DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiry3-hydroxy- α-oxoadamantane-1-acetic acid Basic information Product Name: 3-hydroxy- α-oxoadamantane-1-acetic acid Synonyms: 3-hydroxy- α-oxoadamantane-1-acetic acid;6.
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inquiry3-hydroxy- α-oxoadamantane-1-acetic acid CAS:709031-28-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing i
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiry3-hydroxy- α-oxoadamantane-1-acetic acid is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:solid Storage:Room temperature, Keep in Dark Place. Package:Kilograms/MT Application:
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inquiryProduct name: 2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS No.:709031-28-7 Molecule Formula:C12H16O4 Molecule Weight:224.25 Purity: 98.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard
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inquiryProduct Name: 3-hydroxy- α-oxoadamantane-1-acetic acid Synonyms: 3-hydroxy- α-oxoadamantane-1-acetic acid;6. 3-hydroxy- α-oxoadamantane-1-acetic acid;2-(3-Hydroxy-1-adamantyl)-2-oxoacetic acid;3-Hydroxy-alpha-oxotricyclo[3.
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inquirydichloro-(3-hydroxy-adamantan-1-yl)-acetic acid methyl ester
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Stage #1: dichloro-(3-hydroxy-adamantan-1-yl)-acetic acid methyl ester With sodium hydroxide In tetrahydrofuran; water at 20℃; for 16.7h; Stage #2: With hydrogenchloride; sodium hydrogencarbonate In tetrahydrofuran; water for 5h; pH=7.4; Heating; | 99.53% |
Stage #1: dichloro-(3-hydroxy-adamantan-1-yl)-acetic acid methyl ester With sodium hydroxide In tetrahydrofuran; water at 20℃; for 16h; pH=13.24; Stage #2: With hydrogenchloride; sodium hydrogencarbonate In tetrahydrofuran; water at 4 - 20℃; for 101.76h; pH=1.4 - 1.77; | 86.6% |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Stage #1: dichloro-(3-hydroxy-adamantan-1-yl)-acetic With sodium hydroxide; sodium hydrogencarbonate In water at 80℃; for 6h; pH=7.22; Stage #2: With hydrogenchloride In water pH=0.15; | 99% |
1-hydroxy-3-acetyladamantane
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
With potassium permanganate; tetrabutylammomium bromide; potassium hydroxide In tert-butyl alcohol at 40℃; for 5h; Reagent/catalyst; | 91.8% |
With potassium permanganate; potassium hydroxide In tert-butyl alcohol at 40℃; for 5h; | 90% |
With potassium permanganate; potassium hydroxide In water; tert-butyl alcohol at 35 - 45℃; for 4.5h; | 86.6% |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Stage #1: 3-hydroxy-α-oxotricyclo[3.3.1.13,7]decane-1-acetic acid methyl ester With sodium hydroxide; water In tetrahydrofuran at 5 - 30℃; for 0.5h; pH=7 - 14; Stage #2: With hydrogenchloride In tetrahydrofuran; water; ethyl acetate pH=0.7; | 85% |
With sodium hydroxide In tetrahydrofuran; water at 30℃; pH=Ca. 7 - 14; Cooling with ice; |
1-acetyladamantane
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
With potassium permanganate; potassium hydroxide In water at 90℃; | 84% |
With potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide at 60 - 80℃; for 14.5h; | 47% |
Stage #1: 1-acetyladamantane With sodium hydroxide; potassium permanganate In water at 27 - 55℃; for 24.5 - 25.5h; Stage #2: In water Product distribution / selectivity; Acidic aqueous solution; |
1-acetyladamantane
A
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
B
oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid
Conditions | Yield |
---|---|
With potassium permanganate; potassium hydroxide In water at 50 - 80℃; for 12h; | A 80% B 0.8 g |
With sodium hydroxide; potassium permanganate In water; tert-butyl alcohol at 50 - 65℃; for 35h; Product distribution / selectivity; |
oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Stage #1: oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid With sulfuric acid; nitric acid Stage #2: With hydrogenchloride In water | 76% |
Stage #1: oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid With sodium hydroxide; potassium permanganate In water at 20 - 60℃; for 11h; Stage #2: Acidic aqueous solution; | |
With sodium hydroxide; potassium permanganate In water at 55 - 60℃; for 11h; Product distribution / selectivity; |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
With ω-transaminase |
1-Adamantanecarboxylic acid
