Product Name

  • Name

    trans-4-Methylcyclohexylamine hydrochloride

  • EINECS
  • CAS No. 33483-65-7
  • Article Data37
  • CAS DataBase
  • Density
  • Solubility
  • Melting Point 260 °C
  • Formula C7H15N.HCl
  • Boiling Point 195.9 °C at 760 mmHg
  • Molecular Weight 149.664
  • Flash Point 72.3 °C
  • Transport Information
  • Appearance
  • Safety 24/25
  • Risk Codes
  • Molecular Structure Molecular Structure of 33483-65-7 (trans-4-Methylcyclohexylamine hydrochloride)
  • Hazard Symbols
  • Synonyms Cyclohexanamine,4-methyl-, hydrochloride, trans- (9CI);Cyclohexylamine, 4-methyl-,hydrochloride, trans- (8CI);trans-4-Methylcyclohexanamine hydrochloride;Cyclohexanamine,4-methyl-, hydrochloride (1:1), trans-;
  • PSA 26.02000
  • LogP 3.02610

Synthetic route

trans-4-methylcyclohexylamine hydrochloride
100959-19-1

trans-4-methylcyclohexylamine hydrochloride

trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

Conditions
ConditionsYield
In methanol; acetone at 25 - 30℃; for 3h;
formic acid
64-18-6

formic acid

trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

N-(4-methylcyclohexyl)formamide
26003-39-4

N-(4-methylcyclohexyl)formamide

Conditions
ConditionsYield
With sodium formate at 120 - 140℃; for 2h;
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

trans-N,4-dimethylcyclohexylamine
2523-88-8

trans-N,4-dimethylcyclohexylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCO2Na / 2 h / 120 - 140 °C
2: LiAlH4 / diethyl ether
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

trans-4.N-Dimetil-N-(2.4-dinitrofenil)cicloesilammina
25886-43-5

trans-4.N-Dimetil-N-(2.4-dinitrofenil)cicloesilammina

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: HCO2Na / 2 h / 120 - 140 °C
2: LiAlH4 / diethyl ether
3: NaOEt / ethanol / Heating
View Scheme
quinoxaline-2-carboxylic acid chloride
54745-92-5

quinoxaline-2-carboxylic acid chloride

ethyl acetate n-hexane

ethyl acetate n-hexane

trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

1-methylcyclohexan-4-one
589-92-4

1-methylcyclohexan-4-one

A

N-(trans-4-methylcyclohexyl)-2-quinoxalinecarboxamide
226877-90-3

N-(trans-4-methylcyclohexyl)-2-quinoxalinecarboxamide

B

N-(trans-4-Methylcyclohexyl)-2-qulinoxalinecarboxamide

N-(trans-4-Methylcyclohexyl)-2-qulinoxalinecarboxamide

Conditions
ConditionsYield
With pyridine; hydroxylamine In ethanol; dichloromethane; water; ethyl acetate
...Expand
2-amino-4-chloropyrimidine
3993-78-0

2-amino-4-chloropyrimidine

trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

N4-((1r,4r)-4-methylcyclohexyl)pyridine-2,4-diamine
1401034-42-1

N4-((1r,4r)-4-methylcyclohexyl)pyridine-2,4-diamine

Conditions
ConditionsYield
With triethylamine In butan-1-ol for 36h; Reflux;
With triethylamine In butan-1-ol for 36h; Reflux; Inert atmosphere;1770 g
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

9-((1r,4r)-4-methylcyclohexyl)-N-(5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine
1401033-82-6

9-((1r,4r)-4-methylcyclohexyl)-N-(5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
View Scheme
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere
3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere
3.2: 0.58 h / -60 °C / Inert atmosphere
3.3: Reflux; Inert atmosphere
4.1: lithium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one / 90 °C / Inert atmosphere
5.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 0.17 h / Inert atmosphere
5.2: 3 h / 100 °C / Inert atmosphere
6.1: hydrogenchloride; water / methanol / 20 °C / Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

