Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:53857-57-1
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryhe company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:Whit
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:53857-57-1
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:53857-57-1
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inquirychengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
Cas:53857-57-1
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inquiry5-Bromoindazole Basic information Product Name: 5-Bromoindazole Synonyms: 5-BROMO-1H-INDAZOLE;5-BROMOINDAZOLE;4-BROMOIMIDAZOLE;5-Bromo-1H-indazole 97%;5-Bromo-1H-in
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:53857-57-1
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryProduct Name 5-Bromoindazole CAS 53857-57-1 MF C7H5BrN2 MW 197.03
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inquiryWe are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
Cas:53857-57-1
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Powder Storage:Store in sealed containers at cool & dry pla
Cas:53857-57-1
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:53857-57-1
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inquiryProduct Name: 5-Bromoindazole CAS: 53857-57-1 MF: C7H5BrN2 MW: 197.03 EINECS: Mol File: 53857-57-1.mol 5-Bromoindazole Structure 5-Bromoindazole Chemical Properties Melting point 131-135 °C(lit.) Boiling point 333.8&p
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:53857-57-1
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inquiry5-Bromoindazole CAS:53857-57-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedi
Cas:53857-57-1
Min.Order:1 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:53857-57-1
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h
Cas:53857-57-1
Min.Order:100 Metric Ton
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:53857-57-1
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:53857-57-1
Min.Order:4 Kilogram
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:53857-57-1
Min.Order:1 Gram
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:53857-57-1
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiry5-BromoindazoleAppearance:white powder Storage:Store in dry, dark and ventilated place Package:according to customers' requirements Application:chemical research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect
Product name: 5-Bromoindazole CAS No.:53857-57-1 Molecule Formula: C7H5BrN2 Molecule Weight:197.03 Purity: 99.0% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:53857-57-1
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiry5-bromo-1H-indazole
Conditions | Yield |
---|---|
With potassium tert-butylate In dimethyl sulfoxide for 1.5h; Ambient temperature; | 98% |
5-bromo-2-fluorobenzaldehyde
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With hydrazine hydrate at 100℃; for 12h; | 96% |
With hydrazine at 100℃; | 50% |
With hydrazine hydrate In 1,2-dimethoxyethane for 15h; Heating; | 45% |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide; potassium acetate; acetic anhydride In n-heptane; chloroform; water; ethyl acetate | 94% |
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; Cu(dq)((rac)-2,2′-bis(diphenylphosphino)-1,1′-binaphthalene)BF4; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; Irradiation; | 89% |
3,5-dibromoindazole
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With methanol; magnesium at 20℃; chemoselective reaction; | 84% |
With phosphorus; hydrogen iodide at 110℃; |
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl acetamide at 60℃; for 2h; Inert atmosphere; | 82% |
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With 18-crown-6 ether; potassium acetate In chloroform at 20℃; for 2h; | 80% |
With potassium acetate; 18-crown-6 ether In chloroform at 20℃; for 2h; | 65% |
With 18-crown-6 ether; potassium acetate In chloroform at 20℃; | 60% |
4-Bromo-2-methylaniline
