Product Name

  • Name

    6-Methylpyridine-3-carboxylic acid

  • EINECS -0
  • CAS No. 3222-47-7
  • Article Data31
  • CAS DataBase
  • Density 1.23 g/cm3
  • Solubility Sparingly soluble in water.
  • Melting Point 210-213 °C(lit.)
  • Formula C7H7NO2
  • Boiling Point 296.2 °C at 760 mmHg
  • Molecular Weight 137.138
  • Flash Point 132.9 °C
  • Transport Information
  • Appearance White crystalline
  • Safety 37/39-26-36
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 3222-47-7 (6-Methylpyridine-3-carboxylic acid)
  • Hazard Symbols IrritantXi
  • Synonyms 6-methylpyridine-3-carboxylate;6-methylpyridine-3-carboxylic acid;
  • PSA 50.19000
  • LogP 1.08820

Synthetic route

Methyl 6-methylnicotinate
5470-70-2

Methyl 6-methylnicotinate

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
100%
2-methyl-5-vinylpyridine
140-76-1

2-methyl-5-vinylpyridine

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
With potassium permanganate In water at 80℃; for 0.05h;84.2%
With potassium hydroxide; potassium permanganate In water; acetone at 30℃; for 2h; Title compound not separated from byproducts;
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
With nitric acid for 5h; Heating;75.4%
With nitric acid
2,5-dimethylpyridine
589-93-5

2,5-dimethylpyridine

A

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

B

Pyridine-2,5-dicarboxylic acid
100-26-5

Pyridine-2,5-dicarboxylic acid

Conditions
ConditionsYield
With potassium permanganate In water at 90℃; for 6.2h;A 14.5%
B 70.8%
With potassium permanganate In water at 80℃; for 1.5h; Product distribution; other pyridines, var. temp.;A 47.1%
B 12.3%
5-ethyl-2-methyl-pyridine
104-90-5

5-ethyl-2-methyl-pyridine

A

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

B

5-ethylpyridine-2-carboxylic acid
770-08-1

5-ethylpyridine-2-carboxylic acid

C

Pyridine-2,5-dicarboxylic acid
100-26-5

Pyridine-2,5-dicarboxylic acid

Conditions
ConditionsYield
With potassium permanganate In water at 90℃; for 0.433333h;A 57.5%
B 3.5%
C 18.4%
With potassium permanganate In water at 80℃; for 0.166667h;A 42%
B 5.4%
C 1.6%
2,5-dimethylpyridine
589-93-5

2,5-dimethylpyridine

A

2-carboxy-5-methylpyridine
4434-13-3

2-carboxy-5-methylpyridine

B

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

C

Pyridine-2,5-dicarboxylic acid
100-26-5

Pyridine-2,5-dicarboxylic acid

Conditions
ConditionsYield
With potassium permanganate In water at 80℃; for 1.5h;A 19.1%
B 47.1%
C 12.3%
5-ethyl-2-methyl-pyridine
104-90-5

5-ethyl-2-methyl-pyridine

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
With selenium(IV) oxide; nitric acid
With potassium permanganate at 60℃;
With potassium permanganate; water
With nitric acid; vanadia
6-methylnicotinonitrile
3222-48-8

6-methylnicotinonitrile

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
With sulfuric acid
ethyl 6-methylnicotinate
21684-59-3

ethyl 6-methylnicotinate

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
With potassium hydroxide
With hydrogenchloride In water at 80℃;
With lithium aluminium tetrahydride In tetrahydrofuran
5-ethyl-2-methyl-pyridine
104-90-5

5-ethyl-2-methyl-pyridine

nitric acid
7697-37-2

nitric acid

ammonium vanadate

ammonium vanadate

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
Erhitzen auf Siedetemperatur;
CP289

CP289

A

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

B

3-hydroxy-1-(3-hydroxypropyl)-2-methylpyridin-4(1H)-one

3-hydroxy-1-(3-hydroxypropyl)-2-methylpyridin-4(1H)-one

Conditions
ConditionsYield
With water In acetonitrile at 37℃; for 0.166667h; pH=2.0; Kinetics; Further Variations:; pH-values; reaction time; Acid hydrolysis;
5-Amino-2-methylpyridine
80287-53-2, 3430-14-6

