Products

Refine

Country

Business Type

Certificate

Display

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

TRANS3-HYDROXY-L-PROLINE

Cas:4298-08-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent

Trans-3-Hydroxy-L-Proline CAS 4298-08-2

Cas:4298-08-2

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 4298-08-2 with competitive price

Cas:4298-08-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

L-Proline, 3-hydroxy-,(3S)- 4298-08-2

Cas:4298-08-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

L-Proline, 3-hydroxy-,(3S)-/ LIDE PHARMA- Factory supply / Best price

Cas:4298-08-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

TRANS-3-HYDROXY-L-PROLINECAS:4298-08-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic i

TRANS-3-HYDROXY-L-PROLINECAS:4298-08-2

Cas:4298-08-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

L-Proline, 3-hydroxy-,(3S)-

Cas:4298-08-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

L-Proline, 3-hydroxy-,(3S)-

Cas:4298-08-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TRANS3-HYDROXY-L-PROLINE CAS NO.4298-08-2

Cas:4298-08-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Wuhan BJM Pharm Inc.

Appearance:light yellow powder Storage:Stored in a dark, cool, ventilated and dry place Package:NW 1kg/foil bag; 20-25kg/drum or carton Application:pharm intermediate Transportation:by air/sea/express,according to demand. Port:Shanghai/ Guangzhou/an

TRANS-3-HYDROXY-L-PROLINE

Cas:4298-08-2

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

L-Proline, 3-hydroxy-,(3S)-

Cas:4298-08-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

trans-3-Hydroxy-L-proline

Cas:4298-08-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

TRANS-3-HYDROXY-L-PROLINEAppearance:White to pale beige powder Storage:Keep away from fire and heat Package:according to customers' requirements Application:For Research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or

TRANS-3-HYDROXY-L-PROLINE

Cas:4298-08-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:White to light beige powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used

L-Proline, 3-hydroxy-,(3S)-

Cas:4298-08-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

L-Proline, 3-hydroxy-,(3S)-

Cas:4298-08-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

TRANS3-HYDROXY-L-PROLINE

Cas:4298-08-2

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

High Purity L-Proline, 3-hydroxy-,(3S)-

Cas:4298-08-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

TRANS-3-HYDROXY-L-PROLINE

Cas:4298-08-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Product Name:TRANS-3-HYDROXY-L-PROLINE CAS No:4298-

TRANS-3-HYDROXY-L-PROLINE

Cas:4298-08-2

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TRANS3-HYDROXY-L-PROLINE CAS NO.4298-08-2

Cas:4298-08-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

L-Proline, 3-hydroxy-,(3S)-

Cas:4298-08-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TRANS3-HYDROXY-L-PROLINE CAS NO.4298-08-2

Cas:4298-08-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TRANS3-HYDROXY-L-PROLINE CAS NO.4298-08-2

Cas:4298-08-2

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

trans-L-3-Hydroxyproline

Cas:4298-08-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/TRANS-3-HYDROXY-L-PROLINE

Cas:4298-08-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

L-Proline, 3-hydroxy-,(3S)-

Cas:4298-08-2

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TRANS3-HYDROXY-L-PROLINE CAS NO.4298-08-2

Cas:4298-08-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

trans-3-Hydroxy-L-proline cas no. 4298-08-2 98%

Cas:4298-08-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

cis-3-hydroxy-dl-proline

Cas:4298-08-2

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

L-Proline, 3-hydroxy-,(3S)-

Cas:4298-08-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

(2S,3S)-N-benzyl-2-hydroxyproline
312583-31-6

(2S,3S)-N-benzyl-2-hydroxyproline

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 13h;98%
(S,S)-2-(tert-butoxycarbonyl)-3-acetoxypyrrolidine

(S,S)-2-(tert-butoxycarbonyl)-3-acetoxypyrrolidine

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 16h;89%
(2S,3S)-3-hydroxy-pyrrolidine-2-carboxylic acid methyl ester hydrochloride

(2S,3S)-3-hydroxy-pyrrolidine-2-carboxylic acid methyl ester hydrochloride

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
With potassium hydroxide In methanol; water Ambient temperature;88%
Potassium; (2S,3S)-2-amino-3-hydroxy-5,5-dimethoxy-pentanoate
120789-99-3

