Products

Refine

Country

Business Type

Certificate

Display

Hangzhou Huarong Pharm Co., Ltd.

1. KDMF is available. 2. Registerred in Iran MOH already. 3. Under registerring in Japan. Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small

Apremilast

Cas:608141-41-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Hysen Pharma co.,Ltd.

We can provide high quality,cheap price,spot supply and good service. If you have any questions,pls do not hesitate to contact us. Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&am

Apremilast factory supply

Cas:608141-41-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Apremilast

Cas:608141-41-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 608141-41-9 Apremilast

Cas:608141-41-9

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

lower price Apremilast (CC-10004)(608141-41-9)

Cas:608141-41-9

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Apremilast Cas 608141-41-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:N/A Package:1kg/foil bag Application:Medic

High quality Apremilast Cas 608141-41-9 with favorable price and good service

Cas:608141-41-9

Min.Order:1 Kilogram

FOB Price: $2900.0 / 2985.0

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Apremilast CAS No.:608141-41-9 Name: Apremilast Synonyms: CC 10004; (S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione; (S)-N-(2-(1-(3-Ethoxy-4-met

High purity Apremilast CAS No.:608141-41-9

Cas:608141-41-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Apremilast

Cas:608141-41-9

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Apremilast

Cas:608141-41-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Apremilast

Cas:608141-41-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Chinese Name: Apremilast Chinese alias: (S) - 2 - [1 - (3 - ethoxy - 4 - methoxyphenyl) - 2 - methylsulfonyl ethyl] - 4 - acetylaminoindoline - 1,3 - dione; (S) - 2 - (1 - (3 - ethoxy - 4 - methoxyphenyl) - 2 - methylsulfonyl ethyl) - 4 - acetylam

Apremilast Manufacturer/Cas608141-41-9 /99.9% High purity

Cas:608141-41-9

Min.Order:100 Metric Ton

FOB Price: $2.0 / 3.0

Type:Other

inquiry

Ality Chemical Corporation

ApreMilast Basic information Description Uses Metabolism and Drug interaction safety information side effects References Product Name: ApreMilast Synonyms: (S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl

Factory Supply Apremilast

Cas:608141-41-9

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Apremilast (CC-10004)

Cas:608141-41-9

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 608141-41-9--High purity ApreMilast in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business r

TIANFUCHEM-- 608141-41-9--High purity ApreMilast in stock

Cas:608141-41-9

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

APREMILAST Unii-up7qbp99pn ApreMilast,CC-10004,CAS:608141-41-9

Cas:608141-41-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 608141-41-9 with best quality

Cas:608141-41-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

608141-41-9/Apremilast

Cas:608141-41-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:R.T Package:100G/Bottle, 500G/Bottle, 1KG/Bottle or at customers reqirement. Application:Treat psoriatic arthritis Transportation:Express/Sea/Air Port:Any port in China

Apremilast cas 608141-41-9

Cas:608141-41-9

Min.Order:100 Gram

FOB Price: $4.5 / 7.5

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers

Good quality 99% Powder Apremilast(CAS: 608141-41-9)

Cas:608141-41-9

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Reliable Supplier Apremilast Exwork Price Good After Sales Services Apremilast CAS: 608141-41-9

Cas:608141-41-9

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Shanghai Minstar Chemical Co., Ltd

Product Name: Apremilast Synonyms: (S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide;ApreMilast,CC-10004;brand name: Otezla.;CC10004; CC-10004; CC 10004; APREMILAST; BRAND NAME: OTEZLA.;(S)-4-Ace

Apremilast

Cas:608141-41-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Apremilast CAS 608141-41-9 For research Use only

Cas:608141-41-9

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

ApreMilast

Cas:608141-41-9

Min.Order:1 Kilogram

FOB Price: $6.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Apremilast CAS:608141-41-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Apremilast CAS:608141-41-9

Cas:608141-41-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Apremilast / Otezla/ Intermediates/ APIs/anti-inflammatory

