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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Alendronic acid Manufacturer/High quality/Best price/In stock

Cas:66376-36-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Alendronic Acid supplier in China

Cas:66376-36-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Alendronic Acid

Cas:66376-36-1

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Alendronic acid 66376-36-1 GMP Manufacturer

Cas:66376-36-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Alendronate

Cas:66376-36-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Alendronic acid Basic information Product Name: Alendronic acid Synonyms: 4-AMINO-1-HYDROXY-1,1-BUTYLIDINEDIPHOSPHONIC ACID;(4-AMINO-1-HYDROXY-1-PHOSPHONOBUTYL)PHOSPHONIC ACID;(4-AMINO-1

Alendronic acid_

Cas:66376-36-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 66376-36-1 with best price

Cas:66376-36-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

GMP factory supply 99% raw powder Alendronic acid

Cas:66376-36-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Phosphonic acid,P,P'-(4-amino-1-hydroxybutylidene)bis- 66376-36-1

Cas:66376-36-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Alendronic acid CAS:66376-36-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedi

Alendronic acid CAS:66376-36-1

Cas:66376-36-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Alendronic acid

Cas:66376-36-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Superiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer Product Detail bes

Factory price Alendronic acid CAS:66376-36-1

Cas:66376-36-1

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifi

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ALENDRONIC ACID

Cas:66376-36-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Alendronic Acid

Cas:66376-36-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Alendronic Acid

Cas:66376-36-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

GMP factory supply 99% raw powder Alendronic acid

Cas:66376-36-1

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Alendronic Acid

Cas:66376-36-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

Phosphonic acid,P,P'-(4-amino-1-hydroxybutylidene)bis-CAS NO.: 66376-36-1

Cas:66376-36-1

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Alendronicacid

Cas:66376-36-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

GMP factory supply 99% raw powder Alendronic acid

Cas:66376-36-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Alendronic Acid

Cas:66376-36-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Factory price Alendronic acid CAS:66376-36-1 CAS NO.66376-36-1

Cas:66376-36-1

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Phosphonic acid,P,P'-(4-amino-1-hydroxybutylidene)bis-

Cas:66376-36-1

Min.Order:0

Negotiable

Type:Other

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

GMP factory supply 99% raw powder Alendronic acid

Cas:66376-36-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermediat

Enke Alendronic acid

Cas:66376-36-1

Min.Order:1 Kilogram

FOB Price: $200.0 / 300.0

Type:Lab/Research institutions

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Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

ALENDRONATE

Cas:66376-36-1

Min.Order:0

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Alendronic Acid

Cas:66376-36-1

Min.Order:0

Negotiable

Type:Other

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Phosphonic acid

Cas:66376-36-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment .5) We can do different t

99% up by HPLC Alendronic acid 66376-36-1

Cas:66376-36-1

Min.Order:0

Negotiable

Type:Trading Company

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Synthetic route

4-amino-n-butyric acid
56-12-2

4-amino-n-butyric acid

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

Conditions
ConditionsYield
Stage #1: 4-amino-n-butyric acid With phosphonic Acid; phosphorus trichloride In methoxybenzene at 60 - 105℃; for 5.66667 - 5.75h;
Stage #2: With water In methoxybenzene at 110 - 115℃; for 5 - 6h; Reflux;
90%
Stage #1: 4-amino-n-butyric acid With phosphorus trichloride In methanesulfonic acid at 80 - 85℃;
Stage #2: With water In methanesulfonic acid at 105℃; for 4h;
88%
Stage #1: 4-amino-n-butyric acid With phosphonic Acid; phosphorus trichloride In methanesulfonic acid at 65 - 70℃; for 18h;
Stage #2: With water In methanesulfonic acid for 5h; Reflux;
85%
[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-phosphonobutyl]phosphonic acid
948317-79-1

[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-phosphonobutyl]phosphonic acid

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

Conditions
ConditionsYield
With hydrazine hydrate In water at 20℃; for 0.5h;82%
With hydrogenchloride In water for 5.5h; Reflux;
2-pyrrolidinon
616-45-5

2-pyrrolidinon

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

Conditions
ConditionsYield
Stage #1: 2-pyrrolidinon With methanesulfonic acid at 100 - 105℃; for 6h;
Stage #2: With phosphorus trichloride at 75℃; for 8h;
Stage #3: In water for 5h; Heating;
72%
1-hydroxy-4-pent-4-ynamidobutane-1,1-diyldiphosphonic acid
952615-43-9

1-hydroxy-4-pent-4-ynamidobutane-1,1-diyldiphosphonic acid

copper sulfide pentahydrate

copper sulfide pentahydrate

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

Conditions
ConditionsYield
70%
N-hydroxysuccinimide ester of 4-(tert-butoxycarbonylamino)butyric acid
69038-04-6

