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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Clavulanic acid Manufacturer/High quality/Best price/In stock

Cas:58001-44-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

98% Clavulanic acid powder price cas: 58001-44-8

Cas:58001-44-8

Min.Order:1 Kilogram

FOB Price: $119.0 / 145.0

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Clavulanic acid 58001-44-8 GMP Manufacturer

Cas:58001-44-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Leader Biochemical Group

About Product Technical Details CAS: 58001-44-8 MF: C8H9NO5 MW: 199.16 EINECS: 261-069-2 Product Categories: antibiotic;Antibiotics Mol File: 58001-44-8.mol

China Largest factory Manufacturer Supply High Quality Clavulanic acid CAS 58001-44-8

Cas:58001-44-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Clavulanic acid

Cas:58001-44-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 58001-44-8 with competitive price

Cas:58001-44-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material Clavulanic acid CAS NO.58001-44-8

Cas:58001-44-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name Clavulanic acid CAS NO 58001-44-8 Apparence White Powder Purity 99%

Clavulanic acid

Cas:58001-44-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3-(2-hydroxyethylidene)-7-oxo-, (2R,3Z,5R)-

Cas:58001-44-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Clavulanic acid CAS:58001-44-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedi

Clavulanic acid CAS:58001-44-8

Cas:58001-44-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3-(2-hydroxyethylidene)-7-oxo-, (2R,3Z,5R)-

Cas:58001-44-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3-(2-hydroxyethylidene)-7-oxo-, (2R,3Z,5R)-

Cas:58001-44-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Clavulanic acid

Cas:58001-44-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Hefei Zhaobo Technology Co., Ltd.

Clavulanic acid CAS 58001-44-8 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control

Clavulanic acid CAS 58001-44-8

Cas:58001-44-8

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

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Hebei Miheng Trading Co., Ltd.

Clavulanic acid CAS 58001-44-8 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly.

Clavulanic acid CAS 58001-44-8

Cas:58001-44-8

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Clavulanic acid

Cas:58001-44-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Clavulanic acid CAS NO.58001-44-8

Cas:58001-44-8

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Clavulanic acid

Cas:58001-44-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Clavulanic acid Basic information Product Name: Clavulanic acid Synonyms: (2r-(2-alpha,3z,5-alpha))-xo;3008-b;4-oxa-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,

58001-44-8 Clavulanic acid C8H9NO5

Cas:58001-44-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best OfferClavulanic acid

Cas:58001-44-8

Min.Order:0

Negotiable

Type:Trading Company

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Clavulanicacid

Cas:58001-44-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Clavulanic acid CAS NO.58001-44-8

Cas:58001-44-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Clavulanic acid CAS NO.58001-44-8

Cas:58001-44-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Clavulanic acid CAS NO.58001-44-8

Cas:58001-44-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Clavulanic acid

Cas:58001-44-8

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis:

Clavulanic acid

Cas:58001-44-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Clavulanic acid

Cas:58001-44-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Clavulanic acid CAS NO.58001-44-8

Cas:58001-44-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Clavulanic acid

Cas:58001-44-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

Benzyl Clavulanate
57943-84-7

Benzyl Clavulanate

clavulanic acid
58001-44-8

clavulanic acid

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol under 760 Torr; for 0.75h; Ambient temperature;84%

A

C8H8(3)HNO5

C8H8(3)HNO5

B

clavulanic acid
58001-44-8

clavulanic acid

Conditions
ConditionsYield
With cultures of Streptomyces clavuligerus (ATCC 27064) in a glycerol-based fermentation medium Product distribution; labelling studies also with incorporation (14)C, acid isolated as p-bromobenzyl ester;
(2RS,5RS)-<5-(3)H>Ornithine

