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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3-Acetamidophthalic anhydride

Cas:6296-53-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

3-Acetamidophthalic anhydride CAS No.:6296-53-3 Name: 3-Acetamidophthalic anhydride Synonyms: 3-Acetylaminophthalic anhydride; NSC 16261; NSC 17048 Molecular Structure Molecular Formula:

High purity 3-Acetamidophthalic anhydride CAS No.:6296-53-3

Cas:6296-53-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:White or

1,3-Dioxo-2-isoindolineaceticacid

Cas:6296-53-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

3-Acetamidophthalic anhydride

Cas:6296-53-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Acetamidophthalic anhydride

Cas:6296-53-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1505.html Product Name 3-Acetamidophthalic anhydride CAS No. 6296-53

3-Acetamidophthalic anhydride

Cas:6296-53-3

Min.Order:1 Gram

FOB Price: $11.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

1,3-Dioxo-2-isoindolineaceticacid

Cas:6296-53-3

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Intermediate CAS 6296-53-3 3-Acetamidophthalic Anhydride

Cas:6296-53-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

C10H7NO4 1,3-Dioxo-2-isoindolineaceticacid 6296-53-3

Cas:6296-53-3

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 6296-53-3 with competitive price

Cas:6296-53-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Acetamide,N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)- 6296-53-3

Cas:6296-53-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

For Apremilast: N-(1,3-dihydro-1,3-dioxo 4-isobenzofuranyl)acetamide

Cas:6296-53-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

1,3-Dioxo-2-isoindolineaceticacid

Cas:6296-53-3

Min.Order:1 Kilogram

FOB Price: $500.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

1,3-Dioxo-2-isoindolineaceticacid CAS:86296-53-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality

1,3-Dioxo-2-isoindolineaceticacid CAS:86296-53-3

Cas:6296-53-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Acetamide,N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)-

Cas:6296-53-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

3-Acetamidophthalic Anhydride CAS: 6296-53-3 Specification Name: 3-Acetamidophthalic anhydride Synonyms: 3-Acetylaminophthalic anhydride; NSC 16261; NSC 17048 Molecular Structure Molecular Formula: C10H7NO4 Molecular Weight: 205.17 CAS

Factory supply 3-Acetamidophthalic Anhydride

Cas:6296-53-3

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Acetamide,N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)-

Cas:6296-53-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 1,3-Dioxo-2-isoindolineaceticacid Synonyms: Apremilast Impurity 43;RE-EXPORT OF REJECTED IMPORT MATERIAL: N -(1,3-DIHYDROIS OBENZOFURAN-4-YL) ACETAM IDE SYNONYM: 3-ACETAMIDOPHTHALIC ANHYDRI;Apremilast inter1;Apremilast Intermediate

1,3-Dioxo-2-isoindolineaceticacid supplier best quality

Cas:6296-53-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

3-Acetamidophthalic anhydride CAS NO.6296-53-3

Cas:6296-53-3

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By Se

AcetaMide,N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)

Cas:6296-53-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Aceta Mide,N-(-1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)

Cas:6296-53-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Aceta Mide,N-(-1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)

Cas:6296-53-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3-ACETAMIDOPHTHALICANHYDRIDE

Cas:6296-53-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1,3-Dioxo-2-isoindolineaceticacid

Cas:6296-53-3

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Acetamide,N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)-

Cas:6296-53-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

1,3-Dioxo-2-isoindolineaceticacid/High quality/Best price

Cas:6296-53-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

1,3-Dioxo-2-isoindolineaceticacid

Cas:6296-53-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

3-Acetamidophthalic anhydrideAppearance:Contact me Storage:Store in cool and dry palce. Keep away from strong light ,high temperature. Package:according to customers' requirements Application:API Transportation:By air(EMS or EUB or FedEx or TNT ect..

3-Acetamidophthalic anhydride

Cas:6296-53-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Aceta Mide,N-(-1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)

Cas:6296-53-3

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 3-Acetamidophthalic Anhydride CAS No.:6296-53-3 Molecule Formula:C10H7NO4 Molecule Weight:205.17 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality 3-Acetamidophthalic Anhydride on stock

Cas:6296-53-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

3-aminophthalic acid

3-aminophthalic acid

acetic anhydride
108-24-7

acetic anhydride

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

Conditions
ConditionsYield
In Isopropyl acetate at 75 - 95℃; Temperature; Large scale;88.6%
3-nitrophthalic acid
603-11-2

