Xi'an Xszo Chem Co., Ltd.
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:71-63-6
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryDayang Chem (Hangzhou) Co.,Ltd.
DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Zhuozhou Wenxi import and Export Co., Ltd
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:71-63-6
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryShanghai Upbio Tech Co.,Ltd
1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ
Cas:71-63-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryQingdao Beluga Import and Export Co., LTD
Digitoxin CAS:71-63-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, ste
Cas:71-63-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryShandong Hanjiang Chemical Co., Ltd.
Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:71-63-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAfine Chemicals Limited
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Chengdu Biopurify Phytochemicals Ltd.
Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medic
Hangzhou Keyingchem Co.,Ltd
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Hangzhou J&H Chemical Co., Ltd.
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:71-63-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
HANGZHOU YUNUO CHEMICAL CO.,LTD
Superior quality, moderate price & quick delivery. Appearance:odorless white or pale buff microcrystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your r
Cas:71-63-6
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryTaiChem Taizhou Limited
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Jiangsu Qianyu Molecular Technology Co., LTD.
Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Golden Pharma Co., Limited
GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
shanghai Tauto Biotech Co., Ltd
The quality is guaranteed. If you find the product is wrong compared with COA, we promise 100% refund or change product. COA and HPLC will be shipped out with goods. You can also inform your analysis method and we will follow your analysis me
Sinoway Industrial Co., Ltd.
Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:API
Shanghai Acmec Biochemical Technology Co., Ltd.
Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea
Cas:71-63-6
Min.Order:1 bottle
Negotiable
Type:Lab/Research institutions
inquiryHenan Allgreen Chemical Co.,Ltd
high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
Xian Changyue Biological Technology Co., Ltd.
best seller Application:API
Wuhan Circle Star Chem-medical Technology co.,Ltd.
1,we produce and sell good chemicals around the world.2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.3,our staff consists of highly qualified in
Hangzhou Huarong Pharm Co., Ltd.
High qualityAppearance:White powder Storage:Room temperature Package:Aluminum bag Application:Used in producing API Transportation:By air Port:Beijing
Antimex Chemical Limied
Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
Cas:71-63-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryDB BIOTECH CO., LTD
best seller Application:API
Hangzhou Fandachem Co.,Ltd
Digitoxin cas 71-63-6Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
Henan Kanbei Chemical Co.,LTD
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Hebei Quanhe Biotechnology Co. LTD
1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta
Taixing Hehao Chemical Materials Co.,Ltd
