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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-(3-Hydroxy-1-adamantyl)-2-oxoacetic acid

Cas:709031-28-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:Whit

2-(3-Hydroxy-1-AdaMantyl)-2-Oxoacetic Acid

Cas:709031-28-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (3-hydroxy-1-adamantyl)(oxo)acetic acid

Cas:709031-28-7

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 709031-28-7 Tricyclo[3.3.1.13,7]decane-1-aceticacid, 3-hydroxy-a-oxo-

Cas:709031-28-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less tha

2-(3-Hydroxy-1-adamantyl)-2-oxoacetic acid

Cas:709031-28-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-(3-Hydroxy-1-adamantyl)-2-oxoacetic acid

Cas:709031-28-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

3-hydroxy- α-oxoadamantane-1-acetic acid Basic information Product Name: 3-hydroxy- α-oxoadamantane-1-acetic acid Synonyms: 3-hydroxy- α-oxoadamantane-1-acetic acid;6.

3-hydroxy- α-oxoadamantane-1-acetic acid

Cas:709031-28-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 709031-28-7 with best quality

Cas:709031-28-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

2-(3-Hydroxy-1-AdaMantyl)-2-Oxoacetic Acid

Cas:709031-28-7

Min.Order:10 Kilogram

FOB Price: $60.0 / 80.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Tricyclo[3.3.1.13,7]decane-1-aceticacid, 3-hydroxy-a-oxo- 709031-28-7

Cas:709031-28-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

3-hydroxy- α-oxoadamantane-1-acetic acid CAS:709031-28-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing i

3-hydroxy- α-oxoadamantane-1-acetic acid CAS:709031-28-7

Cas:709031-28-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Tricyclo[3.3.1.13,7]decane-1-aceticacid, 3-hydroxy-a-oxo-

Cas:709031-28-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Tricyclo[3.3.1.13,7]decane-1-aceticacid, 3-hydroxy-a-oxo-

Cas:709031-28-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

3-hydroxy- α-oxoadamantane-1-acetic acid 709031-28-7

Cas:709031-28-7

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Nanjing Fred Technology Co.,Ltd.

3-hydroxy- α-oxoadamantane-1-acetic acid is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:solid Storage:Room temperature, Keep in Dark Place. Package:Kilograms/MT Application:

3-hydroxy- α-oxoadamantane-1-acetic acid

Cas:709031-28-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-(3-Hydroxy-1-AdaMantyl)-2-Oxoacetic Acid

Cas:709031-28-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3-HYDROXY- Α-OXOADAMANTANE-1-ACETIC ACID

Cas:709031-28-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

2-(3-Hydroxyadamantan-1-yl)-2-oxoacetic acid

Cas:709031-28-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Tricyclo[3.3.1.13,7]decane-1-aceticacid, 3-hydroxy-a-oxo-

Cas:709031-28-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-(3-Hydroxy-1-adamantyl)-2-oxoacetic acid

Cas:709031-28-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

2-(3-Hydroxy-1-AdaMantyl)-2-Oxoacetic Acid

Cas:709031-28-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS No.:709031-28-7 Molecule Formula:C12H16O4 Molecule Weight:224.25 Purity: 98.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard

High Quality 2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid in stock

Cas:709031-28-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

3-hydroxy-α-oxoadamantane-1-aceticacid

Cas:709031-28-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 3-hydroxy- α-oxoadamantane-1-acetic acid Synonyms: 3-hydroxy- α-oxoadamantane-1-acetic acid;6. 3-hydroxy- α-oxoadamantane-1-acetic acid;2-(3-Hydroxy-1-adamantyl)-2-oxoacetic acid;3-Hydroxy-alpha-oxotricyclo[3.

3-hydroxy- α-oxoadamantane-1-acetic acid

Cas:709031-28-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-(3-Hydroxy-1-AdaMantyl)-2-Oxoacetic Acid

Cas:709031-28-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-(3-Hydroxy-1-AdaMantyl)-2-Oxoacetic Acid

Cas:709031-28-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2-(3-Hydroxy-1-AdaMantyl)-2-Oxoacetic Acid

Cas:709031-28-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pudong Int’l A

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediate

3-hydroxy- α-oxoadamantane-1-acetic acid

Cas:709031-28-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2-(3-Hydroxy-1-AdaMantyl)-2-Oxoacetic Acid

