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Guang'an Hongyi Bio-technology Co., Ltd

Strengths: stable supply superior quality advanced technology sufficient stock legal /safety production competitive price Appearance:brown powder Storage:cool and dry place avoiding sunlight directly Package:25kg/drum, double-la

Factory supply Salvia Extract with Tanshinone IIA & Salvianolic Acid B

Cas:568-72-9

Min.Order:25 Kilogram

FOB Price: $13.0 / 14.0

Type:Other

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At pres

Herb Medicine Salvia Miltiorrhiza Extract Tanshinone IIA Powder CAS:568-72-9

Cas:568-72-9

Min.Order:1 Kilogram

FOB Price: $286.0 / 300.0

Type:Trading Company

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shanghai Tauto Biotech Co., Ltd

The quality is guaranteed. If you find the product is wrong compared with COA, we promise 100% refund or change product. COA and HPLC will be shipped out with goods. You can also inform your analysis method and we will follow your analysis me

E-0021 Tanshinone II A

Cas:568-72-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Tanshinone IIA Manufacturer/High quality/Best price/In stock

Cas:568-72-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Tanshinone IIA 5%, 10%, 50%, 98% Salvia Miltiorrhiza Extract

Cas:568-72-9

Min.Order:1 Kilogram

FOB Price: $500.0 / 1200.0

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Tanshinone Iia supplier in China

Cas:568-72-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

Specifications CAS No.: 568-72-9 Other Names: Tanshinone IIA MF: C19H18O3 EINECS No.: 568-72-9 Place of Origin: Shaanxi, China (Main

Total tanshinones 98% CAS.no: 568-72-9 extract powder from red sage root

Cas:568-72-9

Min.Order:1 Kilogram

FOB Price: $6.0 / 700.0

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Tanshinone IIA Cas 568-72-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Red powder Storage:Cool dry place Package:10g,100g,1kg/foil bag Appl

Natural Danshen extract Tanshinone IIA Cas 568-72-9 with high quality

Cas:568-72-9

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Natural Extract 98% Tanshinone IIA 568-72-9 HACCP Manufacturer

Cas:568-72-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Xi`an Eastling Biotech Co., Ltd.

Tanshinone IIA CAS: 568-72-9 Molecular Formula: C19H18O3 Home Product Category other other 568-72-9 568-72-9 - Names and Identifiers Name Tanshinone IIA Synonyms NSC 686518 tanshiones Tanshinone B Tanshino

Top Quality Natural Tanshinone IIA

Cas:568-72-9

Min.Order:1 Kilogram

FOB Price: $35.0 / 49.0

Type:Lab/Research institutions

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Tanshinone IIA

Cas:568-72-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Tanshinone IIA CAS NO:568-72-9 Grade:Medical, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability Product Tec

Tanshinone IIA CAS:568-72-9 Chinese manufacturers high-quality

Cas:568-72-9

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scient

TIANFU-CHEM Tanshinone IIA

Cas:568-72-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Extract Tanshinone CAS 568-72-9 Tanshinone Iia

Cas:568-72-9

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 568-72-9 with competitive price

Cas:568-72-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.More than five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Sp

Top Supplier Tanshinone II A 98%

Cas:568-72-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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DB BIOTECH CO., LTD

Quick Details Type: Tanshinone Extract Form: Powder Part: Root Extraction Type: Solvent Extraction Packa

High quality Salvia miltiorrhiza P.E. in bulk supply

Cas:568-72-9

Min.Order:1 Kilogram

FOB Price: $30.0

Type:Trading Company

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

China Biggest factory Supply High Quality Tanshinone IIA CAS 568-72-9

Cas:568-72-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Tanshinone IIA CAS:568-72-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Tanshinone IIA CAS:568-72-9

Cas:568-72-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Tanshinone IIA

Cas:568-72-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Price, service, company and transport advantage: 1.place of origin china with super quality by reasonable price. 2. it's customers' right to choose the package (ems, dhl, fedex, ups); 3. it's custo

BEST PRICE/Tanshinone IIA

Cas:568-72-9

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Tanshinone IIA

Cas:568-72-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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ShangHai Soyoung Biotechnology Inc

