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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Trans-4-Methylcyclohexylamine Hydrochloride supplier in China

Cas:33483-65-7

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

trans-4-Methylcyclohexylamine hydrochloride Manufacturer/High quality/Best price/In stock

Cas:33483-65-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

trans-4-Methylcyclohexanamine hydrochloride

Cas:33483-65-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1069.html Product Name 4-[(5-Bromo-2-chlorophenyl)methyl]phenol CAS No.

trans-4-Methylcyclohexylamine hydrochloride

Cas:33483-65-7

Min.Order:1 Gram

FOB Price: $12.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Trans-4-Methylcyclohexylamine Hydrochloride CAS 33483-65-7

Cas:33483-65-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Best priceCAS 33483-65-7 with high-quality service

Cas:33483-65-7

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

trans-4-Methylcyclohexylamine hydrochloride 33483-65-7

Cas:33483-65-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

trans-4-Methylcyclohexylamine hydrochloride/ LIDE PHARMA- Factory supply / Best price

Cas:33483-65-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

trans-4-Methylcyclohexylamine hydrochloride

Cas:33483-65-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

trans-4-Methylcyclohexylamine hydrochloride

Cas:33483-65-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Trans-4-Methylcyclohexylamine Hydrochloride

Cas:33483-65-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Trans-4-methyl cyclohexyl amine Hydrochloride

Cas:33483-65-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Trans-4-methyl cyclohexyl amine Hydrochloride

Cas:33483-65-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

TRANS-4-METHYLCYCLOHEXYLAMINE HYDROCHLORIDE

Cas:33483-65-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply trans-4-Methylcyclohexylamine hydrochloride

Cas:33483-65-7

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

trans-4-Methylcyclohexylamine hydrochloride

Cas:33483-65-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Trans-4-Methylcyclohexylamine Hydrochloride

Cas:33483-65-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

tianfu chem trans-4-Methylcyclohexylamine hydrochloride

Cas:33483-65-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

tianfu chem trans-4-Methylcyclohexylamine hydrochloride

Cas:33483-65-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

tianfu chem trans-4-Methylcyclohexylamine hydrochloride

Cas:33483-65-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

trans-4-Methylcyclohexylamine hydrochloride

Cas:33483-65-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Trans-4-methyl cyclohexyl amine Hydrochloride

Cas:33483-65-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

trans-4-Methyl-cyclohexylamine HCl

Cas:33483-65-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

trans-4-Methylcyclohexylamine hydrochloride

Cas:33483-65-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Trans-4-methyl cyclohexyl amine Hydrochloride

Cas:33483-65-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratoryAppearance:white powder Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

trans-4-Methylcyclohexylamine hydrochloride cas no. 33483-65-7 98%

Cas:33483-65-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

trans-4-Methylcyclohexylamine hydrochloride

Cas:33483-65-7

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

trans-4-Methylcyclohexylamine hydrochloride

Cas:33483-65-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Trans-4-Methylcyclohexylamine Hydrochloride

Cas:33483-65-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

Cyclohexanamine,4-methyl-, hydrochloride (1:1), trans-

Cas:33483-65-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

trans-4-methylcyclohexylamine hydrochloride
100959-19-1

trans-4-methylcyclohexylamine hydrochloride

trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

Conditions
ConditionsYield
In methanol; acetone at 25 - 30℃; for 3h;
formic acid
64-18-6

formic acid

trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

N-(4-methylcyclohexyl)formamide
26003-39-4

N-(4-methylcyclohexyl)formamide

Conditions
ConditionsYield
With sodium formate at 120 - 140℃; for 2h;
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

trans-N,4-dimethylcyclohexylamine
2523-88-8

trans-N,4-dimethylcyclohexylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCO2Na / 2 h / 120 - 140 °C
2: LiAlH4 / diethyl ether
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

trans-4.N-Dimetil-N-(2.4-dinitrofenil)cicloesilammina
25886-43-5

trans-4.N-Dimetil-N-(2.4-dinitrofenil)cicloesilammina

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: HCO2Na / 2 h / 120 - 140 °C
2: LiAlH4 / diethyl ether
3: NaOEt / ethanol / Heating
View Scheme
quinoxaline-2-carboxylic acid chloride
54745-92-5