5-iodo-N4-((1R,4R)-4-methylcyclohexyl)pyrimidine-2,4-diamine
1401034-43-2

5-iodo-N4-((1R,4R)-4-methylcyclohexyl)pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / butan-1-ol / 36 h / Reflux
2: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere
2: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

5-(3-fluoropyridin-4-yl)-N4-((1R,4R)-4-methylcyclohexyl)pyrimidine-2,4-diamine
1401034-44-3

5-(3-fluoropyridin-4-yl)-N4-((1R,4R)-4-methylcyclohexyl)pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / butan-1-ol / 36 h / Reflux
2: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere
3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere
3.2: 0.58 h / -60 °C / Inert atmosphere
3.3: Reflux; Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine
1401034-45-4

9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / butan-1-ol / 36 h / Reflux
2: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere
3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere
3.2: 0.58 h / -60 °C / Inert atmosphere
3.3: Reflux; Inert atmosphere
4.1: lithium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one / 90 °C / Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

tert-butyl 2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
1401034-46-5

tert-butyl 2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / butan-1-ol / 36 h / Reflux
2: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5: sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere
3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere
3.2: 0.58 h / -60 °C / Inert atmosphere
3.3: Reflux; Inert atmosphere
4.1: lithium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one / 90 °C / Inert atmosphere
5.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 0.17 h / Inert atmosphere
5.2: 3 h / 100 °C / Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

1-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanone

1-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: 1,4-dioxane / 0.17 h
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

2-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-y}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanol
1401033-84-8

2-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-y}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: 1,4-dioxane / 0.08 h
6.2: 0.17 h
7.1: hydrogenchloride / 1,4-dioxane / 0.5 h
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

2-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)-2-oxoethyl acetate
1401034-47-6

2-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)-2-oxoethyl acetate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere
3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere
3.2: 0.58 h / -60 °C / Inert atmosphere
3.3: Reflux; Inert atmosphere
4.1: lithium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one / 90 °C / Inert atmosphere
5.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 0.17 h / Inert atmosphere
5.2: 3 h / 100 °C / Inert atmosphere
6.1: hydrogenchloride; water / methanol / 20 °C / Inert atmosphere
7.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C / Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

2-hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone
1401033-86-0

2-hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
7.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux; Inert atmosphere
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2.16 h / 10 - 20 °C / Inert atmosphere
3.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2.25 h / -74 - 0 °C / Inert atmosphere
3.2: 0.58 h / -60 °C / Inert atmosphere
3.3: Reflux; Inert atmosphere
4.1: lithium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one / 90 °C / Inert atmosphere
5.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 0.17 h / Inert atmosphere
5.2: 3 h / 100 °C / Inert atmosphere
6.1: hydrogenchloride; water / methanol / 20 °C / Inert atmosphere
7.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C / Inert atmosphere
8.1: methanol; sodium methylate / dichloromethane / 1 h / 20 °C / Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

2-hydroxy-1-(2-((9-((1R,4R)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone hydrochloride
1401034-19-2

2-hydroxy-1-(2-((9-((1R,4R)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
7.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
8.1: hydrogenchloride / water
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

2-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]-2-oxoacetic acid
1401033-87-1

2-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]-2-oxoacetic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: pyridine / tetrahydrofuran / 20 °C
7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

methyl 2-{[6-(2-methoxy-2-oxoacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]{9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino}-2-oxoacetate
1401034-48-7

methyl 2-{[6-(2-methoxy-2-oxoacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]{9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino}-2-oxoacetate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: pyridine / tetrahydrofuran / 20 °C
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

9-[(1r,4r)-4-methylcyclohexyl]-N-[6-(3,3,3-trifluoropropyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine
1401033-88-2

9-[(1r,4r)-4-methylcyclohexyl]-N-[6-(3,3,3-trifluoropropyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: sodium tris(acetoxy)borohydride / 1,4-dioxane / 0.25 h
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