Trade Assurance Get full protection for your orders 100% Product quality protection 100% On-time shipment protection 100% Payment protection Appearance:brownish red dry powder Storage:2 years if properly stored Package:25 kgs/ fiber drum or accord

Salvia miltiorrhiza root extract Protocatechuicaldehyde

Cas:568-72-9

Min.Order:25 Kilogram

FOB Price: $158.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Tanshinone IIA

Cas:568-72-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Tanshinone IIA 568-72-9

Cas:568-72-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Purestar Chem Enterprise Co.,Ltd

Salvia Miltiorrhiza Extract Product Name:Danshen Extract Powder Botanical Source:Salvia miltiorrhiza Bge Odor:Characteristic Use Part:Root Test Method:HPLC Particle Size:98% Pass through 80 mesh Extract Method:Water/Ethanol Specification of

Salvia Miltiorrhiza Extract

Cas:568-72-9

Min.Order:1 Kilogram

FOB Price: $8.0

Type:Trading Company

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HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality moderate price & quick delivery Appearance:Orange powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:antineoplastic, bo

Kudzu Root P.E.

Cas:568-72-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

TANSHINONE IIA

Cas:568-72-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Tanshinone IIA

Cas:568-72-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(+/-)-cryptotanshinone
17545-07-2, 35825-57-1

(+/-)-cryptotanshinone

tanshinone IIA
568-72-9

tanshinone IIA

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In benzene at 20℃;95%
Cryptotanshinone
35825-57-1

Cryptotanshinone

tanshinone IIA
568-72-9

tanshinone IIA

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In benzene at 25℃; for 42h;91%
C25H22O4

C25H22O4

tanshinone IIA
568-72-9

tanshinone IIA

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In tetrahydrofuran40%
methyl 2-(1-methoxycarbonyl-5,5-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-4-methylfuran-3- carboxylate

methyl 2-(1-methoxycarbonyl-5,5-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-4-methylfuran-3- carboxylate

tanshinone IIA
568-72-9

tanshinone IIA

Conditions
ConditionsYield
With sodium In tetrahydrofuran at 50℃; for 1h; Inert atmosphere;40%
6,6-dimethyl-1-vinylcyclohex-1-ene
18238-29-4

6,6-dimethyl-1-vinylcyclohex-1-ene

4,5-dihydro-3-methylbenzo[1,2-b]furan-4,5-dione
113297-21-5

4,5-dihydro-3-methylbenzo[1,2-b]furan-4,5-dione

A

tanshinone IIA
568-72-9

tanshinone IIA

B

3,8,8-Trimethyl-8,9,10,11-tetrahydro-phenanthro[4,3-b]furan-4,5-dione
118950-00-8

3,8,8-Trimethyl-8,9,10,11-tetrahydro-phenanthro[4,3-b]furan-4,5-dione

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone 1) neat, ultrasound, 45 deg C, 2h, (or benzene, 12h, reflux), 2) benzene, 12h, reflux; Yield given. Multistep reaction. Yields of byproduct given;
Yield given. Multistep reaction. Yields of byproduct given;
With 2,3-dicyano-5,6-dichloro-p-benzoquinone 1) benzene, reflux, 12h, (or ultrasonification, 45 deg C, 2h), 2) benzene, 12h, reflux; Yield given. Multistep reaction. Yields of byproduct given;
1-bromo-4-methylpent-3-ene
2270-59-9

1-bromo-4-methylpent-3-ene

tanshinone IIA
568-72-9

tanshinone IIA

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 1.) n-BuLi, TMEDA / 1.) hexane, 45 deg C, 30 min, 2.) THF, 55-60 deg C, 20 h
2: 97 percent / AlCl3 / CH2Cl2 / 0.25 h / 0 °C
3: 95 percent / BBr3 / CH2Cl2 / 4 h / -78 - 25 °C
4: 87 percent / DMAP / pyridine / 1.) 0 deg C -> 25 deg C, 1 h, 2.) 25 deg C, 48 h
5: 71 percent / LiCl, 4A sieves, Me4Sn, 2,6-di-tert-butylhydroxytoluene / PdCl2(dppf) / dimethylformamide / 12 h / 90 °C / 2585.7 Torr
6: 1.) LiHMDS, 2,2,2-trifluoroethyl trifluoroacetate, 2.) MsN3, Et3N / 1.) THF, -78 deg C, 45 min, 2.) MeCN, H2O, 25 deg C, 6 h
7: 64 percent / benzene / 24 h / Ambient temperature; Irradiation
8: 84 percent / n-Bu4NF, O2 / tetrahydrofuran / 40 h / 25 °C
9: 100 percent / conc. H2SO4 / ethanol / 0.75 h / 25 °C
10: 91 percent / DDQ / benzene / 42 h / 25 °C
View Scheme
2-bromoanisole
578-57-4