3-nitrophthalic acid

acetic anhydride
108-24-7

acetic anhydride

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen at 80 - 115℃; under 7500.75 Torr; Temperature; Autoclave;83%
3-aminophthalic acid
5434-20-8

3-aminophthalic acid

acetic anhydride
108-24-7

acetic anhydride

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

Conditions
ConditionsYield
for 4h; Concentration; Temperature; Reflux;78.5%
at 0 - 5℃; for 4h; Heating / reflux;61%
for 3h; Reflux;61%
3-nitrophthalic acid anhydride
641-70-3

3-nitrophthalic acid anhydride

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

Conditions
ConditionsYield
With acetic anhydride; palladium Hydrogenation;
3-amino-phthalic acid-hydrochloride

3-amino-phthalic acid-hydrochloride

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

Conditions
ConditionsYield
With acetic anhydride
acetic anhydride
108-24-7

acetic anhydride

<3-amino-phthalic acid >-anhydride

<3-amino-phthalic acid >-anhydride

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

acetic anhydride
108-24-7

acetic anhydride

zinc-acetat-<3-amino phthalate>

zinc-acetat-<3-amino phthalate>

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

3-nitrophthalic acid
603-11-2

3-nitrophthalic acid

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tin dichloride; hydrochloric acid
View Scheme
Multi-step reaction with 2 steps
1: hydrogen / palladium-carbon / ethanol
2: acetic anhydride
View Scheme
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 13 h / 2585.81 - 2844.39 Torr / Inert atmosphere
2: 3 h / Reflux
View Scheme
3-aminophthalic acid
5434-20-8

3-aminophthalic acid

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

Conditions
ConditionsYield
With acetic anhydride
With acetic anhydride
With acetic anhydride
With acetic anhydride
Multi-step reaction with 2 steps
1: hydrogenchloride / water / 15 h / 25 °C
2: water / 15 h / 100 °C
View Scheme
acetic anhydride
108-24-7

acetic anhydride

3-aminophthalic acid hydrochloride
6946-22-1

3-aminophthalic acid hydrochloride

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

Conditions
ConditionsYield
In water at 100℃; for 15h;94 g
at 110℃; for 2h;45 g
at 80 - 140℃; for 3h;
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

3,4,5-tris(dodec-1-yloxy)aniline
151237-05-7

3,4,5-tris(dodec-1-yloxy)aniline

3-acetylamino-N-(3,4,5-tridodecyloxyphenyl)phthalimide

3-acetylamino-N-(3,4,5-tridodecyloxyphenyl)phthalimide

Conditions
ConditionsYield
With acetic acid at 100℃; for 12h;98%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine
608141-42-0

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With acetic acid for 1h; Reflux; Large scale;97%
With acetic acid In acetonitrile at 40℃; for 6h; Reflux;94%
With acetic acid for 3h; Time; Reflux;92%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate
608141-43-1

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 75 - 80℃; for 18h; Reagent/catalyst; Solvent;95.1%
With sodium acetate; acetic acid at 80℃; for 5h; Reagent/catalyst; Temperature;91.3%
Stage #1: (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate With sodium hydroxide In dichloromethane at 0 - 5℃; for 2h;
Stage #2: 3-acetylaminophthalic anhydride With perchloric acid; acetic acid In dichloromethane at 45℃; for 3.33333h; Reflux;
89.2%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

rac-α-aminoglutarimide hydrochloride
24666-56-6

rac-α-aminoglutarimide hydrochloride

N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide
444289-17-2

N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide

Conditions
ConditionsYield
With sodium acetate; acetic acid at 105℃; for 24h; Reagent/catalyst; Temperature;95%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylthio)ethan-1-amine

(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylthio)ethan-1-amine

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Stage #1: 3-acetylaminophthalic anhydride; (1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylthio)ethan-1-amine With acetic acid In acetonitrile for 12h; Reflux;
Stage #2: With sodium tungstate (VI) dihydrate; dihydrogen peroxide In acetonitrile at 20℃; for 7h; Cooling;
94%
Multi-step reaction with 2 steps
1.1: acetic acid / acetonitrile / 12 h / Reflux
2.1: acetic acid / acetonitrile / 20 °C
2.2: 7 h / 20 °C
View Scheme
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate
608141-43-1

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate

toluene
108-88-3

toluene

apremilast hemitoluene

apremilast hemitoluene

Conditions
ConditionsYield
With acetic acid; sodium hydroxide In dichloromethane; water at 90℃; for 3h; Reagent/catalyst; Solvent;91%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(S)-1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-2-(methylsulfonyl)ethanamine N-acetyl-L-leucine salt
1258598-01-4

