purity 6-Methylpyridine-3-carboxylic acid

Cas:3222-47-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 6-Methylpyridine-3-carboxylic acid Synonyms: RARECHEM AL BO 0418;TIMTEC-BB SBB006666;6-METHYLNICOTINIC ACID;6-METHYLPYRIDINE-3-CARBOXYLIC ACID;6-Methylnicotinic;6-METHYL-3-PYRIDINECARBOXYLIC ACID /;6-Methylnicotinicacid,99%;6-METH

6-Methylnicotinic acid 3222-47-7 C7H7NO2

Cas:3222-47-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

High purity 6-Methylnicotinic acid 98% TOP1 supplier in China CAS NO.3222-47-7

Cas:3222-47-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Synthetic route

Methyl 6-methylnicotinate
5470-70-2

Methyl 6-methylnicotinate

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
100%
2-methyl-5-vinylpyridine
140-76-1

2-methyl-5-vinylpyridine

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
With potassium permanganate In water at 80℃; for 0.05h;84.2%
With potassium hydroxide; potassium permanganate In water; acetone at 30℃; for 2h; Title compound not separated from byproducts;
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
With nitric acid for 5h; Heating;75.4%
With nitric acid
2,5-dimethylpyridine
589-93-5

2,5-dimethylpyridine

A

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

B

Pyridine-2,5-dicarboxylic acid
100-26-5

Pyridine-2,5-dicarboxylic acid

Conditions
ConditionsYield
With potassium permanganate In water at 90℃; for 6.2h;A 14.5%
B 70.8%
With potassium permanganate In water at 80℃; for 1.5h; Product distribution; other pyridines, var. temp.;A 47.1%
B 12.3%
5-ethyl-2-methyl-pyridine
104-90-5

5-ethyl-2-methyl-pyridine

A

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

B

5-ethylpyridine-2-carboxylic acid
770-08-1

5-ethylpyridine-2-carboxylic acid

C

Pyridine-2,5-dicarboxylic acid
100-26-5

Pyridine-2,5-dicarboxylic acid

Conditions
ConditionsYield
With potassium permanganate In water at 90℃; for 0.433333h;A 57.5%
B 3.5%
C 18.4%
With potassium permanganate In water at 80℃; for 0.166667h;A 42%
B 5.4%
C 1.6%
2,5-dimethylpyridine
589-93-5

2,5-dimethylpyridine

A

2-carboxy-5-methylpyridine
4434-13-3

2-carboxy-5-methylpyridine

B

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

C

Pyridine-2,5-dicarboxylic acid
100-26-5

Pyridine-2,5-dicarboxylic acid

Conditions
ConditionsYield
With potassium permanganate In water at 80℃; for 1.5h;A 19.1%
B 47.1%
C 12.3%
5-ethyl-2-methyl-pyridine
104-90-5

5-ethyl-2-methyl-pyridine

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
With selenium(IV) oxide; nitric acid
With potassium permanganate at 60℃;
With potassium permanganate; water
With nitric acid; vanadia
6-methylnicotinonitrile
3222-48-8

6-methylnicotinonitrile

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
With sulfuric acid
ethyl 6-methylnicotinate
21684-59-3

ethyl 6-methylnicotinate

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
With potassium hydroxide
With hydrogenchloride In water at 80℃;
With lithium aluminium tetrahydride In tetrahydrofuran
5-ethyl-2-methyl-pyridine
104-90-5

5-ethyl-2-methyl-pyridine

nitric acid
7697-37-2

nitric acid

ammonium vanadate

ammonium vanadate

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
Erhitzen auf Siedetemperatur;
CP289

CP289

A

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

B

3-hydroxy-1-(3-hydroxypropyl)-2-methylpyridin-4(1H)-one

3-hydroxy-1-(3-hydroxypropyl)-2-methylpyridin-4(1H)-one

Conditions
ConditionsYield
With water In acetonitrile at 37℃; for 0.166667h; pH=2.0; Kinetics; Further Variations:; pH-values; reaction time; Acid hydrolysis;
5-Amino-2-methylpyridine
80287-53-2, 3430-14-6

5-Amino-2-methylpyridine

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous CuSO4 / Diazotization
2: aqueous H2SO4
View Scheme
ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate
86129-63-7

ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium; potassium acetate; ethanol / Hydrogenation
2: aqueous KOH
View Scheme
ethyl 2,4-dihydroxy-6-methylnicotinate
10350-10-4, 70254-52-3, 70254-53-4

ethyl 2,4-dihydroxy-6-methylnicotinate

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: POCl3 / 130 °C
2: palladium; potassium acetate; ethanol / Hydrogenation
3: aqueous KOH
View Scheme
5-Hydroxy-2-methylpyridine
1121-78-4

5-Hydroxy-2-methylpyridine

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: fluorosulfonyl fluoride; triethylamine / dichloromethane / 24 h / 20 °C / 760.05 Torr
2: bis(triphenylphosphine)nickel(II) chloride; 2.9-dimethyl-1,10-phenanthroline; manganese / N,N-dimethyl-formamide / 20 h / 20 °C / 760.05 Torr / Schlenk technique; Inert atmosphere; Glovebox
View Scheme
carbon dioxide
124-38-9

carbon dioxide

6-methylpyridin-3-yl sulfurofluoridate

6-methylpyridin-3-yl sulfurofluoridate

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
With manganese; bis(triphenylphosphine)nickel(II) chloride; 2.9-dimethyl-1,10-phenanthroline In N,N-dimethyl-formamide at 20℃; under 760.051 Torr; for 20h; Schlenk technique; Inert atmosphere; Glovebox;
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

glyoxylic acid ethyl ester
924-44-7

glyoxylic acid ethyl ester

6-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]nicotinic acid
1018673-98-7

6-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]nicotinic acid

Conditions
ConditionsYield
With acetic anhydride In toluene at 20 - 130℃; for 20h;100%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

acide methyl-6 nipecotique
116140-16-0

acide methyl-6 nipecotique

Conditions
ConditionsYield
With ammonia; hydrogen; 5% rhodium on alumina In water under 2068.65 Torr; for 72h;100%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

(S)-tert-butyl 4-((6-amino-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-8-yl)methyl)-2-methylpiperazine-1-carboxylate

(S)-tert-butyl 4-((6-amino-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-8-yl)methyl)-2-methylpiperazine-1-carboxylate

tert-butyl (2S)-2-methyl-4-((7-methyl-6-((6-methylpyridine-3-carbonyl)amino)-[1,2,4]triazolo[1,5-a]pyridin-8-yl)methyl)piperazine-1-carboxylate

tert-butyl (2S)-2-methyl-4-((7-methyl-6-((6-methylpyridine-3-carbonyl)amino)-[1,2,4]triazolo[1,5-a]pyridin-8-yl)methyl)piperazine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 70℃; for 13h;100%
2,3-Diaminopyridine
452-58-4

2,3-Diaminopyridine

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

2-(6-Methyl-pyridin-3-yl)-1H-imidazo[4,5-b]pyridine
120623-51-0

2-(6-Methyl-pyridin-3-yl)-1H-imidazo[4,5-b]pyridine

Conditions
ConditionsYield
With PPA at 210℃; for 2h;98%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

tryptamine
61-54-1

tryptamine

N-(2-(1H-indol-3-yl)ethyl)-6-methylpyridine-3-carboxamide

N-(2-(1H-indol-3-yl)ethyl)-6-methylpyridine-3-carboxamide

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid With 1,1'-carbonyldiimidazole In ethyl acetate for 5h; Reflux;
Stage #2: tryptamine In ethyl acetate for 12h; Reflux;
98%
2-amino-3-hydroxypyridine
16867-03-1

2-amino-3-hydroxypyridine

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

2-(6-Methyl-pyridin-3-yl)-oxazolo[4,5-b]pyridine
120623-52-1

2-(6-Methyl-pyridin-3-yl)-oxazolo[4,5-b]pyridine

Conditions
ConditionsYield
With PPA at 210℃; for 2h;96%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

{Cu2(μ-bis(diphenylphosphino)methane)2(CH3CN)2}{BF4}2

{Cu2(μ-bis(diphenylphosphino)methane)2(CH3CN)2}{BF4}2

[Cu2(bis(diphenylphosphino)methane)2(6-methyl-3-pyridylcarboxylato)][BF4]

[Cu2(bis(diphenylphosphino)methane)2(6-methyl-3-pyridylcarboxylato)][BF4]

Conditions
ConditionsYield
In dichloromethane under N2; suspn. of (Cu(dppm)MeCN))2(BF4)2 and 6-methyl-3-pyridinecarboxylic acid in CH2Cl2 was stirred at ambient temp. for 30 min, resulting soln. was stirred for 10 min; evapn. under vac., ppt. was washed with Et2O, recrystn. from CH2Cl2/hexane; elem. anal.;96%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-methoxy-N-methyl-6-methylnicotinamide
221615-71-0