N-hydroxysuccinimide ester of 4-(tert-butoxycarbonylamino)butyric acid

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

Conditions
ConditionsYield
With tris(trimethylsilyl) phosphite In tetrahydrofuran at 50℃; for 72h;61%
tetramethyl (4-phthalimido-1-hydroxybutylidene)bisphosphonate
125040-13-3

tetramethyl (4-phthalimido-1-hydroxybutylidene)bisphosphonate

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

Conditions
ConditionsYield
With hydrogenchloride for 10h; Heating;
4-phthalimidobutyryl chloride
10314-06-4

4-phthalimidobutyryl chloride

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

Conditions
ConditionsYield
With hydrogenchloride; methyl phosphite; phosphorous acid trimethyl ester 1.) 80 deg C, 8 h, 2.) reflux, 20 h; Yield given. Multistep reaction;
sodium alendronate
121268-17-5

sodium alendronate

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

Conditions
ConditionsYield
With hydrogenchloride; ethanol; water at 20 - 50℃; for 2h;
4-amino-n-butyric acid
56-12-2

4-amino-n-butyric acid

A

4-amino-1-hydroxybutylidene-1,1-biphosphonic Acid Monosodium Salt Trihydrate

4-amino-1-hydroxybutylidene-1,1-biphosphonic Acid Monosodium Salt Trihydrate

B

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

C17H39NO8P2Si

C17H39NO8P2Si

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

Conditions
ConditionsYield
With hydrogen bromide In water for 17h; Reflux;
C19H31NO9P2Si

C19H31NO9P2Si

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

Conditions
ConditionsYield
With hydrogenchloride In water for 17h; Reflux;
4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

tetra(n-butyl)ammonium hydroxide
2052-49-5

tetra(n-butyl)ammonium hydroxide

tetrabutylammonium alendronate

tetrabutylammonium alendronate

Conditions
ConditionsYield
In water at 40℃; for 0.5h;100%
In water at 20℃; for 2h;100%
4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

1-(2-hydroxyethyl)-3-methylimidazolium halide

1-(2-hydroxyethyl)-3-methylimidazolium halide

[C2OHMIM]2[ALN]

[C2OHMIM]2[ALN]

Conditions
ConditionsYield
With anion-exchange column Amberlyst A26-OH In methanol; water at 20℃; for 1h;100%
4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

1-(2-hydroxyethyl)-3-methylimidazolium halide

1-(2-hydroxyethyl)-3-methylimidazolium halide

[C2OHMIM][ALN]

[C2OHMIM][ALN]

Conditions
ConditionsYield
With anion-exchange column Amberlyst A26-OH In methanol; water at 20℃; for 1h;100%
2,4,6-triamino-s-triazine
108-78-1

2,4,6-triamino-s-triazine

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

1,3,5-triazine-2,4,6-triamine

1,3,5-triazine-2,4,6-triamine

Conditions
ConditionsYield
With water pH=Ca. 6 - 8; Heating;99%
4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

C29H23N5O6

C29H23N5O6

(1-hydroxy-4-(((2-((4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl)oxy)ethoxy)carbonyl)amino)butane-1,1-diyl)bis(phosphonic acid)

(1-hydroxy-4-(((2-((4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl)oxy)ethoxy)carbonyl)amino)butane-1,1-diyl)bis(phosphonic acid)

Conditions
ConditionsYield
Stage #1: 4-amino-1-hydroxybutylidenebisphosphonic acid; C29H23N5O6 With triethylamine In 1,4-dioxane; water at 25℃; Inert atmosphere;
Stage #2: With sodium acetate; acetic acid In methanol at 80℃; for 1h;
93.1%
4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid N-succinimidyl ester
64987-85-5

4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid N-succinimidyl ester

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

{4‐[({4‐[(2,5‐dioxo‐2,5‐dihydro‐1H‐pyrrol‐1‐yl)methyl]cyclohexyl}carbonyl)amino]‐1‐hydroxybutane‐1,1‐diyl}bis(phosphonic acid)

{4‐[({4‐[(2,5‐dioxo‐2,5‐dihydro‐1H‐pyrrol‐1‐yl)methyl]cyclohexyl}carbonyl)amino]‐1‐hydroxybutane‐1,1‐diyl}bis(phosphonic acid)

Conditions
ConditionsYield
With sodium hydroxide In water; acetone at 20℃; pH=8 - 9;93%
2,5-dioxopyrrolidin-1-yl pent-4-ynoate
132178-37-1

