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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryProduct Name: 4-Nitropyrazole-3-carboxylic acid Synonyms: 4-Nitro-1H-pyrazole-3-carboxylic acid 98%;4-Nitro-3-pyrazolecarboxylic acid,95%;4-nitro-1H-pyrazole-5-carboxylic acid;4-nitro-1H-pyrazole-3-carboxylic acid(SALTDATA: FREE);NSC 1411;Pyrazole
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryConditions | Yield |
---|---|
With sodium dichromate; sulfuric acid; nitric acid 1.) 100 deg C, 4 h, 2.) 60 deg C, 10 h; Yield given. Multistep reaction; |
methanol
4-nitro-1H-pyrazole-3-carboxylic acid
methyl 4-nitro-1H-pyrazole-3-carboxylate
Conditions | Yield |
---|---|
Stage #1: methanol; 4-nitro-1H-pyrazole-3-carboxylic acid With acetyl chloride at 20℃; for 16h; Stage #2: With water; sodium hydrogencarbonate In methanol; ethyl acetate pH=8 - 9; Product distribution / selectivity; | 100% |
Stage #1: methanol; 4-nitro-1H-pyrazole-3-carboxylic acid With acetyl chloride Stage #2: With sodium hydrogencarbonate In methanol; water; ethyl acetate pH=8 - 9; | 100% |
With thionyl chloride at 0 - 20℃; | 100% |
methanol
thionyl chloride
4-nitro-1H-pyrazole-3-carboxylic acid
methyl 4-nitro-1H-pyrazole-3-carboxylate
Conditions | Yield |
---|---|
at 0 - 25℃; for 16 - 48h; Product distribution / selectivity; | 99.5% |
methanol
4-nitro-1H-pyrazole-3-carboxylic acid
4-nitro-2H-pyrazole-3-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 20℃; for 16.5h; | 99% |
With thionyl chloride at 0 - 20℃; | 82% |
With thionyl chloride at 0 - 35℃; | 82% |
4-nitro-1H-pyrazole-3-carboxylic acid
methyl 4-nitro-1H-pyrazole-3-carboxylate
Conditions | Yield |
---|---|
With thionyl chloride In methanol at 70℃; for 5h; | 99% |
With thionyl chloride In methanol; toluene | |
With thionyl chloride In methanol | |
With thionyl chloride In methanol; toluene | |
In methanol; toluene |
ethanol
4-nitro-1H-pyrazole-3-carboxylic acid
4-nitro-1H-pyrazole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With hydrogenchloride Reflux; | 98% |
With hydrogenchloride Reflux; Inert atmosphere; | 98% |
With thionyl chloride at 20℃; for 2h; Cooling with ice; | 98% |
4-fluoroaniline
4-nitro-1H-pyrazole-3-carboxylic acid
4-nitro-1H-pyrazole-3-carboxylic acid (4-fluorophenyl)amide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 16h; | 97% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 2h; | 82% |
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; | |
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; | |
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In DMF (N,N-dimethyl-formamide) at 20℃; |
4-nitro-1H-pyrazole-3-carboxylic acid
4-nitro-1H-pyrazole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With thionyl chloride In ethanol at 20℃; for 48h; | 96% |
Stage #1: ethanol With acetyl chloride at 0 - 20℃; for 0.5h; Stage #2: 4-nitro-1H-pyrazole-3-carboxylic acid at 20℃; for 48h; |
4-nitro-1H-pyrazole-3-carboxylic acid
4-nitro-1H-pyrazole-3-carboxamide
Conditions | Yield |
---|---|
Stage #1: 4-nitro-1H-pyrazole-3-carboxylic acid With oxalyl dichloride In tetrahydrofuran at 25℃; for 0.5h; Stage #2: With ammonium hydroxide In tetrahydrofuran at 25℃; for 3h; Cooling with ice; | 96% |
Stage #1: 4-nitro-1H-pyrazole-3-carboxylic acid With thionyl chloride; N,N-dimethyl-formamide Stage #2: With ammonium hydroxide at 20℃; | 57% |
3,4-dihydro-2H-pyran
4-nitro-1H-pyrazole-3-carboxylic acid
4-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylic acid
Conditions | Yield |
---|---|
With p-toluenesulfonic acid monohydrate In tetrahydrofuran at 20℃; for 16h; | 95% |