hight degree of purityAppearance:COA mentioned Storage:COA mentioned Package:Standard or custom package Application:hight degree of purity Transportation:Express/Sea/Air Port:Any port in China
BOC Sciences
BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.Appearanc
Changzhou Helios Biomedical Science and Technology Co.,LTD.
Changzhou Helios Biochemical Co., Ltd is a leading manufacturer and supplier for medical intermediates and pesticide intermediates . We specialize in custom synthesis of benzene ring, pyridine and pyrimidine derivatives to help customers to accelerat
Synthetic route
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57292-22-5
digitoxigen O-[2'',6''-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-O-[3'-O-acetyl-2',6'-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| With lithium hydroxide In methanol; water at 20℃; for 2h; | 83% |
| With lithium hydroxide | 83% |
| With water; lithium hydroxide In methanol at 20℃; for 3h; | 74% |
| With lithium hydroxide |
-
-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| With biocellulase In water at 37℃; for 48h; | 68% |
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-
14912-58-4
(21',23'-epoxy-14'-hydroxy-24'-nor-5'β,14'β-chola-10',22'-dien-3'β-yl) O-<2''',6'''-dideoxy-β-D-ribo-hexopyranosyl>-(1->4)-O-<2'',6''-dideoxy-β-D-ribo-hexopyranosyl>-(1->4)-<2,6-dideoxy-β-D-ribo-hexopyranoside>
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate; sodium acetate; 3-chloro-benzenecarboperoxoic acid 1.) CH2Cl2, RT, 2 h; 2.) THF/MeOH, 3h, RT; Yield given. Multistep reaction; |
| Conditions | Yield |
|---|---|
| With alkaline saponification |
-
-
17575-20-1
Digitoxigenin 3-O-bisdigitoxosideacetyldigilanidobioside, or lanatoside A
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A
-
2280-44-6
D-Glucose
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B
-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| With water; enzyme |
-
-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| mit Hilfe eines Enzym-Praeparats aus Blaettern von Digitalis purpurea; | |
| mit Hilfe eines Enzym-Praeparats aus Blaettern von Digitalis lanata; |
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-
25876-27-1
3"',4"'-di-O-acetyl digitoxin
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| With sodium methylate In methanol | |
| With sodium methylate In methanol |
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-
912454-82-1
tert-butyl ((2S,6R)-6-methyl-5-oxo-5,6-dihydro-2H-pyran-2-yl) carbonate
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: 90 percent / PPh3 / Pd2(DBA)3*CHCl3 / CH2Cl2 / 8 h / 0 °C 2: CeCl3; NaBH4 / methanol / 3 h / -78 °C 3: 89 percent / N-methylmorpholine; Ph3P; diethyl azodicarboxylate / o-nitrobenzenesulfonyl hydrazide / -30 - 20 °C 4: 91 percent / N-methylmorpholine N-oxide; OsO4 / H2O / 3 h / 0 °C 5: 83 percent / LiOH / methanol; H2O / 2 h / 20 °C View Scheme |
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-
912454-95-6
digitoxigen 3-O-acetyl-2,6-dideoxy-4-O-((2'R,6'R)-3',6'-dihydro-6'-methyl-2H-pyran-2'-yl)-β-D-ribo-hexopyranoside
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1.1: 91 percent / N-methylmorpholine N-oxide; OsO4 / H2O / 8 h / 0 °C 2.1: p-TsOH / benzene / 20 °C 2.2: 99 percent / p-TsOH / tetrahydrofuran; H2O 3.1: 90 percent / PPh3 / Pd2(DBA)3*CHCl3 / CH2Cl2 / 8 h / 0 °C 4.1: CeCl3; NaBH4 / methanol / 3 h / -78 °C 5.1: 89 percent / N-methylmorpholine; Ph3P; diethyl azodicarboxylate / o-nitrobenzenesulfonyl hydrazide / -30 - 20 °C 6.1: 91 percent / N-methylmorpholine N-oxide; OsO4 / H2O / 3 h / 0 °C 7.1: 83 percent / LiOH / methanol; H2O / 2 h / 20 °C View Scheme |
