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Shandong Kehui Pharmaceutical Co., Ltd

Shandong Kehui Pharmaceutical Co., Ltd. is a modern high-tech pharmaceutical company that strictly complies with GMP requirements and produces high standards. The company was established in May 2017 and is located in the Yellow River Delta Medicine V

Nitrendipine

Cas:39562-70-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Nitrendipine Manufacturer/High quality/Best price/In stock

Cas:39562-70-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF Nitrendipine 39562-70-4

Cas:39562-70-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Nitrendipine manufacturer with low price

Cas:39562-70-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Nitrendipine Cas 39562-70-4 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Yellow crystalline powder Storage:Cool dry place Package:100g,1kg/foil bag

Factory supply Nitrendipine Cas 39562-70-4 with high quality and good service

Cas:39562-70-4

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Hefei TNJ chemical industry co.,ltd

Specifications 1.Clean, Nitrendipine/ 39562-70-4 2.yellow crystalline powder 3.Best price,Excellent quality 4.Quick shipping,MOQ Appearance: powder Storage:dry environment Package:25kg/drum or as your needs Application:Blood System

Nitrendipine 39562-70-4

Cas:39562-70-4

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Nitrendipine 39562-70-4 GMP manufacturer

Cas:39562-70-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Nitrendipine

Cas:39562-70-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(meta-nitrophenyl)-3,5-pyridinedicarboxylate Basic information Product Name: Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(meta-nitrophenyl)-3,5-pyridinedicarboxylate

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Nitrendipine CAS 39562-70-4

Cas:39562-70-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 39562-70-4 with competitive price

Cas:39562-70-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Nitrendipine

Cas:39562-70-4

Min.Order:1 Kilogram

FOB Price: $289.0 / 499.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Prouduct name: Nitrendipine CAS: 39562-70-4 Appearance: yellow crystalline powder Purity: 99.0%min Appearance: yellow powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:Cardiovascular Drug; Anti-Angi

Nitrendipine

Cas:39562-70-4

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

High Quality Nitrendipine CAS No 39562-70-4 Nitrendipine

Cas:39562-70-4

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

High quality Nitrendipine 99%min

Cas:39562-70-4

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

High Quality API Nitrendipine Powder with safe shipping

Cas:39562-70-4

Min.Order:10 Gram

FOB Price: $1.2

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Nitrendipine CAS:39562-70-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Nitrendipine CAS:39562-70-4

Cas:39562-70-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Nitrendipine

Cas:39562-70-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:39562-70-4

Cas:39562-70-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei CuiRan Biotechnology Co., Ltd

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)

Nitrendipine

Cas:39562-70-4

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Nitrendipine

Cas:39562-70-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Nitrendipine CAS 39562-70-4 with Fast Shipment

Cas:39562-70-4

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Nitrendipine

Cas:39562-70-4

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Nitrendipine

Cas:39562-70-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Miheng Trading Co., Ltd.

Nitrendipine CAS 39562-70-4 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2

Nitrendipine CAS 39562-70-4

Cas:39562-70-4

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

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Shaanxi New nine Material Technology Co., Ltd.

Our Advantage: 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good quali

Nitrendipine

Cas:39562-70-4

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Trading Company

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Hefei Zhaobo Technology Co., Ltd.

Nitrendipine CAS 39562-70-4 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control sys

Nitrendipine CAS 39562-70-4

Cas:39562-70-4

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

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Wuhan Xinhao Biotechnology Co., Ltd.

Our Strengths 1.Place of Origin China with Super quality by reasonable price. 2.Fast delivery by safe express way to all the country. 3.Has a number of highly qualified engineers and experts to provide guidance for reagents. 4.When you meet problems

Factory supply Nitrendipine with Good Price CAS NO. 39562-70-4

Cas:39562-70-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Nitrendipine

Cas:39562-70-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

High quality NitrendipineAppearance:yellow crystal or crystalline powder Storage:Kept in a cool, dry and ventilated place Package:according to customers' requirements Application:nootropics material Transportation:By air(EMS or EUB or FedEx or TNT ec