Cas:608141-41-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

Apremilast cas:608141-41-9

Cas:608141-41-9

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Lonwin Chemical Group Limited

Apremilast CAS: 608141-41-9 Specification Item Standard Identification A.H-NMR:Comply with the structure B.LC-MS:Comply with the structure C.The IR spectrum of

Factory supply Apremilast

Cas:608141-41-9

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Synthetic route

4-amino-2-[(1S)-1-(3-ethoxy 4-methoxyphenyl)-2-methanesulfonylethyl]-2,3-dihydro-1H-isoindole-1,3-dione
635705-72-5

4-amino-2-[(1S)-1-(3-ethoxy 4-methoxyphenyl)-2-methanesulfonylethyl]-2,3-dihydro-1H-isoindole-1,3-dione

acetic anhydride
108-24-7

acetic anhydride

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
at 135 - 139℃; Large scale;98.2%
at 70℃; for 3h; Inert atmosphere; enantioselective reaction;94%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine
608141-42-0

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With acetic acid for 1h; Reflux; Large scale;97%
With acetic acid In acetonitrile at 40℃; for 6h; Reflux;94%
With acetic acid for 3h; Time; Reflux;92%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate
608141-43-1

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 75 - 80℃; for 18h; Reagent/catalyst; Solvent;95.1%
With sodium acetate; acetic acid at 80℃; for 5h; Reagent/catalyst; Temperature;91.3%
Stage #1: (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate With sodium hydroxide In dichloromethane at 0 - 5℃; for 2h;
Stage #2: 3-acetylaminophthalic anhydride With perchloric acid; acetic acid In dichloromethane at 45℃; for 3.33333h; Reflux;
89.2%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylthio)ethan-1-amine

(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylthio)ethan-1-amine

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Stage #1: 3-acetylaminophthalic anhydride; (1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylthio)ethan-1-amine With acetic acid In acetonitrile for 12h; Reflux;
Stage #2: With sodium tungstate (VI) dihydrate; dihydrogen peroxide In acetonitrile at 20℃; for 7h; Cooling;
94%
Multi-step reaction with 2 steps
1.1: acetic acid / acetonitrile / 12 h / Reflux
2.1: acetic acid / acetonitrile / 20 °C
2.2: 7 h / 20 °C
View Scheme
N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)(methylthio)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide

N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)(methylthio)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Stage #1: N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)(methylthio)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide With acetic acid In acetonitrile at 20℃;
Stage #2: With sodium tungstate (VI) dihydrate; dihydrogen peroxide In acetonitrile at 20℃; for 7h;
91%
(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate
608141-43-1

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate

3-acetylaminophthalic acid
15371-06-9

3-acetylaminophthalic acid

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With acetic acid at 100 - 120℃; for 2h; Reagent/catalyst;86.7%
With acetic acid at 110 - 115℃; for 1h;3.4 g
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

C12H19NO4S*C10H10ClNO5

C12H19NO4S*C10H10ClNO5

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With acetic acid for 24h; Time; Reflux;85%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(R,R)-O,O’-di-p-toluoyl-tartrate

(R,R)-O,O’-di-p-toluoyl-tartrate

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With acetic acid for 24h; Reflux;83%
4-amino-2-[(1S)-1-(3-ethoxy 4-methoxyphenyl)-2-methanesulfonylethyl]-2,3-dihydro-1H-isoindole-1,3-dione
635705-72-5

4-amino-2-[(1S)-1-(3-ethoxy 4-methoxyphenyl)-2-methanesulfonylethyl]-2,3-dihydro-1H-isoindole-1,3-dione

acetyl chloride
75-36-5

acetyl chloride

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With iodine In dichloromethane at 25 - 30℃;81%
With potassium carbonate In ethyl acetate at 25 - 30℃; for 3h; Solvent; Temperature; Concentration; Reflux;9 g
4-amino-2-[(1S)-1-(3-ethoxy 4-methoxyphenyl)-2-methanesulfonylethyl]-2,3-dihydro-1H-isoindole-1,3-dione
635705-72-5