N-methoxy-N-methyl-6-methylnicotinamide

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 1h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With pyridine In dichloromethane at 0 - 20℃; for 18h;
95%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃;91%
With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20 - 23℃;90%
With 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In tetrahydrofuran; methanol at 20℃; for 3h;82%
Stage #1: 6-methylnicotinic acid With pivaloyl chloride In dichloromethane at 0℃; for 1h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃; for 2.5h;
51%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

(S)-3-[3-(trimethylsilanyl)prop-2-ynyl]morpholine
1008510-61-9

(S)-3-[3-(trimethylsilanyl)prop-2-ynyl]morpholine

(6-methylpyridin-3-yl)-{(S)-[3-(trimethylsilanyl)prop-2-ynyl]morpholin-4-yl}-methanone
1258972-08-5

(6-methylpyridin-3-yl)-{(S)-[3-(trimethylsilanyl)prop-2-ynyl]morpholin-4-yl}-methanone

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; for 16h;93%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

C21H24N2O2

C21H24N2O2

[(S)-3-(5-benzyloxy-1-methyl-1H-indol-3-ylmethyl)morpholine-4-yl]-(6-methylpyridin-3-yl)-methanone
1258972-14-3

[(S)-3-(5-benzyloxy-1-methyl-1H-indol-3-ylmethyl)morpholine-4-yl]-(6-methylpyridin-3-yl)-methanone

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;93%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

D-threoninol
44520-55-0

D-threoninol

N-(2-hydroxy-1-hydroxymethylpropyl)-6-methyl-nicotinamide
672291-92-8

N-(2-hydroxy-1-hydroxymethylpropyl)-6-methyl-nicotinamide

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: D-threoninol In N,N-dimethyl-formamide at 20℃;
92%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

(3R)-1-[bis-(4-chlorophenyl)methyl]-3-aminopyrrolidine
870632-94-3

(3R)-1-[bis-(4-chlorophenyl)methyl]-3-aminopyrrolidine

(3R)-1-[bis-(4-chlorophenyl)methyl]-3-[(6-methylnicotinoyl)amino]pyrrolidine

(3R)-1-[bis-(4-chlorophenyl)methyl]-3-[(6-methylnicotinoyl)amino]pyrrolidine

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid; (3R)-1-[bis-(4-chlorophenyl)methyl]-3-aminopyrrolidine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In DMF (N,N-dimethyl-formamide); chloroform at 20℃;
Stage #2: With sodium hydrogencarbonate In DMF (N,N-dimethyl-formamide); chloroform; water for 0.25h;
92%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

4-fluoroaniline
371-40-4

4-fluoroaniline

N-(4-fluorophenyl)-6-methylnicotinamide
1061394-94-2

N-(4-fluorophenyl)-6-methylnicotinamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux;92%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

3-aminophenylboronic acid pinacolate
210907-84-9

3-aminophenylboronic acid pinacolate

6-methyl-N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)nicotinamide

6-methyl-N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)nicotinamide

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid; 3-aminophenylboronic acid pinacolate With HATU In N,N-dimethyl-formamide at 30℃; for 0.0833333h;
Stage #2: With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 30℃; for 16h;
92%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

benzyl bromide
100-39-0

benzyl bromide

benzyl 6-methylnicotinate

benzyl 6-methylnicotinate

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid With tetrabutylammomium bromide; potassium hydroxide In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: benzyl bromide In tetrahydrofuran at 20℃; for 48h;
92%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 6-methylnicotinate

tert-butyl 6-methylnicotinate

Conditions
ConditionsYield
With dmap In toluene Concentration; Reflux;91.9%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

tert-butyl alcohol
75-65-0

tert-butyl alcohol

tert-butyl N-(6-methylpyridin-3-yl)carbamate
323578-37-6

tert-butyl N-(6-methylpyridin-3-yl)carbamate

Conditions
ConditionsYield
With diphenyl phosphoryl azide; triethylamine In 1,4-dioxane at 20℃; for 18h; Product distribution / selectivity; Heating / reflux;88%
With diphenyl phosphoryl azide; triethylamine In 1,4-dioxane at 20℃; for 18h; Heating / reflux;88%
With diphenyl phosphoryl azide; triethylamine for 19h; Product distribution / selectivity; Heating / reflux;87%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

manganese(II) chloride tetrahydrate

manganese(II) chloride tetrahydrate

C14H16MnN2O6
1567762-05-3

C14H16MnN2O6

Conditions
ConditionsYield
In methanol at 20℃; for 0.166667h;88%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