(2RS,5RS)-<5-(3)H>Ornithine

A

C8H8(3)HNO5

C8H8(3)HNO5

B

clavulanic acid
58001-44-8

clavulanic acid

Conditions
ConditionsYield
With cultures of Streptomyces clavuligerus (ATCC 27064) in a glycerol-based fermentation medium Product distribution; labelling studies also with incorporation (14)C, acid isolated as p-bromobenzyl ester;
(3R,5R) clavulanate-9-aldehyde

(3R,5R) clavulanate-9-aldehyde

clavulanic acid
58001-44-8

clavulanic acid

Conditions
ConditionsYield
Streptomyces clavuligerus SC 2;

A

(2S,5S)-3-[2-(2-Acetylamino-acetylamino)-eth-(Z)-ylidene]-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5S)-3-[2-(2-Acetylamino-acetylamino)-eth-(Z)-ylidene]-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

B

clavulanic acid
58001-44-8

clavulanic acid

Conditions
ConditionsYield
Streptomyces clavuligerus; examination of incorporation by labelled <5-(14)C, 5-(3)H>ornithine;
methyl clavulanate
57943-82-5

methyl clavulanate

clavulanic acid
58001-44-8

clavulanic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 70 percent / sodium hydroxide / H2O / 1.17 h / 0 °C
2: 69 percent / dimethylformamide / 1.5 h / Ambient temperature
3: 84 percent / H2 / palladium on carbon / ethanol / 0.75 h / 760 Torr / Ambient temperature
View Scheme
potassium clavulanate
57943-81-4

potassium clavulanate

clavulanic acid
58001-44-8

clavulanic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 69 percent / dimethylformamide / 1.5 h / Ambient temperature
2: 84 percent / H2 / palladium on carbon / ethanol / 0.75 h / 760 Torr / Ambient temperature
View Scheme
sodium 3-oxoethylidene-7-oxo-4-oxa-1-azabicyclo-[3.2.0] heptane-2-carboxylate

sodium 3-oxoethylidene-7-oxo-4-oxa-1-azabicyclo-[3.2.0] heptane-2-carboxylate

clavulanic acid
58001-44-8

clavulanic acid

Conditions
ConditionsYield
With NADPH at 26℃; pH=7.0;
N,N-diisopropyl-1,2-ethanediamine
4013-94-9

N,N-diisopropyl-1,2-ethanediamine

clavulanic acid
58001-44-8

clavulanic acid

N,N'-diisopropylethylenediammonium diclavulanate

N,N'-diisopropylethylenediammonium diclavulanate

Conditions
ConditionsYield
In methanol; water; ethyl acetate for 0.25h;96%
In ethyl acetate; isopropyl alcohol84%
In methanol; ethyl acetate81%
N-tert-butylbenzylamine
3378-72-1

N-tert-butylbenzylamine

clavulanic acid
58001-44-8

clavulanic acid

C8H9NO5*C11H17N

C8H9NO5*C11H17N

Conditions
ConditionsYield
In ethyl acetate83%
In ethanol; ethyl acetate for 1h;68%
In ethyl acetate; isopropyl alcohol67%
1-Adamantanamine
768-94-5

1-Adamantanamine

clavulanic acid
58001-44-8

clavulanic acid

(2R,5R)-3-[2-Hydroxy-eth-(Z)-ylidene]-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid; compound with adamantan-1-ylamine
66069-33-8

(2R,5R)-3-[2-Hydroxy-eth-(Z)-ylidene]-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid; compound with adamantan-1-ylamine

Conditions
ConditionsYield
In ethyl acetate81%
In ethanol; ethyl acetate80%
In methanol; ethyl acetate for 1h;76%
In ethyl acetate; isopropyl alcohol76%
tert-butylamine
75-64-9

tert-butylamine

clavulanic acid
58001-44-8

clavulanic acid

clavulanic acid tert-butylamine
66069-34-9

clavulanic acid tert-butylamine

Conditions
ConditionsYield
In ethyl acetate81%
In ethyl acetate; isopropyl alcohol for 1h;77%
In ethanol; ethyl acetate43%
Stage #1: clavulanic acid With ammonium sulfate In water; ethyl acetate at 5℃; pH=1.30;
Stage #2: tert-butylamine In methanol; ethyl acetate at 5℃; for 2h; pH-value; Concentration;
tert-Octylamine
107-45-9

tert-Octylamine

clavulanic acid
58001-44-8

clavulanic acid

(2R,5R)-3-[2-Hydroxy-eth-(Z)-ylidene]-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid; compound with 1,1,3,3-tetramethyl-butylamine
66069-32-7