High quality Nitrendipine

Cas:39562-70-4

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Synthetic route

ethyl acetoacetate
141-97-9

ethyl acetoacetate

3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

methyl 3-aminocrotonate
14205-39-1

methyl 3-aminocrotonate

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
With sodium tosylate In water for 0.4h; Reagent/catalyst; Time; Hantzsch Dihydropyridine Synthesis; Microwave irradiation; Reflux; Green chemistry;94%
With C21H38N(1+)*Mo11O40PV(4-)*3H(1+) In ethanol at 78℃; for 8h; Catalytic behavior; Hantzsch Pyridine Synthesis; Green chemistry;78%
Hantzsch Dihydropyridine Synthesis; Darkness; Reflux;59%
Benzyl-{2-[5-methoxycarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonyloxy]-ethyl}-dimethyl-ammonium; iodide

Benzyl-{2-[5-methoxycarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonyloxy]-ethyl}-dimethyl-ammonium; iodide

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 25℃;92%
(S)-1,1-Dibenzyl-3-[(R)-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonyloxy]-piperidinium; bromide

(S)-1,1-Dibenzyl-3-[(R)-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonyloxy]-piperidinium; bromide

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 25℃; for 24h;92%
Multi-step reaction with 3 steps
1: 67 percent / KOH / tetrahydrofuran / 24 h / 25 °C
2: 93 percent / acetone / Heating
3: 92 percent / KOH / ethanol / 25 °C
View Scheme
methanol
67-56-1

methanol

C23H27N4O6(1+)*F6P(1-)

C23H27N4O6(1+)*F6P(1-)

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
With sodium methylate for 16h; Reflux;92%
(S)-1-Benzyl-3-[(R)-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonyloxy]-1-methyl-piperidinium; iodide

(S)-1-Benzyl-3-[(R)-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonyloxy]-1-methyl-piperidinium; iodide

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 25℃;91%
Multi-step reaction with 3 steps
1: 32 percent / KOH / tetrahydrofuran / 25 °C
2: 93 percent / acetone / Heating
3: 92 percent / KOH / ethanol / 25 °C
View Scheme
ethyl aminocrotonate

ethyl aminocrotonate

methyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate
119128-13-1

methyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
In isopropyl alcohol for 10h; Heating / reflux;89%
methyl 2-(3-nitrophenylmethylene)acetoacetate
39562-17-9

methyl 2-(3-nitrophenylmethylene)acetoacetate

ethyl aminocrotonate
626-34-6, 7318-00-5, 41867-20-3

ethyl aminocrotonate

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
In ethanol for 6h; Reflux;86%
at 90℃; for 0.15h; Microwave irradiation;
methyl 3-aminocrotonate
21731-17-9

methyl 3-aminocrotonate

ethyl 2-[(3-Nitrophenyl)methylene]-3-oxobutanoate
39562-16-8

ethyl 2-[(3-Nitrophenyl)methylene]-3-oxobutanoate

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
Stage #1: methyl 3-aminocrotonate; ethyl 2-[(3-Nitrophenyl)methylene]-3-oxobutanoate In ethanol at 75 - 80℃; for 1h;
Stage #2: With acetic anhydride In ethanol at 75 - 80℃; for 1h; Solvent;
86%
(S)-1-Allyl-1-benzyl-3-[(R)-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonyloxy]-piperidinium; bromide

(S)-1-Allyl-1-benzyl-3-[(R)-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonyloxy]-piperidinium; bromide

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 25℃;85%
Multi-step reaction with 3 steps
1: 26 percent / KOH / tetrahydrofuran / 25 °C
2: 93 percent / acetone / Heating
3: 92 percent / KOH / ethanol / 25 °C
View Scheme
ethyl 2-(3-nitrophenylmethylene)-3-oxobutanoate
39562-16-8

ethyl 2-(3-nitrophenylmethylene)-3-oxobutanoate

methyl 3-aminocrotonate
14205-39-1

methyl 3-aminocrotonate

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
Stage #1: ethyl 2-(3-nitrophenylmethylene)-3-oxobutanoate; methyl 3-aminocrotonate In ethanol at 70 - 75℃; for 1h;
Stage #2: With hydrogenchloride In ethanol; water at 70 - 75℃;
80%
In ethanol for 8h; Heating;79%
With acetic acid; N-ethyl-N,N-diisopropylamine In ethanol Reflux;
ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate
39562-16-8

ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate

1,1,1-Triphenyl-3-methyl-4-(methoxycarbonyl)-2-aza-1λ5-phosphabuta-1,3-diene
81777-30-2