2-bromoanisole

BBr3

BBr3

tanshinone IIA
568-72-9

tanshinone IIA

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 93 percent / PdCl2(dppf) / tetrahydrofuran / 15 h / Heating
2: 97 percent / AlCl3 / CH2Cl2 / 0.25 h / 0 °C
3: 95 percent / BBr3 / CH2Cl2 / 4 h / -78 - 25 °C
4: 87 percent / DMAP / pyridine / 1.) 0 deg C -> 25 deg C, 1 h, 2.) 25 deg C, 48 h
5: 71 percent / LiCl, 4A sieves, Me4Sn, 2,6-di-tert-butylhydroxytoluene / PdCl2(dppf) / dimethylformamide / 12 h / 90 °C / 2585.7 Torr
6: 1.) LiHMDS, 2,2,2-trifluoroethyl trifluoroacetate, 2.) MsN3, Et3N / 1.) THF, -78 deg C, 45 min, 2.) MeCN, H2O, 25 deg C, 6 h
7: 64 percent / benzene / 24 h / Ambient temperature; Irradiation
8: 84 percent / n-Bu4NF, O2 / tetrahydrofuran / 40 h / 25 °C
9: 100 percent / conc. H2SO4 / ethanol / 0.75 h / 25 °C
10: 91 percent / DDQ / benzene / 42 h / 25 °C
View Scheme
5,5-dimethyl-5,6,7,8-tetrahydronaphthalen-1-ol
171979-69-4

5,5-dimethyl-5,6,7,8-tetrahydronaphthalen-1-ol

tanshinone IIA
568-72-9

tanshinone IIA

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 87 percent / DMAP / pyridine / 1.) 0 deg C -> 25 deg C, 1 h, 2.) 25 deg C, 48 h
2: 71 percent / LiCl, 4A sieves, Me4Sn, 2,6-di-tert-butylhydroxytoluene / PdCl2(dppf) / dimethylformamide / 12 h / 90 °C / 2585.7 Torr
3: 1.) LiHMDS, 2,2,2-trifluoroethyl trifluoroacetate, 2.) MsN3, Et3N / 1.) THF, -78 deg C, 45 min, 2.) MeCN, H2O, 25 deg C, 6 h
4: 64 percent / benzene / 24 h / Ambient temperature; Irradiation
5: 84 percent / n-Bu4NF, O2 / tetrahydrofuran / 40 h / 25 °C
6: 100 percent / conc. H2SO4 / ethanol / 0.75 h / 25 °C
7: 91 percent / DDQ / benzene / 42 h / 25 °C
View Scheme
1,1-dimethyl-5-methoxytetralin
33214-70-9

1,1-dimethyl-5-methoxytetralin

tanshinone IIA
568-72-9

tanshinone IIA

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 95 percent / BBr3 / CH2Cl2 / 4 h / -78 - 25 °C
2: 87 percent / DMAP / pyridine / 1.) 0 deg C -> 25 deg C, 1 h, 2.) 25 deg C, 48 h
3: 71 percent / LiCl, 4A sieves, Me4Sn, 2,6-di-tert-butylhydroxytoluene / PdCl2(dppf) / dimethylformamide / 12 h / 90 °C / 2585.7 Torr
4: 1.) LiHMDS, 2,2,2-trifluoroethyl trifluoroacetate, 2.) MsN3, Et3N / 1.) THF, -78 deg C, 45 min, 2.) MeCN, H2O, 25 deg C, 6 h
5: 64 percent / benzene / 24 h / Ambient temperature; Irradiation
6: 84 percent / n-Bu4NF, O2 / tetrahydrofuran / 40 h / 25 °C
7: 100 percent / conc. H2SO4 / ethanol / 0.75 h / 25 °C
8: 91 percent / DDQ / benzene / 42 h / 25 °C
View Scheme
methoxybenzene
100-66-3