quinoxaline-2-carboxylic acid chloride

ethyl acetate n-hexane

ethyl acetate n-hexane

trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

1-methylcyclohexan-4-one
589-92-4

1-methylcyclohexan-4-one

A

N-(trans-4-methylcyclohexyl)-2-quinoxalinecarboxamide
226877-90-3

N-(trans-4-methylcyclohexyl)-2-quinoxalinecarboxamide

B

N-(trans-4-Methylcyclohexyl)-2-qulinoxalinecarboxamide

N-(trans-4-Methylcyclohexyl)-2-qulinoxalinecarboxamide

Conditions
ConditionsYield
With pyridine; hydroxylamine In ethanol; dichloromethane; water; ethyl acetate
2-amino-4-chloropyrimidine
3993-78-0

2-amino-4-chloropyrimidine

trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

N4-((1r,4r)-4-methylcyclohexyl)pyridine-2,4-diamine
1401034-42-1

N4-((1r,4r)-4-methylcyclohexyl)pyridine-2,4-diamine

Conditions
ConditionsYield
With triethylamine In butan-1-ol for 36h; Reflux;
With triethylamine In butan-1-ol for 36h; Reflux; Inert atmosphere;1770 g
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

9-((1r,4r)-4-methylcyclohexyl)-N-(5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine
1401033-82-6

9-((1r,4r)-4-methylcyclohexyl)-N-(5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
View Scheme
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere
3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere
3.2: 0.58 h / -60 °C / Inert atmosphere
3.3: Reflux; Inert atmosphere
4.1: lithium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one / 90 °C / Inert atmosphere
5.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 0.17 h / Inert atmosphere
5.2: 3 h / 100 °C / Inert atmosphere
6.1: hydrogenchloride; water / methanol / 20 °C / Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

5-iodo-N4-((1R,4R)-4-methylcyclohexyl)pyrimidine-2,4-diamine
1401034-43-2

5-iodo-N4-((1R,4R)-4-methylcyclohexyl)pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / butan-1-ol / 36 h / Reflux
2: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere
2: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

5-(3-fluoropyridin-4-yl)-N4-((1R,4R)-4-methylcyclohexyl)pyrimidine-2,4-diamine
1401034-44-3

5-(3-fluoropyridin-4-yl)-N4-((1R,4R)-4-methylcyclohexyl)pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / butan-1-ol / 36 h / Reflux
2: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere
3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere
3.2: 0.58 h / -60 °C / Inert atmosphere
3.3: Reflux; Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine
1401034-45-4

9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / butan-1-ol / 36 h / Reflux
2: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere
3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere
3.2: 0.58 h / -60 °C / Inert atmosphere
3.3: Reflux; Inert atmosphere
4.1: lithium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one / 90 °C / Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

tert-butyl 2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
1401034-46-5

tert-butyl 2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / butan-1-ol / 36 h / Reflux
2: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5: sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere
3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere
3.2: 0.58 h / -60 °C / Inert atmosphere
3.3: Reflux; Inert atmosphere
4.1: lithium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one / 90 °C / Inert atmosphere
5.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 0.17 h / Inert atmosphere
5.2: 3 h / 100 °C / Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

1-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanone

1-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: 1,4-dioxane / 0.17 h
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

2-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-y}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanol
1401033-84-8

2-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-y}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: 1,4-dioxane / 0.08 h
6.2: 0.17 h
7.1: hydrogenchloride / 1,4-dioxane / 0.5 h
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

2-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)-2-oxoethyl acetate
1401034-47-6

2-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)-2-oxoethyl acetate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere
3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere
3.2: 0.58 h / -60 °C / Inert atmosphere
3.3: Reflux; Inert atmosphere
4.1: lithium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one / 90 °C / Inert atmosphere
5.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 0.17 h / Inert atmosphere
5.2: 3 h / 100 °C / Inert atmosphere
6.1: hydrogenchloride; water / methanol / 20 °C / Inert atmosphere
7.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C / Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