Cas:709031-28-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Synthetic route

dichloro-(3-hydroxy-adamantan-1-yl)-acetic acid methyl ester
709031-35-6

dichloro-(3-hydroxy-adamantan-1-yl)-acetic acid methyl ester

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Stage #1: dichloro-(3-hydroxy-adamantan-1-yl)-acetic acid methyl ester With sodium hydroxide In tetrahydrofuran; water at 20℃; for 16.7h;
Stage #2: With hydrogenchloride; sodium hydrogencarbonate In tetrahydrofuran; water for 5h; pH=7.4; Heating;
99.53%
Stage #1: dichloro-(3-hydroxy-adamantan-1-yl)-acetic acid methyl ester With sodium hydroxide In tetrahydrofuran; water at 20℃; for 16h; pH=13.24;
Stage #2: With hydrogenchloride; sodium hydrogencarbonate In tetrahydrofuran; water at 4 - 20℃; for 101.76h; pH=1.4 - 1.77;
86.6%
dichloro-(3-hydroxy-adamantan-1-yl)-acetic

dichloro-(3-hydroxy-adamantan-1-yl)-acetic

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Stage #1: dichloro-(3-hydroxy-adamantan-1-yl)-acetic With sodium hydroxide; sodium hydrogencarbonate In water at 80℃; for 6h; pH=7.22;
Stage #2: With hydrogenchloride In water pH=0.15;
99%
1-hydroxy-3-acetyladamantane
39917-38-9

1-hydroxy-3-acetyladamantane

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
With potassium permanganate; tetrabutylammomium bromide; potassium hydroxide In tert-butyl alcohol at 40℃; for 5h; Reagent/catalyst;91.8%
With potassium permanganate; potassium hydroxide In tert-butyl alcohol at 40℃; for 5h;90%
With potassium permanganate; potassium hydroxide In water; tert-butyl alcohol at 35 - 45℃; for 4.5h;86.6%
3-hydroxy-α-oxotricyclo[3.3.1.13,7]decane-1-acetic acid methyl ester

3-hydroxy-α-oxotricyclo[3.3.1.13,7]decane-1-acetic acid methyl ester

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Stage #1: 3-hydroxy-α-oxotricyclo[3.3.1.13,7]decane-1-acetic acid methyl ester With sodium hydroxide; water In tetrahydrofuran at 5 - 30℃; for 0.5h; pH=7 - 14;
Stage #2: With hydrogenchloride In tetrahydrofuran; water; ethyl acetate pH=0.7;
85%
With sodium hydroxide In tetrahydrofuran; water at 30℃; pH=Ca. 7 - 14; Cooling with ice;
1-acetyladamantane
1660-04-4

1-acetyladamantane

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
With potassium permanganate; potassium hydroxide In water at 90℃;84%
With potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide at 60 - 80℃; for 14.5h;47%
Stage #1: 1-acetyladamantane With sodium hydroxide; potassium permanganate In water at 27 - 55℃; for 24.5 - 25.5h;
Stage #2: In water Product distribution / selectivity; Acidic aqueous solution;
1-acetyladamantane
1660-04-4

1-acetyladamantane

A

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

B

oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid
16091-98-8

oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid

Conditions
ConditionsYield
With potassium permanganate; potassium hydroxide In water at 50 - 80℃; for 12h;A 80%
B 0.8 g
With sodium hydroxide; potassium permanganate In water; tert-butyl alcohol at 50 - 65℃; for 35h; Product distribution / selectivity;
oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid
16091-98-8

oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Stage #1: oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid With sulfuric acid; nitric acid
Stage #2: With hydrogenchloride In water
76%
Stage #1: oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid With sodium hydroxide; potassium permanganate In water at 20 - 60℃; for 11h;
Stage #2: Acidic aqueous solution;
With sodium hydroxide; potassium permanganate In water at 55 - 60℃; for 11h; Product distribution / selectivity;
3-hydroxy-1-adamantyl-glycine

3-hydroxy-1-adamantyl-glycine

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
With ω-transaminase
1-Adamantanecarboxylic acid
828-51-3

1-Adamantanecarboxylic acid

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 25 °C
1.2: 2 h / 25 °C
2.1: tetrahydrofuran / 10 - 20 °C / Inert atmosphere
3.1: potassium permanganate; potassium hydroxide / water / 90 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium permanganate; potassium hydroxide / water; tert-butyl alcohol / 8.5 h / 45 - 60 °C
2.1: thionyl chloride / 6 h / Reflux
3.1: sodium / Petroleum ether / 20 °C
3.2: 20 °C / Reflux
3.3: 6 h / Reflux
4.1: potassium permanganate; potassium hydroxide / tert-butyl alcohol / 5 h / 40 °C
View Scheme
1-Adamantanecarboxylic acid
828-51-3