1,1,1-Triphenyl-3-methyl-4-(methoxycarbonyl)-2-aza-1λ5-phosphabuta-1,3-diene

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
In chloroform at 25℃; for 0.5h;77%
ethyl acetoacetate
141-97-9

ethyl acetoacetate

3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

methyl (E)-3-aminocrotonate
14205-39-1

methyl (E)-3-aminocrotonate

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
With sodium butylmonoglycolsulphate In water for 0.0833333h; Heating; Irradiation; microwave irradiation;72%
3'-nitrobenzylideneacetoacetic acid ethyl ester
70076-42-5

3'-nitrobenzylideneacetoacetic acid ethyl ester

methyl 3-aminocrotonate
21731-17-9

methyl 3-aminocrotonate

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
In ethanol67%
ethyl acetoacetate
141-97-9

ethyl acetoacetate

3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
With aluminum oxide; ammonia In methanol Hantzsch pyridine synthesis; Heating;50%
With pyridine; 4 A molecular sieve; polysterene-based acid-cleavable Rink amine resin; trifluoroacetic acid 1) CH2Cl2, rt, 3 d; 2) 45 deg C, 24 h; 3) CH2Cl2, 45 min;; Yield given. Multistep reaction;
methyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate
119128-13-1

methyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate

ethyl acetoacetate
141-97-9

ethyl acetoacetate

A

m-nifedipine
21881-77-6

m-nifedipine

B

2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester
21829-28-7

2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

C

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
With ammonium hydroxide In ethanol for 24h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
ethyl acetoacetate
141-97-9

ethyl acetoacetate

3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

methyl (E)-3-aminocrotonate
14205-39-1

methyl (E)-3-aminocrotonate

A

m-nifedipine
21881-77-6

m-nifedipine

B

2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester
21829-28-7

2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

C

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
In ethanol for 10h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

ethyl (E)-3-aminobut-2-enoate
41867-20-3

ethyl (E)-3-aminobut-2-enoate

acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

A

m-nifedipine
21881-77-6

m-nifedipine

B

2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester
21829-28-7

2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

C

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
In ethanol for 10h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate
39562-16-8

ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate

acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

A

m-nifedipine
21881-77-6

m-nifedipine

B

2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester
21829-28-7

2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

C

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
With ammonium hydroxide In ethanol for 24h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
Nicardipine
55985-32-5

Nicardipine

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / acetone / Heating
2: 92 percent / KOH / ethanol / 25 °C
View Scheme
(R)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((S)-1-benzyl-piperidin-3-yl) ester 5-methyl ester

(R)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((S)-1-benzyl-piperidin-3-yl) ester 5-methyl ester

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 93 percent / CHCl3 / Heating
2: 67 percent / KOH / tetrahydrofuran / 24 h / 25 °C
3: 93 percent / acetone / Heating
4: 92 percent / KOH / ethanol / 25 °C
View Scheme
Multi-step reaction with 2 steps
1: 93 percent / CHCl3 / Heating
2: 92 percent / KOH / ethanol / 24 h / 25 °C
View Scheme
Multi-step reaction with 4 steps
1: 95 percent / CHCl3 / Heating
2: 26 percent / KOH / tetrahydrofuran / 25 °C
3: 93 percent / acetone / Heating
4: 92 percent / KOH / ethanol / 25 °C
View Scheme
3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: gaseous HCl / toluene / 40 h / Ambient temperature
2: 79 percent / ethanol / 8 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: piperidine; acetic acid / 30 °C / Neat (no solvent)
2: ethanol / 6 h / Reflux
View Scheme
acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

n-C7H15Br or n-C7H15I

n-C7H15Br or n-C7H15I

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: gaseous NH3, p-toluenesulfonic acid / toluene / Heating
2: 79 percent / ethanol / 8 h / Heating
View Scheme
(+)-2-methylthiomethyl-6-methyl-5-carbomethoxy-3-carboethoxy-4-(3-nitrophenyl)-1,4-dihydropyridine
131767-68-5, 131796-79-7

(+)-2-methylthiomethyl-6-methyl-5-carbomethoxy-3-carboethoxy-4-(3-nitrophenyl)-1,4-dihydropyridine

methyl iodide
74-88-4

methyl iodide

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
With sodium borohydrid In N,N-dimethyl-formamide
methyl (S)-3-[(2-methoxy-methylpyrrolidin-1-yl)-imino]-butyrate