With toluene-4-sulfonic acid In tetrahydrofuran at 20℃; | 95% |
With toluene-4-sulfonic acid In tetrahydrofuran Inert atmosphere; Reflux; | 93.2% |
methanol
4-nitro-1H-pyrazole-3-carboxylic acid
methyl 4-nitro-1H-pyrazole-3-carboxylate hydrochloride
Conditions | Yield |
---|---|
With acetyl chloride | 90% |
With acetyl chloride at 0 - 20℃; for 24h; | |
With thionyl chloride at 20℃; Cooling with ice; |
4-[(4-methyl-1-piperazinyl)methyl]aniline
4-nitro-1H-pyrazole-3-carboxylic acid
N-(4-((4-methylpiperazin-1-yl)methyl))phenyl-4-nitro-1H-pyrazole-3-carboxamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 24h; | 88.2% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 24h; | |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 24h; | 11.1 g |
1,2-diamino-benzene
4-nitro-1H-pyrazole-3-carboxylic acid
2-(4-nitro-1H-pyrazol-3-yl)-1H-benzoimidazole
Conditions | Yield |
---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine for 5h; Reflux; Inert atmosphere; | 85% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 27h; Reflux; | 69% |
Stage #1: 1,2-diamino-benzene; 4-nitro-1H-pyrazole-3-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; Stage #2: With acetic acid Reflux; |
1-(tert-butoxycarbonyl)-4-aminopiperidine
4-nitro-1H-pyrazole-3-carboxylic acid
4-[(4-nitro-1H-pyrazole-3-carbonyl)amino]piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 16h; | 84% |
With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; | |
With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; |
Conditions | Yield |
---|---|
With phosphoric acid In acetic acid at 60℃; for 3h; | 82% |
1,3-diazido 2-propanol
4-nitro-1H-pyrazole-3-carboxylic acid
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Green chemistry; | 78% |
Conditions | Yield |
---|---|
With sodium dichromate; sulfuric acid; nitric acid 1.) 100 deg C, 4 h, 2.) 60 deg C, 10 h; Yield given. Multistep reaction; |
methanol
4-nitro-1H-pyrazole-3-carboxylic acid
methyl 4-nitro-1H-pyrazole-3-carboxylate
Conditions | Yield |
---|---|
Stage #1: methanol; 4-nitro-1H-pyrazole-3-carboxylic acid With acetyl chloride at 20℃; for 16h; Stage #2: With water; sodium hydrogencarbonate In methanol; ethyl acetate pH=8 - 9; Product distribution / selectivity; | 100% |
Stage #1: methanol; 4-nitro-1H-pyrazole-3-carboxylic acid With acetyl chloride Stage #2: With sodium hydrogencarbonate In methanol; water; ethyl acetate pH=8 - 9; | 100% |
With thionyl chloride at 0 - 20℃; | 100% |
methanol
thionyl chloride
4-nitro-1H-pyrazole-3-carboxylic acid
methyl 4-nitro-1H-pyrazole-3-carboxylate
Conditions | Yield |
---|---|
at 0 - 25℃; for 16 - 48h; Product distribution / selectivity; | 99.5% |
methanol
4-nitro-1H-pyrazole-3-carboxylic acid
4-nitro-2H-pyrazole-3-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 20℃; for 16.5h; | 99% |
With thionyl chloride at 0 - 20℃; | 82% |
With thionyl chloride at 0 - 35℃; | 82% |
4-nitro-1H-pyrazole-3-carboxylic acid
methyl 4-nitro-1H-pyrazole-3-carboxylate
Conditions | Yield |
---|---|
With thionyl chloride In methanol at 70℃; for 5h; | 99% |
With thionyl chloride In methanol; toluene | |
With thionyl chloride In methanol | |
With thionyl chloride In methanol; toluene | |
In methanol; toluene |
ethanol
4-nitro-1H-pyrazole-3-carboxylic acid
4-nitro-1H-pyrazole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With hydrogenchloride Reflux; | 98% |
With hydrogenchloride Reflux; Inert atmosphere; | 98% |
With thionyl chloride at 20℃; for 2h; Cooling with ice; | 98% |
4-fluoroaniline
4-nitro-1H-pyrazole-3-carboxylic acid