1-Adamantanecarboxylic acid

A

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

B

oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid
16091-98-8

oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 25 °C
1.2: 2 h / 25 °C
2.1: tetrahydrofuran / 10 - 20 °C / Inert atmosphere
3.1: potassium permanganate; potassium hydroxide / water / 12 h / 50 - 80 °C
View Scheme
(3r,5r,7r)-N-methoxy-N-methyladamantane-1-carboxamide
351464-84-1

(3r,5r,7r)-N-methoxy-N-methyladamantane-1-carboxamide

A

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

B

oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid
16091-98-8

oxo-tricyclo[3.3.1.13,7]decan-1-yl-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran / 10 - 20 °C / Inert atmosphere
2: potassium permanganate; potassium hydroxide / water / 12 h / 50 - 80 °C
View Scheme
1-acetyl-3-chloroadamantane
143467-20-3

1-acetyl-3-chloroadamantane

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium hydroxide / water / 6 h / Reflux
2: potassium hydroxide; potassium permanganate / water; tert-butyl alcohol / 4.5 h / 35 - 45 °C
View Scheme
1-Adamantyl bromide
768-90-1

1-Adamantyl bromide

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: zinc(II) chloride / dichloromethane / 20 °C
2.1: sulfuric acid; nitric acid / water / 25 h / 1 °C / Cooling with ice
3.1: sodium hydroxide / water; tetrahydrofuran / 16.7 h / 20 °C
3.2: 5 h / pH 7.4 / Heating
View Scheme
Multi-step reaction with 5 steps
1: zinc(II) chloride / dichloromethane / 0.08 h / 20 °C / Large scale
2: acetyl chloride / 2 h / 0 - 25 °C / Inert atmosphere; Large scale
3: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.83 h / -60 °C / Inert atmosphere; Cooling with acetone-dry ice
4: sulfuric acid; nitric acid / water / Cooling with ice
5: sodium hydroxide / water; tetrahydrofuran / 30 °C / pH Ca. 7 - 14 / Cooling with ice
View Scheme
α-oxotricyclo[3.3.1.13,7]decane-1-acetic acid methyl ester

α-oxotricyclo[3.3.1.13,7]decane-1-acetic acid methyl ester

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid; nitric acid / water / Cooling with ice
2: sodium hydroxide / water; tetrahydrofuran / 30 °C / pH Ca. 7 - 14 / Cooling with ice
View Scheme
dichloro-(tricyclo[3.3.1.13,7]decan-1-yl)acetic acid methyl ester
709031-34-5

dichloro-(tricyclo[3.3.1.13,7]decan-1-yl)acetic acid methyl ester

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sulfuric acid; nitric acid / water / 25 h / 1 °C / Cooling with ice
2.1: sodium hydroxide / water; tetrahydrofuran / 16.7 h / 20 °C
2.2: 5 h / pH 7.4 / Heating
View Scheme
α-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid methyl ester
128665-98-5

α-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid methyl ester

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.83 h / -60 °C / Inert atmosphere; Cooling with acetone-dry ice
2: sulfuric acid; nitric acid / water / Cooling with ice
3: sodium hydroxide / water; tetrahydrofuran / 30 °C / pH Ca. 7 - 14 / Cooling with ice
View Scheme
α-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid
30074-09-0

α-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetyl chloride / 2 h / 0 - 25 °C / Inert atmosphere; Large scale
2: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.83 h / -60 °C / Inert atmosphere; Cooling with acetone-dry ice
3: sulfuric acid; nitric acid / water / Cooling with ice
4: sodium hydroxide / water; tetrahydrofuran / 30 °C / pH Ca. 7 - 14 / Cooling with ice
View Scheme
3-hydroxy-1-adamantanecarbonyl chloride

3-hydroxy-1-adamantanecarbonyl chloride

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium / Petroleum ether / 20 °C
1.2: 20 °C / Reflux
1.3: 6 h / Reflux
2.1: potassium permanganate; potassium hydroxide / tert-butyl alcohol / 5 h / 40 °C
View Scheme
3-hydroxyadamantane-1-carboxylic acid
42711-75-1

