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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-Fluoro-3-nitrobenzoic acid Manufacturer/High quality/Best price/In stock

Cas:453-71-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-Nitro -4-Fluoride Benzoic Acids supplier in China

Cas:453-71-4

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-Nitro -4-Fluoride Benzoic Acids

Cas:453-71-4

Min.Order:1

Negotiable

Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 453-71-4 with best quality

Cas:453-71-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Fluoro-3-nitrobenzoic acid 453-71-4

Cas:453-71-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

4-Fluoro-3-nitrobenzoic acid CAS:453-71-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organ

4-Fluoro-3-nitrobenzoic acid CAS:453-71-4

Cas:453-71-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-nitro -4-fluoride benzoic acids

Cas:453-71-4

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-Fluoro-3-nitrobenzoicacid CAS NO.453-71-4

Cas:453-71-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

4-fluoro-3-nitrobenzoic acid Melting point 123-126 ° C (lit.) Boiling point 92 ° C 15mm Flash point 92 ° C / 15mm Storage conditions Solubility 95% ethanol: soluble50mg / mL, clear, light yellow Morphology Powder or Crystals

4-Carboxy-2-nitrofluorobenzene

Cas:453-71-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

4-Fluoro-3-nitrobenzoic acid Chemical Properties Melting point 123-126 °C (lit.) Boiling point 92°C 15mm density 1.5071 (estimate) Fp 92°C/15mm storage temp. Refrigerator solubility 95% ethanol: soluble50mg/mL, cle

4-Fluoro-3-nitrobenzoic Acid

Cas:453-71-4

Min.Order:1 Gram

FOB Price: $65.0

Type:Lab/Research institutions

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3-Nitro-4-fluorobenzoic acid

Cas:453-71-4

Min.Order:0

Negotiable

Type:Manufacturers

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Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Fluoro-3-Nitrobenzoic Acid cas no. 453-71-4 98%

Cas:453-71-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

good quality and cheap price Package:25kg/200kg Application:as intermediates Transportation:by courier/sea/air

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:0

Negotiable

Type:Trading Company

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:White to yellow crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:It i

4-Fluoro-3-nitrobenzoic acid

Cas:453-71-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 4-Fluoro-3-nitrobenzoic acid 500g

Cas:453-71-4

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-Fluorobenzoic acid
456-22-4

4-Fluorobenzoic acid

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

Conditions
ConditionsYield
With sulfuric acid; potassium nitrate at 20℃;90%
With sulfuric acid; potassium nitrate at 20℃;88%
With sulfuric acid; nitric acid at 20℃; for 10h;75%
trimethylsilylazide
4648-54-8

trimethylsilylazide

4-fluoro-3-nitrobenzoyl chloride
400-94-2

4-fluoro-3-nitrobenzoyl chloride

A

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

B

1-(4-fluoro-3-nitrophenyl)-1,4-dihydro-5H-tetrazol-5-one
1309832-87-8

1-(4-fluoro-3-nitrophenyl)-1,4-dihydro-5H-tetrazol-5-one

Conditions
ConditionsYield
at 20 - 90℃; Inert atmosphere;A n/a
B 70%
4-fluoro-3-nitrobenzonitrile
1009-35-4

4-fluoro-3-nitrobenzonitrile

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

Conditions
ConditionsYield
With sulfuric acid at 120℃; for 8h; Sealed tube;52%
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

Conditions
ConditionsYield
With nitric acid
4-Fluorobenzoic acid
456-22-4

4-Fluorobenzoic acid

nitric acid
7697-37-2

nitric acid

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

4-Fluorobenzoic acid
456-22-4

4-Fluorobenzoic acid

nitric acid
7697-37-2

nitric acid

A

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

B

4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

p-fluorotoluene
352-32-9

p-fluorotoluene

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: KMnO4
2: nitric acid
View Scheme
toluene-4-diazonium ; sulfate

toluene-4-diazonium ; sulfate

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: KMnO4
3: nitric acid
View Scheme
C7H3FNO4Pol

C7H3FNO4Pol

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

Conditions
ConditionsYield
Stage #1: C7H3FNO4Pol With acetic anhydride In dichloromethane for 2h;
Stage #2: With trifluoroacetic acid In 1,2-dichloro-ethane for 1h;
TFAN1,2-dichloroethane