methyl (S)-3-[(2-methoxy-methylpyrrolidin-1-yl)-imino]-butyrate

2,3-dimethyl-2,3-diaminobutane
20485-44-3

2,3-dimethyl-2,3-diaminobutane

ethyl 2-[(3-Nitrophenyl)methylene]-3-oxobutanoate
39562-16-8

ethyl 2-[(3-Nitrophenyl)methylene]-3-oxobutanoate

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
With n-butyllithium; ammonium chloride In tetrahydrofuran; methanol; hexane; dichloromethane
acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: piperidine; acetic acid / 30 °C / Neat (no solvent)
2: ethanol / 6 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: ammonia / ethanol / 4 h / 2 - 20 °C
2: acetic acid; N-ethyl-N,N-diisopropylamine / ethanol / Reflux
View Scheme
3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: alumina / neat (no solvent) / 120 °C / Microwave irradiation; Green chemistry
2: 0.15 h / 90 °C / Microwave irradiation
View Scheme
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

(+/-)-Oxidized Nitrendipine
89267-41-4

(+/-)-Oxidized Nitrendipine

Conditions
ConditionsYield
With ammonium cerium(IV) nitrate In water; acetone for 0.166667h; Ambient temperature;100%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; iron(III) chloride hexahydrate; oxygen; sodium nitrite In acetic acid; acetonitrile at 20℃; for 0.75h;97%
With lead(IV) acetate In dichloromethane; acetic acid at 20℃; for 1.25h;96%
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

methyl iodide
74-88-4

methyl iodide

N-methylnitrendipine
50698-12-9

N-methylnitrendipine

Conditions
ConditionsYield
95%
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

phenylboronic acid
98-80-6

phenylboronic acid

3-ethyl 5-methyl 2,6-dimethyl-4-(3-(phenylsulfonamido)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate

3-ethyl 5-methyl 2,6-dimethyl-4-(3-(phenylsulfonamido)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Conditions
ConditionsYield
With potassium pyrosulfite; tetrabutyl-ammonium chloride; potassium carbonate In acetonitrile at 130℃; for 24h; Sealed tube;61%
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

N-nitroso-nitrendipine

N-nitroso-nitrendipine

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In water at 37℃; for 6h; pH=3 - 3.5;44%
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

allyl bromide
106-95-6

allyl bromide

1-allyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

1-allyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

Conditions
ConditionsYield
22%
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

propargyl bromide
106-96-7

propargyl bromide

MRS 1845

MRS 1845

Conditions
ConditionsYield
22%
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

ethyl iodide
75-03-6

ethyl iodide

1-ethyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

1-ethyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

Conditions
ConditionsYield
21%
benzyl chloride
100-44-7

benzyl chloride

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

1-benzyl-2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl ester 5-ethyl ester

1-benzyl-2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl ester 5-ethyl ester

Conditions
ConditionsYield
16%
1H-imidazole
288-32-4

1H-imidazole

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

1,4-dihydro-2,6-bis(1H-imidazol-1-ylmethyl)-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid ethyl methyl diester
123754-04-1

1,4-dihydro-2,6-bis(1H-imidazol-1-ylmethyl)-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid ethyl methyl diester

Conditions
ConditionsYield
With phenyltrimethylammonium tribromide 1.) MeCN, below 10 deg C, 0.75 h, 2.) below 30 deg C, 2 h; Yield given. Multistep reaction;
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

A

SL 5721
64603-72-1

SL 5721

B

5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid
74936-72-4

5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

C

methyl 2-methyl-4-(3-nitrophenyl)-5-oxo-5,7-dihydro-furo<3,4-b>pyridine-3-carboxylate
64603-74-3

methyl 2-methyl-4-(3-nitrophenyl)-5-oxo-5,7-dihydro-furo<3,4-b>pyridine-3-carboxylate

D

ethyl-2-methyl-4-(3-nitrophenyl)-5-oxo-5,7-dihydrofuro<3,4-b>3-pyridinecarboxylate
89288-25-5

ethyl-2-methyl-4-(3-nitrophenyl)-5-oxo-5,7-dihydrofuro<3,4-b>3-pyridinecarboxylate

E

(R)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl) ester 5-methyl ester
138135-46-3

(R)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl) ester 5-methyl ester

F

(S)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl) ester 5-methyl ester
138135-45-2

(S)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl) ester 5-methyl ester

Conditions
ConditionsYield
biotransformation in rat, dog, and mouse (in vivo and in vitro);
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester
39562-70-4

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

2,6-Dimethyl-4-(3-nitro-phenyl)-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester; compound with nitric acid

2,6-Dimethyl-4-(3-nitro-phenyl)-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester; compound with nitric acid

Conditions
ConditionsYield
With nitric acid for 4h; Heating;
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