4-nitro-1H-pyrazole-3-carboxylic acid (4-fluorophenyl)amide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 16h; | 97% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 2h; | 82% |
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; | |
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; | |
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In DMF (N,N-dimethyl-formamide) at 20℃; |
4-nitro-1H-pyrazole-3-carboxylic acid
4-nitro-1H-pyrazole-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With thionyl chloride In ethanol at 20℃; for 48h; | 96% |
Stage #1: ethanol With acetyl chloride at 0 - 20℃; for 0.5h; Stage #2: 4-nitro-1H-pyrazole-3-carboxylic acid at 20℃; for 48h; |
4-nitro-1H-pyrazole-3-carboxylic acid
4-nitro-1H-pyrazole-3-carboxamide
Conditions | Yield |
---|---|
Stage #1: 4-nitro-1H-pyrazole-3-carboxylic acid With oxalyl dichloride In tetrahydrofuran at 25℃; for 0.5h; Stage #2: With ammonium hydroxide In tetrahydrofuran at 25℃; for 3h; Cooling with ice; | 96% |
Stage #1: 4-nitro-1H-pyrazole-3-carboxylic acid With thionyl chloride; N,N-dimethyl-formamide Stage #2: With ammonium hydroxide at 20℃; | 57% |
3,4-dihydro-2H-pyran
4-nitro-1H-pyrazole-3-carboxylic acid
4-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylic acid
Conditions | Yield |
---|---|
With p-toluenesulfonic acid monohydrate In tetrahydrofuran at 20℃; for 16h; | 95% |
With toluene-4-sulfonic acid In tetrahydrofuran at 20℃; | 95% |
With toluene-4-sulfonic acid In tetrahydrofuran Inert atmosphere; Reflux; | 93.2% |
methanol
4-nitro-1H-pyrazole-3-carboxylic acid
methyl 4-nitro-1H-pyrazole-3-carboxylate hydrochloride
Conditions | Yield |
---|---|
With acetyl chloride | 90% |
With acetyl chloride at 0 - 20℃; for 24h; | |
With thionyl chloride at 20℃; Cooling with ice; |
4-[(4-methyl-1-piperazinyl)methyl]aniline
4-nitro-1H-pyrazole-3-carboxylic acid
N-(4-((4-methylpiperazin-1-yl)methyl))phenyl-4-nitro-1H-pyrazole-3-carboxamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 24h; | 88.2% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 24h; | |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 24h; | 11.1 g |
1,2-diamino-benzene
4-nitro-1H-pyrazole-3-carboxylic acid
2-(4-nitro-1H-pyrazol-3-yl)-1H-benzoimidazole
Conditions | Yield |
---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine for 5h; Reflux; Inert atmosphere; | 85% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 27h; Reflux; | 69% |
Stage #1: 1,2-diamino-benzene; 4-nitro-1H-pyrazole-3-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; Stage #2: With acetic acid Reflux; |
1-(tert-butoxycarbonyl)-4-aminopiperidine
4-nitro-1H-pyrazole-3-carboxylic acid
4-[(4-nitro-1H-pyrazole-3-carbonyl)amino]piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 16h; | 84% |
With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; | |
With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; |
Conditions | Yield |
---|---|
With phosphoric acid In acetic acid at 60℃; for 3h; | 82% |
1,3-diazido 2-propanol
4-nitro-1H-pyrazole-3-carboxylic acid
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Green chemistry; | 78% |
4-nitro-1H-pyrazole-3-carboxylic acid
4-(4-tert-butoxycarbonyl-piperazino-methyl)-aniline
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 12h; | 76% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 24h; |
methanol
4-nitro-1H-pyrazole-3-carboxylic acid
methyl iodide
1-methyl-4-nitro-1H-pyrazole-3-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: methanol; 4-nitro-1H-pyrazole-3-carboxylic acid With thionyl chloride at 0 - 20℃; Stage #2: methyl iodide With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; | 75% |
4-nitro-1H-pyrazole-3-carboxylic acid