Potassium; (2S,3S)-2-amino-3-hydroxy-5,5-dimethoxy-pentanoate

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
With hydrogen; trifluoroacetic acid; platinum(IV) oxide In ethanol; water for 15h; Ambient temperature;87%
(S,S)-N-(1)-(tert-butoxycarbonyl)-2-(tert-butoxycarbonyl)-3-hydroxypyrrolidine

(S,S)-N-(1)-(tert-butoxycarbonyl)-2-(tert-butoxycarbonyl)-3-hydroxypyrrolidine

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 16h;87%
(2S,3S)-1-(tert-butoxycarbonyl)-3-(tert-butyldimethylsiloxy)pyrrolidine-2-carboxylic acid
156045-82-8

(2S,3S)-1-(tert-butoxycarbonyl)-3-(tert-butyldimethylsiloxy)pyrrolidine-2-carboxylic acid

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 3h; Inert atmosphere; Reflux;80%
With hydrogenchloride for 3h; Heating;70%
FR901469 hydrochloride

FR901469 hydrochloride

A

threo-β-hydroxy-L-glutamic acid (threo-L-BHGA)
6208-98-6

threo-β-hydroxy-L-glutamic acid (threo-L-BHGA)

B

(R)-β-hydroxypalmitic acid
928-17-6, 2398-34-7, 83780-74-9, 20595-04-4

(R)-β-hydroxypalmitic acid

C

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

D

4R-4-hydroxyproline
51-35-4

4R-4-hydroxyproline

Conditions
ConditionsYield
With hydrogenchloride at 110℃; for 16h;A 14.7 mg
B 19 mg
C 14.2 mg
D 15.6 mg
(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-pyrrolidine-2-carboxylic acid methyl ester

(2S,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-pyrrolidine-2-carboxylic acid methyl ester

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
With Dowex 50W-X8; water In tetrahydrofuran Heating;0.14 g
L-proline
147-85-3

L-proline

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
With α-ketoglutaric acid; iron(II) sulfate; ascorbic acid; Aeromonas caviae In water at 25℃; for 24h; pH=7; Enzymatic reaction;
(2R,3S)-1-Benzyl-3-hydroxy-pyrrolidine-2-carbonitrile

(2R,3S)-1-Benzyl-3-hydroxy-pyrrolidine-2-carbonitrile

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 83 percent / aq. hydrochloric acid / 8 h / 45 - 50 °C
2: 98 percent / H2 / Pd-C / methanol / 13 h / 20 °C
View Scheme
methyl (2S,3S)-3-hydroxy-2-[(9-phenyl-9-fluorenyl)-amino]-4-pentenoate
404369-20-6

methyl (2S,3S)-3-hydroxy-2-[(9-phenyl-9-fluorenyl)-amino]-4-pentenoate

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 98 percent / imidazole / dimethylformamide / 12 h / 20 °C
2.1: BH3*SMe2 / tetrahydrofuran / 10 h / 20 °C
2.2: 70 percent / NaOH; aq. H2O2 / tetrahydrofuran
3.1: 87 percent / MsCl; Et3N / tetrahydrofuran / 3 h / 0 °C
4.1: H2 / Pd/C / methanol / 3 h / 60 °C
5.1: 0.14 g / Dowex 50W-X8; H2O / tetrahydrofuran / Heating
View Scheme
(2S,3S)-1-Allyl-3-hydroxy-pyrrolidine-2-carboxylic acid amide

(2S,3S)-1-Allyl-3-hydroxy-pyrrolidine-2-carboxylic acid amide

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Amberlyst 15 / 65 °C
2: 70 percent / 1.) Pd(dba)2, Dppb, mercaptobenzoic acid, 2.) 1M HCl / tetrahydrofuran / Ambient temperature
3: 88 percent / KOH / methanol; H2O / Ambient temperature
View Scheme
(2S,3S)-1-Allyl-3-hydroxy-pyrrolidine-2-carboxylic acid methyl ester
213131-33-0

(2S,3S)-1-Allyl-3-hydroxy-pyrrolidine-2-carboxylic acid methyl ester

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / 1.) Pd(dba)2, Dppb, mercaptobenzoic acid, 2.) 1M HCl / tetrahydrofuran / Ambient temperature
2: 88 percent / KOH / methanol; H2O / Ambient temperature
View Scheme
(2R,3S)-1-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbonitrile
213131-29-4