2,5-dioxopyrrolidin-1-yl pent-4-ynoate

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

1-hydroxy-4-pent-4-ynamidobutane-1,1-diyldiphosphonic acid
952615-43-9

1-hydroxy-4-pent-4-ynamidobutane-1,1-diyldiphosphonic acid

Conditions
ConditionsYield
In water; acetonitrile at 20℃; for 12h; pH=7.0;90%
With sodium hydroxide In water; acetonitrile at 0℃; for 18h; pH=7.2 - 7.4; Inert atmosphere;277 mg
pentynoic acid 2,5-dioxo-pyrrolidin-1-yl ester

pentynoic acid 2,5-dioxo-pyrrolidin-1-yl ester

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

1-hydroxy-4-pent-4-ynamidobutane-1,1-diyldiphosphonic acid
952615-43-9

1-hydroxy-4-pent-4-ynamidobutane-1,1-diyldiphosphonic acid

Conditions
ConditionsYield
90%
4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

4-amino-1-hydroxybutylidene-1,1-biphosphonato hexaccordinated octahedral sodium monoaquo complex dihydrate

4-amino-1-hydroxybutylidene-1,1-biphosphonato hexaccordinated octahedral sodium monoaquo complex dihydrate

Conditions
ConditionsYield
In water for 4 - 5h; pH=4.2 - 4.8; Na+ Exchange resin AMBERLITE SR1L; Product distribution / selectivity;89.2%
In water for 4 - 5h; pH=4.2 - 4.8; Na+ Exchange resin AMBERJET 1200; Product distribution / selectivity;89.9%
4-{2-azatricyclo[10.4.0.04'9]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl}-4-oxobutanoic acid
1353016-71-3

4-{2-azatricyclo[10.4.0.04'9]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl}-4-oxobutanoic acid

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

C23H26N2O9P2

C23H26N2O9P2

Conditions
ConditionsYield
In water; dimethyl sulfoxide pH=8.1;89%
4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

lithium alendronate dihydrate

lithium alendronate dihydrate

Conditions
ConditionsYield
With lithium carbonate In water87%
K(2-x)(NMe4)(x)[I2Mo10O10S10(OH)10(H2O)5*20H2O

K(2-x)(NMe4)(x)[I2Mo10O10S10(OH)10(H2O)5*20H2O

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

rubidium chloride

rubidium chloride

water
7732-18-5

water

Rb4.75K3.25[(Mo2O2S2(H2O))4(Alendronic acid-4H)4]*25H2O

Rb4.75K3.25[(Mo2O2S2(H2O))4(Alendronic acid-4H)4]*25H2O

Conditions
ConditionsYield
With NaOH In water to an aq. soln. of I2Mo10-contg. compd. (0.417 mmol) was added a ligand (2.09 mmol); pH=5 (NaOH); stirring at 80°C for 30 min; cooling toroom temp.; powder was eliminated by centrifugation; addn. of RbCl (8.1 0 mmol); stirring for 1 h; the powder was filtered off, the soln. was left to evap. at room temp.; crystals were collected by filtration; elem. anal.;86%
4-chloroquinazoline
5190-68-1

4-chloroquinazoline

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

[1-hydroxy-4-(quinazolin-4-ylamino)butane-1,1-diyl]bis(phosphonic acid)

[1-hydroxy-4-(quinazolin-4-ylamino)butane-1,1-diyl]bis(phosphonic acid)

Conditions
ConditionsYield
Stage #1: 4-chloroquinazoline; 4-amino-1-hydroxybutylidenebisphosphonic acid With potassium carbonate In water at 95℃; for 20h; Reflux;
Stage #2: With hydrogenchloride In water at 5℃; for 24h; pH=1;
83%
3-thiophene carboxaldehyde
498-62-4

3-thiophene carboxaldehyde

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

C9H15NO7P2S(2-)*2Na(1+)

C9H15NO7P2S(2-)*2Na(1+)

Conditions
ConditionsYield
Stage #1: 3-thiophene carboxaldehyde; 4-amino-1-hydroxybutylidenebisphosphonic acid With triethylamine In methanol at 65℃; for 1.5h;
Stage #2: With tetramethylammonium borohydride In methanol at 65℃;
Stage #3: With sodium hexaflorophosphate In methanol at 20℃;
82%
4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

2,5-dioxopyrrolidin-1-yl 4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)benzoate

2,5-dioxopyrrolidin-1-yl 4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)benzoate

sodium (4-(4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)benzamido)-1-hydroxybutane-1,1-diyl)bis(hydrogenphosphonate)

sodium (4-(4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)benzamido)-1-hydroxybutane-1,1-diyl)bis(hydrogenphosphonate)

Conditions
ConditionsYield
With triethylamine In water; N,N-dimethyl-formamide at 20℃; for 0.166667h;80%
2-chloroquinazoline
6141-13-5

2-chloroquinazoline

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

[1-hydroxy-4-(quinazolin-2-ylamino)butane-1,1-diyl]bis(phosphonic acid)