TFAN1,2-dichloroethane

4-fluoro-3-nitrobenzoyl chloride
400-94-2

4-fluoro-3-nitrobenzoyl chloride

isopropyl alcohol
67-63-0

isopropyl alcohol

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

Conditions
ConditionsYield
With acetic anhydride; N-ethyl-N,N-diisopropylamine In water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; acetonitrile
4-fluoro-3-nitrotoluene
446-11-7

4-fluoro-3-nitrotoluene

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

Conditions
ConditionsYield
With potassium dichromate; sulfuric acid; acetic acid Reflux;
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

4-fluoro-3-nitrobenzoyl chloride
400-94-2

4-fluoro-3-nitrobenzoyl chloride

Conditions
ConditionsYield
With thionyl chloride In 1,2-dichloro-ethane at 80℃; for 12 - 16h; Product distribution / selectivity;100%
With thionyl chloride for 4h; Reflux;100%
With oxalyl dichloride In N,N-dimethyl-formamide; benzene at 0℃; for 6h; Chlorination;99%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

aniline
62-53-3

aniline

2-nitrodiphenylamine-4-carboxylic acid
16927-49-4

2-nitrodiphenylamine-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-nitro-4-fluorobenzoic acid; aniline In ethanol for 16h; Reflux;
Stage #2: With hydrogenchloride In ethanol; water
100%
In ethanol at 20℃; for 1h;81%
cetyltrimethylammonim bromide In water at 73℃; Mechanism; Rate constant; or without CTAB-catalysis;
2-[(2-pyridin-2-ylquinoline-4-carbonyl)amino]ethylammonium chloride

2-[(2-pyridin-2-ylquinoline-4-carbonyl)amino]ethylammonium chloride

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

2-pyridin-2-yl-quinoline-4-carboxylic acid [2-(4-fluoro-3-nitro-benzoylamino)-ethyl]-amide
778647-45-3

2-pyridin-2-yl-quinoline-4-carboxylic acid [2-(4-fluoro-3-nitro-benzoylamino)-ethyl]-amide

Conditions
ConditionsYield
With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 66h;100%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

4-fluoro-3-nitro-benzoic acid methyl ester
329-59-9

4-fluoro-3-nitro-benzoic acid methyl ester

Conditions
ConditionsYield
100%
Multi-step reaction with 2 steps
1: (COCl)2; DMF / CH2Cl2 / 0 - 25 °C
2: 0 °C
View Scheme
Multi-step reaction with 2 steps
1: oxalyl chloride; N,N-dimethylformamide / CH2Cl2 / 16 h / 22 °C
2: 52.4 g / triethylamine / CH2Cl2 / 16 h / 22 °C
View Scheme
methanol
67-56-1

methanol

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

4-fluoro-3-nitro-benzoic acid methyl ester
329-59-9

4-fluoro-3-nitro-benzoic acid methyl ester

Conditions
ConditionsYield
Stage #1: methanol; 3-nitro-4-fluorobenzoic acid With thionyl chloride at 0 - 20℃;
Stage #2: With water; sodium hydrogencarbonate In ethyl acetate
100%
With sulfuric acid at 80℃;100%
With sulfuric acid at 65℃; for 36h; Large scale;100%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

L-valine methylester hydrochloride
6306-52-1

L-valine methylester hydrochloride

4-((S)-1-(methoxycarbonyl)-2-methylpropylamino)-3-nitrobenzoic acid

4-((S)-1-(methoxycarbonyl)-2-methylpropylamino)-3-nitrobenzoic acid

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20 - 80℃; for 16h;100%
tert-butyl (4-amino-2-methylbutan-2-yl)carbamate
880100-43-6

tert-butyl (4-amino-2-methylbutan-2-yl)carbamate

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

4-(3-tert-butoxycarbonylamino-3-methyl-butylamino)-3-nitro-benzoic acid
935873-16-8

4-(3-tert-butoxycarbonylamino-3-methyl-butylamino)-3-nitro-benzoic acid

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 60℃; for 168h;100%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