4-amino-1H-pyrazole-3-carboxylic acid
Conditions | Yield |
---|---|
With iron(III) chloride hexahydrate; pyrographite; hydrazine hydrate In water for 30h; Reflux; | 75% |
isopropylamine
4-nitro-1H-pyrazole-3-carboxylic acid
N-isopropyl-4-nitro-1H-pyrazole-3-carboxamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 16h; | 70% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 16h; | 70% |
methyl 4-(aminomethyl)benzoate hydrochloride
4-nitro-1H-pyrazole-3-carboxylic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 12h; | 65% |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; | 63% |
4-nitro-1H-pyrazole-3-carboxylic acid
N,N-dimethylformamide di-tert-butyl acetal
Conditions | Yield |
---|---|
at 100℃; for 12h; Inert atmosphere; | 63% |
methoxycyclohexanamine hydrochloride
4-nitro-1H-pyrazole-3-carboxylic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere; | 62% |
4-morpholin-4-ylmethylbenzene-1,2-diamine
4-nitro-1H-pyrazole-3-carboxylic acid
4-((2-(4-nitro-1H-pyrazol-3-yl)-1H-benzo[d]imidazole-5-yl)methyl)morpholine
Conditions | Yield |
---|---|
Stage #1: 4-morpholin-4-ylmethylbenzene-1,2-diamine; 4-nitro-1H-pyrazole-3-carboxylic acid With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; for 24h; Stage #2: With acetic acid for 3h; Product distribution / selectivity; Heating / reflux; | 61% |
Stage #1: 4-morpholin-4-ylmethylbenzene-1,2-diamine; 4-nitro-1H-pyrazole-3-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 24h; Stage #2: With acetic acid for 3h; Reflux; | 61% |
Stage #1: 4-morpholin-4-ylmethylbenzene-1,2-diamine; 4-nitro-1H-pyrazole-3-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 24h; Stage #2: With acetic acid for 3h; Product distribution / selectivity; Heating / reflux; | 61% |
2-amino-benzenethiol
4-nitro-1H-pyrazole-3-carboxylic acid
2-(4-nitro-1H-pyrazol-3-yl)-benzothiazole
Conditions | Yield |
---|---|
Stage #1: 4-nitro-1H-pyrazole-3-carboxylic acid With oxalyl dichloride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 2-amino-benzenethiol In tetrahydrofuran; N,N-dimethyl-formamide at 100℃; for 1h; | 61% |
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine for 5h; Reflux; Inert atmosphere; |
4-[(diethylamino)methyl]benzene-1,2-diamine
4-nitro-1H-pyrazole-3-carboxylic acid
N-ethyl-N-{[2-(4-nitro-1H-pyrazol-3-yl)-1H-benzo[d]imidazol-5-yl]methyl}ethanamine
Conditions | Yield |
---|---|
Stage #1: 4-[(diethylamino)methyl]benzene-1,2-diamine; 4-nitro-1H-pyrazole-3-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 24h; Stage #2: With acetic acid for 3h; Reflux; | 57.8% |
4-methyl-1,2-diaminobenzene
4-nitro-1H-pyrazole-3-carboxylic acid
5-methyl-2-(4-nitro-1H-pyrazol-3-yl)-1H-benzo[d]imidazole
Conditions | Yield |
---|---|
Stage #1: 4-methyl-1,2-diaminobenzene; 4-nitro-1H-pyrazole-3-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 24h; Stage #2: With acetic acid for 3h; Reflux; | 57.3% |
methanol
p-methoxybenzyl chloride
4-nitro-1H-pyrazole-3-carboxylic acid
methyl 1-(4-methoxybenzyl)-4-nitro-1H-pyrazole-3-carboxylate
Conditions | Yield |
---|---|
Stage #1: methanol; 4-nitro-1H-pyrazole-3-carboxylic acid With thionyl chloride Stage #2: p-methoxybenzyl chloride With potassium carbonate In acetonitrile | 56% |
4-nitro-1H-pyrazole-3-carboxylic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 20℃; | 54% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 20℃; |
benzyl bromide
4-nitro-1H-pyrazole-3-carboxylic acid
benzyl 1-benzyl-4-nitro-1H-pyrazole-3-carboxylate
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 1.5h; | 51% |
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