4-amino-2-[(1S)-1-(3-ethoxy 4-methoxyphenyl)-2-methanesulfonylethyl]-2,3-dihydro-1H-isoindole-1,3-dione

acetic anhydride
108-24-7

acetic anhydride

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
at 135 - 139℃; Large scale;98.2%
at 70℃; for 3h; Inert atmosphere; enantioselective reaction;94%
at 70℃; for 3h;97 %Chromat.
(3-ethoxy-4-methoxyphenyl)boronic acid
915201-13-7

(3-ethoxy-4-methoxyphenyl)boronic acid

C13H12N2O5S

C13H12N2O5S

A

Apremilast
608141-41-9

Apremilast

B

C22H30O6S

C22H30O6S

Conditions
ConditionsYield
With chlorobis(ethylene)rhodium(I) dimer; triethylamine In methanol at 60℃;A 7%
B 81%
With chlorobis(ethylene)rhodium(I) dimer; triethylamine In methanol at 0℃;A 10%
B 7%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine (-)-dibenzoyl-L-tartaric acid salt

1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine (-)-dibenzoyl-L-tartaric acid salt

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20 - 95℃; for 8h; Concentration; Reagent/catalyst; Temperature; Solvent;77%
3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

(S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine N-acetyl-L-leucine salt

(S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine N-acetyl-L-leucine salt

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With acetic acid Reflux;75%
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine
253168-94-4

2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine

3-acetylaminophthalic anhydride
6296-53-3

3-acetylaminophthalic anhydride

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With acetic acid at 50℃; Reflux;73.4%
In acetic acid for 15h; Reflux;59%
Stage #1: 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine With N-Ac-Leu In methanol
Stage #2: 3-acetylaminophthalic anhydride With sodium hydroxide In N,N-dimethyl acetamide
3-acetamidophthalimide
6118-65-6

3-acetamidophthalimide

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethanol

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethanol

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 4h;70%
3-acetamidophthalimide
6118-65-6

3-acetamidophthalimide

(R)-3-ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzyl alcohol
1450657-24-5

(R)-3-ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzyl alcohol

A

Apremilast
608141-41-9

Apremilast

B

R-Apremilast
608141-44-2

R-Apremilast

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at -5 - 20℃; for 7h; Mitsunobu Displacement; Inert atmosphere;A 65%
B n/a
With triphenylphosphine; diethylazodicarboxylate In dichloromethane; toluene at 20℃; Cooling with ice;A 22%
B n/a
3-acetamidophthalimide
6118-65-6

3-acetamidophthalimide

(R)-3-ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzyl alcohol
1450657-24-5

(R)-3-ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzyl alcohol

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran; toluene at 20℃; for 15h; Solvent; Inert atmosphere;62%
Stage #1: 3-acetamidophthalimide With triphenylphosphine In dichloromethane at 20℃; for 0.25h;
Stage #2: (R)-3-ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzyl alcohol With diethylazodicarboxylate In dichloromethane; toluene at 20℃; Cooling with ice;
22%
1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine
1450657-31-4