1,1,1,3,3,3-hexafluoro-2-(4-fluoro-3-nitrophenyl)propan-2-ol
35445-59-1

1,1,1,3,3,3-hexafluoro-2-(4-fluoro-3-nitrophenyl)propan-2-ol

Conditions
ConditionsYield
Stage #1: 3-nitro-4-fluorobenzoic acid With thionyl chloride In N,N-dimethyl-formamide for 2h; Reflux;
Stage #2: (trifluoromethyl)trimethylsilane With tetramethylammonium fluoride In 1,2-dimethoxyethane at 20℃; for 12.3333h; Inert atmosphere; Cooling with ice;
100%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

ethyl 2-sulfanylacetate
623-51-8

ethyl 2-sulfanylacetate

4-ethoxycarbonylmethylsulfanyl-3-nitrobenzoic acid
204863-51-4

4-ethoxycarbonylmethylsulfanyl-3-nitrobenzoic acid

Conditions
ConditionsYield
With sodium acetate In water at 90℃; for 24h; Inert atmosphere;100%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

phenol
108-95-2

phenol

3-nitro-4-phenoxybenzoic acid
202209-14-1

3-nitro-4-phenoxybenzoic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In water at 80℃; for 6h;100%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

L-leucine tert-butyl ester hydrochloride
2748-02-9

L-leucine tert-butyl ester hydrochloride

(S)-2-(4-fluoro-3-nitro-benzoylamino)-4-methyl-pentanoic acid tert-butyl ester
1586791-32-3

(S)-2-(4-fluoro-3-nitro-benzoylamino)-4-methyl-pentanoic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: 3-nitro-4-fluorobenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: L-leucine tert-butyl ester hydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 4h;
100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 4h;
hexamethylene imine
111-49-9

hexamethylene imine

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

4-azepan-1-yl-3-nitro-benzoic acid
92109-03-0

4-azepan-1-yl-3-nitro-benzoic acid

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 1h;100%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

(4-fluoro-3-nitrophenyl)methanol
20274-69-5

(4-fluoro-3-nitrophenyl)methanol

Conditions
ConditionsYield
Stage #1: 3-nitro-4-fluorobenzoic acid With sodium tetrahydroborate In tetrahydrofuran at 0℃; for 1h;
Stage #2: With boron trifluoride diethyl etherate In tetrahydrofuran at 0 - 20℃; for 3h;
99.1%
Stage #1: 3-nitro-4-fluorobenzoic acid With sodium tetrahydroborate In tetrahydrofuran at 0℃; for 1h;
Stage #2: With boron trifluoride diethyl etherate In tetrahydrofuran at 0 - 20℃; for 3h;
99.1%
Stage #1: 3-nitro-4-fluorobenzoic acid With sodium tetrahydroborate In tetrahydrofuran at 0℃; for 1h;
Stage #2: With boron trifluoride dimethyl etherate In tetrahydrofuran at 0 - 20℃; for 3h;
97.4%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

4-fluoro-3-nitro-benzoic acid methyl ester
329-59-9

4-fluoro-3-nitro-benzoic acid methyl ester

Conditions
ConditionsYield
In diethyl ether ice cooling;99%
methanol
67-56-1

methanol

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

isobutylamine
78-81-9

isobutylamine

ethyl iodide
75-03-6

ethyl iodide

1,1'-Thiocarbonyldiimidazole
6160-65-2

1,1'-Thiocarbonyldiimidazole

2-ethylsulfanyl-1-isobutyl-1H-benzoimidazole-5-carboxylic acid methyl ester

2-ethylsulfanyl-1-isobutyl-1H-benzoimidazole-5-carboxylic acid methyl ester

Conditions
ConditionsYield
Multistep reaction;99%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

methylamine
74-89-5

methylamine

4-(methylamino)-3-nitrobenzoic acid
41263-74-5

4-(methylamino)-3-nitrobenzoic acid

Conditions
ConditionsYield
In methanol; ethanol at 20℃; for 2h;99%
In methanol at 20℃; for 18h;99%
In methanol at 20℃; for 10h;98%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

4-fluoro-3-nitro-benzoic acid methyl ester
329-59-9

4-fluoro-3-nitro-benzoic acid methyl ester

Conditions
ConditionsYield
With methanol In hexanes; dichloromethane at 0℃; for 1h;99%
In methanol; hexane; toluene at 0 - 20℃; for 0.5h;92%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

methyl iodide
74-88-4

methyl iodide

4-fluoro-3-nitro-benzoic acid methyl ester
329-59-9

4-fluoro-3-nitro-benzoic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;99%
With potassium carbonate In acetone
Trimethyl orthoacetate
1445-45-0