(2R,5R)-3-[2-Hydroxy-eth-(Z)-ylidene]-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid; compound with 1,1,3,3-tetramethyl-butylamine

Conditions
ConditionsYield
In ethyl acetate80%
In ethyl acetate; isopropyl alcohol for 1h;67%
In ethanol; ethyl acetate35%
clavulanic acid
58001-44-8

clavulanic acid

methyl-4-aza-8-hydroxy-6-oxo-oct-2-enoate
83670-77-3

methyl-4-aza-8-hydroxy-6-oxo-oct-2-enoate

Conditions
ConditionsYield
With methanol; diethylamine for 0.166667h; Ambient temperature;78%
clavulanic acid
58001-44-8

clavulanic acid

methyl clavulanate
57943-82-5

methyl clavulanate

Conditions
ConditionsYield
In ethanol Ambient temperature;75%
clavulanic acid
58001-44-8

clavulanic acid

9-chloro-9-deoxyclavulanic acid
477947-66-3

9-chloro-9-deoxyclavulanic acid

Conditions
ConditionsYield
With pyridine; methanesulfonyl chloride In acetonitrile at 25℃; for 24h;75%
benzylamine
100-46-9

benzylamine

clavulanic acid
58001-44-8

clavulanic acid

N-benzylclavulanamide
62868-57-9

N-benzylclavulanamide

Conditions
ConditionsYield
With sodium hydroxide; dicyclohexyl-carbodiimide In tetrahydrofuran; dichloromethane; ethyl acetate67%
N,N'-diethylethylenediamine
111-74-0

N,N'-diethylethylenediamine

clavulanic acid
58001-44-8

clavulanic acid

C6H16N2*2C8H9NO5

C6H16N2*2C8H9NO5

Conditions
ConditionsYield
In ethanol; ethyl acetate for 0.5h;61%
diazodiphenylmethane
908093-98-1

diazodiphenylmethane

clavulanic acid
58001-44-8

clavulanic acid

benzhydryl clavulanate
64018-86-6

benzhydryl clavulanate

Conditions
ConditionsYield
In tetrahydrofuran Ambient temperature;60%
clavulanic acid
58001-44-8

clavulanic acid

phenol
108-95-2

phenol

phenyl clavulanate
57943-88-1

phenyl clavulanate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In acetonitrile Ambient temperature;59%
N,N'-Dibenzylethylenediamine
140-28-3

N,N'-Dibenzylethylenediamine

clavulanic acid
58001-44-8

clavulanic acid

2C8H9NO5*C16H20N2

2C8H9NO5*C16H20N2

Conditions
ConditionsYield
In ethanol; ethyl acetate for 1h;54%
In ethyl acetate; isopropyl alcohol31%
In ethyl acetate3%
SEC-BUTYLAMINE
33966-50-6

SEC-BUTYLAMINE

clavulanic acid
58001-44-8

clavulanic acid

C4H11N*C8H9NO5

C4H11N*C8H9NO5

Conditions
ConditionsYield
In ethanol; ethyl acetate for 1h;52.6%
In ethyl acetate; isopropyl alcohol52%
In ethyl acetate8%
2-(2-Hydroxyethyl)pyridine
103-74-2

2-(2-Hydroxyethyl)pyridine

clavulanic acid
58001-44-8

clavulanic acid

2-(2-pyridyl)ethyl clavulanate
91022-06-9

2-(2-pyridyl)ethyl clavulanate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In acetonitrile Ambient temperature;50%
N,N,N,N,-tetramethylethylenediamine
110-18-9