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; hydrogen; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine / 2,2,2-trifluoroethanol / 18 h / 50 °C / 4654.46 Torr / Inert atmosphere
2: acetic acid / Reflux
View Scheme
Multi-step reaction with 3 steps
1: sodium cyanoborohydride; citric acid / methanol / 1 h / 5 °C
2: acetic acid / water / 3 h / 20 - 97 °C
3: N,N-dimethyl-formamide / 8 h / 20 - 95 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium cyanoborohydride; citric acid / methanol / 1 h / 5 °C
2: acetic acid / water / 3 h / 20 - 97 °C
3: sodium hydroxide / water; toluene / 3 h / 20 °C
4: acetic acid / toluene / 100 - 105 °C
View Scheme
3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 0 - 5 °C
1.2: 2 h / 0 - 30 °C
2.1: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; hydrogen; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine / 2,2,2-trifluoroethanol / 18 h / 50 °C / 4654.46 Torr / Inert atmosphere
3.1: acetic acid / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / 0 - 10 °C / Inert atmosphere
1.2: 6 h / 0 - 20 °C
2.1: (S)-diphenylprolinol; Trimethyl borate; borane dimethyl sulphide complex / tetrahydrofuran / 8 h / 0 - 25 °C / Inert atmosphere
3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran / 1.5 h / 0 - 5 °C
1.2: 1.5 h / 0 - 30 °C
2.1: methanol / 5.5 h / 45 °C / Reflux
3.1: acetic acid / 15 h / Reflux
View Scheme
3-aminophthalic acid
5434-20-8

3-aminophthalic acid

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 3 h / Reflux
2: acetic acid / Reflux
View Scheme
Multi-step reaction with 2 steps
1: 3 h / Reflux
2: acetic acid / 15 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: 3 h / Reflux
2: acetic acid / Reflux
View Scheme
3-nitrophthalic acid
603-11-2

3-nitrophthalic acid

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 13 h / 2585.81 - 2844.39 Torr / Inert atmosphere
2: 3 h / Reflux
3: acetic acid / Reflux
View Scheme
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 13 h / 2585.81 - 2844.39 Torr
2: 3 h / Reflux
3: acetic acid / 15 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 13 h / 2585.81 - 2844.39 Torr
2: 3 h / Reflux
3: acetic acid / Reflux
View Scheme
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine
253168-94-4

2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanol / 1 h / Reflux
2: acetic acid / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: methanol / 1 h / Inert atmosphere; Reflux
2.1: sodium hydroxide / dichloromethane / 2 h / 0 - 5 °C
2.2: 3.33 h / 45 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1: methanol / 1 h / Inert atmosphere; Reflux
2: sodium hydroxide / dichloromethane / 2 h / 0 - 5 °C
3: acetic acid; perchloric acid / 2.5 h / 85 °C / Reflux
View Scheme
1-Bromo-3-ethoxy-4-methoxybenzene
52849-52-2

1-Bromo-3-ethoxy-4-methoxybenzene

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium; iodine / tetrahydrofuran / 3.83 h / 45 - 60 °C
1.2: 3.67 h / -5 - 0 °C
1.3: Raney nickel / 3 h / 20 - 25 °C / 760.05 - 1520.1 Torr / Autoclave
2.1: methanol / 1 h / Inert atmosphere; Reflux
3.1: sodium hydroxide / dichloromethane / 2 h / 0 - 5 °C
3.2: 3.33 h / 45 °C / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: magnesium; iodine / tetrahydrofuran / 3.83 h / 45 - 60 °C
1.2: 3.67 h / -5 - 0 °C
1.3: Raney nickel / 3 h / 20 - 25 °C / 760.05 - 1520.1 Torr / Autoclave
2.1: methanol / 1 h / Inert atmosphere; Reflux
3.1: sodium hydroxide / dichloromethane / 2 h / 0 - 5 °C
4.1: acetic acid; perchloric acid / 2.5 h / 85 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
1.2: 16 h / -78 - 20 °C / Inert atmosphere
2.1: triethylamine; chlorobis(ethylene)rhodium(I) dimer; (1S,4S)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene / methanol / 2 h / 60 °C / Inert atmosphere
3.1: 3 h / 70 °C / Inert atmosphere
View Scheme
2-chloro-1-(3-ethoxy-4-methoxyphenyl)ethanone