2-hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone
1401033-86-0

2-hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
7.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere
3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere
3.2: 0.58 h / -60 °C / Inert atmosphere
3.3: Reflux; Inert atmosphere
4.1: lithium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one / 90 °C / Inert atmosphere
5.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 0.17 h / Inert atmosphere
5.2: 3 h / 100 °C / Inert atmosphere
6.1: hydrogenchloride; water / methanol / 20 °C / Inert atmosphere
7.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C / Inert atmosphere
8.1: methanol; sodium methylate / dichloromethane / 1 h / 20 °C / Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

2-hydroxy-1-(2-((9-((1R,4R)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone hydrochloride
1401034-19-2

2-hydroxy-1-(2-((9-((1R,4R)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
7.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
8.1: hydrogenchloride / water
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

2-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]-2-oxoacetic acid
1401033-87-1

2-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]-2-oxoacetic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: pyridine / tetrahydrofuran / 20 °C
7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

methyl 2-{[6-(2-methoxy-2-oxoacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]{9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino}-2-oxoacetate
1401034-48-7

methyl 2-{[6-(2-methoxy-2-oxoacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]{9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino}-2-oxoacetate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: pyridine / tetrahydrofuran / 20 °C
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

9-[(1r,4r)-4-methylcyclohexyl]-N-[6-(3,3,3-trifluoropropyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine
1401033-88-2

9-[(1r,4r)-4-methylcyclohexyl]-N-[6-(3,3,3-trifluoropropyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: sodium tris(acetoxy)borohydride / 1,4-dioxane / 0.25 h
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

N-[6-(2-fluoroethyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]-9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine
1401033-90-6

N-[6-(2-fluoroethyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]-9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N,N-dimethyl-formamide; ethanol / 8.67 h / 90 °C
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

N-[6-(2-methoxyethyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]-9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine
1401033-91-7

N-[6-(2-methoxyethyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]-9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 °C
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

tert-butyl 8-methyl-2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
1401034-52-3

tert-butyl 8-methyl-2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / butan-1-ol / 36 h / Reflux
2: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 1.5 h / 100 °C / Microwave radiation
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

5-(5-fluoro-2-methoxypyridin-4-yl)-N4-[(1r,4r)-4-methylcyclohexyl]pyrimidine-2,4-diamine
1401034-56-7

5-(5-fluoro-2-methoxypyridin-4-yl)-N4-[(1r,4r)-4-methylcyclohexyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: lithium diisopropyl amide / tetrahydrofuran / 1.83 h / -78 °C
3.2: Reflux
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

6-methoxy-9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine
1401034-57-8

6-methoxy-9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: lithium diisopropyl amide / tetrahydrofuran / 1.83 h / -78 °C
3.2: Reflux
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 105 °C / Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

(S)-2-hydroxy-1-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]propan-1-one
1401034-13-6

(S)-2-hydroxy-1-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]propan-1-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1,2-dichloro-ethane / chloroform / 4 h / 20 °C
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

C26H29N7O2*(x)H3O4P

C26H29N7O2*(x)H3O4P

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
7.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
8.1: phosphoric acid / dichloromethane; ethanol / 0.02 h
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

(x)C6H8O7*C26H29N7O2

(x)C6H8O7*C26H29N7O2

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
7.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
8.1: dichloromethane; ethanol / 0.02 h
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

(x)C4H6O6*C26H29N7O2

(x)C4H6O6*C26H29N7O2

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
7.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
8.1: dichloromethane; ethanol / 0.02 h
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

(x)C7H6O3*C26H29N7O2

(x)C7H6O3*C26H29N7O2

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
7.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
8.1: dichloromethane; ethanol / 0.02 h
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

(x)C6H6O3S*C26H29N7O2

(x)C6H6O3S*C26H29N7O2

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
7.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
8.1: dichloromethane; ethanol / 0.02 h
View Scheme

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