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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2-Bromo-5-(trifluoromethyl)aniline Manufacturer/High quality/Best price/In stock

Cas:454-79-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Bromo-5-(Trifluoromethyl) Aniline with high purity

Cas:454-79-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

2-Bromo-5-(trifluoromethyl)aniline

Cas:454-79-5

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:Whit

3-AMino-4-broMobenzotrifluoride

Cas:454-79-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

2-Bromo-5-(trifluoromethyl)aniline

Cas:454-79-5

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Amino-4-bromobenzotrifluoride

Cas:454-79-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c

2-Bromo-5-(trifluoromethyl)aniline CAS: 454-79-5

Cas:454-79-5

Min.Order:1 Kilogram

FOB Price: $245.0 / 255.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 454-79-5 with best quality

Cas:454-79-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Bromo-5-(trifluoromethyl)aniline 454-79-5

Cas:454-79-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Bromo-5-(trifluoromethyl)aniline

Cas:454-79-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Bromo-5-(Trifluoromethyl) Aniline

Cas:454-79-5

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Bromo-5-(trifluoromethyl)aniline

Cas:454-79-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Amino-4-bromobenzotrifluoride

Cas:454-79-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-Bromo-5-(trifluoromethyl)aniline;3-Amino-4-bromobenzotrifluoride

Cas:454-79-5

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 2-Bromo-5-(trifluoromethyl)aniline

Cas:454-79-5

Min.Order:100 Gram

Negotiable

Type:Other

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Henan Tianfu Chemical Co., Ltd.

2-Bromo-5-(trifluoromethyl)aniline 2-bromo-5- (trifluoromethyl) benzenamine; 2-BROMO-5- (TRIFLUOROMETHYL) ANILIME; 5- (Trifluoromethyl) benzene; 2-bromo-5-trifluoromethylaniline; 1-amino- -2-bromoaniline; CAS: 454-79-5 Molecular formula: C7

454-79-5

Cas:454-79-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 2-Bromo-5-(trifluoromethyl)aniline Synonyms: 2-amino-4-trifluoromthylbromobenzene;2-BROMO-5-(TRIFLUOROMETHYL)ANILINE/3-AMINO-4-BROMOBENZOTRIFLUORIDE/;2-Bromo-5-trifluoromethylphenylamine;5-(Trifluoromethyl)-2-bromoaniline;2-Bromo-

2-Bromo-5-trifluoromethylaniline 454-79-5 C7H5BrF3N

Cas:454-79-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-Bromo-5-(trifluoromethyl)aniline

Cas:454-79-5

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Bromo-5-(trifluoromethyl)aniline

Cas:454-79-5

Min.Order:0

Negotiable

Type:Manufacturers

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SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/2-Bromo-5-trifluoromethylaniline

Cas:454-79-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-bromo-5-(trifluoromethyl)aniline

Cas:454-79-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

3-Amino-4-bromobenzotrifluoride

Cas:454-79-5

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Beijing Greenchem Technology Co.,Ltd. ( Panjin Greenchem Technology Co.Ltd .)

Capability on chemical synthesis1. Beijing High-Tech Enterprises2. Strong R&D Team3. 8 years of experiences in R & D of high-tech Catalyst;4. 5000 production techniques, 69 items of national patents, and 360 kinds of products on sales;5. The producti

2-Bromo-5-trifluoromethylaniline

Cas:454-79-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Changzhou Anchor Biological Technology Co., Ltd.

Our company is engaged in customizing the benzene ring and pyridine derivative organic intermediates, and the quantity is flexible according to customer's needs. It mainly provides high-quality intermediates for domestic and foreign pharmaceutical an

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-Bromo-5-(Trifluoromethyl)Aniline cas no. 454-79-5 98%

Cas:454-79-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

2-Bromo-5-trifluoromethylaniline

Cas:454-79-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

3-Amino-4-bromobenzotrifluoride

Cas:454-79-5

Min.Order:0

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Yellow crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:It is an imp

2-Bromo-5-(trifluoromethyl)aniline

Cas:454-79-5

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

2-Bromo-5-(Trifluoromethyl) Aniline

Cas:454-79-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Nanjing Fred Technology Co.,Ltd.