2-chloro-1-(3-ethoxy-4-methoxyphenyl)ethanone

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: ethanol / 15 h / Reflux
2.1: ammonium formate; palladium on activated charcoal / methanol; water / 15 h / Reflux
3.1: methanol / 4 h / 25 °C / Reflux
4.1: acetic acid / 15 h / Reflux
4.2: 3.25 h / 25 °C / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: ethanol / 3 h / Reflux
2.1: D-glucose / water / 48 h / 30 °C / Enzymatic reaction
3.1: tributylphosphine; diethylazodicarboxylate; hydrogen azide / toluene; tetrahydrofuran / 22 h / -70 - 20 °C / Inert atmosphere
4.1: triphenylphosphine / water; tetrahydrofuran / Inert atmosphere; Reflux; Sealed tube
4.2: Reflux
4.3: 1 h / 80 °C / Sealed tube
5.1: acetic acid / Reflux
View Scheme
1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one
1450657-28-9

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ammonium formate; palladium on activated charcoal / methanol; water / 15 h / Reflux
2.1: methanol / 4 h / 25 °C / Reflux
3.1: acetic acid / 15 h / Reflux
3.2: 3.25 h / 25 °C / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: D-glucose / water / 48 h / 30 °C / Enzymatic reaction
2.1: tributylphosphine; diethylazodicarboxylate; hydrogen azide / toluene; tetrahydrofuran / 22 h / -70 - 20 °C / Inert atmosphere
3.1: triphenylphosphine / water; tetrahydrofuran / Inert atmosphere; Reflux; Sealed tube
3.2: Reflux
3.3: 1 h / 80 °C / Sealed tube
4.1: acetic acid / Reflux
View Scheme
3-aminophthalic acid hydrochloride
6946-22-1

3-aminophthalic acid hydrochloride

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: water / 15 h / 100 °C
2.1: acetic acid / 15 h / Reflux
2.2: 3.25 h / 25 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: 2 h / 110 °C
2.1: acetonitrile / 80 - 85 °C
2.2: 60 - 65 °C
View Scheme
Multi-step reaction with 2 steps
1: 2 h / 110 °C
2: acetonitrile / 3 h / Reflux
View Scheme
3-hydroxy-4-methoxyacetophenone
6100-74-9

3-hydroxy-4-methoxyacetophenone

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 °C
2.1: 1,3-dichloro-5,5-dimethylhydantoin; toluene-4-sulfonic acid / methanol / 15 h / 5 - 25 °C
3.1: ethanol / 15 h / Reflux
4.1: ammonium formate; palladium on activated charcoal / methanol; water / 15 h / Reflux
5.1: methanol / 4 h / 25 °C / Reflux
6.1: acetic acid / 15 h / Reflux
6.2: 3.25 h / 25 °C / Reflux
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 30 - 35 °C
2.1: toluene-4-sulfonic acid; N-Bromosuccinimide / ethyl acetate / 16 h / 25 - 30 °C
3.1: methanol; water / 0.01 h / 35 - 40 °C
4.1: titanium(IV) isopropylate; (R)-2-methylpropane-2-sulfinamide / ethyl acetate / 65 h / 45 °C
4.2: 0.75 h / 0 - 20 °C
4.3: 1 h / 20 °C
5.1: sodium hydroxide / water
6.1: acetic acid / acetonitrile / 12 h / Reflux
6.2: 7 h / 20 °C / Cooling
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 30 - 35 °C
2.1: toluene-4-sulfonic acid; N-Bromosuccinimide / ethyl acetate / 16 h / 25 - 30 °C
3.1: methanol; water / 0.01 h / 35 - 40 °C
4.1: titanium(IV) isopropylate; (R)-2-methylpropane-2-sulfinamide / ethyl acetate / 65 h / 45 °C
4.2: 0.75 h / 0 - 20 °C
4.3: 1 h / 20 °C
5.1: sodium hydroxide / water
6.1: acetic acid / acetonitrile / 12 h / Reflux
6.2: 7 h / 20 °C / Cooling
View Scheme
Multi-step reaction with 7 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 30 - 35 °C
2.1: toluene-4-sulfonic acid; N-Bromosuccinimide / ethyl acetate / 16 h / 25 - 30 °C
3.1: methanol; water / 0.01 h / 35 - 40 °C
4.1: titanium(IV) isopropylate; (R)-2-methylpropane-2-sulfinamide / ethyl acetate / 65 h / 45 °C
4.2: 0.75 h / 0 - 20 °C
4.3: 1 h / 20 °C
5.1: sodium hydroxide / water
6.1: acetic acid / acetonitrile / 12 h / Reflux
7.1: acetic acid / acetonitrile / 20 °C
7.2: 7 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 30 - 35 °C
2.1: toluene-4-sulfonic acid; N-Bromosuccinimide / ethyl acetate / 16 h / 25 - 30 °C
3.1: methanol; water / 0.01 h / 35 - 40 °C
4.1: titanium(IV) isopropylate; (R)-2-methylpropane-2-sulfinamide / ethyl acetate / 65 h / 45 °C
4.2: 0.75 h / 0 - 20 °C
4.3: 1 h / 20 °C
5.1: sodium hydroxide / water
6.1: acetic acid / acetonitrile / 12 h / Reflux
7.1: acetic acid / acetonitrile / 20 °C
7.2: 7 h / 20 °C
View Scheme
3-ethoxy-4-methoxy-acetophenone
31526-71-3

