100% owned factory, regulatory compliance and be audited. Shandong Shining Pharm:Provincial chemical industry park(the first batch of certified park in Shandong Province), raw material and intermediate production base. Bromination, high pressure, hig
Cas:856866-72-3
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:856866-72-3
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
Cas:856866-72-3
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryTorezolid CAS No.:856866-72-3 Name: Torezolid Synonyms: 3-[3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-(hydroxymethyl)-2-oxazolidinone Molecular Structure Molecular Formula:
Cas:856866-72-3
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:856866-72-3
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Cas:856866-72-3
Min.Order:1 Kilogram
FOB Price: $5.0 / 10.0
Type:Manufacturers
inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less
Cas:856866-72-3
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:856866-72-3
Min.Order:1 Kilogram
FOB Price: $70.0 / 90.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:856866-72-3
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:856866-72-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryTorezolid CAS:856866-72-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:856866-72-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:856866-72-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:856866-72-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:856866-72-3
Min.Order:100 Milligram
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
ProName: Torezolid CAS NO.856866-72-3 CasNo: 856866-72-3 Molecular Formula: C17H15FN6O3 Appearance: crystal, powder Application: Pharmaceutical intermediates DeliveryTime: 1-2 days PackAge: as your request Port: Qingdao port ProductionCapac
Cas:856866-72-3
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:856866-72-3
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech bio chemical products enterprises. The company's sales and marketing division is located in Shanghai, serving
Cas:856866-72-3
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:856866-72-3
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:856866-72-3
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Product name: Tedizolid CAS No.:856866-72-3 Molecule Formula:C17H15FN6O3 Molecule Weight:370.34 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPE
Cas:856866-72-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:856866-72-3
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
Cas:856866-72-3
Min.Order:1 Gram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
With cesium fluoride In tetrahydrofuran at 20℃; for 1h; | 99% |
3-fluoro-4-(6-(2-methyl-2H-tetrazole-5-yl)pyridin-3-yl)phenyl-carbamic acid benzylester
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tert.-butyl lithium; (R)-glycidyl butyrate In tetrahydrofuran at 0 - 30℃; for 15h; Reagent/catalyst; Large scale; | 95% |
3-fluoro-4-(6-(2-methyl-2H-tetrazole-5-yl)pyridin-3-yl)phenyl-carbamic acid benzylester
(R)-glycidyl butyrate
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Stage #1: 3-fluoro-4-(6-(2-methyl-2H-tetrazole-5-yl)pyridin-3-yl)phenyl-carbamic acid benzylester With potassium tert-butylate; lithium tert-butoxide In tetrahydrofuran; acetonitrile at 25℃; for 2h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; acetonitrile for 3h; | 86.7% |
Stage #1: 3-fluoro-4-(6-(2-methyl-2H-tetrazole-5-yl)pyridin-3-yl)phenyl-carbamic acid benzylester With lithium hexamethyldisilazane In tetrahydrofuran at 20℃; for 1.41667h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone In tetrahydrofuran at 20℃; for 15h; Inert atmosphere; cooling with ice; | 85% |
Stage #1: 3-fluoro-4-(6-(2-methyl-2H-tetrazole-5-yl)pyridin-3-yl)phenyl-carbamic acid benzylester With lithium hexamethyldisilazane In tetrahydrofuran at 10 - 15℃; for 2h; Inert atmosphere; Large scale; Stage #2: (R)-glycidyl butyrate With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone In tetrahydrofuran at 0 - 15℃; Inert atmosphere; Large scale; | 84.4% |
2-(2-methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
(5R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
With palladium diacetate; potassium carbonate; triphenylphosphine In 1,4-dioxane at 20℃; Reagent/catalyst; Solvent; Temperature; Reflux; Inert atmosphere; | 84% |
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; tricyclohexylphosphine In 1,4-dioxane; water for 4h; Reagent/catalyst; Solvent; Suzuki Coupling; Inert atmosphere; Reflux; | 78% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; toluene for 12h; Solvent; Reflux; Inert atmosphere; | 63.7% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate Suzuki Coupling; | |