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 8 steps 1.1: 82 percent / N-methylmorpholine; Ph3P; diethyl azodicarboxylate / o-nitrobenzenesulfonyl hydrazide / 6 h / -30 - 20 °C 2.1: 91 percent / N-methylmorpholine N-oxide; OsO4 / H2O / 8 h / 0 °C 3.1: p-TsOH / benzene / 20 °C 3.2: 99 percent / p-TsOH / tetrahydrofuran; H2O 4.1: 90 percent / PPh3 / Pd2(DBA)3*CHCl3 / CH2Cl2 / 8 h / 0 °C 5.1: CeCl3; NaBH4 / methanol / 3 h / -78 °C 6.1: 89 percent / N-methylmorpholine; Ph3P; diethyl azodicarboxylate / o-nitrobenzenesulfonyl hydrazide / -30 - 20 °C 7.1: 91 percent / N-methylmorpholine N-oxide; OsO4 / H2O / 3 h / 0 °C 8.1: 83 percent / LiOH / methanol; H2O / 2 h / 20 °C View Scheme |
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-
30788-61-5
digitoxigen O-[2',6'-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside)
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1.1: p-TsOH / benzene / 20 °C 1.2: 99 percent / p-TsOH / tetrahydrofuran; H2O 2.1: 90 percent / PPh3 / Pd2(DBA)3*CHCl3 / CH2Cl2 / 8 h / 0 °C 3.1: CeCl3; NaBH4 / methanol / 3 h / -78 °C 4.1: 89 percent / N-methylmorpholine; Ph3P; diethyl azodicarboxylate / o-nitrobenzenesulfonyl hydrazide / -30 - 20 °C 5.1: 91 percent / N-methylmorpholine N-oxide; OsO4 / H2O / 3 h / 0 °C 6.1: 83 percent / LiOH / methanol; H2O / 2 h / 20 °C View Scheme |
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912454-96-7
digitoxigenin 3''-O-acetyl-2'',6''-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-3'-O-acetyl-2',6'-dideoxy-β-D-ribo-hexopyranoside
-
-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: 90 percent / PPh3 / Pd2(DBA)3*CHCl3 / CH2Cl2 / 8 h / 0 °C 2: CeCl3; NaBH4 / methanol / 3 h / -78 °C 3: 89 percent / N-methylmorpholine; Ph3P; diethyl azodicarboxylate / o-nitrobenzenesulfonyl hydrazide / -30 - 20 °C 4: 91 percent / N-methylmorpholine N-oxide; OsO4 / H2O / 3 h / 0 °C 5: 83 percent / LiOH / methanol; H2O / 2 h / 20 °C View Scheme |
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-
912454-98-9
digitoxigen O-[3'-O-acetyl-2',6'-dideoxy-4'-O-((2''R,6''R)-3'',6''-dihydro-6''-methyl-2H-pyran-2''-yl)-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside)
-
-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 91 percent / N-methylmorpholine N-oxide; OsO4 / H2O / 3 h / 0 °C 2: 83 percent / LiOH / methanol; H2O / 2 h / 20 °C View Scheme | |
| Multi-step reaction with 2 steps 1: 91 percent / N-methyl morpholine N-oxide; OsO4 / CH2Cl2; H2O / 4 h 2: 83 percent / LiOH / methanol; H2O / 2 h / 20 °C View Scheme |
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934021-90-6
digitoxigen O-[3'-O-acetyl-2',6'-dideoxy-4'-O-((2''R,6''R)-5'',6''-dihydro-6''-methyl-5''-hydroxyl-2H-pyran-2''-yl)-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside)
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 89 percent / N-methylmorpholine; Ph3P; diethyl azodicarboxylate / o-nitrobenzenesulfonyl hydrazide / -30 - 20 °C 2: 91 percent / N-methylmorpholine N-oxide; OsO4 / H2O / 3 h / 0 °C 3: 83 percent / LiOH / methanol; H2O / 2 h / 20 °C View Scheme | |
| Multi-step reaction with 3 steps 1: 89 percent / N-methyl morpholine; o-nitrobenzenesulfonyl hydrazide; diethylazodicarboxylate / triphenylphosphine / 5 h / -30 - 20 °C 2: 91 percent / N-methyl morpholine N-oxide; OsO4 / CH2Cl2; H2O / 4 h 3: 83 percent / LiOH / methanol; H2O / 2 h / 20 °C View Scheme |