(S)-1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-2-(methylsulfonyl)ethanamine N-acetyl-L-leucine salt

(S)-N-(2-(1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
1258597-45-3

(S)-N-(2-(1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide

Conditions
ConditionsYield
With acetic acid for 24h; Reflux;89%
With acetic acid for 24h; Reflux;89%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(S)-1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-2-(methylsulfonyl)ethylamine N-acetyl-L-leucine

(S)-1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-2-(methylsulfonyl)ethylamine N-acetyl-L-leucine

(S)-N-(2-(1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
1258597-45-3

(S)-N-(2-(1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide

Conditions
ConditionsYield
With acetic acid for 24h; Reflux;89%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(S)-1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-1-d-2-(methylsulfonyl)ethanamine N-acetyl-leucine salt
1258597-97-5

(S)-1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-1-d-2-(methylsulfonyl)ethanamine N-acetyl-leucine salt

(S)-N-(2-(1-d-1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
1258597-44-2

(S)-N-(2-(1-d-1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide

Conditions
ConditionsYield
Stage #1: 3-acetylaminophthalic anhydride; (S)-1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-1-d-2-(methylsulfonyl)ethanamine N-acetyl-leucine salt With acetic acid for 24h; Reflux;
Stage #2: With sodium hydrogencarbonate In water
87%
With acetic acid for 24h; Reflux;87%
With acetic acid for 24h; Reflux;87%
tetrahydrofuran
109-99-9

tetrahydrofuran

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine
608141-42-0

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine

2C22H24N2O7S*C4H8O

2C22H24N2O7S*C4H8O

Conditions
ConditionsYield
With acetic acid for 4h; Reagent/catalyst; Reflux;87%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

3-acetamidophthalimide
6118-65-6

3-acetamidophthalimide

Conditions
ConditionsYield
With urea In N,N-dimethyl-formamide at 100℃; for 6h; Concentration; Temperature; Solvent;85%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

C12H19NO4S*C10H10ClNO5

C12H19NO4S*C10H10ClNO5

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With acetic acid for 24h; Time; Reflux;85%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(S)-1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-2-((methyl-d3)sulfonyl)-2,2-d2-ethanamine N-acetyl-L-leucine salt
1258598-13-8

(S)-1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-2-((methyl-d3)sulfonyl)-2,2-d2-ethanamine N-acetyl-L-leucine salt

(S)-N-(2-(1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-2-((methyl-d3)sulfonyl)-2,2-d2-ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
1258597-49-7

(S)-N-(2-(1-(3-(ethoxy-d5)-4-(methoxy-d3)phenyl)-2-((methyl-d3)sulfonyl)-2,2-d2-ethyl)-1,3-dioxoisoindolin-4-yl)acetamide

Conditions
ConditionsYield
With deuteroacetic acid for 24h; Reflux;84%
With acetic acid for 24h; Reflux;84%
With acetic acid for 24h; Reflux;84%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

C13H21NO3S

C13H21NO3S

C23H26N2O6S

C23H26N2O6S

Conditions
ConditionsYield
With formic acid In methanol at 30℃; for 12h; Reagent/catalyst;84%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

C17H19F2NO4S

C17H19F2NO4S

C27H24F2N2O7S

C27H24F2N2O7S

Conditions
ConditionsYield
With acetic acid at 100 - 110℃; for 2h;83.7%
C2H4O2*C12H16N2O2

C2H4O2*C12H16N2O2

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

C22H21N3O5
882052-94-0

C22H21N3O5

Conditions
ConditionsYield
With acetic acid for 17h;83%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(R,R)-O,O’-di-p-toluoyl-tartrate

(R,R)-O,O’-di-p-toluoyl-tartrate

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With acetic acid for 24h; Reflux;83%
tetrahydrofuran
109-99-9

tetrahydrofuran

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

C12H19NO4S*C10H10ClNO5

C12H19NO4S*C10H10ClNO5

2C22H24N2O7S*C4H8O

2C22H24N2O7S*C4H8O

Conditions
ConditionsYield
Stage #1: tetrahydrofuran; C12H19NO4S*C10H10ClNO5 With potassium carbonate In dichloromethane; water at 30 - 33℃; for 0.5h;
Stage #2: 3-acetylaminophthalic anhydride With acetic acid Reflux;
83%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine
608141-42-0