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 25 °C 1.2: 2 h / 25 °C 2.1: tetrahydrofuran / 10 - 20 °C / Inert atmosphere 3.1: potassium permanganate; potassium hydroxide / water / 90 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium permanganate; potassium hydroxide / water; tert-butyl alcohol / 8.5 h / 45 - 60 °C 2.1: thionyl chloride / 6 h / Reflux 3.1: sodium / Petroleum ether / 20 °C 3.2: 20 °C / Reflux 3.3: 6 h / Reflux 4.1: potassium permanganate; potassium hydroxide / tert-butyl alcohol / 5 h / 40 °C View Scheme |
1-Adamantanecarboxylic acid
A
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
B
oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 25 °C 1.2: 2 h / 25 °C 2.1: tetrahydrofuran / 10 - 20 °C / Inert atmosphere 3.1: potassium permanganate; potassium hydroxide / water / 12 h / 50 - 80 °C View Scheme |
(3r,5r,7r)-N-methoxy-N-methyladamantane-1-carboxamide
A
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
B
oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tetrahydrofuran / 10 - 20 °C / Inert atmosphere 2: potassium permanganate; potassium hydroxide / water / 12 h / 50 - 80 °C View Scheme |
1-acetyl-3-chloroadamantane
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium hydroxide / water / 6 h / Reflux 2: potassium hydroxide; potassium permanganate / water; tert-butyl alcohol / 4.5 h / 35 - 45 °C View Scheme |
1-Adamantyl bromide
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: zinc(II) chloride / dichloromethane / 20 °C 2.1: sulfuric acid; nitric acid / water / 25 h / 1 °C / Cooling with ice 3.1: sodium hydroxide / water; tetrahydrofuran / 16.7 h / 20 °C 3.2: 5 h / pH 7.4 / Heating View Scheme | |
Multi-step reaction with 5 steps 1: zinc(II) chloride / dichloromethane / 0.08 h / 20 °C / Large scale 2: acetyl chloride / 2 h / 0 - 25 °C / Inert atmosphere; Large scale 3: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.83 h / -60 °C / Inert atmosphere; Cooling with acetone-dry ice 4: sulfuric acid; nitric acid / water / Cooling with ice 5: sodium hydroxide / water; tetrahydrofuran / 30 °C / pH Ca. 7 - 14 / Cooling with ice View Scheme |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfuric acid; nitric acid / water / Cooling with ice 2: sodium hydroxide / water; tetrahydrofuran / 30 °C / pH Ca. 7 - 14 / Cooling with ice View Scheme |
dichloro-(tricyclo[3.3.1.13,7]decan-1-yl)acetic acid methyl ester
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sulfuric acid; nitric acid / water / 25 h / 1 °C / Cooling with ice 2.1: sodium hydroxide / water; tetrahydrofuran / 16.7 h / 20 °C 2.2: 5 h / pH 7.4 / Heating View Scheme |
α-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid methyl ester
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.83 h / -60 °C / Inert atmosphere; Cooling with acetone-dry ice 2: sulfuric acid; nitric acid / water / Cooling with ice 3: sodium hydroxide / water; tetrahydrofuran / 30 °C / pH Ca. 7 - 14 / Cooling with ice View Scheme |
α-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: acetyl chloride / 2 h / 0 - 25 °C / Inert atmosphere; Large scale 2: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.83 h / -60 °C / Inert atmosphere; Cooling with acetone-dry ice 3: sulfuric acid; nitric acid / water / Cooling with ice 4: sodium hydroxide / water; tetrahydrofuran / 30 °C / pH Ca. 7 - 14 / Cooling with ice View Scheme |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium / Petroleum ether / 20 °C 1.2: 20 °C / Reflux 1.3: 6 h / Reflux 2.1: potassium permanganate; potassium hydroxide / tert-butyl alcohol / 5 h / 40 °C View Scheme |
3-hydroxyadamantane-1-carboxylic acid
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: thionyl chloride / 6 h / Reflux 2.1: sodium / Petroleum ether / 20 °C 2.2: 20 °C / Reflux 2.3: 6 h / Reflux 3.1: potassium permanganate; potassium hydroxide / tert-butyl alcohol / 5 h / 40 °C View Scheme |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
With NAD; ammonium formate; diothiothreitol In ammonium hydroxide at 40℃; for 38h; pH=8.0; Enzymatic reaction; | 100% |
With glutamate at 37℃; for 0.5h; pH=8; Kinetics; Reagent/catalyst; aq. phosphate buffer; Enzymatic reaction; optical yield given as %ee; | 100% |
With 4-aminomethylphenol; Na(1+)*C20H23N2O4S(1-); sodium hydroxide In water at 40℃; for 12h; Reagent/catalyst; Temperature; enantioselective reaction; | 98.2% |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
ethanol