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912454-97-8
digitoxigen O-[3'-O-acetyl-2',6'-dideoxy-4'-O-((2''R,6''R)-5'',6''-dihydro-6''-methyl-5''-oxo-2H-pyran-2''-yl)-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside)
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: CeCl3; NaBH4 / methanol / 3 h / -78 °C 2: 89 percent / N-methylmorpholine; Ph3P; diethyl azodicarboxylate / o-nitrobenzenesulfonyl hydrazide / -30 - 20 °C 3: 91 percent / N-methylmorpholine N-oxide; OsO4 / H2O / 3 h / 0 °C 4: 83 percent / LiOH / methanol; H2O / 2 h / 20 °C View Scheme |
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222986-40-5
(5R)-1-hydroxy-5-tert-butyldimethylsilanyloxymethyl-5H-pyran-4-(1H)-one
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1: sodium acetate / benzene / 2 h / 80 °C 2: 90 percent / PPh3 / Pd2(DBA)3*CHCl3 / CH2Cl2 / 8 h / 0 °C 3: CeCl3; NaBH4 / methanol / 3 h / -78 °C 4: 89 percent / N-methylmorpholine; Ph3P; diethyl azodicarboxylate / o-nitrobenzenesulfonyl hydrazide / -30 - 20 °C 5: 91 percent / N-methylmorpholine N-oxide; OsO4 / H2O / 3 h / 0 °C 6: 83 percent / LiOH / methanol; H2O / 2 h / 20 °C View Scheme |
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279684-76-3
3,4-bis-(tert-butyldimethylsilyl)-1,5-anhydro-2,6-dideoxy-D-ribo-hex-1-enitol
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 12 steps 1: PPh3; HBr / toluene / 6 h 2: 99 percent / DIBAL / CH2Cl2 / -78 °C 3: 96 percent / DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation 4: Bu4NF / tetrahydrofuran 5: Et3N; DMAP / CH2Cl2 6: 71 percent / PPh3; HBr / toluene / 6 h 7: 98 percent / DIBAL / CH2Cl2 / -78 °C 8: DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation 9: Et3N; DMAP / CH2Cl2 10: PPh3; HBr / CHCl3 11: (NH4)HF2; N-methylpyrrolidine / dimethylformamide / 70 °C 12: NaOMe / methanol View Scheme |
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279684-79-6
(2R,3R,4S)-4-(tert-butyldimethylsiloxy)-hex-5-yne-2,3-diol 2-benzoate ester
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 12 steps 1: PPh3; HBr / toluene / 6 h 2: 99 percent / DIBAL / CH2Cl2 / -78 °C 3: 96 percent / DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation 4: Bu4NF / tetrahydrofuran 5: Et3N; DMAP / CH2Cl2 6: 71 percent / PPh3; HBr / toluene / 6 h 7: 98 percent / DIBAL / CH2Cl2 / -78 °C 8: DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation 9: Et3N; DMAP / CH2Cl2 10: PPh3; HBr / CHCl3 11: (NH4)HF2; N-methylpyrrolidine / dimethylformamide / 70 °C 12: NaOMe / methanol View Scheme |
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279684-92-3
4-O-[3,4-bis-(tert-butyldimethylsilyl)-2,6-dideoxy-β-D-allopyranosyl]-3-(tert-butyldimethylsilyl)-1,5-anhydro-2,6-dideoxy-D-ribo-hex-1-entol
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 9 steps 1: Bu4NF / tetrahydrofuran 2: Et3N; DMAP / CH2Cl2 3: 71 percent / PPh3; HBr / toluene / 6 h 4: 98 percent / DIBAL / CH2Cl2 / -78 °C 5: DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation 6: Et3N; DMAP / CH2Cl2 7: PPh3; HBr / CHCl3 8: (NH4)HF2; N-methylpyrrolidine / dimethylformamide / 70 °C 9: NaOMe / methanol View Scheme |
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279684-91-2
(2R,3R,4S)-3-[(2S,4S,5R,6R)-4,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-tetrahydro-pyran-2-yloxy]-4-(tert-butyl-dimethyl-silanyloxy)-hex-5-yn-2-ol