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With acetic acid; sodium nitrite In water at 20℃; for 5h; | 61% |
Stage #1: 4-Bromo-2-methylaniline With acetic anhydride In chloroform at 0 - 40℃; for 1h; Stage #2: With potassium acetate; isopentyl nitrite In chloroform for 18h; Heating / reflux; Stage #3: With hydrogenchloride In water at 50℃; for 2h; | 60% |
Stage #1: 4-Bromo-2-methylaniline With tetrafluoroboric acid; sodium nitrite In water at 0℃; Stage #2: With 18-crown-6 ether; potassium acetate In chloroform at 20℃; Further stages.; | |
Multi-step reaction with 2 steps 1.1: water / 0.25 h / 20 °C 1.2: 0 - 5 °C 2.1: 18-crown-6 ether; potassium acetate / chloroform / 2 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium acetate / toluene / 0.67 h / 85 °C 2: toluene / 4.25 h / 65 °C View Scheme |
3-amino-5-bromo-1H-indazole
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With nitrous acid isobutyl ester; hypophosphorous acid In ethanol; water at 0 - 20℃; for 3h; | 40% |
5-bromobenzopyrazole-3-carboxylic acid
5-bromo-1H-indazole
Conditions | Yield |
---|---|
at 320℃; |
3-Diazo-3H-indazol
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With hydrogen bromide |
acetic acid-(4-bromo-2-methyl-N-nitroso-anilide)
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With benzene |
acetic acid-(4-bromo-2-methyl-N-nitroso-anilide)
benzene
5-bromo-1H-indazole
Conditions | Yield |
---|---|
at 60℃; |
5-bromo-1H-indazole
5-bromo-1H-indazole
Conditions | Yield |
---|---|
at 110℃; |
5-bromobenzopyrazole-3-carboxylic acid
water
A
5-bromo-1H-indazole
B
methylammonium carbonate
Conditions | Yield |
---|---|
at 200℃; |
3-Diazo-3H-indazol
hydrogen bromide
A
benzimidazole
B
5-bromo-1H-indazole
C
3-bromo-1H-indazole
D
3,5-dibromoindazole
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With hydrazine In 1,2-dimethoxyethane Heating; | |
With hydrazine hydrate Reflux; | |
With hydrazine hydrate Reflux; |
Conditions | Yield |
---|---|
In toluene at 65℃; for 4.25h; |
4'-bromo-2'-methylacetanilide
5-bromo-1H-indazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: glacial acetic acid / Einleiten von nitrosen Gasen 2: benzene View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogenchloride / ethanol / 3 h / Reflux 1.2: 0.5 h / 20 °C 2.1: water / 0.25 h / 20 °C 2.2: 0 - 5 °C 3.1: 18-crown-6 ether; potassium acetate / chloroform / 2 h / 20 °C View Scheme |
3-bromo-1H-indazole
5-bromo-1H-indazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: glacial acetic acid / durch Bromierung 2: concentrated hydriodic acid; red phosphorus / 110 °C View Scheme |
ammonium tetrafluroborate
4-Bromo-2-methylaniline
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With potassium acetate; sodium nitrite In chloroform; acetic acid | |
With potassium acetate; sodium nitrite In chloroform; acetic acid | |
With potassium acetate; sodium nitrite In chloroform; acetic acid |
ammonium tetrafluroborate
4-Bromo-2-methylaniline
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With hydrogenchloride; potassium acetate; acetic acid; sodium nitrite In chloroform; water |
5-bromo-2-fluorobenzaldehyde
A
5-bromo-2-fluorotoluene
B
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With hydrazine Inert atmosphere; Reflux; |
o-toluidine
5-bromo-1H-indazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 2 h / 110 - 115 °C 2.1: bromine; acetic acid / 1.5 h / 50 °C 3.1: hydrogenchloride / ethanol / 3 h / Reflux 3.2: 0.5 h / 20 °C 4.1: water / 0.25 h / 20 °C 4.2: 0 - 5 °C 5.1: 18-crown-6 ether; potassium acetate / chloroform / 2 h / 20 °C View Scheme |
N-(2-methylphenyl)acetamide
5-bromo-1H-indazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: bromine; acetic acid / 1.5 h / 50 °C 2.1: hydrogenchloride / ethanol / 3 h / Reflux 2.2: 0.5 h / 20 °C 3.1: water / 0.25 h / 20 °C 3.2: 0 - 5 °C 4.1: 18-crown-6 ether; potassium acetate / chloroform / 2 h / 20 °C View Scheme |
N-methoxylamine hydrochloride
5-bromo-2-fluorobenzaldehyde
5-bromo-1H-indazole