5-Amino-2-methylpyridine

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous CuSO4 / Diazotization
2: aqueous H2SO4
View Scheme
ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate
86129-63-7

ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium; potassium acetate; ethanol / Hydrogenation
2: aqueous KOH
View Scheme
ethyl 2,4-dihydroxy-6-methylnicotinate
10350-10-4, 70254-52-3, 70254-53-4

ethyl 2,4-dihydroxy-6-methylnicotinate

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: POCl3 / 130 °C
2: palladium; potassium acetate; ethanol / Hydrogenation
3: aqueous KOH
View Scheme
5-Hydroxy-2-methylpyridine
1121-78-4

5-Hydroxy-2-methylpyridine

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: fluorosulfonyl fluoride; triethylamine / dichloromethane / 24 h / 20 °C / 760.05 Torr
2: bis(triphenylphosphine)nickel(II) chloride; 2.9-dimethyl-1,10-phenanthroline; manganese / N,N-dimethyl-formamide / 20 h / 20 °C / 760.05 Torr / Schlenk technique; Inert atmosphere; Glovebox
View Scheme
carbon dioxide
124-38-9

carbon dioxide

6-methylpyridin-3-yl sulfurofluoridate

6-methylpyridin-3-yl sulfurofluoridate

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
With manganese; bis(triphenylphosphine)nickel(II) chloride; 2.9-dimethyl-1,10-phenanthroline In N,N-dimethyl-formamide at 20℃; under 760.051 Torr; for 20h; Schlenk technique; Inert atmosphere; Glovebox;
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

glyoxylic acid ethyl ester
924-44-7

glyoxylic acid ethyl ester

6-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]nicotinic acid
1018673-98-7

6-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]nicotinic acid

Conditions
ConditionsYield
With acetic anhydride In toluene at 20 - 130℃; for 20h;100%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

acide methyl-6 nipecotique
116140-16-0

acide methyl-6 nipecotique

Conditions
ConditionsYield
With ammonia; hydrogen; 5% rhodium on alumina In water under 2068.65 Torr; for 72h;100%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

(S)-tert-butyl 4-((6-amino-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-8-yl)methyl)-2-methylpiperazine-1-carboxylate

(S)-tert-butyl 4-((6-amino-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-8-yl)methyl)-2-methylpiperazine-1-carboxylate

tert-butyl (2S)-2-methyl-4-((7-methyl-6-((6-methylpyridine-3-carbonyl)amino)-[1,2,4]triazolo[1,5-a]pyridin-8-yl)methyl)piperazine-1-carboxylate

tert-butyl (2S)-2-methyl-4-((7-methyl-6-((6-methylpyridine-3-carbonyl)amino)-[1,2,4]triazolo[1,5-a]pyridin-8-yl)methyl)piperazine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 70℃; for 13h;100%
2,3-Diaminopyridine
452-58-4

2,3-Diaminopyridine

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

2-(6-Methyl-pyridin-3-yl)-1H-imidazo[4,5-b]pyridine
120623-51-0

2-(6-Methyl-pyridin-3-yl)-1H-imidazo[4,5-b]pyridine

Conditions
ConditionsYield
With PPA at 210℃; for 2h;98%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

tryptamine
61-54-1

tryptamine

N-(2-(1H-indol-3-yl)ethyl)-6-methylpyridine-3-carboxamide

N-(2-(1H-indol-3-yl)ethyl)-6-methylpyridine-3-carboxamide

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid With 1,1'-carbonyldiimidazole In ethyl acetate for 5h; Reflux;
Stage #2: tryptamine In ethyl acetate for 12h; Reflux;
98%
2-amino-3-hydroxypyridine
16867-03-1

2-amino-3-hydroxypyridine

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

2-(6-Methyl-pyridin-3-yl)-oxazolo[4,5-b]pyridine
120623-52-1

2-(6-Methyl-pyridin-3-yl)-oxazolo[4,5-b]pyridine

Conditions
ConditionsYield
With PPA at 210℃; for 2h;96%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