3-ethoxy-4-methoxy-acetophenone

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 1,3-dichloro-5,5-dimethylhydantoin; toluene-4-sulfonic acid / methanol / 15 h / 5 - 25 °C
2.1: ethanol / 15 h / Reflux
3.1: ammonium formate; palladium on activated charcoal / methanol; water / 15 h / Reflux
4.1: methanol / 4 h / 25 °C / Reflux
5.1: acetic acid / 15 h / Reflux
5.2: 3.25 h / 25 °C / Reflux
View Scheme
Multi-step reaction with 6 steps
1.1: N-chloro-succinimide; toluene-4-sulfonic acid / acetonitrile / 40 °C
2.1: ethanol / 3 h / Reflux
3.1: D-glucose / water / 48 h / 30 °C / Enzymatic reaction
4.1: tributylphosphine; diethylazodicarboxylate; hydrogen azide / toluene; tetrahydrofuran / 22 h / -70 - 20 °C / Inert atmosphere
5.1: triphenylphosphine / water; tetrahydrofuran / Inert atmosphere; Reflux; Sealed tube
5.2: Reflux
5.3: 1 h / 80 °C / Sealed tube
6.1: acetic acid / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid; N-Bromosuccinimide / ethyl acetate / 16 h / 25 - 30 °C
2.1: methanol; water / 0.01 h / 35 - 40 °C
3.1: titanium(IV) isopropylate; (R)-2-methylpropane-2-sulfinamide / ethyl acetate / 65 h / 45 °C
3.2: 0.75 h / 0 - 20 °C
3.3: 1 h / 20 °C
4.1: sodium hydroxide / water
5.1: acetic acid / acetonitrile / 12 h / Reflux
5.2: 7 h / 20 °C / Cooling
View Scheme
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid; N-Bromosuccinimide / ethyl acetate / 16 h / 25 - 30 °C
2.1: methanol; water / 0.01 h / 35 - 40 °C
3.1: titanium(IV) isopropylate; (R)-2-methylpropane-2-sulfinamide / ethyl acetate / 65 h / 45 °C
3.2: 0.75 h / 0 - 20 °C
3.3: 1 h / 20 °C
4.1: sodium hydroxide / water
5.1: acetic acid / acetonitrile / 12 h / Reflux
6.1: acetic acid / acetonitrile / 20 °C
6.2: 7 h / 20 °C
View Scheme
(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine
608141-42-0

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine

3-acetylaminophthalic acid
15371-06-9

3-acetylaminophthalic acid

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
With triethanolamine; benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 1h;4.2 g
isovanillin
621-59-0

isovanillin

Apremilast
608141-41-9

Apremilast

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium formate; hydroxylamine hydrochloride / formic acid / 5 h / 85 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / 0 - 10 °C / Inert atmosphere
3.2: 6 h / 0 - 20 °C
4.1: (S)-diphenylprolinol; Trimethyl borate; borane dimethyl sulphide complex / tetrahydrofuran / 8 h / 0 - 25 °C / Inert atmosphere
5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C
View Scheme
Apremilast
608141-41-9