Stage #1: 2-(2-methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane at 60℃; for 5h; Suzuki Coupling; Inert atmosphere; Large scale; Stage #2: With L-Cysteine; triethylamine at 60℃; for 16h; Inert atmosphere; Darkness; Large scale; |
(5R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one
5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Stage #1: (R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; bis(pinacol)diborane In dimethyl sulfoxide at 80℃; for 14h; Inert atmosphere; Stage #2: 5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate In 1,4-dioxane; water at 70℃; for 3h; Inert atmosphere; | 83% |
(5R)-3-(3-fluoro-4-iodo-phenyl)-5-hydroxymethyl-1,3-oxazolidin-2-one
2-(2-methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
With palladium diacetate; potassium carbonate In water; N,N-dimethyl-formamide at 90℃; for 6h; Catalytic behavior; Reagent/catalyst; Temperature; Suzuki Coupling; Sealed tube; Inert atmosphere; Green chemistry; | 77.6% |
5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium chloride In N,N-dimethyl-formamide at 90℃; for 4h; Temperature; Reagent/catalyst; | 48% |
With lithium chloride; bis-triphenylphosphine-palladium(II) chloride In 1-methyl-pyrrolidin-2-one at 20 - 120℃; for 4h; | 26% |
With bis-triphenylphosphine-palladium(II) chloride; lithium chloride In 1-methyl-pyrrolidin-2-one at 120℃; for 4h; Stille coupling; Inert atmosphere; | 26% |
With bis-triphenylphosphine-palladium(II) chloride; lithium chloride at 120℃; for 4h; |
2,5-dibromopyridine
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium cyanide / N,N-dimethyl-formamide / 7 h / 150 °C / Inert atmosphere 2: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3 h / 110 °C / Inert atmosphere 3: sodium hydroxide / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere 4: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C / Inert atmosphere View Scheme |
2-Cyano-5-bromopyridine
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3 h / 110 °C / Inert atmosphere 2: sodium hydroxide / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere 3: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C / Inert atmosphere View Scheme |
meta-fluoroaniline
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium hydrogencarbonate / tetrahydrofuran / 2 h / 0 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere 2.2: 26 h / -78 - 20 °C / Inert atmosphere 3.1: N-iodo-succinimide; trifluoroacetic acid / 3 h / 20 °C 4.1: potassium carbonate; palladium diacetate / N,N-dimethyl-formamide; water / 6 h / 90 °C / Sealed tube; Inert atmosphere; Green chemistry View Scheme | |
Multi-step reaction with 5 steps 1: ethanol / 12 h / Reflux 2: triethylamine / N,N-dimethyl-formamide / 4 h / 65 °C 3: trifluorormethanesulfonic acid; N-iodo-succinimide / dichloromethane / 2 h / 0 °C 4: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 4 h 5: lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 4 h / 90 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: sodium hydrogencarbonate / dichloromethane / 20 - 25 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -65 - -60 °C / Inert atmosphere 2.2: 20 h / -65 - 25 °C / Inert atmosphere 3.1: trifluoroacetic acid; N-iodo-succinimide / 0.17 h / 20 - 25 °C 3.2: 4 h / 20 - 25 °C 4.1: dmap / toluene / 7 h / 45 - 50 °C 5.1: tris-(o-tolyl)phosphine; potassium carbonate / dimethyl sulfoxide / 20 - 25 °C / Inert atmosphere 5.2: 5.17 h / 20 - 85 °C / Inert atmosphere 6.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 4 h / 95 - 100 °C / Inert atmosphere 7.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 5 h / 20 - 25 °C / Inert atmosphere 7.2: 3 h / 20 - 25 °C View Scheme |
N-(carbobenzyloxy)-3-fluoroaniline
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere 1.2: 26 h / -78 - 20 °C / Inert atmosphere 2.1: N-iodo-succinimide; trifluoroacetic acid / 3 h / 20 °C 3.1: potassium carbonate; palladium diacetate / N,N-dimethyl-formamide; water / 6 h / 90 °C / Sealed tube; Inert atmosphere; Green chemistry View Scheme |
(5R)-3-(3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-iodo-succinimide; trifluoroacetic acid / 3 h / 20 °C 2: potassium carbonate; palladium diacetate / N,N-dimethyl-formamide; water / 6 h / 90 °C / Sealed tube; Inert atmosphere; Green chemistry View Scheme | |