(2R,3S)-1-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbonitrile

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: HCl / methanol / -20 °C
2: Amberlyst 15 / 65 °C
3: 70 percent / 1.) Pd(dba)2, Dppb, mercaptobenzoic acid, 2.) 1M HCl / tetrahydrofuran / Ambient temperature
4: 88 percent / KOH / methanol; H2O / Ambient temperature
View Scheme
(3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one
134107-65-6

(3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 63 percent / t-BuOOH, n-Bu4NF, K2CO3 / dimethylformamide; 2,2,4-trimethyl-pentane; tetrahydrofuran / 2 h
2: 79 percent / aluminum amalgam, NaHCO3 (half sat.) / ethanol; acetone / 2 h
3: 74 percent / imidazole / dimethylformamide / 6 h / 40 °C
4: 1.) BH3*SMe, 2.) TMEDA / 1.) THF, 70 deg C, 2 h, 2.) THF, Et2O, RT, 6 h
5: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr
6: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature
7: 70 percent / 6 M aq. HCl / 3 h / Heating
View Scheme
(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one
103201-79-2

(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 1.) n-BuLi, hexamethyldisilazane / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h
2: 30percent aq. H2O2 / ethyl acetate / 0.67 h / 0 - 22 °C
3: 63 percent / t-BuOOH, n-Bu4NF, K2CO3 / dimethylformamide; 2,2,4-trimethyl-pentane; tetrahydrofuran / 2 h
4: 79 percent / aluminum amalgam, NaHCO3 (half sat.) / ethanol; acetone / 2 h
5: 74 percent / imidazole / dimethylformamide / 6 h / 40 °C
6: 1.) BH3*SMe, 2.) TMEDA / 1.) THF, 70 deg C, 2 h, 2.) THF, Et2O, RT, 6 h
7: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr
8: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature
9: 70 percent / 6 M aq. HCl / 3 h / Heating
View Scheme
bicyclic (2R,5R,6R)-6-hydroxy-2-phenyl-3-oxa-1-azabicyclo<3.3.0>octan-8-one
156045-79-3

bicyclic (2R,5R,6R)-6-hydroxy-2-phenyl-3-oxa-1-azabicyclo<3.3.0>octan-8-one

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 74 percent / imidazole / dimethylformamide / 6 h / 40 °C
2: 1.) BH3*SMe, 2.) TMEDA / 1.) THF, 70 deg C, 2 h, 2.) THF, Et2O, RT, 6 h
3: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr
4: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature
5: 70 percent / 6 M aq. HCl / 3 h / Heating
View Scheme
(2R,3S)-1-benzyl-3-tert-butyldimethylsilyloxy-2-hydroxymethylpyrrolidine
156045-81-7

(2R,3S)-1-benzyl-3-tert-butyldimethylsilyloxy-2-hydroxymethylpyrrolidine

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr
2: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature
3: 70 percent / 6 M aq. HCl / 3 h / Heating
View Scheme
tert-butyl (2R,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-(hydroxymethyl)pyrrolidine-1-carboxylate
156129-73-6

tert-butyl (2R,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-(hydroxymethyl)pyrrolidine-1-carboxylate

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature
2: 70 percent / 6 M aq. HCl / 3 h / Heating
View Scheme
(2R,5R,6S)-6-tert-butyldimethylsiloxy-3-oxa-2-phenyl-1-azabicyclo<3.3.0>octane-8-one
156045-80-6

(2R,5R,6S)-6-tert-butyldimethylsiloxy-3-oxa-2-phenyl-1-azabicyclo<3.3.0>octane-8-one

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) BH3*SMe, 2.) TMEDA / 1.) THF, 70 deg C, 2 h, 2.) THF, Et2O, RT, 6 h
2: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr
3: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature
4: 70 percent / 6 M aq. HCl / 3 h / Heating
View Scheme
(3R,7aS)-3-phenyl-6-(phenylselanyl)tetrahydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one

(3R,7aS)-3-phenyl-6-(phenylselanyl)tetrahydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 30percent aq. H2O2 / ethyl acetate / 0.67 h / 0 - 22 °C
2: 63 percent / t-BuOOH, n-Bu4NF, K2CO3 / dimethylformamide; 2,2,4-trimethyl-pentane; tetrahydrofuran / 2 h
3: 79 percent / aluminum amalgam, NaHCO3 (half sat.) / ethanol; acetone / 2 h
4: 74 percent / imidazole / dimethylformamide / 6 h / 40 °C
5: 1.) BH3*SMe, 2.) TMEDA / 1.) THF, 70 deg C, 2 h, 2.) THF, Et2O, RT, 6 h
6: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr
7: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature
8: 70 percent / 6 M aq. HCl / 3 h / Heating
View Scheme
(2R,5R,6R,7R)-6,7-epoxy-2-phenyl-3-oxa-1-aza-bicyclo<3.3.0>octane-8-one
154631-82-0