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 10 steps 1: 96 percent / DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation 2: Bu4NF / tetrahydrofuran 3: Et3N; DMAP / CH2Cl2 4: 71 percent / PPh3; HBr / toluene / 6 h 5: 98 percent / DIBAL / CH2Cl2 / -78 °C 6: DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation 7: Et3N; DMAP / CH2Cl2 8: PPh3; HBr / CHCl3 9: (NH4)HF2; N-methylpyrrolidine / dimethylformamide / 70 °C 10: NaOMe / methanol View Scheme |
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279684-80-9
Benzoic acid (1R,2R,3S)-2-[(2S,4S,5R,6R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-tetrahydro-pyran-2-yloxy]-3-(tert-butyl-dimethyl-silanyloxy)-1-methyl-pent-4-ynyl ester
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 11 steps 1: 99 percent / DIBAL / CH2Cl2 / -78 °C 2: 96 percent / DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation 3: Bu4NF / tetrahydrofuran 4: Et3N; DMAP / CH2Cl2 5: 71 percent / PPh3; HBr / toluene / 6 h 6: 98 percent / DIBAL / CH2Cl2 / -78 °C 7: DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation 8: Et3N; DMAP / CH2Cl2 9: PPh3; HBr / CHCl3 10: (NH4)HF2; N-methylpyrrolidine / dimethylformamide / 70 °C 11: NaOMe / methanol View Scheme |
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 8 steps 1: Et3N; DMAP / CH2Cl2 2: 71 percent / PPh3; HBr / toluene / 6 h 3: 98 percent / DIBAL / CH2Cl2 / -78 °C 4: DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation 5: Et3N; DMAP / CH2Cl2 6: PPh3; HBr / CHCl3 7: (NH4)HF2; N-methylpyrrolidine / dimethylformamide / 70 °C 8: NaOMe / methanol View Scheme |
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389860-84-8
Acetic acid (2R,3R,4S,6S)-3-acetoxy-6-[(2R,3R,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methyl-3,4-dihydro-2H-pyran-3-yloxy]-2-methyl-tetrahydro-pyran-4-yl ester
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1: 71 percent / PPh3; HBr / toluene / 6 h 2: 98 percent / DIBAL / CH2Cl2 / -78 °C 3: DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation 4: Et3N; DMAP / CH2Cl2 5: PPh3; HBr / CHCl3 6: (NH4)HF2; N-methylpyrrolidine / dimethylformamide / 70 °C 7: NaOMe / methanol View Scheme |
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1054632-09-5
(2R,3S,4S,6S)-6-{(2R,3R,4S,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[(2R,3R,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methyl-3,4-dihydro-2H-pyran-3-yloxy]-2-methyl-tetrahydro-pyran-3-yloxy}-2-methyl-tetrahydro-pyran-3,4-diol
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: Et3N; DMAP / CH2Cl2 2: PPh3; HBr / CHCl3 3: (NH4)HF2; N-methylpyrrolidine / dimethylformamide / 70 °C 4: NaOMe / methanol View Scheme |
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation 2: Et3N; DMAP / CH2Cl2 3: PPh3; HBr / CHCl3 4: (NH4)HF2; N-methylpyrrolidine / dimethylformamide / 70 °C 5: NaOMe / methanol View Scheme |
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-
389860-87-1
Acetic acid (2R,3R,4S,6S)-3-acetoxy-6-{(2R,3R,4S,6S)-4-(tert-butyl-dimethyl-silanyloxy)-6-[(2R,3R,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methyl-3,4-dihydro-2H-pyran-3-yloxy]-2-methyl-tetrahydro-pyran-3-yloxy}-2-methyl-tetrahydro-pyran-4-yl ester
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-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: PPh3; HBr / CHCl3 2: (NH4)HF2; N-methylpyrrolidine / dimethylformamide / 70 °C 3: NaOMe / methanol View Scheme |
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-
389860-85-9
Benzoic acid (1R,2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-2-[(2S,4S,5R,6R)-4-(tert-butyl-dimethyl-silanyloxy)-5-((2S,4S,5R,6R)-4,5-diacetoxy-6-methyl-tetrahydro-pyran-2-yloxy)-6-methyl-tetrahydro-pyran-2-yloxy]-1-methyl-pent-4-ynyl ester