Conditions | Yield |
---|---|
Stage #1: N-methoxylamine hydrochloride; 5-bromo-2-fluorobenzaldehyde With potassium carbonate In 1,2-dimethoxyethane at 40℃; Stage #2: With hydrazine In 1,2-dimethoxyethane Reflux; |
5-bromo-1H-indazole
5-bromo-3-iodo-1H-indazole
Conditions | Yield |
---|---|
With iodine; potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 3h; | 100% |
Stage #1: 5-bromo-1H-indazole With potassium tert-butylate In tetrahydrofuran at 0℃; Stage #2: With iodine In tetrahydrofuran at 0 - 20℃; | 99% |
With iodine; potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; | 97.9% |
di-tert-butyl dicarbonate
5-bromo-1H-indazole
tert-butyl 5-bromo-1H-indazole-1-carboxylate
Conditions | Yield |
---|---|
With dmap In dichloromethane at 20℃; | 100% |
With dmap; triethylamine In acetonitrile for 3h; | 99% |
With dmap In acetonitrile at 23℃; for 0.25h; Inert atmosphere; | 99% |
5-bromo-1H-indazole
bis(pinacol)diborane
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In N,N-dimethyl-formamide at 100℃; Inert atmosphere; | 100% |
With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In N,N-dimethyl-formamide at 90℃; for 24h; | 84% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 90℃; for 24h; Inert atmosphere; | 81% |
5-bromo-1H-indazole
5-iodo-1H-indazole
Conditions | Yield |
---|---|
With sodium iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide In 1,4-dioxane at 110℃; for 68h; | 100% |
5-bromo-1H-indazole
ethyl vinyl ether
5-bromo-1-(1-ethoxyethyl)-1H-indazole
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In dichloromethane for 18h; regioselective reaction; | 99% |
5-bromo-1H-indazole
N,2-dimethylaniline
N-methyl-N-(o-tolyl)-1H-indazol-5-amine
Conditions | Yield |
---|---|
With chloro-(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); lithium hexamethyldisilazane; ruphos In tetrahydrofuran at 65℃; for 4h; Inert atmosphere; Sealed vial; | 99% |
With [Pd(RuPhos)(dvtms)]; lithium hexamethyldisilazane In tetrahydrofuran at 65℃; for 16h; Buchwald-Hartwig Coupling; Sealed tube; |
3,4-dihydro-2H-pyran
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In dichloromethane for 1h; regioselective reaction; | 98.2% |
With toluene-4-sulfonic acid In toluene at 15 - 75℃; for 2h; Inert atmosphere; | 98% |
With toluene-4-sulfonic acid In dichloromethane at 20℃; for 3h; | 97% |
5-bromo-1H-indazole
(2-trimethylethylsilylethoxy)methyl chloride
5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole
Conditions | Yield |
---|---|
Stage #1: 5-bromo-1H-indazole With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Stage #2: (2-trimethylethylsilylethoxy)methyl chloride In tetrahydrofuran at 20℃; for 16h; | 98% |
With potassium hydroxide; tetrabutylammomium bromide In dichloromethane; water at 0 - 20℃; for 3h; | 81% |
With tetrabutylammomium bromide; sodium hydroxide In dichloromethane; water for 3h; Inert atmosphere; | 81% |
Stage #1: 5-bromo-1H-indazole With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Stage #2: (2-trimethylethylsilylethoxy)methyl chloride In tetrahydrofuran; mineral oil at 20℃; for 3h; | 70% |
Stage #1: 5-bromo-1H-indazole With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Inert atmosphere; Stage #2: (2-trimethylethylsilylethoxy)methyl chloride In N,N-dimethyl-formamide at 0℃; for 2h; | 63% |
5-bromo-1H-indazole
1-(4-chlorophenyl)piperazine hydrochloride
5-(4-(4-chlorophenyl)piperazin-1-yl)-1H-indazole
Conditions | Yield |
---|---|
With RuPhos palladacycle; lithium hexamethyldisilazane; ruphos In tetrahydrofuran at 65℃; for 4h; Inert atmosphere; Sealed vial; | 98% |
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 50℃; Reagent/catalyst; Temperature; | 97% |
With triethylamine In acetonitrile at 50℃; for 8h; | 93% |
3-Dimethylaminopropanethiol
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With lithium hexamethyldisilazane In tetrahydrofuran at 120℃; for 16h; Inert atmosphere; | 97% |
Conditions | Yield |
---|---|