tert-butyl 3-(3-amino-5-chloro-2-methylbenzyl)-3,8-diazabicyclo[3.2.1]octan-8-carboxylate

tert-butyl 3-(3-amino-5-chloro-2-methylbenzyl)-3,8-diazabicyclo[3.2.1]octan-8-carboxylate

tert-butyl 3-(5-chloro-2-methyl-3-(6-methylnicotinamido)benzyl)-3,8-diazabicyclo[3.2.1]octan-8-carboxylate

tert-butyl 3-(5-chloro-2-methyl-3-(6-methylnicotinamido)benzyl)-3,8-diazabicyclo[3.2.1]octan-8-carboxylate

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 1h;
Stage #2: tert-butyl 3-(3-amino-5-chloro-2-methylbenzyl)-3,8-diazabicyclo[3.2.1]octan-8-carboxylate With triethylamine In dichloromethane at 0 - 20℃;
87.5%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

(S)-N-[1-(3-aminophenyl)ethyl]-6-chloropyrazin-2-amine
1027255-35-1

(S)-N-[1-(3-aminophenyl)ethyl]-6-chloropyrazin-2-amine

N-(3-{(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl}phenyl)-6-methylnicotinamide
1027253-43-5

N-(3-{(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl}phenyl)-6-methylnicotinamide

Conditions
ConditionsYield
With 4-pyrrolidin-1-ylpyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 72h;86%
With 4-pyrrolidin-1-ylpyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 48h;
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

8-bromo-7-methyl-[1,2,4] triazolo[1,5-a]pyridin-6-amine

8-bromo-7-methyl-[1,2,4] triazolo[1,5-a]pyridin-6-amine

N-(8-bromo-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-6-methylnicotinamide

N-(8-bromo-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-6-methylnicotinamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 60℃; for 2h;86%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

6-methyl-N-(2-morpholinoethyl)nicotinamide
1221489-83-3

6-methyl-N-(2-morpholinoethyl)nicotinamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux;85%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

C12H11BrN4O3

C12H11BrN4O3

1-(4-bromophenyl)-2-(2-methyl-4-nitro-1H-imidazol-1-yl)ethanone-(6-methylnicotinoyl)oxime

1-(4-bromophenyl)-2-(2-methyl-4-nitro-1H-imidazol-1-yl)ethanone-(6-methylnicotinoyl)oxime

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;85%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

4-(aminomethyl)-1-methyl-5,6,7,8-tetrahydroisoquinolin-3(2H)-one

4-(aminomethyl)-1-methyl-5,6,7,8-tetrahydroisoquinolin-3(2H)-one

6-methyl-N-((1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolin-4-yl)methyl)nicotinamide

6-methyl-N-((1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolin-4-yl)methyl)nicotinamide

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h;
Stage #2: 4-(aminomethyl)-1-methyl-5,6,7,8-tetrahydroisoquinolin-3(2H)-one In dichloromethane at 20℃; for 7h;
85%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

1-[2'-(hydroxy)ethyl]-2-ethyl-3-benzyloxy-4(1H)-pyridinone
210244-51-2

1-[2'-(hydroxy)ethyl]-2-ethyl-3-benzyloxy-4(1H)-pyridinone

6-methyl-nicotinic acid 2-(3-benzyloxy-2-ethyl-4-oxo-4H-pyridin-1-yl)-ethyl ester
243658-72-2

6-methyl-nicotinic acid 2-(3-benzyloxy-2-ethyl-4-oxo-4H-pyridin-1-yl)-ethyl ester

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Esterification;81%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine
1428929-08-1, 1428954-51-1

4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine

6-methyl-N-[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]pyridine-3-carboxamide
1428926-16-2, 1428947-91-4, 1428947-92-5

6-methyl-N-[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]pyridine-3-carboxamide

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine With 4-methyl-morpholine In N,N-dimethyl-formamide for 18h;
81%
Stage #1: 6-methylnicotinic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine With 4-methyl-morpholine In N,N-dimethyl-formamide for 18h;
81%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

para-fluorobenzylamine
140-75-0

para-fluorobenzylamine

C14H13FN2O
1061380-08-2

C14H13FN2O

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;80%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

C14H18Cl2N2NiO6*4H2O

C14H18Cl2N2NiO6*4H2O

Conditions
ConditionsYield
In acetonitrile at 20℃; for 0.166667h;80%

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