-
-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1: 98 percent / DIBAL / CH2Cl2 / -78 °C 2: DABCO / W(CO)6 / tetrahydrofuran / 65 °C / Irradiation 3: Et3N; DMAP / CH2Cl2 4: PPh3; HBr / CHCl3 5: (NH4)HF2; N-methylpyrrolidine / dimethylformamide / 70 °C 6: NaOMe / methanol View Scheme |
-
-
389860-88-2
C57H96O15Si2
-
-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: (NH4)HF2; N-methylpyrrolidine / dimethylformamide / 70 °C 2: NaOMe / methanol View Scheme |
-
-
1512847-02-7
phenyl 3-O-benzyl-4-O-tert-butyldimethylsilyl-2,6-dideoxy-β-D-ribohexapyranosyl-(1→4)-3-O-benzyl-2,6-dideoxy-β-D-ribo-hexapyranosyl-(1→4)-3-O-benzyl-6-deoxy-2-O-methyl-1-thio-α-D-ribohexopyranoside
-
A
-
1512847-12-9
C1′-epi-digitoxin
-
B
-
71-63-6
digitoxin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: lithium 4,4′-di(tert-butyl)biphenyl / tetrahydrofuran / 0.25 h / -20 °C 2: 1H-imidazole / N,N-dimethyl-formamide / 40 h / 20 - 50 °C 3: triphenylphosphine hydrobromide / chloroform / 24 h / 20 °C / Molecular sieve 4: ammonium fluoride-hydrogen fluoride / N,N-dimethyl-formamide; 1-methyl-pyrrolidin-2-one / 144 h / 80 °C View Scheme | |
| Multi-step reaction with 5 steps 1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 40 °C 2: lithium 4,4′-di(tert-butyl)biphenyl / tetrahydrofuran / 0.25 h / -20 °C 3: 1H-imidazole / N,N-dimethyl-formamide / 0.75 h / 20 °C 4: triphenylphosphine hydrobromide / chloroform / 3.17 h / 20 °C / Molecular sieve 5: ammonium fluoride-hydrogen fluoride / N,N-dimethyl-formamide; 1-methyl-pyrrolidin-2-one / 4 h / 70 °C View Scheme |
| Conditions | Yield |
|---|---|
| Stage #1: digitoxin With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine In chloroform at 20℃; for 0.166667h; Stage #2: acetic anhydride In chloroform at 20℃; for 24h; regioselective reaction; | 98% |
| Conditions | Yield |
|---|---|
| Stage #1: digitoxin With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine In chloroform at 20℃; for 0.166667h; Stage #2: 2-Methylpropionic anhydride In chloroform at 20℃; for 24h; regioselective reaction; | 98% |
| Conditions | Yield |
|---|---|
| Stage #1: digitoxin With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine In chloroform at 20℃; for 0.166667h; Stage #2: docosanoic acid anhydride In chloroform at 20℃; for 24h; regioselective reaction; | 96% |
| Conditions | Yield |
|---|---|
| With sulfuric acid In methanol at 0℃; for 5h; | 95% |
| With toluene-4-sulfonic acid In methanol at 20℃; | 79% |
| With hydrogenchloride; ethanol; water |
-
-
25569-97-5
thiophen-2-carboxylic anhydride
-
-
71-63-6
digitoxin
-
-
1250858-22-0
digitoxin 4"'-(thiophene-2-carboxylate)
| Conditions | Yield |
|---|---|
| Stage #1: digitoxin With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine In chloroform at 20℃; for 0.166667h; Stage #2: thiophen-2-carboxylic anhydride In chloroform at 20℃; for 24h; regioselective reaction; | 94% |
| Conditions | Yield |
|---|---|
| Stage #1: digitoxin With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine In chloroform at 20℃; for 0.166667h; Stage #2: β-furan carboxylic anhydride In chloroform at 20℃; for 24h; regioselective reaction; | 93% |
| Conditions | Yield |
|---|---|
| Stage #1: digitoxin With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine In chloroform at 20℃; for 0.166667h; Stage #2: lauric anhydride In chloroform at 20℃; for 24h; regioselective reaction; | 92% |