{Cu2(μ-bis(diphenylphosphino)methane)2(CH3CN)2}{BF4}2

{Cu2(μ-bis(diphenylphosphino)methane)2(CH3CN)2}{BF4}2

[Cu2(bis(diphenylphosphino)methane)2(6-methyl-3-pyridylcarboxylato)][BF4]

[Cu2(bis(diphenylphosphino)methane)2(6-methyl-3-pyridylcarboxylato)][BF4]

Conditions
ConditionsYield
In dichloromethane under N2; suspn. of (Cu(dppm)MeCN))2(BF4)2 and 6-methyl-3-pyridinecarboxylic acid in CH2Cl2 was stirred at ambient temp. for 30 min, resulting soln. was stirred for 10 min; evapn. under vac., ppt. was washed with Et2O, recrystn. from CH2Cl2/hexane; elem. anal.;96%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-methoxy-N-methyl-6-methylnicotinamide
221615-71-0

N-methoxy-N-methyl-6-methylnicotinamide

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 1h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With pyridine In dichloromethane at 0 - 20℃; for 18h;
95%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃;91%
With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20 - 23℃;90%
With 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In tetrahydrofuran; methanol at 20℃; for 3h;82%
Stage #1: 6-methylnicotinic acid With pivaloyl chloride In dichloromethane at 0℃; for 1h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃; for 2.5h;
51%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

(S)-3-[3-(trimethylsilanyl)prop-2-ynyl]morpholine
1008510-61-9

(S)-3-[3-(trimethylsilanyl)prop-2-ynyl]morpholine

(6-methylpyridin-3-yl)-{(S)-[3-(trimethylsilanyl)prop-2-ynyl]morpholin-4-yl}-methanone
1258972-08-5

(6-methylpyridin-3-yl)-{(S)-[3-(trimethylsilanyl)prop-2-ynyl]morpholin-4-yl}-methanone

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; for 16h;93%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

C21H24N2O2

C21H24N2O2

[(S)-3-(5-benzyloxy-1-methyl-1H-indol-3-ylmethyl)morpholine-4-yl]-(6-methylpyridin-3-yl)-methanone
1258972-14-3

[(S)-3-(5-benzyloxy-1-methyl-1H-indol-3-ylmethyl)morpholine-4-yl]-(6-methylpyridin-3-yl)-methanone

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;93%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

D-threoninol
44520-55-0

D-threoninol

N-(2-hydroxy-1-hydroxymethylpropyl)-6-methyl-nicotinamide
672291-92-8

N-(2-hydroxy-1-hydroxymethylpropyl)-6-methyl-nicotinamide

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: D-threoninol In N,N-dimethyl-formamide at 20℃;
92%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

(3R)-1-[bis-(4-chlorophenyl)methyl]-3-aminopyrrolidine
870632-94-3

(3R)-1-[bis-(4-chlorophenyl)methyl]-3-aminopyrrolidine

(3R)-1-[bis-(4-chlorophenyl)methyl]-3-[(6-methylnicotinoyl)amino]pyrrolidine

(3R)-1-[bis-(4-chlorophenyl)methyl]-3-[(6-methylnicotinoyl)amino]pyrrolidine

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid; (3R)-1-[bis-(4-chlorophenyl)methyl]-3-aminopyrrolidine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In DMF (N,N-dimethyl-formamide); chloroform at 20℃;
Stage #2: With sodium hydrogencarbonate In DMF (N,N-dimethyl-formamide); chloroform; water for 0.25h;
92%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

4-fluoroaniline
371-40-4

4-fluoroaniline

N-(4-fluorophenyl)-6-methylnicotinamide
1061394-94-2

N-(4-fluorophenyl)-6-methylnicotinamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux;92%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