Conditions | Yield |
---|---|
With acetyl chloride at 5℃; for 3h; Inert atmosphere; Reflux; | 95% |
With thionyl chloride at 0 - 5℃; for 1h; Inert atmosphere; | 90% |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
isopropyl alcohol
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 5℃; for 1h; Inert atmosphere; | 95% |
With acetyl chloride at 5℃; for 3h; Inert atmosphere; Reflux; | 80% |
methanol
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
With acetyl chloride at 5℃; for 3h; Inert atmosphere; Reflux; | 93% |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; sodium hydroxide In water at 0 - 5℃; for 2h; pH=7; | 90% |
With hydroxylamine hydrochloride; sodium hydroxide In water for 4h; Cooling with ice; | 90% |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
With ammonium formate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer In methanol at 50℃; for 24h; Inert atmosphere; | 86% |
With α-transaminase |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
2-methyl-propan-1-ol
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 5℃; for 1h; | 80% |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
isobutene
Conditions | Yield |
---|---|
With sulfuric acid In 1,4-dioxane; dichloromethane at -30 - 20℃; for 20h; Sealed tube; High pressure; | 75% |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
rac-methylbenzylamine
B
acetophenone
Conditions | Yield |
---|---|
With L-2-aminobutyric acid; pyridoxal 5'-phosphate; (S)-selective ω-transaminase from Paracoccus denitrificans; branched-chain aminoacid transaminase In aq. phosphate buffer; hexane at 37℃; for 61h; pH=7; Reagent/catalyst; Enzymatic reaction; enantioselective reaction; | A 62% B n/a |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In acetonitrile at -5 - 15℃; for 1.5h; | 4.38 g |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 1.5 h / -5 - 15 °C 2: hydroxylamine hydrochloride; sodium acetate / water; methanol / 23 h / 40 °C View Scheme |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 1.5 h / -5 - 15 °C 2.1: 3-pyridinecarboxylic acid ethyl ester; trifluoroacetic anhydride / ethyl acetate / 1 h / 0 °C 2.2: 10 - 15 °C 3.1: hydroxylamine hydrochloride / water; methanol / 40 °C View Scheme |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 1.5 h / -5 - 15 °C 2: hydroxylamine hydrochloride; sodium acetate / water; methanol / 23 h / 40 °C 3: hydrogen / methanol View Scheme |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 1.5 h / -5 - 15 °C 2.1: 3-pyridinecarboxylic acid ethyl ester; trifluoroacetic anhydride / ethyl acetate / 1 h / 0 °C 2.2: 10 - 15 °C 3.1: pyridoxamine dihydrochloride; potassium carbonate; cinchonidine / water; methanol / 48 h / 50 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: pyrographite / water / 0.08 h / pH Ca. 8 / Large scale 1.2: 42 h / 40 °C / pH 7.5 - 8 / Large scale 2.1: sodium hydroxide / Isopropyl acetate / 4 h / 20 °C / pH 10 / Large scale 3.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Cooling with acetone-dry ice 3.2: 20 °C 4.1: pyridine; trifluoroacetic anhydride / 0.5 h / Cooling with ice 4.2: 7.55 h / Cooling 5.1: dichloromethane / methanol / 20 °C / Inert atmosphere 6.1: water; dichloromethane View Scheme |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 1.5 h / -5 - 15 °C 2.1: 3-pyridinecarboxylic acid ethyl ester; trifluoroacetic anhydride / ethyl acetate / 1 h / 0 °C 2.2: 10 - 15 °C View Scheme |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetyl chloride / 3 h / 5 °C / Inert atmosphere; Reflux 2: palladium 10% on activated carbon; ammonium formate / ethanol / 40 °C / 4560.31 Torr / Inert atmosphere View Scheme |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetyl chloride / 3 h / 5 °C / Inert atmosphere; Reflux 2: palladium 10% on activated carbon; ammonium formate / ethanol / 40 °C / 4560.31 Torr / Inert atmosphere View Scheme |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetyl chloride / 3 h / 5 °C / Inert atmosphere; Reflux 2: palladium 10% on activated carbon; ammonium formate / ethanol / 40 °C / 4560.31 Torr / Inert atmosphere View Scheme |
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfuric acid / 1,4-dioxane; dichloromethane / 20 h / -30 - 20 °C / Sealed tube; High pressure 2: palladium 10% on activated carbon; ammonium formate / ethanol / 40 °C / 4560.31 Torr / Inert atmosphere View Scheme |
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