-
-
71-63-6
digitoxin
-
-
16479-50-8
digitoxigen O-[2',6'-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-(2,6-dideoxy-β-D-ribo-hexopyranoside)
| Conditions | Yield |
|---|---|
| Stage #1: digitoxin With sodium periodate In ethanol; water Stage #2: With sodium tetrahydroborate; ethanol for 4h; Stage #3: With hydrogenchloride In methanol; water | 90% |
| With hydrogenchloride |
| Conditions | Yield |
|---|---|
| Stage #1: digitoxin With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine In chloroform at 20℃; for 0.166667h; Stage #2: palmitic anhydride In chloroform at 20℃; for 24h; regioselective reaction; | 90% |
| Conditions | Yield |
|---|---|
| Stage #1: digitoxin With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine In chloroform at 20℃; for 0.166667h; Stage #2: cinnamic anhydride In chloroform at 20℃; for 24h; regioselective reaction; | 90% |
| Conditions | Yield |
|---|---|
| Stage #1: digitoxin With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine In chloroform at 20℃; for 0.166667h; Stage #2: 4-pentenoic anhydride In chloroform at 20℃; for 24h; regioselective reaction; | 90% |
| Conditions | Yield |
|---|---|
| Stage #1: digitoxin With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine In chloroform at 20℃; for 0.166667h; Stage #2: benzoic acid anhydride In chloroform at 20℃; for 24h; regioselective reaction; | 90% |
-
-
71-63-6
digitoxin
-
-
14912-58-4
(21',23'-epoxy-14'-hydroxy-24'-nor-5'β,14'β-chola-10',22'-dien-3'β-yl) O-<2''',6'''-dideoxy-β-D-ribo-hexopyranosyl>-(1->4)-O-<2'',6''-dideoxy-β-D-ribo-hexopyranosyl>-(1->4)-<2,6-dideoxy-β-D-ribo-hexopyranoside>
| Conditions | Yield |
|---|---|
| 86% | |
| With diisobutylaluminium hydride In tetrahydrofuran at -70℃; for 1h; | 86% |
-
-
97-72-3
2-Methylpropionic anhydride
-
-
71-63-6
digitoxin
-
A
-
1250858-26-4
4"'-O-isobutyryl digitoxin
-
B
-
1250858-29-7
3"',4"'-O-di-isobutyryl digitoxin
| Conditions | Yield |
|---|---|
| Stage #1: digitoxin With 2,4,6-trimethyl-pyridine; dmap In chloroform at -20℃; for 0.166667h; Stage #2: 2-Methylpropionic anhydride In chloroform at -20℃; for 24h; regioselective reaction; | A 80% B 10% |
-
-
71-63-6
digitoxin
-
-
572-09-8
2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide
-
-
1426432-90-7
digitoxigen (2,3,4,6-tetraacetyl-β-D-glucopyranosyl)-(1→4)-(2,6-dideoxy-β-D-ribohexopyranosyl)-(1→4)-(2,6-dideoxy-β-D-ribohexopyranosyl)-(1→4)-2,6-dideoxy-β-D-ribohexopyranoside
| Conditions | Yield |
|---|---|
| With diphenylborate ethanolamine ester; silver(l) oxide In dichloromethane at 20℃; for 20h; Reagent/catalyst; regioselective reaction; | 77% |
| Conditions | Yield |
|---|---|
| With Jones reagent In acetone at 0 - 20℃; for 3h; Jones oxidation; | 75% |
| Multi-step reaction with 2 steps 1: H2O 2: 15 g / CrO3; pyridine / CHCl3 / 10 h / 20 °C View Scheme | |
| With chromium(VI) oxide; sulfuric acid In acetone | |
| With chromium(VI) oxide; sulfuric acid; water In acetone |
-
-
71-63-6
digitoxin
-
-
14227-66-8
acetobromocellobiose
-
-
1426432-96-3
digitoxigen (2,3,4,6-tetracetyl-β-D-glucopyranosyl)-(1→4)-(2,3,6-triacetyl-β-D-glucopyranosyl)-(1→4)-(2,6-dideoxy-β-D-ribohexopyranosyl)-(1→4)-2,6-dideoxy-β-D-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribohexopyranoside
| Conditions | Yield |
|---|---|
| With diphenylborate ethanolamine ester; silver(l) oxide In dichloromethane at 20℃; for 20h; regioselective reaction; | 74% |
-
-
71-63-6
digitoxin
-
-