3-aminophenylboronic acid pinacolate
210907-84-9

3-aminophenylboronic acid pinacolate

6-methyl-N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)nicotinamide

6-methyl-N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)nicotinamide

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid; 3-aminophenylboronic acid pinacolate With HATU In N,N-dimethyl-formamide at 30℃; for 0.0833333h;
Stage #2: With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 30℃; for 16h;
92%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

benzyl bromide
100-39-0

benzyl bromide

benzyl 6-methylnicotinate

benzyl 6-methylnicotinate

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid With tetrabutylammomium bromide; potassium hydroxide In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: benzyl bromide In tetrahydrofuran at 20℃; for 48h;
92%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 6-methylnicotinate

tert-butyl 6-methylnicotinate

Conditions
ConditionsYield
With dmap In toluene Concentration; Reflux;91.9%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

tert-butyl alcohol
75-65-0

tert-butyl alcohol

tert-butyl N-(6-methylpyridin-3-yl)carbamate
323578-37-6

tert-butyl N-(6-methylpyridin-3-yl)carbamate

Conditions
ConditionsYield
With diphenyl phosphoryl azide; triethylamine In 1,4-dioxane at 20℃; for 18h; Product distribution / selectivity; Heating / reflux;88%
With diphenyl phosphoryl azide; triethylamine In 1,4-dioxane at 20℃; for 18h; Heating / reflux;88%
With diphenyl phosphoryl azide; triethylamine for 19h; Product distribution / selectivity; Heating / reflux;87%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

manganese(II) chloride tetrahydrate

manganese(II) chloride tetrahydrate

C14H16MnN2O6
1567762-05-3

C14H16MnN2O6

Conditions
ConditionsYield
In methanol at 20℃; for 0.166667h;88%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

tert-butyl 3-(3-amino-5-chloro-2-methylbenzyl)-3,8-diazabicyclo[3.2.1]octan-8-carboxylate

tert-butyl 3-(3-amino-5-chloro-2-methylbenzyl)-3,8-diazabicyclo[3.2.1]octan-8-carboxylate

tert-butyl 3-(5-chloro-2-methyl-3-(6-methylnicotinamido)benzyl)-3,8-diazabicyclo[3.2.1]octan-8-carboxylate

tert-butyl 3-(5-chloro-2-methyl-3-(6-methylnicotinamido)benzyl)-3,8-diazabicyclo[3.2.1]octan-8-carboxylate

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 1h;
Stage #2: tert-butyl 3-(3-amino-5-chloro-2-methylbenzyl)-3,8-diazabicyclo[3.2.1]octan-8-carboxylate With triethylamine In dichloromethane at 0 - 20℃;
87.5%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

(S)-N-[1-(3-aminophenyl)ethyl]-6-chloropyrazin-2-amine
1027255-35-1

(S)-N-[1-(3-aminophenyl)ethyl]-6-chloropyrazin-2-amine

N-(3-{(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl}phenyl)-6-methylnicotinamide
1027253-43-5

N-(3-{(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl}phenyl)-6-methylnicotinamide

Conditions
ConditionsYield
With 4-pyrrolidin-1-ylpyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 72h;86%
With 4-pyrrolidin-1-ylpyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 48h;
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

8-bromo-7-methyl-[1,2,4] triazolo[1,5-a]pyridin-6-amine

8-bromo-7-methyl-[1,2,4] triazolo[1,5-a]pyridin-6-amine

N-(8-bromo-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-6-methylnicotinamide

N-(8-bromo-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-6-methylnicotinamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 60℃; for 2h;86%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

6-methyl-N-(2-morpholinoethyl)nicotinamide
1221489-83-3

6-methyl-N-(2-morpholinoethyl)nicotinamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Reflux;85%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

C12H11BrN4O3

C12H11BrN4O3

1-(4-bromophenyl)-2-(2-methyl-4-nitro-1H-imidazol-1-yl)ethanone-(6-methylnicotinoyl)oxime

1-(4-bromophenyl)-2-(2-methyl-4-nitro-1H-imidazol-1-yl)ethanone-(6-methylnicotinoyl)oxime

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;85%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

4-(aminomethyl)-1-methyl-5,6,7,8-tetrahydroisoquinolin-3(2H)-one

4-(aminomethyl)-1-methyl-5,6,7,8-tetrahydroisoquinolin-3(2H)-one

6-methyl-N-((1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolin-4-yl)methyl)nicotinamide

6-methyl-N-((1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolin-4-yl)methyl)nicotinamide