Multi-step reaction with 3 steps 1: trifluorormethanesulfonic acid; N-iodo-succinimide / dichloromethane / 2 h / 0 °C 2: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 4 h 3: lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 4 h / 90 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: trifluoroacetic acid; N-iodo-succinimide / 0.17 h / 20 - 25 °C 1.2: 4 h / 20 - 25 °C 2.1: dmap / toluene / 7 h / 45 - 50 °C 3.1: tris-(o-tolyl)phosphine; potassium carbonate / dimethyl sulfoxide / 20 - 25 °C / Inert atmosphere 3.2: 5.17 h / 20 - 85 °C / Inert atmosphere 4.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 4 h / 95 - 100 °C / Inert atmosphere 5.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 5 h / 20 - 25 °C / Inert atmosphere 5.2: 3 h / 20 - 25 °C View Scheme |
5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Sealed tube; Inert atmosphere 2: potassium carbonate; palladium diacetate / N,N-dimethyl-formamide; water / 6 h / 90 °C / Sealed tube; Inert atmosphere; Green chemistry View Scheme | |
Multi-step reaction with 2 steps 1.1: tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate / tetrahydrofuran / 20 - 70 °C / Inert atmosphere; Large scale 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 10 - 15 °C / Inert atmosphere; Large scale 2.2: 0 - 15 °C / Inert atmosphere; Large scale View Scheme | |
Multi-step reaction with 2 steps 1.1: tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine; potassium carbonate / 1,4-dioxane; water / 1 h / 70 °C / Inert atmosphere 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 10 - 15 °C / Inert atmosphere; Large scale 2.2: 0 - 15 °C / Inert atmosphere; Large scale View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium acetate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 4 h / 70 °C / Inert atmosphere; Large scale 2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,4-dioxane / 5 h / 60 °C / Inert atmosphere; Large scale 2.2: 16 h / 60 °C / Inert atmosphere; Darkness; Large scale View Scheme |
(3-fluoro-phenyl)-carbamic acid methyl ester
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -65 - -60 °C / Inert atmosphere 1.2: 20 h / -65 - 25 °C / Inert atmosphere 2.1: trifluoroacetic acid; N-iodo-succinimide / 0.17 h / 20 - 25 °C 2.2: 4 h / 20 - 25 °C 3.1: dmap / toluene / 7 h / 45 - 50 °C 4.1: tris-(o-tolyl)phosphine; potassium carbonate / dimethyl sulfoxide / 20 - 25 °C / Inert atmosphere 4.2: 5.17 h / 20 - 85 °C / Inert atmosphere 5.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 4 h / 95 - 100 °C / Inert atmosphere 6.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 5 h / 20 - 25 °C / Inert atmosphere 6.2: 3 h / 20 - 25 °C View Scheme |
(5R)-3-(3-fluoro-4-iodo-phenyl)-5-hydroxymethyl-1,3-oxazolidin-2-one
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: dmap / toluene / 7 h / 45 - 50 °C 2.1: tris-(o-tolyl)phosphine; potassium carbonate / dimethyl sulfoxide / 20 - 25 °C / Inert atmosphere 2.2: 5.17 h / 20 - 85 °C / Inert atmosphere 3.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 4 h / 95 - 100 °C / Inert atmosphere 4.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 5 h / 20 - 25 °C / Inert atmosphere 4.2: 3 h / 20 - 25 °C View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: tris-(o-tolyl)phosphine; potassium carbonate / dimethyl sulfoxide / 20 - 25 °C / Inert atmosphere 1.2: 5.17 h / 20 - 85 °C / Inert atmosphere 2.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 4 h / 95 - 100 °C / Inert atmosphere 3.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 5 h / 20 - 25 °C / Inert atmosphere 3.2: 3 h / 20 - 25 °C View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 4 h / 95 - 100 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 5 h / 20 - 25 °C / Inert atmosphere 2.2: 3 h / 20 - 25 °C View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Stage #1: tert-butyl [(5R)-3-{3-fluoro-4-[6-(2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl carbonate With triphenylphosphine; diethylazodicarboxylate In dichloromethane at 20 - 25℃; for 5h; Inert atmosphere; Stage #2: With trifluoroacetic acid In dichloromethane at 20 - 25℃; for 3h; Further stages; |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylamine / N,N-dimethyl-formamide / 4 h / 65 °C 2: trifluorormethanesulfonic acid; N-iodo-succinimide / dichloromethane / 2 h / 0 °C 3: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 4 h 4: lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 4 h / 90 °C View Scheme |