Apremilast

Trimethylboroxine
823-96-1

Trimethylboroxine

C23H26N2O7S

C23H26N2O7S

Conditions
ConditionsYield
With pentamethylcyclopentadienyl(benzene)cobalt(III) hexafluorophosphate; potassium carbonate; silver carbonate In 2-methyltetrahydrofuran at 100℃; for 16h; Inert atmosphere; Sealed tube;23%
Apremilast
608141-41-9

Apremilast

octa-acetyl lactulose

octa-acetyl lactulose

C48H58N2O24S

C48H58N2O24S

Conditions
ConditionsYield
Stage #1: Apremilast With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile for 3h; Reflux;
Stage #2: octa-acetyl lactulose With trimethylsilyl trifluoromethanesulfonate at 20℃; for 14h;
16.7%
Stage #1: Apremilast With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile for 3h; Reflux;
Stage #2: octa-acetyl lactulose With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 20℃; for 14.0833h;
16.7%
Apremilast
608141-41-9

Apremilast

(S)-N-{2-[1-(3-hydroxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide
1384967-20-7

(S)-N-{2-[1-(3-hydroxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 20℃; for 1h;
Apremilast
608141-41-9

Apremilast

(S)-N-(2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
1384441-38-6

(S)-N-(2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide

Conditions
ConditionsYield
With trimethylsilyl iodide In dichloromethane at 20℃; for 24h;
Apremilast
608141-41-9

Apremilast

(S)-N-{2-[1-(3,4-dihydroxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide
1384439-79-5

(S)-N-{2-[1-(3,4-dihydroxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trimethylsilyl iodide / dichloromethane / 24 h / 20 °C
2: aluminum (III) chloride / dichloromethane / 1 h / 20 °C
View Scheme
Apremilast
608141-41-9

Apremilast

(2S,3R,4S,5S,6S)-2-(4-((S)-1-(4-acetamido-1,3-dioxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)-6-((benzyloxy)carbonyl)tetrahydro-2H-pyran-3,4,5-triyltriacetate
1384967-21-8

(2S,3R,4S,5S,6S)-2-(4-((S)-1-(4-acetamido-1,3-dioxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)-6-((benzyloxy)carbonyl)tetrahydro-2H-pyran-3,4,5-triyltriacetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trimethylsilyl iodide / dichloromethane / 24 h / 20 °C
2: boron trifluoride diethyl etherate / dichloromethane / 6 h / -18 - 25 °C / Molecular sieve
View Scheme
Apremilast
608141-41-9

Apremilast

C33H36N2O16S
1384967-22-9

C33H36N2O16S

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: trimethylsilyl iodide / dichloromethane / 24 h / 20 °C
2: boron trifluoride diethyl etherate / dichloromethane / 6 h / -18 - 25 °C / Molecular sieve
3: hydrogen / palladium 10% on activated carbon / ethyl acetate / 12 h / 1551.49 - 2068.65 Torr
View Scheme
Apremilast
608141-41-9

Apremilast

(S)-N-{2-[1-(3-ethoxy-4-glucopyranuroxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide
1384814-89-4

(S)-N-{2-[1-(3-ethoxy-4-glucopyranuroxy-phenyl)-2-methanesulfonyl-ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-acetamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: trimethylsilyl iodide / dichloromethane / 24 h / 20 °C
2: boron trifluoride diethyl etherate / dichloromethane / 6 h / -18 - 25 °C / Molecular sieve
3: hydrogen / palladium 10% on activated carbon / ethyl acetate / 12 h / 1551.49 - 2068.65 Torr
4: sodium carbonate / methanol / 2 h / 60 °C
View Scheme
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View