(2R,5R,6R,7R)-6,7-epoxy-2-phenyl-3-oxa-1-aza-bicyclo<3.3.0>octane-8-one

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 79 percent / aluminum amalgam, NaHCO3 (half sat.) / ethanol; acetone / 2 h
2: 74 percent / imidazole / dimethylformamide / 6 h / 40 °C
3: 1.) BH3*SMe, 2.) TMEDA / 1.) THF, 70 deg C, 2 h, 2.) THF, Et2O, RT, 6 h
4: 80 percent / H2 / 10percent Pd/C / methanol / 3 h / 15001.2 Torr
5: 51 percent / NaIO4, RuCl3 / acetonitrile; CCl4; H2O / 1.5 h / Ambient temperature
6: 70 percent / 6 M aq. HCl / 3 h / Heating
View Scheme
C51H89N11O18

C51H89N11O18

A

L-erythro-3-amino-butane-1,2,4-triol
736129-34-3

L-erythro-3-amino-butane-1,2,4-triol

B

L-serin
56-45-1

L-serin

C

L-threonine
72-19-5

L-threonine

D

L-arginine
74-79-3

L-arginine

E

2-(S)-amino-3-(R)-hydroxysuccinic acid
7298-98-8

2-(S)-amino-3-(R)-hydroxysuccinic acid

F

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

G

L-proline
147-85-3

L-proline

H

(R)-3-hydroxy-13-methyltetradecanoic acid
221695-92-7

(R)-3-hydroxy-13-methyltetradecanoic acid

Conditions
ConditionsYield
With hydrogenchloride; water for 20h; Reflux;
C51H89N11O18

C51H89N11O18

A

L-serin
56-45-1

L-serin

B

L-threonine
72-19-5

L-threonine

C

(2S,3S)-3-amino-2,4-dihydroxy-butyric acid
29621-86-1

(2S,3S)-3-amino-2,4-dihydroxy-butyric acid

D

L-arginine
74-79-3

L-arginine

E

2-amino-2-deoxy-L-erythronic acid
21768-43-4

2-amino-2-deoxy-L-erythronic acid

F

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

G

L-proline
147-85-3

L-proline

H

(R)-3-hydroxy-13-methyltetradecanoic acid
221695-92-7

(R)-3-hydroxy-13-methyltetradecanoic acid

Conditions
ConditionsYield
With hydrogenchloride; water for 20h; Reflux;
tripropeptin C

tripropeptin C

A

L-serin
56-45-1

L-serin

B

L-threonine
72-19-5

L-threonine

C

L-arginine
74-79-3

L-arginine

E

2-(S)-amino-3-(R)-hydroxysuccinic acid
7298-98-8

2-(S)-amino-3-(R)-hydroxysuccinic acid

F

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

G

L-proline
147-85-3

L-proline

H

(R)-3-hydroxy-13-methyltetradecanoic acid
221695-92-7

(R)-3-hydroxy-13-methyltetradecanoic acid

Conditions
ConditionsYield
With hydrogenchloride; water for 20h; Reflux;
L-proline
147-85-3

L-proline

A

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

B

4R-4-hydroxyproline
51-35-4

4R-4-hydroxyproline

Conditions
ConditionsYield
With His-tagged eukaryotic α-ketoglutarate/FeII-dependent proline hydroxylase F from Glarea lozoyensis ATCC 74030; ascorbate; α-ketoglutarate; iron(II) sulfate In aq. buffer at 20℃; for 1h; pH=6; Kinetics; Enzymatic reaction; stereoselective reaction;
(S,S)-N-(1)-benzyl-2-(tert-butoxycarbonyl)-3-acetoxypyrrolidine-2-carboxylate

(S,S)-N-(1)-benzyl-2-(tert-butoxycarbonyl)-3-acetoxypyrrolidine-2-carboxylate

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 25% Pd(OH)2/C; acetic acid / methanol; water / 20 °C / 3800.26 Torr
2: hydrogenchloride / water / 16 h / 20 °C
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid
187039-57-2