(5R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 1H-imidazole / N,N-dimethyl-formamide / 6 h / 60 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C 2.2: 0.5 h 3.1: bis[2-(diphenylphosphino)phenyl] ether; bis(1,5-cyclooctadiene)nickel (0) / tetrahydrofuran; hexane / 12 h / 20 °C 4.1: cesium fluoride / tetrahydrofuran / 1 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 1H-imidazole / N,N-dimethyl-formamide / 6 h / 60 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C 2.2: 0.5 h 3.1: bis[2-(diphenylphosphino)phenyl] ether; bis(1,5-cyclooctadiene)nickel (0) / tetrahydrofuran; hexane / 12 h / 20 °C 4.1: cesium fluoride / tetrahydrofuran / 1 h / 20 °C View Scheme |
(R)-3-(4-bromo-3-fluoro-phenyl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-oxazolidin-2-one
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C 1.2: 0.5 h 2.1: bis[2-(diphenylphosphino)phenyl] ether; bis(1,5-cyclooctadiene)nickel (0) / tetrahydrofuran; hexane / 12 h / 20 °C 3.1: cesium fluoride / tetrahydrofuran / 1 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C 1.2: 0.5 h 2.1: bis[2-(diphenylphosphino)phenyl] ether; bis(1,5-cyclooctadiene)nickel (0) / tetrahydrofuran; hexane / 12 h / 20 °C 3.1: cesium fluoride / tetrahydrofuran / 1 h / 20 °C View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: bis[2-(diphenylphosphino)phenyl] ether; bis(1,5-cyclooctadiene)nickel (0) / tetrahydrofuran; hexane / 12 h / 20 °C 2: cesium fluoride / tetrahydrofuran / 1 h / 20 °C View Scheme |
2-fluoro-4-(benzyloxycarbonyl)aminophenylboronic acid
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine; potassium carbonate / 1,4-dioxane; water / 1 h / 70 °C / Inert atmosphere 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 10 - 15 °C / Inert atmosphere; Large scale 2.2: 0 - 15 °C / Inert atmosphere; Large scale View Scheme |
(4-bromo-3-fluorophenyl)carbamic acid benzyl ester
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 10 - 15 °C / Inert atmosphere 2.1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 35 - 85 °C / Inert atmosphere 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 10 - 15 °C / Inert atmosphere; Large scale 3.2: 0 - 15 °C / Inert atmosphere; Large scale View Scheme | |
Multi-step reaction with 3 steps 1.1: cobaltocene / tetrahydrofuran / 20 - 30 °C / Inert atmosphere; Large scale 2.1: tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate / tetrahydrofuran / 20 - 70 °C / Inert atmosphere; Large scale 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 10 - 15 °C / Inert atmosphere; Large scale 3.2: 0 - 15 °C / Inert atmosphere; Large scale View Scheme | |
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran / -75 - -70 °C / Inert atmosphere; Cooling with acetone-dry ice 1.2: Inert atmosphere 2.1: tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine; potassium carbonate / 1,4-dioxane; water / 1 h / 70 °C / Inert atmosphere 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 10 - 15 °C / Inert atmosphere; Large scale 3.2: 0 - 15 °C / Inert atmosphere; Large scale View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate / tetrahydrofuran / 20 - 70 °C / Inert atmosphere; Large scale 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 10 - 15 °C / Inert atmosphere; Large scale 2.2: 0 - 15 °C / Inert atmosphere; Large scale View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
With triethylamine; trichlorophosphate In tetrahydrofuran at 0℃; for 3h; | 97% |
Stage #1: (5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one With triethylamine; trichlorophosphate In tetrahydrofuran at 0 - 2.2℃; for 3.73333h; Stage #2: With water In tetrahydrofuran at 11.9℃; for 1h; cooling with ice/salt; | 96% |
Stage #1: (5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one With triethylamine In tetrahydrofuran at 0℃; Stage #2: With trichlorophosphate In tetrahydrofuran at 1 - 2℃; for 3h; | 84.8% |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 95% |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
benzyl alcohol
Conditions | Yield |
---|---|
Stage #1: (5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one With N-ethyl-N,N-diisopropylamine; trichlorophosphate In tetrahydrofuran at 0 - 20℃; for 4h; Stage #2: benzyl alcohol With N-ethyl-N,N-diisopropylamine at 0 - 20℃; for 8h; | 84% |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
dibenzyl N,N-diisopropylphosphoroamidate
Conditions | Yield |
---|---|
Stage #1: (5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one; dibenzyl N,N-diisopropylphosphoroamidate With 1H-tetrazole In dichloromethane at 25 - 30℃; for 0.5h; Stage #2: With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 5 - 10℃; for 0.5h; | 83.1% |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
methanesulfonyl chloride