Trimethyl orthoacetate

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

4-fluoro-3-nitro-benzoic acid methyl ester
329-59-9

4-fluoro-3-nitro-benzoic acid methyl ester

Conditions
ConditionsYield
In toluene at 80℃; for 8h; Esterification;98%
methanol
67-56-1

methanol

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

isobutylamine
78-81-9

isobutylamine

allyl bromide
106-95-6

allyl bromide

3-allyl-1-isobutyl-2-oxo-2,3-dihydro-1H-benzoimidazole-5-carboxylic acid methyl ester

3-allyl-1-isobutyl-2-oxo-2,3-dihydro-1H-benzoimidazole-5-carboxylic acid methyl ester

Conditions
ConditionsYield
Solid phase reaction;98%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

2-hydroxyethanethiol
60-24-2

2-hydroxyethanethiol

4-(2-hydroxyethylthio)-3-nitrobenzoic acid
124416-06-4

4-(2-hydroxyethylthio)-3-nitrobenzoic acid

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide98%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol
678-39-7

3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol

3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl 4-fluoro-3-nitrobenzoate
1390621-27-8

3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl 4-fluoro-3-nitrobenzoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 0.5h; Microwave irradiation; Inert atmosphere;98%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

isopropyl alcohol
67-63-0

isopropyl alcohol

3-nitro-4-isopropoxybenzoic acid
156629-52-6

3-nitro-4-isopropoxybenzoic acid

Conditions
ConditionsYield
Stage #1: isopropyl alcohol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.25h; Inert atmosphere;
Stage #2: 3-nitro-4-fluorobenzoic acid In tetrahydrofuran; mineral oil at 0 - 20℃; for 3.5h; Inert atmosphere;
98%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

1-amino-3-methylbenzene
108-44-1

1-amino-3-methylbenzene

3-nitro-4-(m-tolylamino)benzoic acid
452088-49-2

3-nitro-4-(m-tolylamino)benzoic acid

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one at 90℃; for 16h; Inert atmosphere;98%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

3-amino-4-fluorobenzoic acid
2365-85-7

3-amino-4-fluorobenzoic acid

Conditions
ConditionsYield
With hydrogen; 5%-palladium/activated carbon In methanol for 6h;97%
With hydrogen; palladium 10% on activated carbon In methanol under 760.051 Torr; for 3h;96%
With 5%-palladium/activated carbon; hydrogen In ethanol under 12001.2 Torr; Flow reactor;95%
ethanol
64-17-5

ethanol

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

ethyl 4-fluoro-3-nitrobenzoate
367-80-6

ethyl 4-fluoro-3-nitrobenzoate

Conditions
ConditionsYield
With sulfuric acid97%
With hydrogenchloride for 15h; Heating / reflux;95%
With sulfuric acid for 8h; Reflux;93%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

ethanolamine
141-43-5

ethanolamine

4-(2-hydroxy-ethylamino)-3-nitro-benzoic acid
59320-14-8

4-(2-hydroxy-ethylamino)-3-nitro-benzoic acid

Conditions
ConditionsYield
In isopropyl alcohol at 20℃; for 18h;97%
In methanol at 20℃; for 4h;89%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

borane tetrahydrofuran

borane tetrahydrofuran

(4-fluoro-3-nitrophenyl)methanol
20274-69-5

(4-fluoro-3-nitrophenyl)methanol

Conditions
ConditionsYield
In tetrahydrofuran; water97%
3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

4-fluoro-3-nitrobenzamide
349-02-0

4-fluoro-3-nitrobenzamide

Conditions
ConditionsYield
With N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide; acetonitrile at 0 - 20℃; for 4h;97%
With N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide; acetonitrile at 0 - 20℃; for 4h;97%
Stage #1: 3-nitro-4-fluorobenzoic acid With thionyl chloride at 80℃; for 2h;
Stage #2: With ammonia In tetrahydrofuran; dichloromethane at 0℃; for 1h;
96%
1-amino-3-methylbutane
107-85-7

1-amino-3-methylbutane

ethanol
64-17-5

ethanol

3-nitro-4-fluorobenzoic acid
453-71-4

3-nitro-4-fluorobenzoic acid

ethyl 4-(isopentylamino)-3-nitrobenzoate

ethyl 4-(isopentylamino)-3-nitrobenzoate

Conditions
ConditionsYield
Stage #1: ethanol; 3-nitro-4-fluorobenzoic acid With sulfuric acid Reflux;
Stage #2: 1-amino-3-methylbutane With triethylamine Reflux;
97%

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