Fredchem focus on CRO/CMO business and its own R&D of API/Intermediates Package:Grams, Kilograms Application:Pharmaceutical field Transportation:According to customer request Port:Shanghai

2-Bromo-5-(trifluoromethyl)aniline

Cas:454-79-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-bromo-4-trifluoromethyl-2-nitrobenzene
349-03-1

1-bromo-4-trifluoromethyl-2-nitrobenzene

2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

Conditions
ConditionsYield
With iron; ammonium chloride In ethanol; water for 1h; Reflux;58%
With tin(ll) chloride
3-trifluoromethylaniline
98-16-8

3-trifluoromethylaniline

A

2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

B

4-bromo-3-(trifluoromethyl)aniline
393-36-2

4-bromo-3-(trifluoromethyl)aniline

Conditions
ConditionsYield
With tetrabutylammomium bromide; copper(ll) bromide In ethanol at 45℃; regioselective reaction;A 28%
B 33%
With bromine; acetic acid
3-trifluoromethylaniline
98-16-8

3-trifluoromethylaniline

2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

Conditions
ConditionsYield
With bromine; iron
3-trifluoromethylaniline
98-16-8

3-trifluoromethylaniline

A

2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

B

bromo-3-(trifluoromethyl)-aniline
58458-10-9

bromo-3-(trifluoromethyl)-aniline

C

4-bromo-3-(trifluoromethyl)aniline
393-36-2

4-bromo-3-(trifluoromethyl)aniline

Conditions
ConditionsYield
With N-Bromosuccinimide In 1,4-dioxane at 20℃;A 32 %Chromat.
B 36 %Chromat.
C 32 %Chromat.
With N-Bromosuccinimide In EtCN at 20℃;A 8 %Chromat.
B 12 %Chromat.
C 80 %Chromat.
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

N-(2-bromo-5-trifluoromethylphenyl)carbamic acid ethyl ester
336608-64-1

N-(2-bromo-5-trifluoromethylphenyl)carbamic acid ethyl ester

Conditions
ConditionsYield
With pyridine In tetrahydrofuran at 20℃; for 3h;100%
With pyridine In diethyl ether; water at 20℃; for 18h; Cooling with ice;
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

3-pyridylboronic acid
1692-25-7

3-pyridylboronic acid

2-(pyridin-3-yl)-5-(trifluoromethyl)benzeneamine
158461-54-2

2-(pyridin-3-yl)-5-(trifluoromethyl)benzeneamine

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane; water at 80℃; for 2.5h; Suzuki cross-coupling; Inert atmosphere;100%
With sodium carbonate; trans-bis(triphenylphosphine)palladium dichloride In 1,4-dioxane; water for 24h; Suzuki cross-coupling; Heating;91%
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In water; acetonitrile at 100℃; for 14h; Inert atmosphere;7.62 g
With potassium phosphate; methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) In 1,4-dioxane; water at 80℃; Inert atmosphere;
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

potassium ethyl xanthogenate
140-89-6

potassium ethyl xanthogenate

2-mercapto-5-(trifluoromethyl)benzothiazole
23420-87-3

2-mercapto-5-(trifluoromethyl)benzothiazole

Conditions
ConditionsYield
With copper(l) chloride In N,N-dimethyl-formamide at 110℃; for 6h; Inert atmosphere; Sealed tube;98.1%
In N,N-dimethyl-formamide for 4h; Heating / reflux;92%
Stage #1: 2-Bromo-5-trifluoromethylaniline; potassium ethyl xanthogenate In N,N-dimethyl-formamide at 130℃;
Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 20℃; for 0.5h;
91%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

acetyl chloride
75-36-5

acetyl chloride

N-(2-bromo-5-(trifluoromethyl)phenyl)acetamide
331005-35-7

N-(2-bromo-5-(trifluoromethyl)phenyl)acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 16h;98%
With sodium hydrogencarbonate; triethylamine In dichloromethane at 0 - 20℃; for 2h;75.6%
In ethyl acetate at 85℃;71%
In ethyl acetate Heating;
In dichloromethane at 20℃; for 24h;
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

benzoyl chloride
98-88-4

benzoyl chloride

N-(2-bromo-5-(trifluoromethyl)phenyl)benzamide

N-(2-bromo-5-(trifluoromethyl)phenyl)benzamide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 24h;97%
In dichloromethane at 20℃; for 24h;
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

tris-iso-propylsilyl acetylene
89343-06-6

tris-iso-propylsilyl acetylene

5-(trifluoromethyl)-2-((triisopropylsilyl)ethynyl)aniline

5-(trifluoromethyl)-2-((triisopropylsilyl)ethynyl)aniline

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine at 100℃; Sonogashira Cross-Coupling; Inert atmosphere;97%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

N,N'-bis(tert-butyloxycarbonyl)-2-bromo-5-trifluoromethylaniline
880384-45-2

N,N'-bis(tert-butyloxycarbonyl)-2-bromo-5-trifluoromethylaniline

Conditions
ConditionsYield
In tetrahydrofuran Heating;96%
With dmap In tetrahydrofuran at 20℃;96%
With dmap In tetrahydrofuran Heating;
5-methylfuran-2-boronic acid
62306-79-0