(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran at 20℃;100%
With sodium hydroxide In tetrahydrofuran; water100%
With sodium hydroxide In tetrahydrofuran92%
methanol
67-56-1

methanol

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

(2S,3S)-methyl 3-hydroxypyrrolidine-2-carboxylate
496841-04-4

(2S,3S)-methyl 3-hydroxypyrrolidine-2-carboxylate

Conditions
ConditionsYield
With thionyl chloride100%
With thionyl chloride
With hydrogenchloride
methanol
67-56-1

methanol

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

(2S,3S)-3-hydroxy-pyrrolidine-2-carboxylic acid methyl ester hydrochloride

(2S,3S)-3-hydroxy-pyrrolidine-2-carboxylic acid methyl ester hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 0 - 20℃;100%
With hydrogenchloride at 0 - 20℃;99%
With thionyl chloride at 0℃; for 16h;99%
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

(2S,3S)-(3-hydroxy)pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester
296774-32-8

(2S,3S)-(3-hydroxy)pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In 1,4-dioxane at 0 - 20℃; for 9h;98%
With sodium hydrogencarbonate In 1,4-dioxane at 0 - 20℃; for 9h;98%
With sodium carbonate In 1,4-dioxane; water at 0 - 20℃; for 3h;59%
With sodium carbonate In 1,4-dioxane; water at 0 - 20℃; for 3h;59.2%
With sodium hydrogencarbonate In 1,4-dioxane; water at 4 - 20℃; for 10h;58%
methanol
67-56-1

methanol

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

(2S,3S)-1-tert-butyl-2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate
184046-78-4

(2S,3S)-1-tert-butyl-2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate

Conditions
ConditionsYield
Stage #1: methanol; trans-3-hydroxy-L-proline With thionyl chloride at 0 - 20℃; for 16h;
Stage #2: di-tert-butyl dicarbonate With triethylamine In dichloromethane at 20℃; for 2h;
96%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

benzyl bromide
100-39-0

benzyl bromide

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

2-benzyl 1-(tert-butyl) (2S,3S)-3-hydroxypyrrolidine-1,2-dicarboxylate
330945-07-8

2-benzyl 1-(tert-butyl) (2S,3S)-3-hydroxypyrrolidine-1,2-dicarboxylate

Conditions
ConditionsYield
Stage #1: di-tert-butyl dicarbonate; trans-3-hydroxy-L-proline With sodium hydroxide; water In tetrahydrofuran at 20℃; for 19h;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
Stage #3: benzyl bromide With hydrogenchloride; potassium hydrogencarbonate more than 3 stages;
91%
methanol
67-56-1

methanol

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

methyl (3S)-3-hydroxy-L-prolinate hydrochloride

methyl (3S)-3-hydroxy-L-prolinate hydrochloride

Conditions
ConditionsYield
With acetyl chloride at 0 - 65℃; for 6h;91%
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile
58632-95-4

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid
187039-57-2

(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; methanol; water at 20℃; for 4h;88%
With sodium hydroxide In 1,4-dioxane; water at 0℃; for 12h;
N-Fmoc L-Phe
35661-40-6

N-Fmoc L-Phe

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

(2S,3S)-1-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionyl]-3-hydroxy-pyrrolidine-2-carboxylic acid
847978-88-5

(2S,3S)-1-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionyl]-3-hydroxy-pyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: N-Fmoc L-Phe With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 4h;
Stage #2: trans-3-hydroxy-L-proline With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃;
88%
trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

benzyl chloroformate
501-53-1

benzyl chloroformate

(2S,3S)-1-((benzyloxy)carbonyl)-3-hydroxypyrrolidine-2-carboxylic acid
62182-54-1

(2S,3S)-1-((benzyloxy)carbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In water for 20h;78%
With N-ethyl-N,N-diisopropylamine In water; N,N-dimethyl-formamide at 0 - 20℃;
With sodium hydrogencarbonate
tert-butyldicarbonate
34619-03-9

tert-butyldicarbonate

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid
187039-57-2

(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In water for 24h;75%
trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

isobutene
115-11-7

isobutene

3(S)-tert-butoxy-L-proline tert-butyl ester tosylate

3(S)-tert-butoxy-L-proline tert-butyl ester tosylate

Conditions
ConditionsYield
In dichloromethane at -78 - 20℃; for 72h;72%
methanol
67-56-1