methoxybenzene

2-chloro-decalin

2-chloro-decalin

tanshinone IIA
568-72-9

tanshinone IIA

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 1.) n-BuLi, TMEDA / 1.) hexane, 45 deg C, 30 min, 2.) THF, 55-60 deg C, 20 h
2: 97 percent / AlCl3 / CH2Cl2 / 0.25 h / 0 °C
3: 95 percent / BBr3 / CH2Cl2 / 4 h / -78 - 25 °C
4: 87 percent / DMAP / pyridine / 1.) 0 deg C -> 25 deg C, 1 h, 2.) 25 deg C, 48 h
5: 71 percent / LiCl, 4A sieves, Me4Sn, 2,6-di-tert-butylhydroxytoluene / PdCl2(dppf) / dimethylformamide / 12 h / 90 °C / 2585.7 Torr
6: 1.) LiHMDS, 2,2,2-trifluoroethyl trifluoroacetate, 2.) MsN3, Et3N / 1.) THF, -78 deg C, 45 min, 2.) MeCN, H2O, 25 deg C, 6 h
7: 64 percent / benzene / 24 h / Ambient temperature; Irradiation
8: 84 percent / n-Bu4NF, O2 / tetrahydrofuran / 40 h / 25 °C
9: 100 percent / conc. H2SO4 / ethanol / 0.75 h / 25 °C
10: 91 percent / DDQ / benzene / 42 h / 25 °C
View Scheme
4-methylpent-3-enylzinc(II) bromide

4-methylpent-3-enylzinc(II) bromide

tanshinone IIA
568-72-9

tanshinone IIA

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 93 percent / PdCl2(dppf) / tetrahydrofuran / 15 h / Heating
2: 97 percent / AlCl3 / CH2Cl2 / 0.25 h / 0 °C
3: 95 percent / BBr3 / CH2Cl2 / 4 h / -78 - 25 °C
4: 87 percent / DMAP / pyridine / 1.) 0 deg C -> 25 deg C, 1 h, 2.) 25 deg C, 48 h
5: 71 percent / LiCl, 4A sieves, Me4Sn, 2,6-di-tert-butylhydroxytoluene / PdCl2(dppf) / dimethylformamide / 12 h / 90 °C / 2585.7 Torr
6: 1.) LiHMDS, 2,2,2-trifluoroethyl trifluoroacetate, 2.) MsN3, Et3N / 1.) THF, -78 deg C, 45 min, 2.) MeCN, H2O, 25 deg C, 6 h
7: 64 percent / benzene / 24 h / Ambient temperature; Irradiation
8: 84 percent / n-Bu4NF, O2 / tetrahydrofuran / 40 h / 25 °C
9: 100 percent / conc. H2SO4 / ethanol / 0.75 h / 25 °C
10: 91 percent / DDQ / benzene / 42 h / 25 °C
View Scheme
5,6,7,8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-1,4-phenanthrenedione
109664-02-0

5,6,7,8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-1,4-phenanthrenedione

tanshinone IIA
568-72-9

tanshinone IIA

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / conc. H2SO4 / ethanol / 0.75 h / 25 °C
2: 91 percent / DDQ / benzene / 42 h / 25 °C
View Scheme
1,1-dimethyl-5-tetralyl trifluoromethanesulfonate
171979-71-8

1,1-dimethyl-5-tetralyl trifluoromethanesulfonate

tanshinone IIA
568-72-9

tanshinone IIA

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 71 percent / LiCl, 4A sieves, Me4Sn, 2,6-di-tert-butylhydroxytoluene / PdCl2(dppf) / dimethylformamide / 12 h / 90 °C / 2585.7 Torr
2: 1.) LiHMDS, 2,2,2-trifluoroethyl trifluoroacetate, 2.) MsN3, Et3N / 1.) THF, -78 deg C, 45 min, 2.) MeCN, H2O, 25 deg C, 6 h
3: 64 percent / benzene / 24 h / Ambient temperature; Irradiation
4: 84 percent / n-Bu4NF, O2 / tetrahydrofuran / 40 h / 25 °C
5: 100 percent / conc. H2SO4 / ethanol / 0.75 h / 25 °C
6: 91 percent / DDQ / benzene / 42 h / 25 °C
View Scheme
3-((S)-1-((tert-butyldimethylsilyl)oxy)-2-propyl)-7,7-dimethyl-4-hydroxy-2-((triisopropylsilyl)oxy)-7,8,9,10-tetrahydrophenanthrene
171979-72-9