N,N,N,N,-tetramethylethylenediamine

clavulanic acid
58001-44-8

clavulanic acid

N,N,N',N'-tetramethylethylenediammonium diclavulanate

N,N,N',N'-tetramethylethylenediammonium diclavulanate

Conditions
ConditionsYield
In ethyl acetate; isopropyl alcohol for 1h;37%
In ethyl acetate30%
clavulanic acid
58001-44-8

clavulanic acid

A

methyl (E)-3-(diethylamino)-2-propenoate
58243-07-5

methyl (E)-3-(diethylamino)-2-propenoate

B

methyl 3-(2-hydroxyethyl)-pyrrole-4-carboxylate
83670-73-9

methyl 3-(2-hydroxyethyl)-pyrrole-4-carboxylate

C

methyl-4-aza-8-hydroxy-6-oxo-oct-2-enoate
83670-77-3

methyl-4-aza-8-hydroxy-6-oxo-oct-2-enoate

Conditions
ConditionsYield
With diethylamine In methanol for 48h; Ambient temperature;A 20%
B 14%
C 18%
With Diethyl amine In methanol for 48h; Ambient temperature;A 20%
B 14%
C 18%
para-thiocresol
106-45-6

para-thiocresol

clavulanic acid
58001-44-8

clavulanic acid

p-tolyl thioclavulanate
91022-05-8

p-tolyl thioclavulanate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In acetonitrile Ambient temperature;17%
clavulanic acid
58001-44-8

clavulanic acid

A

(E)-(5R)-3-(2-hydroxyethylidene)-4-oxa-1-azabicyclo<3.2.0>heptan-7-one

(E)-(5R)-3-(2-hydroxyethylidene)-4-oxa-1-azabicyclo<3.2.0>heptan-7-one

B

(Z)-(5R)-3-(2-hydroxyethylidene)-4-oxa-1-azabicyclo<3.2.0>heptan-7-one

(Z)-(5R)-3-(2-hydroxyethylidene)-4-oxa-1-azabicyclo<3.2.0>heptan-7-one

Conditions
ConditionsYield
With mercury(II) diacetate In 1,2-dimethoxyethane 1) r.t., 15 min, 2) 90-95 deg C (bath), 20 min;A 5%
B 5.5%
clavulanic acid
58001-44-8

clavulanic acid

(5R)-7-oxo-3-vinyl-4-oxa-1-azabicyclo[3.2.0]hept-2-ene
71019-00-6

(5R)-7-oxo-3-vinyl-4-oxa-1-azabicyclo[3.2.0]hept-2-ene

Conditions
ConditionsYield
With N,N-dimethyl-formamide dimethyl acetal In tetrahydrofuran
With N,N-dimethyl-formamide dimethyl acetal In tetrahydrofuran for 0.133333h; Ambient temperature; Yield given;
With N,N-dimethyl-formamide dimethyl acetal
benzyl chloroformate
501-53-1

benzyl chloroformate

clavulanic acid
58001-44-8

clavulanic acid

1-benzyloxycarbonylamino-4-hydroxybutan-2-one
92632-80-9

1-benzyloxycarbonylamino-4-hydroxybutan-2-one

Conditions
ConditionsYield
With hydrogenchloride; water; sodium hydrogencarbonate 1.) 2 h, 2.) water, THF, ice-cooling, 40 min; Yield given. Multistep reaction;
3-chloro-benzenecarboperoxoic acid
937-14-4