3-hydroxyadamantane-1-carboxylic acid

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / 6 h / Reflux
2.1: sodium / Petroleum ether / 20 °C
2.2: 20 °C / Reflux
2.3: 6 h / Reflux
3.1: potassium permanganate; potassium hydroxide / tert-butyl alcohol / 5 h / 40 °C
View Scheme
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

(αS)-α-amino-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

(αS)-α-amino-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

Conditions
ConditionsYield
With NAD; ammonium formate; diothiothreitol In ammonium hydroxide at 40℃; for 38h; pH=8.0; Enzymatic reaction;100%
With glutamate at 37℃; for 0.5h; pH=8; Kinetics; Reagent/catalyst; aq. phosphate buffer; Enzymatic reaction; optical yield given as %ee;100%
With 4-aminomethylphenol; Na(1+)*C20H23N2O4S(1-); sodium hydroxide In water at 40℃; for 12h; Reagent/catalyst; Temperature; enantioselective reaction;98.2%
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

ethanol
64-17-5

ethanol

2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid ethyl ester

2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid ethyl ester

Conditions
ConditionsYield
With acetyl chloride at 5℃; for 3h; Inert atmosphere; Reflux;95%
With thionyl chloride at 0 - 5℃; for 1h; Inert atmosphere;90%
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

isopropyl alcohol
67-63-0

isopropyl alcohol

2-(3-hydroxy-1-adamantyl)-2-oxo acetic acid isopropyl ester

2-(3-hydroxy-1-adamantyl)-2-oxo acetic acid isopropyl ester

Conditions
ConditionsYield
With thionyl chloride at 0 - 5℃; for 1h; Inert atmosphere;95%
With acetyl chloride at 5℃; for 3h; Inert atmosphere; Reflux;80%
methanol
67-56-1

methanol

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

3-hydroxy-α-oxotricyclo[3.3.1.13,7]decane-1-acetic acid methyl ester

3-hydroxy-α-oxotricyclo[3.3.1.13,7]decane-1-acetic acid methyl ester

Conditions
ConditionsYield
With acetyl chloride at 5℃; for 3h; Inert atmosphere; Reflux;93%
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

2-(3-hydroxy-1-adamantyl)-2-hydroxyiminoacetic acid

2-(3-hydroxy-1-adamantyl)-2-hydroxyiminoacetic acid

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium hydroxide In water at 0 - 5℃; for 2h; pH=7;90%
With hydroxylamine hydrochloride; sodium hydroxide In water for 4h; Cooling with ice;90%
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

3-hydroxy-1-adamantyl-glycine

3-hydroxy-1-adamantyl-glycine

Conditions
ConditionsYield
With ammonium formate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer In methanol at 50℃; for 24h; Inert atmosphere;86%
With α-transaminase
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

2-methyl-propan-1-ol
78-83-1

2-methyl-propan-1-ol

C16H24O4

C16H24O4

Conditions
ConditionsYield
With thionyl chloride at 0 - 5℃; for 1h;80%
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

isobutene
115-11-7

isobutene

tert-butyl 2-(3-hydroxy-1-adamantyl)-2-oxoacetate

tert-butyl 2-(3-hydroxy-1-adamantyl)-2-oxoacetate

Conditions
ConditionsYield
With sulfuric acid In 1,4-dioxane; dichloromethane at -30 - 20℃; for 20h; Sealed tube; High pressure;75%
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

rac-methylbenzylamine
618-36-0

rac-methylbenzylamine

A

(αS)-α-amino-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

(αS)-α-amino-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

B

acetophenone
98-86-2

acetophenone

Conditions
ConditionsYield
With L-2-aminobutyric acid; pyridoxal 5'-phosphate; (S)-selective ω-transaminase from Paracoccus denitrificans; branched-chain aminoacid transaminase In aq. phosphate buffer; hexane at 37℃; for 61h; pH=7; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;A 62%
B n/a
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide

(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide

(1S,3S,5S)-2-(2-(3-hydroxyadamantan-1-yl)-2-oxoacetyl)-2-azabicyclo[3.1.0]hexan-3-carboxamide

(1S,3S,5S)-2-(2-(3-hydroxyadamantan-1-yl)-2-oxoacetyl)-2-azabicyclo[3.1.0]hexan-3-carboxamide

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In acetonitrile at -5 - 15℃; for 1.5h;4.38 g
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

(1S,3S,5S)-2-(2-(3-hydroxyadamantan-1-yl)-2-(hydroxyimino)acetyl)-2-azabicyclo[3.1.0]hexan-3-carboxamide