N-[6-(2-fluoroethyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]-9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine
1401033-90-6

N-[6-(2-fluoroethyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]-9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N,N-dimethyl-formamide; ethanol / 8.67 h / 90 °C
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

N-[6-(2-methoxyethyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]-9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine
1401033-91-7

N-[6-(2-methoxyethyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]-9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 °C
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

tert-butyl 8-methyl-2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
1401034-52-3

tert-butyl 8-methyl-2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / butan-1-ol / 36 h / Reflux
2: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 1.5 h / 100 °C / Microwave radiation
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

5-(5-fluoro-2-methoxypyridin-4-yl)-N4-[(1r,4r)-4-methylcyclohexyl]pyrimidine-2,4-diamine
1401034-56-7

5-(5-fluoro-2-methoxypyridin-4-yl)-N4-[(1r,4r)-4-methylcyclohexyl]pyrimidine-2,4-diamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: lithium diisopropyl amide / tetrahydrofuran / 1.83 h / -78 °C
3.2: Reflux
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

6-methoxy-9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine
1401034-57-8

6-methoxy-9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: lithium diisopropyl amide / tetrahydrofuran / 1.83 h / -78 °C
3.2: Reflux
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 105 °C / Inert atmosphere
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

(S)-2-hydroxy-1-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]propan-1-one
1401034-13-6

(S)-2-hydroxy-1-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]propan-1-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1,2-dichloro-ethane / chloroform / 4 h / 20 °C
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

C26H29N7O2*(x)H3O4P

C26H29N7O2*(x)H3O4P

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
7.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
8.1: phosphoric acid / dichloromethane; ethanol / 0.02 h
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

(x)C6H8O7*C26H29N7O2

(x)C6H8O7*C26H29N7O2

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
7.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
8.1: dichloromethane; ethanol / 0.02 h
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

(x)C4H6O6*C26H29N7O2

(x)C4H6O6*C26H29N7O2

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
7.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
8.1: dichloromethane; ethanol / 0.02 h
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

(x)C7H6O3*C26H29N7O2

(x)C7H6O3*C26H29N7O2

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
7.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
8.1: dichloromethane; ethanol / 0.02 h
View Scheme
trans-4-methylcyclohexylamine hydrochloride
33483-65-7

trans-4-methylcyclohexylamine hydrochloride

(x)C6H6O3S*C26H29N7O2

(x)C6H6O3S*C26H29N7O2

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: triethylamine / butan-1-ol / 36 h / Reflux
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
4.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
5.1: hydrogenchloride / water; methanol / 20 °C
5.2: 0 °C / pH 9
6.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
7.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
8.1: dichloromethane; ethanol / 0.02 h
View Scheme

trans-4-Methylcyclohexylamine hydrochloride Specification

trans-4-Methylcyclohexylamine hydrochloride is an organic compound with the formula C7H15N.HCl, and its systematic name is the same with the product name. With the CAS registry number 33483-65-7, it is also named as Cyclohexanamine,4-methyl-, hydrochloride (1:1), trans-. In addition, the molecular weight is 149.66.

Physical properties of trans-4-Methylcyclohexylamine hydrochloride are: (1)ACD/LogP: 1.887; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 1; (4)#H bond donors: 2; (5)#Freely Rotating Bonds: 1; (6)Polar Surface Area: 26.02 Å2; (7)Flash Point: 72.3 °C; (8)Enthalpy of Vaporization: 44.09 kJ/mol; (9)Boiling Point: 195.9 °C at 760 mmHg; (10)Vapour Pressure: 0.347 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl.C[C@H]1CC[C@H](N)CC1
(2)Std. InChI: InChI=1S/C7H15N.ClH/c1-6-2-4-7(8)5-3-6;/h6-7H,2-5,8H2,1H3;1H/t6-,7-;
(3)Std. InChIKey: GIRKJSRZELQHDX-MEZFUOHNSA-N  

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View