methanol

trityl chloride
76-83-5

trityl chloride

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

(2S,3S)-1-(triphenylmethyl)-3-hydroxyproline methyl ester
401909-57-7

(2S,3S)-1-(triphenylmethyl)-3-hydroxyproline methyl ester

Conditions
ConditionsYield
Stage #1: methanol; trans-3-hydroxy-L-proline With thionyl chloride
Stage #2: trityl chloride With triethylamine In dichloromethane at 0 - 20℃;
72%
trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

isobutene
115-11-7

isobutene

trans-3-tert-butoxy-L-proline

trans-3-tert-butoxy-L-proline

Conditions
ConditionsYield
Stage #1: trans-3-hydroxy-L-proline; isobutene With toluene-4-sulfonic acid In dichloromethane at -78 - 20℃; for 72h;
Stage #2: With sodium hydroxide In dichloromethane; water at 0℃; for 4h;
Stage #3: With hydrogenchloride In dichloromethane; water at 0℃; for 0.5h;
69%
trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

1H,2H,4H-thieno[2,3-d][1,3]oxazine-2,4-dione
103979-54-0

1H,2H,4H-thieno[2,3-d][1,3]oxazine-2,4-dione

(8S,8aS)-8-hydroxy-6,7,8,8a-tetrahydro-4H-pyrrolo[1,2-a]thieno[2,3-e][1,4]diazepine-4,9(10H)-dione
1140528-76-2

(8S,8aS)-8-hydroxy-6,7,8,8a-tetrahydro-4H-pyrrolo[1,2-a]thieno[2,3-e][1,4]diazepine-4,9(10H)-dione

Conditions
ConditionsYield
In water Reflux; regioselective reaction;35%
trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

2-aminobenzaldehyde
529-23-7

2-aminobenzaldehyde

1,2,3,3a,4,9-hexahydro-pyrrolo[2,1-b]quinazolin-3-ol
55727-58-7

1,2,3,3a,4,9-hexahydro-pyrrolo[2,1-b]quinazolin-3-ol

Conditions
ConditionsYield
In butan-1-ol at 150℃; for 0.25h; Microwave irradiation; Sealed tube; regioselective reaction;11%
3,5-dichlorobenzensulfonyl chloride
705-21-5

3,5-dichlorobenzensulfonyl chloride

trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

(2S,3S)-1-(3,5-Dichloro-benzenesulfonyl)-3-hydroxy-pyrrolidine-2-carboxylic acid
425403-87-8

(2S,3S)-1-(3,5-Dichloro-benzenesulfonyl)-3-hydroxy-pyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With sodium carbonate In water at 20℃;
trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

(2S,3R)-N-tert-Butyloxycarbonyl-3-benzoyloxy-2-pyrrolidinecarboxylic Acid Methyl Ester
496841-07-7

(2S,3R)-N-tert-Butyloxycarbonyl-3-benzoyloxy-2-pyrrolidinecarboxylic Acid Methyl Ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 99 percent / HCl / 0 - 20 °C
2: 80 percent / Et3N / CH2Cl2 / 0 - 20 °C
3: 90 percent / PPh3; DEAD / tetrahydrofuran / 9 h / 0 - 20 °C
View Scheme
trans-3-hydroxy-L-proline
4298-08-2

trans-3-hydroxy-L-proline

(2S,3S)-N-tert-butyloxycarbonyl-3-(tert-butyldimethylsilyloxy)-2-pyrrolidinecarboxylic acid methyl ester
850003-05-3

(2S,3S)-N-tert-butyloxycarbonyl-3-(tert-butyldimethylsilyloxy)-2-pyrrolidinecarboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 99 percent / HCl / 0 - 20 °C
2: 80 percent / Et3N / CH2Cl2 / 0 - 20 °C
3: 90 percent / i-Pr2NEt / DMAP / CH2Cl2 / 48 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: acetyl chloride / 6 h / 0 - 65 °C
2: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C
3: 1H-imidazole / N,N-dimethyl-formamide / 3.5 h
View Scheme
Multi-step reaction with 3 steps
1: acetyl chloride / 20 h / 0 - 65 °C
2: sodium hydrogencarbonate / tetrahydrofuran / 10 h / 0 - 20 °C
3: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: acetyl chloride / 0 - 65 °C / Cooling with ice bath; Inert atmosphere
2: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere; Cooling with ice bath
3: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / 6.17 h / 0 - 20 °C
2: triethylamine / dichloromethane / 0 - 20 °C
3: 1H-imidazole / dichloromethane / 20 °C
View Scheme
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View