5-methylfuran-2-boronic acid

2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

2-(5-methylfuran-2-yl)-5-(trifluoromethyl)aniline

2-(5-methylfuran-2-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In water; N,N-dimethyl-formamide at 80℃; for 3h; Inert atmosphere;95%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

trans-2-phenylvinylboronic acid
6783-05-7

trans-2-phenylvinylboronic acid

(E)-2-styryl-5-(trifluoromethyl)aniline
1054567-68-8

(E)-2-styryl-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene for 24h; Reflux;94%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene at 100℃; for 16h; Suzuki Coupling; Inert atmosphere;81%
(E)-1-octen-1-ylboronic acid
42599-16-6

(E)-1-octen-1-ylboronic acid

2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

(E)-2-(oct-1-enyl)-5-(trifluoromethyl)aniline

(E)-2-(oct-1-enyl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene for 20h; Reflux; Inert atmosphere;94%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

2-(5-fluoro-thiophen-2-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

2-(5-fluoro-thiophen-2-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

2-(5-fluorothiophen-2-yl)-5-(trifluoromethyl)aniline

2-(5-fluorothiophen-2-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With potassium phosphate; methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) In 1,4-dioxane; water at 80℃; for 1h; Inert atmosphere;94%
2-phenylimidazo[2,1-b]benzothiazole
17833-07-7

2-phenylimidazo[2,1-b]benzothiazole

2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

(E)-3-((2-bromo-5-(trifluoromethyl)phenyl)diazenyl)-2-phenylbenzo[d]imidazo[2,1-b]thiazole

(E)-3-((2-bromo-5-(trifluoromethyl)phenyl)diazenyl)-2-phenylbenzo[d]imidazo[2,1-b]thiazole

Conditions
ConditionsYield
With tert.-butylnitrite In ethanol at 20℃; for 1h; Green chemistry;93%
formic acid
64-18-6

formic acid

2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

N-(2-bromo-5-(trifluoromethyl)phenyl)formamide
1536478-90-6

N-(2-bromo-5-(trifluoromethyl)phenyl)formamide

Conditions
ConditionsYield
In toluene at 100℃; for 16h;93%
With acetic anhydride In dichloromethane at 20℃; for 2h; Inert atmosphere;91%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

4-trifluoromethylphenylboronic acid
128796-39-4

4-trifluoromethylphenylboronic acid

4,4'-bis(trifluoromethyl)-[1,1'-biphenyl]-2-amine

4,4'-bis(trifluoromethyl)-[1,1'-biphenyl]-2-amine

Conditions
ConditionsYield
With palladium diacetate; diisopropylamine In water at 100℃; for 0.5h; Suzuki-Miyaura Coupling;93%
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In ethanol; water; toluene at 96℃; for 24h; Inert atmosphere;85%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

acetic anhydride
108-24-7

acetic anhydride

N-(2-bromo-5-(trifluoromethyl)phenyl)acetamide
331005-35-7

N-(2-bromo-5-(trifluoromethyl)phenyl)acetamide

Conditions
ConditionsYield
With dmap In chloroform for 24h; Reflux;93%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

2-mercapto-5-(trifluoromethyl)benzothiazole
23420-87-3

2-mercapto-5-(trifluoromethyl)benzothiazole

Conditions
ConditionsYield
In chloroform; N,N-dimethyl-formamide92%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

Propiolic acid
471-25-0

Propiolic acid

N-(2-bromo-5-(trifluoromethyl)phenyl)propiolamide
1477484-83-5

N-(2-bromo-5-(trifluoromethyl)phenyl)propiolamide

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere;92%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

C11H10F3NO2

C11H10F3NO2

Conditions
ConditionsYield
With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine In acetonitrile at 90℃; for 16h; Heck Reaction; Inert atmosphere; Sealed tube;92%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

phenylacetylene
536-74-3

phenylacetylene

2-(phenylethynyl)-5-(trifluoromethyl)aniline
1181455-55-9

2-(phenylethynyl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ethanolamine In tetrahydrofuran; water for 19h; Sonogashira coupling; Inert atmosphere; Reflux;91%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 90℃; Sonogashira Cross-Coupling; Inert atmosphere;75%
With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide at 80℃; for 48h; Sonogashira coupling; Inert atmosphere;54%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