3-((S)-1-((tert-butyldimethylsilyl)oxy)-2-propyl)-7,7-dimethyl-4-hydroxy-2-((triisopropylsilyl)oxy)-7,8,9,10-tetrahydrophenanthrene

tanshinone IIA
568-72-9

tanshinone IIA

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 84 percent / n-Bu4NF, O2 / tetrahydrofuran / 40 h / 25 °C
2: 100 percent / conc. H2SO4 / ethanol / 0.75 h / 25 °C
3: 91 percent / DDQ / benzene / 42 h / 25 °C
View Scheme
tanshinone IIA
568-72-9

tanshinone IIA

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

1,6,6-trimethyl-6,7,8,9,10,11-hexahydro-10,11-dioxophenanthro[1,2-b]furan-2-carbaldehyde

1,6,6-trimethyl-6,7,8,9,10,11-hexahydro-10,11-dioxophenanthro[1,2-b]furan-2-carbaldehyde

Conditions
ConditionsYield
With trichlorophosphate at 20℃; for 2h;100%
With trichlorophosphate at 20℃; for 2.5h; Vilsmeier-Haack Formylation;97.3%
With trichlorophosphate at 70 - 80℃; for 2h;67%
tanshinone IIA
568-72-9

tanshinone IIA

2-iodo-10,11-dioxo-1,6,6-trimethyl-6,7,8,9,10,11-hexahydro-phenanthro[1,2-b]furan

2-iodo-10,11-dioxo-1,6,6-trimethyl-6,7,8,9,10,11-hexahydro-phenanthro[1,2-b]furan

Conditions
ConditionsYield
With potassium iodate; acetic acid; potassium iodide In water at 80℃; for 1h;98.99%
With N-iodo-succinimide; acetic acid In dichloromethane at -40℃; for 6h;
tanshinone IIA
568-72-9

tanshinone IIA

sodium 1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7Hnaphtho[1,2-g][1]benzofuran-2-sulfonate

sodium 1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7Hnaphtho[1,2-g][1]benzofuran-2-sulfonate

Conditions
ConditionsYield
With sodium hydrogen sulfate; acetic anhydride; 1,4,7,10-tetraoxa-15-azacyclopentadecane at 20℃; for 1h; Reagent/catalyst; Temperature; Green chemistry;96%
Stage #1: tanshinone-IIA With sulfur trioxide-N,N-dimethylformamide complex In N,N-dimethyl-formamide at 100℃;
Stage #2: With sodium hydroxide In ethanol; water pH=7.5 - 9; Reagent/catalyst; Solvent; Temperature;
93%
Stage #1: tanshinone-IIA With sulfuric acid; acetic anhydride; acetic acid In dichloromethane at 25℃; for 0.0666667h;
Stage #2: With sodium chloride In dichloromethane; water; Petroleum ether for 0.0833333h; Temperature;
72.6%
Stage #1: tanshinone-IIA With sulfuric acid; acetic anhydride; acetic acid at 25℃;
Stage #2: With sodium chloride In water Product distribution / selectivity;
Stage #1: tanshinone-IIA With sulfuric acid; acetic anhydride; acetic acid In dichloromethane Flow reactor; Heating;
Stage #2: With sodium chloride
tanshinone IIA
568-72-9

tanshinone IIA

benzoic acid
65-85-0

benzoic acid

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl benzoate
1392502-49-6

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl benzoate

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In chlorobenzene at 120℃; for 24h; Sealed tube; regioselective reaction;95%
tanshinone IIA
568-72-9

tanshinone IIA

methyl trifluoromethanesulfonate
333-27-7

methyl trifluoromethanesulfonate

10,11-Dimethoxy-1,6,6-trimethyl-6,7,8,9-tetrahydro-phenanthro[1,2-b]furan
120727-43-7