(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(methanesulfonyloxymethyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 0.5h; | 82% |
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; | 82% |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
Conditions | Yield |
---|---|
Stage #1: (5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one With sodium hydride In tetrahydrofuran at 20℃; for 5h; Inert atmosphere; Cooling with ice; Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran at 20℃; for 10h; Inert atmosphere; | 82% |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide at 80℃; for 3h; | 81% |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
With diethylamino-sulfur trifluoride; triethylamine In dichloromethane at 20℃; for 24h; Inert atmosphere; | 75% |
With diethylamino-sulfur trifluoride; triethylamine In dichloromethane for 24h; |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
di-tert-butyl diisopropylphosphoramide
Conditions | Yield |
---|---|
Stage #1: (5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one; di-tert-butyl diisopropylphosphoramide With 1H-tetrazole In tetrahydrofuran; dichloromethane at 20℃; for 15h; Stage #2: With 3-chloro-benzenecarboperoxoic acid In tetrahydrofuran; dichloromethane at -78℃; for 4h; | 71% |
Stage #1: (5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one; di-tert-butyl diisopropylphosphoramide With 1H-tetrazole In tetrahydrofuran; dichloromethane at 20℃; for 15h; Stage #2: With 3-chloro-benzenecarboperoxoic acid In tetrahydrofuran; dichloromethane at -78℃; for 2h; | 68% |
Stage #1: (5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one; di-tert-butyl diisopropylphosphoramide With 1H-tetrazole In tetrahydrofuran; dichloromethane at 20 - 25℃; for 16h; Stage #2: With 3-chloro-benzenecarboperoxoic acid In tetrahydrofuran; dichloromethane at -70 - 25℃; for 2h; |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
isoxazol-3-ol
(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(isoxazol-3-yl)oxymethyloxazolidin-2-one
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 12h; Mitsunobu reaction; Inert atmosphere; | 51% |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
C34H29F2N12O8P
Conditions | Yield |
---|---|
With triethylamine; trichlorophosphate In tetrahydrofuran at 20 - 25℃; for 16h; Inert atmosphere; | 20% |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
BOC-glycine
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In DMF (N,N-dimethyl-formamide) at 20℃; for 10h; | |
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 10h; Inert atmosphere; |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethyl phosphate; trichlorophosphate / 2 h / 20 °C / Inert atmosphere 2: sodium methylate / methanol / 2 h / 20 °C / Inert atmosphere View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: methanol / 24 h / 20 °C / Inert atmosphere View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide / 30 h / 60 °C / Inert atmosphere View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 48 h / 20 °C / Inert atmosphere View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
A
(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-([1,2,3]triazol-1-yl)methyloxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 48 h / 20 °C / Inert atmosphere View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(azidomethyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
(S)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-(aminomethyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere 3: 10% palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
(S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)-2-methoxyacetamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere 3: 10% palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C 4: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
(S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)furan-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere 3: 10% palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C 4: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
(S)-N-((3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-oxazolidin-5-yl)methyl)thiopene-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere 3: 10% palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C 4: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one
(S)-2-(benzyloxy)-N-((3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere 3: 10% palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C 4: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View