4-((3S,5R,8R,10S,13R,14S,17R)-14-hydroxy-3-(((2R,4S,5S,6R)-4-hydroxy-5-(((2S,4S,5S,6R)-4-hydroxy-5-(((2S,4S,5R,6R)-5-hydroxy-6-methyl-4-(((R)-1-phenylprop-2-yn-1-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
| Conditions | Yield |
|---|---|
| With 2,6-bis[(4S)-4-methyl-4,5-dihydrooxazol-2-yl]pyridine; tetrakis(acetonitrile)copper(I)tetrafluoroborate; triethylamine; 10-hydroxy-4a,10a-dihydrobenzo[b][1,4]benzoxaborinine In tetrahydrofuran at -20℃; for 24h; | 74% |
-
-
71-63-6
digitoxin
-
-
4-((3S,5R,8R,10S,13R,14S,17R)-14-hydroxy-3-(((2R,4S,5S,6R)-4-hydroxy-5-(((2S,4S,5S,6R)-4-hydroxy-5-(((2S,4S,5S,6R)-4-hydroxy-6-methyl-5-(((S)-1-phenylprop-2-yn-1-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
| Conditions | Yield |
|---|---|
| With tetrakis(acetonitrile)copper(I)tetrafluoroborate; R,R-C5H3N(C3H3NOPh)2; triethylamine; 10-hydroxy-4a,10a-dihydrobenzo[b][1,4]benzoxaborinine In tetrahydrofuran at -20℃; for 24h; | 70% |
-
-
71-63-6
digitoxin
-
-
4-((3S,5R,8R,10S,13R,14S,17R)-3-(((2R,4S,5S,6R)-5-(((2S,4S,5S,6R)-5-(((2S,4S,5S,6R)-5-(((R)-5-(4-benzoylphenoxy)pent-1-yn-3-yl)oxy)-4-hydroxy-6-methyltetrahydro-2Hpyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
| Conditions | Yield |
|---|---|
| With tetrakis(acetonitrile)copper(I)tetrafluoroborate; R,R-C5H3N(C3H3NOPh)2; triethylamine; 10-hydroxy-4a,10a-dihydrobenzo[b][1,4]benzoxaborinine In tetrahydrofuran at 20℃; for 24h; Molecular sieve; | 68% |
-
-
108-24-7
acetic anhydride
-
-
71-63-6
digitoxin
-
A
-
25876-27-1
3"',4"'-di-O-acetyl digitoxin
-
B
-
1264-51-3
4"'-O-acetyl digitoxin
| Conditions | Yield |
|---|---|
| Stage #1: digitoxin With 2,4,6-trimethyl-pyridine; dmap In chloroform at 20℃; for 0.166667h; Stage #2: acetic anhydride In chloroform at 20℃; for 24h; regioselective reaction; | A 18% B 66% |
-
-
71-63-6
digitoxin
-
-
4753-07-5
2,3,6,2',3',4',6'-hepta-O-acetyl-lactosyl bromide
-
-
1426432-95-2
digitoxigen (2,3,4,6-tetracetyl-β-D-galactopyranosyl)-(1→4)-(2,3,6-triacetyl-β-D-glucopyranosyl)-(1→4)-(2,6-dideoxy-β-D-ribohexopyranosyl)-(1→4)-2,6-dideoxy-β-D-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribohexopyranoside
| Conditions | Yield |
|---|---|
| With diphenylborate ethanolamine ester; silver(l) oxide In dichloromethane at 20℃; for 20h; regioselective reaction; | 64% |
| Conditions | Yield |
|---|---|
| With diphenylborate ethanolamine ester; silver(l) oxide In dichloromethane at 20℃; for 20h; regioselective reaction; | 63% |
-
-
16741-27-8
2,3,4-tri-O-acetyl-α-L-fucopyranosyl bromide
-
-
71-63-6
digitoxin
-
-
1426432-94-1
digitoxigen (2,3,4,6-triacetyl-β-L-fucopyranosyl)-(1→4)-(2,6-dideoxy-β-D-ribohexopyranosyl)-(1→4)-(2,6-dideoxy-β-D-ribohexopyranosyl)-(1→4)-2,6-dideoxy-β-D-ribohexopyranoside
| Conditions | Yield |
|---|---|
| With diphenylborate ethanolamine ester; silver(l) oxide In dichloromethane at 20℃; for 20h; regioselective reaction; | 51% |
-
-
71-63-6
digitoxin
-
-
133657-78-0
21-hydroxyiminodigitoxin
| Conditions | Yield |
|---|---|
| With hydrogenchloride; sodium nitrite In methanol | 17% |
-
-
71-63-6
digitoxin
-
-
135613-87-5
3β-
| Conditions | Yield |
|---|---|
| for 96h; Irradiation; | 7.5% |
| Conditions | Yield |
|---|---|
| With acetic anhydride |
-
-
108-24-7
acetic anhydride
-
-
71-63-6
digitoxin
-
-
13238-31-8
14-hydroxy-3β-(tetra-O-acetyl-lin-tri[1β=>4]-D-ribo-2,6-dideoxy-hexopyranosyloxy)-5β,14β-card-20(22)-enolide
| Conditions | Yield |
|---|---|
| With pyridine | |
| In pyridine at 85℃; for 5h; | 590 mg |
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