[1-hydroxy-4-(quinazolin-2-ylamino)butane-1,1-diyl]bis(phosphonic acid)

Conditions
ConditionsYield
Stage #1: 2-chloroquinazoline; 4-amino-1-hydroxybutylidenebisphosphonic acid With potassium carbonate In water at 90 - 180℃; for 25h; Reflux;
Stage #2: With hydrogenchloride In water at 5℃; for 24h; pH=1;
80%
4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

sodium alendronate
121268-17-5

sodium alendronate

Conditions
ConditionsYield
With sodium carbonate In water for 3h; Heating;79%
With sodium hydroxide In water at 0 - 5℃; for 3h; pH=4.3;
With sodium hydroxide In water at 30 - 70℃;
6-maleimidohexanoic acid N-hydroxylsuccinimide ester
55750-63-5

6-maleimidohexanoic acid N-hydroxylsuccinimide ester

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

(4‐{[6‐(2,5‐dioxo‐2,5‐dihydro‐1H‐pyrrol‐1‐yl)hexanoyl]amino}‐1‐hydroxybutane‐1,1‐diyl)bis(phosphonic acid)

(4‐{[6‐(2,5‐dioxo‐2,5‐dihydro‐1H‐pyrrol‐1‐yl)hexanoyl]amino}‐1‐hydroxybutane‐1,1‐diyl)bis(phosphonic acid)

Conditions
ConditionsYield
With sodium hydroxide In water; acetone at 20℃; pH=8 - 9;79%
4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

ethylenediamine
107-15-3

ethylenediamine

C2H8N2*C4H13NO7P2*2H2O

C2H8N2*C4H13NO7P2*2H2O

Conditions
ConditionsYield
With water pH=Ca. 6 - 8; Heating;77%
4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

N-methyl-ethane-1,2-diamine
109-81-9

N-methyl-ethane-1,2-diamine

C3H10N2*C4H13NO7P2*3H2O

C3H10N2*C4H13NO7P2*3H2O

Conditions
ConditionsYield
With water pH=Ca. 6 - 8; Heating;76%
2-chloropyrimidine
1722-12-9

2-chloropyrimidine

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

[1-hydroxy-4-(pyrimidin-2-ylamino)butane-1,1-diyl]bis(phosphonic acid)

[1-hydroxy-4-(pyrimidin-2-ylamino)butane-1,1-diyl]bis(phosphonic acid)

Conditions
ConditionsYield
Stage #1: 2-chloropyrimidine; 4-amino-1-hydroxybutylidenebisphosphonic acid With potassium carbonate In water at 90 - 180℃; for 5h; Reflux;
Stage #2: With hydrogenchloride In water at 5℃; pH=1;
76%
4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

2-(triphenylmethylthio)ethanoic acid-N-hydroxysuccinimido ester
91425-31-9

2-(triphenylmethylthio)ethanoic acid-N-hydroxysuccinimido ester

(1-hydroxy-4-(2-(tritylthio)acetamido)butane-1,1-diyl)diphosphonic acid

(1-hydroxy-4-(2-(tritylthio)acetamido)butane-1,1-diyl)diphosphonic acid

Conditions
ConditionsYield
Stage #1: 4-amino-1-hydroxybutylidenebisphosphonic acid With triethylamine In water for 0.0833333h;
Stage #2: 2-(triphenylmethylthio)ethanoic acid-N-hydroxysuccinimido ester In water; N,N-dimethyl-formamide at 20℃; for 1h;
76%
Stage #1: 4-amino-1-hydroxybutylidenebisphosphonic acid With triethylamine In water for 0.0833333h;
Stage #2: 2-(triphenylmethylthio)ethanoic acid-N-hydroxysuccinimido ester In water; N,N-dimethyl-formamide at 20℃; for 1h;
76%
4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

N,N-diethylethylenediamine
100-36-7

N,N-diethylethylenediamine

C6H16N2*C4H13NO7P2*2H2O

C6H16N2*C4H13NO7P2*2H2O

Conditions
ConditionsYield
With water pH=Ca. 6 - 8; Heating;67%
4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

C6H14N2*C4H13NO7P2*3H2O

C6H14N2*C4H13NO7P2*3H2O

Conditions
ConditionsYield
With water pH=Ca. 6 - 8; Heating;66%
1,3-di(aminomethyl)benzene
1477-55-0

1,3-di(aminomethyl)benzene

4-amino-1-hydroxybutylidenebisphosphonic acid
66376-36-1

4-amino-1-hydroxybutylidenebisphosphonic acid

benzene-1,3-dimethylamine

benzene-1,3-dimethylamine

Conditions
ConditionsYield
With water pH=Ca. 6 - 8; Heating;62%

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