3-chloro-benzenecarboperoxoic acid

clavulanic acid
58001-44-8

clavulanic acid

(Z)-(3S,5R)-2-(2-hydroxyethylidene)-3-(m-chlorobenzoyloxy)clavam
71916-37-5

(Z)-(3S,5R)-2-(2-hydroxyethylidene)-3-(m-chlorobenzoyloxy)clavam

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In 1,2-dimethoxyethane; dichloromethane 1.) 0 deg C, 3 h, 2.) room temperature, 15 h;60 mg
methanol
67-56-1

methanol

clavulanic acid
58001-44-8

clavulanic acid

A

methyl clavulanate
57943-82-5

methyl clavulanate

B

(Z)-(2R)-5-(2-hydroxyethylidene)-2-methoxycarbonylmethyl-2,5-dihydro-oxazole
88367-33-3

(Z)-(2R)-5-(2-hydroxyethylidene)-2-methoxycarbonylmethyl-2,5-dihydro-oxazole

C

(Z)-(3S,5R)-2-(2-hydroxyethylidene)-3-methoxyclavam
88391-46-2

(Z)-(3S,5R)-2-(2-hydroxyethylidene)-3-methoxyclavam

Conditions
ConditionsYield
With triethylamine at -30℃; for 0.833333h; electrolysis: platinum electrodes, I=200-250 mA;A 5 mg
B 75 mg
C 10 mg
With triethylamine at -30℃; for 0.833333h; electrolysis: platinum electrodes, current 200-250 mA;A 5 mg
B 75 mg
C 10 mg
methanol
67-56-1

methanol

clavulanic acid
58001-44-8

clavulanic acid

A

methyl clavulanate
57943-82-5

methyl clavulanate

B

(Z)-(3S,5R)-2-(2-hydroxyethylidene)-3-methoxyclavam
88391-46-2

(Z)-(3S,5R)-2-(2-hydroxyethylidene)-3-methoxyclavam

C

(E)-(3S,5R)-3-acetoxy-2-formylmethyleneclavam
71916-39-7, 88391-48-4, 88391-49-5

(E)-(3S,5R)-3-acetoxy-2-formylmethyleneclavam

D

(Z)-(3S,5R)-3-acetoxy-2-formylmethyleneclavam
88391-49-5

(Z)-(3S,5R)-3-acetoxy-2-formylmethyleneclavam

Conditions
ConditionsYield
With triethylamine at -30℃; for 0.833333h; Product distribution; electrolysis, platinum electrodes, current 200-250 mA; reactions of oxidative decarboxylation ( electrolysis, with Pb(OAc)4, decarboxylative rearrangement of diacyl peroxide) of clavulanic acid and its methyl ether;A 5 mg
B 10 mg
C n/a
D n/a
lead(IV) tetraacetate
546-67-8

lead(IV) tetraacetate

clavulanic acid
58001-44-8

clavulanic acid

A

(Z)-(3S,5R)-3-acetoxy-2-(2-hydroxyethylidene)clavam
88391-50-8

(Z)-(3S,5R)-3-acetoxy-2-(2-hydroxyethylidene)clavam

B

(Z)-(3S,5R)-3-acetoxy-2-(2-acetoxyethylidene)clavam
88391-47-3

(Z)-(3S,5R)-3-acetoxy-2-(2-acetoxyethylidene)clavam

C

(E)-(3S,5R)-3-acetoxy-2-formylmethyleneclavam
71916-39-7, 88391-48-4, 88391-49-5

(E)-(3S,5R)-3-acetoxy-2-formylmethyleneclavam

D

(Z)-(3S,5R)-3-acetoxy-2-formylmethyleneclavam
88391-49-5

(Z)-(3S,5R)-3-acetoxy-2-formylmethyleneclavam

Conditions
ConditionsYield
In 1,2-dimethoxyethane; benzene at 70℃; for 0.333333h;A 145 mg
B 20 mg
C n/a
D n/a
In 1,2-dimethoxyethane; benzene at 70℃; for 0.333333h; Yields of byproduct given;A 145 mg
B 20 mg
C n/a
D n/a
In 1,2-dimethoxyethane; benzene at 70℃; for 0.333333h; Yield given. Title compound not separated from byproducts;A 145 mg
B 20 mg
C n/a
D n/a

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