10,11-Dimethoxy-1,6,6-trimethyl-6,7,8,9-tetrahydro-phenanthro[1,2-b]furan

Conditions
ConditionsYield
Stage #1: tanshinone-IIA In tetrahydrofuran at -30℃; for 0.0833333h;
Stage #2: methyl trifluoromethanesulfonate In tetrahydrofuran for 0.5h;
95%
BOC-glycine
4530-20-5

BOC-glycine

tanshinone IIA
568-72-9

tanshinone IIA

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl 2-((tert-butoxycarbonyl)amino)acetate

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl 2-((tert-butoxycarbonyl)amino)acetate

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In chlorobenzene at 120℃; for 24h; Sealed tube; regioselective reaction;92%
tanshinone IIA
568-72-9

tanshinone IIA

p-Toluic acid
99-94-5

p-Toluic acid

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl 4-methylbenzoate

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl 4-methylbenzoate

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In chlorobenzene at 120℃; for 24h; Sealed tube; regioselective reaction;92%
tanshinone IIA
568-72-9

tanshinone IIA

propionic acid
802294-64-0

propionic acid

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propionate

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl propionate

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In chlorobenzene at 120℃; for 24h; Reagent/catalyst; Solvent; Sealed tube; regioselective reaction;91%
tanshinone IIA
568-72-9

tanshinone IIA

cyclopropanecarboxylic acid
1759-53-1

cyclopropanecarboxylic acid

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl cyclopropanecarboxylate

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl cyclopropanecarboxylate

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In chlorobenzene at 120℃; for 24h; Sealed tube; regioselective reaction;90%
tanshinone IIA
568-72-9

tanshinone IIA

2-Methoxybenzoic acid
579-75-9

2-Methoxybenzoic acid

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl 2-methoxybenzoate
1392502-51-0

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl 2-methoxybenzoate

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In chlorobenzene at 120℃; for 24h; Sealed tube; regioselective reaction;90%
tanshinone IIA
568-72-9

tanshinone IIA

acetic anhydride
108-24-7

acetic anhydride

10,11-Diacetoxy-1,6,6-trimethyl-6,7,8,9-tetrahydro-phenanthro[1,2-b]furan
98796-69-1

10,11-Diacetoxy-1,6,6-trimethyl-6,7,8,9-tetrahydro-phenanthro[1,2-b]furan

Conditions
ConditionsYield
Stage #1: tanshinone-IIA With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 15 - 25℃;
Stage #2: acetic anhydride With pyridine In tetrahydrofuran at 15 - 25℃; for 3h;
90%
formaldehyd
50-00-0

formaldehyd

4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride
1151904-84-5

4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride

tanshinone IIA
568-72-9

tanshinone IIA

C29H29NO5S

C29H29NO5S

Conditions
ConditionsYield
With zinc diacetate In dimethyl sulfoxide at 60℃; for 24h;89%
formaldehyd
50-00-0

formaldehyd

diphenylmethylpiperazine
841-77-0

diphenylmethylpiperazine

tanshinone IIA
568-72-9

tanshinone IIA

C37H38N2O3

C37H38N2O3

Conditions
ConditionsYield
With zinc diacetate; acetic acid In chloroform Reflux; Inert atmosphere;89%
tanshinone IIA
568-72-9

tanshinone IIA

butyric acid
107-92-6

butyric acid

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl butyrate

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl butyrate

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In chlorobenzene at 120℃; for 24h; Sealed tube; regioselective reaction;88%
tanshinone IIA
568-72-9

tanshinone IIA

6,7,8,9-tetrahydro-1,6,6-trimethylfuronaphth<2,1-e>oxepine-10,12-dione
61077-78-9