(1S,3S,5S)-2-(2-(3-hydroxyadamantan-1-yl)-2-(hydroxyimino)acetyl)-2-azabicyclo[3.1.0]hexan-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 1.5 h / -5 - 15 °C
2: hydroxylamine hydrochloride; sodium acetate / water; methanol / 23 h / 40 °C
View Scheme
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

(1S,3S,5S)-2-(2-(3-hydroxyadamantan-1-yl)-2-(hydroxyimino)acetyl)-2-azabicyclo[3.1.0]hexan-3-carbonitrile

(1S,3S,5S)-2-(2-(3-hydroxyadamantan-1-yl)-2-(hydroxyimino)acetyl)-2-azabicyclo[3.1.0]hexan-3-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 1.5 h / -5 - 15 °C
2.1: 3-pyridinecarboxylic acid ethyl ester; trifluoroacetic anhydride / ethyl acetate / 1 h / 0 °C
2.2: 10 - 15 °C
3.1: hydroxylamine hydrochloride / water; methanol / 40 °C
View Scheme
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

(1S,3S,5S)-2-((S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexan-3-carboxamide

(1S,3S,5S)-2-((S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexan-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 1.5 h / -5 - 15 °C
2: hydroxylamine hydrochloride; sodium acetate / water; methanol / 23 h / 40 °C
3: hydrogen / methanol
View Scheme
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

saxagliptin

saxagliptin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 1.5 h / -5 - 15 °C
2.1: 3-pyridinecarboxylic acid ethyl ester; trifluoroacetic anhydride / ethyl acetate / 1 h / 0 °C
2.2: 10 - 15 °C
3.1: pyridoxamine dihydrochloride; potassium carbonate; cinchonidine / water; methanol / 48 h / 50 °C
View Scheme
Multi-step reaction with 6 steps
1.1: pyrographite / water / 0.08 h / pH Ca. 8 / Large scale
1.2: 42 h / 40 °C / pH 7.5 - 8 / Large scale
2.1: sodium hydroxide / Isopropyl acetate / 4 h / 20 °C / pH 10 / Large scale
3.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Cooling with acetone-dry ice
3.2: 20 °C
4.1: pyridine; trifluoroacetic anhydride / 0.5 h / Cooling with ice
4.2: 7.55 h / Cooling
5.1: dichloromethane / methanol / 20 °C / Inert atmosphere
6.1: water; dichloromethane
View Scheme
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

(1S,3S,5S)-2-(2-(3-hydroxyadamantan-1-yl)-2-oxoacetyl)-2-azabicyclo[3.1.0]hexan-3-carbonitrile

(1S,3S,5S)-2-(2-(3-hydroxyadamantan-1-yl)-2-oxoacetyl)-2-azabicyclo[3.1.0]hexan-3-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 1.5 h / -5 - 15 °C
2.1: 3-pyridinecarboxylic acid ethyl ester; trifluoroacetic anhydride / ethyl acetate / 1 h / 0 °C
2.2: 10 - 15 °C
View Scheme
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

C13H21NO3

C13H21NO3

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetyl chloride / 3 h / 5 °C / Inert atmosphere; Reflux
2: palladium 10% on activated carbon; ammonium formate / ethanol / 40 °C / 4560.31 Torr / Inert atmosphere
View Scheme
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

C14H23NO3

C14H23NO3

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetyl chloride / 3 h / 5 °C / Inert atmosphere; Reflux
2: palladium 10% on activated carbon; ammonium formate / ethanol / 40 °C / 4560.31 Torr / Inert atmosphere
View Scheme
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

isopropyl 2-amino-2-(3-hydroxy-1-adamantyl)acetate

isopropyl 2-amino-2-(3-hydroxy-1-adamantyl)acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetyl chloride / 3 h / 5 °C / Inert atmosphere; Reflux
2: palladium 10% on activated carbon; ammonium formate / ethanol / 40 °C / 4560.31 Torr / Inert atmosphere
View Scheme
3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid
709031-28-7

3-hydroxy-α-oxotricyclo [3.3.1.13,7]decane-1-acetic acid

C16H27NO3

C16H27NO3

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid / 1,4-dioxane; dichloromethane / 20 h / -30 - 20 °C / Sealed tube; High pressure
2: palladium 10% on activated carbon; ammonium formate / ethanol / 40 °C / 4560.31 Torr / Inert atmosphere
View Scheme
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