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h;
Stage #2: 4-(aminomethyl)-1-methyl-5,6,7,8-tetrahydroisoquinolin-3(2H)-one In dichloromethane at 20℃; for 7h;
85%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

1-[2'-(hydroxy)ethyl]-2-ethyl-3-benzyloxy-4(1H)-pyridinone
210244-51-2

1-[2'-(hydroxy)ethyl]-2-ethyl-3-benzyloxy-4(1H)-pyridinone

6-methyl-nicotinic acid 2-(3-benzyloxy-2-ethyl-4-oxo-4H-pyridin-1-yl)-ethyl ester
243658-72-2

6-methyl-nicotinic acid 2-(3-benzyloxy-2-ethyl-4-oxo-4H-pyridin-1-yl)-ethyl ester

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Esterification;81%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine
1428929-08-1, 1428954-51-1

4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine

6-methyl-N-[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]pyridine-3-carboxamide
1428926-16-2, 1428947-91-4, 1428947-92-5

6-methyl-N-[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]pyridine-3-carboxamide

Conditions
ConditionsYield
Stage #1: 6-methylnicotinic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine With 4-methyl-morpholine In N,N-dimethyl-formamide for 18h;
81%
Stage #1: 6-methylnicotinic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: 4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine With 4-methyl-morpholine In N,N-dimethyl-formamide for 18h;
81%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

para-fluorobenzylamine
140-75-0

para-fluorobenzylamine

C14H13FN2O
1061380-08-2

C14H13FN2O

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;80%
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

C14H18Cl2N2NiO6*4H2O

C14H18Cl2N2NiO6*4H2O

Conditions
ConditionsYield
In acetonitrile at 20℃; for 0.166667h;80%

6-Methylnicotinic acid Standards and Recommendations

Assay of 6-Methylnicotinic acid: 99%

6-Methylnicotinic acid Specification

The 6-Methylnicotinic acid is an organic compound with the formula C7H7NO2. The IUPAC name of this chemical is 6-methylpyridine-3-carboxylic acid. With the CAS registry number 3222-47-7, it is also named as 3-Pyridinecarboxylic acid, 6-methyl-. The product's categories are Acids and Derivatives; Heterocycles; Pharmacetical; Pyridine; Organic Acids. Besides, it is a white crystalline, which should be stored in a cool dry and well-ventilated area away from incompatible substances.

Physical properties about 6-Methylnicotinic acid are: (1)ACD/LogP: 0.61 ; (2)ACD/LogD (pH 5.5): -1.41; (3)ACD/LogD (pH 7.4): -2.43; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 1; (11)Polar Surface Area: 39.19 Å2; (12)Index of Refraction: 1.561; (13)Molar Refractivity: 36.09 cm3; (14)Molar Volume: 111.4 cm3; (15)Polarizability: 14.31×10-24cm3; (16)Surface Tension: 53.3 dyne/cm; (17)Density: 1.23 g/cm3; (18)Flash Point: 132.9 °C; (19)Enthalpy of Vaporization: 56.6 kJ/mol; (20)Boiling Point: 296.2 °C at 760 mmHg; (21)Vapour Pressure: 0.000659 mmHg at 25°C.

Preparation: this chemical can be prepared by 1-(6-methyl-pyridin-3-yl)-ethanone. This reaction will need reagent nitric acid.



Uses of 6-Methylnicotinic acid: it can be used to produce 2-(6-methyl-pyridin-3-yl)-1H-imidazo[4,5-b]pyridine at temperature of 210 °C. It will need reagent polyphosphoric acid with reaction time of 2 hours. The yield is about 98%.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)c1cnc(cc1)C
(2)InChI: InChI=1/C7H7NO2/c1-5-2-3-6(4-8-5)7(9)10/h2-4H,1H3,(H,9,10)
(3)InChIKey: RZOKQIPOABEQAM-UHFFFAOYAJ
(4)Std. InChI: InChI=1S/C7H7NO2/c1-5-2-3-6(4-8-5)7(9)10/h2-4H,1H3,(H,9,10)
(5)Std. InChIKey: RZOKQIPOABEQAM-UHFFFAOYSA-N

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