6,7,8,9-tetrahydro-1,6,6-trimethylfuronaphth<2,1-e>oxepine-10,12-dione

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen; acetic acid In water; benzene at 25℃; for 8h;86%
With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 1h;21%
tanshinone IIA
568-72-9

tanshinone IIA

acetic acid
64-19-7

acetic acid

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl acetate

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl acetate

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical at 120℃; for 24h; Sealed tube; regioselective reaction;85%
tanshinone IIA
568-72-9

tanshinone IIA

aniline
62-53-3

aniline

C25H19NO3

C25H19NO3

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In toluene at 120℃; for 48h; Sealed tube;85%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In toluene at 120℃; for 48h;85%
2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

tanshinone IIA
568-72-9

tanshinone IIA

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl thiophene-2-carboxylate

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl thiophene-2-carboxylate

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In chlorobenzene at 120℃; for 24h; Sealed tube; regioselective reaction;81%
indole
120-72-9

indole

tanshinone IIA
568-72-9

tanshinone IIA

C35H30N2O2

C35H30N2O2

Conditions
ConditionsYield
With toluene-4-sulfonic acid In acetonitrile at 50℃; for 72h;81%
glutaric anhydride,
108-55-4

glutaric anhydride,

tanshinone IIA
568-72-9

tanshinone IIA

C24H24O5

C24H24O5

Conditions
ConditionsYield
With dmap; iron In tetrahydrofuran for 6h; Reflux; Inert atmosphere;81%
tanshinone IIA
568-72-9

tanshinone IIA

2-bromo-10,11-dioxo-1,6,6-trimethyl-6,7,8,9,10,11-hexahydro-phenanthro[1,2-b]furan
120727-39-1

2-bromo-10,11-dioxo-1,6,6-trimethyl-6,7,8,9,10,11-hexahydro-phenanthro[1,2-b]furan

Conditions
ConditionsYield
With bromine; acetic acid at 20℃; for 4h;80%
With bromine In tetrachloromethane at 20℃; for 0.333333h;
With N-Bromosuccinimide; acetic acid at 20℃; for 6h;
With hydrogen bromide; bromine In dichloromethane at 20℃; for 0.5h; Darkness;
tanshinone IIA
568-72-9

tanshinone IIA

hexanoic acid
142-62-1

hexanoic acid

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl hexanoate

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl hexanoate

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In chlorobenzene at 120℃; for 24h; Sealed tube; regioselective reaction;80%
tanshinone IIA
568-72-9

tanshinone IIA

naphthalene-2-carboxylate
93-09-4

naphthalene-2-carboxylate

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl 2-naphthoate

1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl 2-naphthoate

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In chlorobenzene at 120℃; for 24h; Sealed tube; regioselective reaction;80%
tanshinone IIA
568-72-9

tanshinone IIA

4-bromo-aniline
106-40-1

4-bromo-aniline

C25H18BrNO3

C25H18BrNO3

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In toluene at 120℃; for 48h;80%
tanshinone IIA
568-72-9

tanshinone IIA

chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

1,6,6-trimethyl-6,7,8,9,10,11-hexahydro-10,11-dioxophenanthro[1,2-b]furan-2-acetic acid ethyl ester

1,6,6-trimethyl-6,7,8,9,10,11-hexahydro-10,11-dioxophenanthro[1,2-b]furan-2-acetic acid ethyl ester

Conditions
ConditionsYield
With zirconium(IV) chloride In dichloromethane Reflux;79%
6-fluoro-1H-indole
399-51-9

6-fluoro-1H-indole

tanshinone IIA
568-72-9

tanshinone IIA

C35H28F2N2O2

C35H28F2N2O2

Conditions
ConditionsYield
With toluene-4-sulfonic acid In acetonitrile at 50℃; for 72h;79%
tanshinone IIA
568-72-9

tanshinone IIA

phenol
108-95-2

phenol

C25H22O4

C25H22O4

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In chlorobenzene at 120℃; for 36h; Reagent/catalyst; Solvent; Sealed tube; regioselective reaction;78%
tanshinone IIA
568-72-9

tanshinone IIA

2,2-difluoro-3,3-dihydroxy-8,8-dimethyl-2,3,5,6,7,8-hexahydrophenanthrene-1,4-dione

2,2-difluoro-3,3-dihydroxy-8,8-dimethyl-2,3,5,6,7,8-hexahydrophenanthrene-1,4-dione

Conditions
ConditionsYield
With Selectfluor In water; acetonitrile at 80℃; for 12h; Reagent/catalyst; Solvent; Sealed tube;77%
With Selectfluor In water; acetonitrile at 80℃; for 12h;77%

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