4'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-amine
700802-70-6

4'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-amine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene at 100℃; for 16h;91%
thiophene boronic acid
6165-68-0

thiophene boronic acid

2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

2-(thiophen-2-yl)-5-(trifluoromethyl)aniline

2-(thiophen-2-yl)-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
With potassium phosphate; methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) In 1,4-dioxane; water at 80℃; Inert atmosphere;91%
Stage #1: thiophene boronic acid; 2-Bromo-5-trifluoromethylaniline With bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 20℃; for 1.5h; Inert atmosphere;
Stage #2: With sodium carbonate In 1,4-dioxane; water at 80℃; for 12h; Inert atmosphere;
75%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

2-iodobiphenyl
2113-51-1

2-iodobiphenyl

7-(trifluoromethyl)-9H-tribenzo[b,d,f]azepine

7-(trifluoromethyl)-9H-tribenzo[b,d,f]azepine

Conditions
ConditionsYield
With palladium diacetate; tetra-(n-butyl)ammonium iodide; caesium carbonate; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 120℃; for 36h; Reagent/catalyst; Schlenk technique; Inert atmosphere;89%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

(2S,4R)-1-((S)-2-tert-butoxycarbonylamino-3,3-dimethyl-butyryl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carboxylic acid
445306-08-1

(2S,4R)-1-((S)-2-tert-butoxycarbonylamino-3,3-dimethyl-butyryl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carboxylic acid

C39H42BrF3N4O6
1028412-38-5

C39H42BrF3N4O6

Conditions
ConditionsYield
With pyridine; trichlorophosphate at -15 - 20℃;88%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

2-nitro-benzaldehyde
552-89-6

2-nitro-benzaldehyde

N-(2-nitrobenzylidene)-2-bromo-5-trifluoromethylaniline
1453279-85-0

N-(2-nitrobenzylidene)-2-bromo-5-trifluoromethylaniline

Conditions
ConditionsYield
In isopropyl alcohol for 0.166667h; Reflux;88%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

α-trifluoromethylmaleic anhydride
700-27-6

α-trifluoromethylmaleic anhydride

1-(2-bromo-5-trifluoromethylphenyl)-3-trifluoromethyl-1H-pyrrole-2,5-dione

1-(2-bromo-5-trifluoromethylphenyl)-3-trifluoromethyl-1H-pyrrole-2,5-dione

Conditions
ConditionsYield
With acetic acid Reflux;88%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

3-fluorophenylboronic acid
768-35-4

3-fluorophenylboronic acid

3'-fluoro-4-(trifluoromethyl)-[1,1'-biphenyl]-2-amine

3'-fluoro-4-(trifluoromethyl)-[1,1'-biphenyl]-2-amine

Conditions
ConditionsYield
With palladium diacetate; diisopropylamine In water at 100℃; for 0.5h; Suzuki-Miyaura Coupling;88%
With potassium phosphate; methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) In 1,4-dioxane; water at 80℃; Inert atmosphere;78%
2-hydroxymethyl-4-methylphenol
4383-07-7

2-hydroxymethyl-4-methylphenol

2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

2-methyl-8-trifluoromethyldibenz[b,f][1,4]oxazepin-11(10H)-one

2-methyl-8-trifluoromethyldibenz[b,f][1,4]oxazepin-11(10H)-one

Conditions
ConditionsYield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium hydroxide; copper(I) bromide In 1,4-dioxane at 110℃; for 30h;87%
citraconic acid anhydride
616-02-4

citraconic acid anhydride

2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

1-(2-bromo-5-trifluoromethylphenyl)-3-methyl-1H-pyrrole-2,5-dione

1-(2-bromo-5-trifluoromethylphenyl)-3-methyl-1H-pyrrole-2,5-dione

Conditions
ConditionsYield
With acetic acid Reflux;87%
2-iodo-propane
75-30-9

2-iodo-propane

2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

2-bromo-N-isopropyl-5-(trifluoromethyl)aniline

2-bromo-N-isopropyl-5-(trifluoromethyl)aniline

Conditions
ConditionsYield
Stage #1: 2-Bromo-5-trifluoromethylaniline With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: 2-iodo-propane In N,N-dimethyl-formamide at 0 - 20℃; for 12h;
86%
2-Bromo-5-trifluoromethylaniline
454-79-5

2-Bromo-5-trifluoromethylaniline

2-Methoxybenzoyl chloride
21615-34-9

2-Methoxybenzoyl chloride

2-(2-methoxyphenyl)-5-trifluoromethylbenzoxazole
1021439-40-6

2-(2-methoxyphenyl)-5-trifluoromethylbenzoxazole

Conditions
ConditionsYield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In acetonitrile at 210℃; for 0.25h; microwave irradiation;85%

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