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine

C21H22N2O7S

C21H22N2O7S

Conditions
ConditionsYield
In acetic acid butyl ester at 110 - 125℃; Temperature; Large scale;80.4%
R-4-amino-4-(3-ethoxy-4-methoxyphenyl)butan-2-ol
340020-00-0

R-4-amino-4-(3-ethoxy-4-methoxyphenyl)butan-2-ol

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

N-{2-[1-(R)-(3-ethoxy-4-methoxyphenyl)-3-hydroxybutyl]-1,3-dioxoisoindolin-4-yl}acetamide

N-{2-[1-(R)-(3-ethoxy-4-methoxyphenyl)-3-hydroxybutyl]-1,3-dioxoisoindolin-4-yl}acetamide

Conditions
ConditionsYield
With triethylamine at 80 - 90℃; for 7h;80%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

((S)-1-(ethoxy-d5)-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine N-acetyl-L-leucine salt
1258598-09-2

((S)-1-(ethoxy-d5)-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine N-acetyl-L-leucine salt

(S)-N-(2-(1-(3-(ethoxy-d5)-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
1258597-47-5

(S)-N-(2-(1-(3-(ethoxy-d5)-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide

Conditions
ConditionsYield
With acetic acid for 24h; Reflux;80%
With acetic acid for 24h; Reflux;80%
With acetic acid for 24h; Reflux;80%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine
608141-42-0

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine

4-amino-2-[(1S)-1-(3-ethoxy 4-methoxyphenyl)-2-methanesulfonylethyl]-2,3-dihydro-1H-isoindole-1,3-dione
635705-72-5

4-amino-2-[(1S)-1-(3-ethoxy 4-methoxyphenyl)-2-methanesulfonylethyl]-2,3-dihydro-1H-isoindole-1,3-dione

Conditions
ConditionsYield
With perchloric acid; acetic acid at 65 - 85℃; for 2.5h; Inert atmosphere; Reflux;80%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

aniline
62-53-3

aniline

3-acetylamino-N-phenylphthalimide
20871-13-0

3-acetylamino-N-phenylphthalimide

Conditions
ConditionsYield
With acetic acid at 100℃; for 17h;79%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(S)-1-(3-(ethoxy)-4-(methoxy-d3)phenyl)-2-(methylsulfonyl)ethylamine N-acetyl-L-leucine

(S)-1-(3-(ethoxy)-4-(methoxy-d3)phenyl)-2-(methylsulfonyl)ethylamine N-acetyl-L-leucine

C22H21(2)H3N2O7S

C22H21(2)H3N2O7S

Conditions
ConditionsYield
Stage #1: (S)-1-(3-(ethoxy)-4-(methoxy-d3)phenyl)-2-(methylsulfonyl)ethylamine N-acetyl-L-leucine With sodium hydroxide In dichloromethane for 0.0833333h;
Stage #2: 3-acetylaminophthalic anhydride With acetic acid In tetrahydrofuran at 70℃; for 24h;
79%
tetrahydrofuran
109-99-9

tetrahydrofuran

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(R,R)-O,O’-di-p-toluoyl-tartrate

(R,R)-O,O’-di-p-toluoyl-tartrate

2C22H24N2O7S*C4H8O

2C22H24N2O7S*C4H8O

Conditions
ConditionsYield
Stage #1: (R,R)-O,O’-di-p-toluoyl-tartrate With potassium carbonate In dichloromethane; water at 30 - 33℃; for 0.5h;
Stage #2: tetrahydrofuran; 3-acetylaminophthalic anhydride With acetic acid
79%
S-4-amino-4-(3-ethoxy-4-methoxyphenyl)butan-2-ol
340020-01-1

S-4-amino-4-(3-ethoxy-4-methoxyphenyl)butan-2-ol

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

N-{2-[1S-(3-ethoxy-4-methoxyphenyl)-3-hydroxybutyl]-1,3-dioxoisoindolin-4-yl}acetamide

N-{2-[1S-(3-ethoxy-4-methoxyphenyl)-3-hydroxybutyl]-1,3-dioxoisoindolin-4-yl}acetamide

Conditions
ConditionsYield
With triethylamine In DMF (N,N-dimethyl-formamide) at 80 - 90℃; for 7h;78%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-ethylamine
608142-27-4

(R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-ethylamine

R-Apremilast
608141-44-2

R-Apremilast

Conditions
ConditionsYield
With acetic acid Microwave irradiation;78%
With acetic acid Reflux;
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