With RuPhos palladacycle; lithium hexamethyldisilazane; ruphos In tetrahydrofuran at 65℃; for 4h; Inert atmosphere; Sealed vial; | 96% |
Conditions | Yield |
---|---|
With pyridine; oxygen; copper diacetate In dichloromethane at 15℃; for 12h; | 96% |
5-bromo-1H-indazole
Acetic formic anhydride
1H-indazole-5-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 5-bromo-1H-indazole; formyl acetic anhydride With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 90℃; for 2h; Inert atmosphere; Stage #2: With hydrogenchloride In water pH=Ca. 4 - 6; | 95% |
3-mercaptopropionic acid ethyl ester
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 2h; Inert atmosphere; | 95% |
5-bromo-1H-indazole
[2-(2-fluorophenyl)ethyl]amine
N-(2-fluorophenethyl)-1H-indazol-5-amine
Conditions | Yield |
---|---|
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); lithium hexamethyldisilazane In tetrahydrofuran at 65℃; for 4h; Inert atmosphere; Sealed vial; | 94% |
Conditions | Yield |
---|---|
With C31H49O2P*C12H10N(1-)*CH3O3S(1-)*Pd(2+)*CH2Cl2; lithium hexamethyldisilazane In tetrahydrofuran at 20℃; | 93% |
5-bromo-1H-indazole
acetic anhydride
1-(5-bromo-1H-indazol-1-yl)ethanone
Conditions | Yield |
---|---|
for 2h; Reflux; | 92% |
Stage #1: 5-bromo-1H-indazole With ferrocene; tert-butylammonium hexafluorophosphate(V) In acetonitrile at 20℃; for 3h; Electrochemical reaction; Inert atmosphere; Glovebox; Stage #2: acetic anhydride In acetonitrile for 2h; Electrochemical reaction; Inert atmosphere; Glovebox; | 72% |
With pyridine; dmap In dichloromethane at 40℃; | 70% |
5-bromo-1H-indazole
benzyl bromide
A
2-benzyl-5-bromo-2H-indazole
B
1-benzyl-5-bromo-1H-indazole
Conditions | Yield |
---|---|
Stage #1: 5-bromo-1H-indazole With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: benzyl bromide In N,N-dimethyl-formamide at 0 - 20℃; for 2h; | A 88% B 92% |
With tetra-(n-butyl)ammonium iodide; sodium hydroxide In para-xylene at 130℃; | A 302 mg B 364 mg |
Conditions | Yield |
---|---|
Stage #1: 5-bromo-1H-indazole; methyl iodide With sodium hydroxide In methanol at 100℃; Sealed tube; Stage #2: With perchloric acid In water at 20℃; | 92% |
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 90℃; for 4h; Inert atmosphere; | 92% |
With tris-(dibenzylideneacetone)dipalladium(0); N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 90℃; for 4h; Inert atmosphere; | 92% |
3,4-dihydro-2H-pyran
5-bromo-1H-indazole
5-bromo-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole
Conditions | Yield |
---|---|
With pyridinium p-toluenesulfonate In dichloromethane for 5h; regioselective reaction; | 91.8% |
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); tripotassium phosphate "n" hydrate; XPhos In butan-1-ol at 100℃; for 18h; Inert atmosphere; | 91.1% |
With palladium diacetate; sodium carbonate; triphenylphosphine In 1,2-dimethoxyethane; water Suzuki Coupling; |
5-bromo-1H-indazole
5-bromo-3-chloro-1H-indazole
Conditions | Yield |
---|---|
With N-chloro-succinimide; 2,4,6-trimethylaniline In acetonitrile at 20℃; for 24h; Inert atmosphere; | 91% |
With 1-chloro-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one In N,N-dimethyl-formamide at 20℃; for 12h; regioselective reaction; | 86% |
With N-chloro-succinimide In acetonitrile at 65℃; for 3h; | 48.7% |
Conditions | Yield |
---|---|
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis(dibenzylideneacetone)-palladium(0) In water; N,N-dimethyl-formamide at 150℃; for 0.75h; Sealed vial; | 91% |
With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In water; N,N-dimethyl-formamide at 150℃; for 1.5h; Inert atmosphere; Microwave irradiation; | 24% |
methanol
carbon monoxide
5-bromo-1H-indazole
1H-indazole-5-carboxylic acid
Conditions | Yield |
---|---|
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; palladium dichloride In acetonitrile at 100℃; under 30003 Torr; for 18h; | 90% |
5-bromo-1H-indazole
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid In water at 0℃; for 1h; | 90% |
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