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inquiryHigh quality 5-Bromo-2-pyridinecarbonitrile CAS 97483-77-7 with factory price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, F
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inquiry5-Bromo-2-pyridinecarbonitrile CAS No.:97483-77-7 Name: 5-Bromo-2-pyridinecarbonitrile Synonyms: 5-Bromo-2-cyanopyridine Molecular Structure Molecular Formula: C6
Cas:97483-77-7
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inquiryvT he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:White or
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:97483-77-7
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:97483-77-7
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryDensity: 1.72 ± 0.1 g/cm3 (Predicted) Melting point: 128-132 ° C (lit.) Boiling point: 100-110 ° C/3 mmHg (lit.) Flash point: 111.2 ° C Steam pressure: 0.0124mmHg at 25 ° C Solubility in dichloromethane, ether, ethyl acetate an
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
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inquiryName: 5-Bromo-2-cyanopyridine Molecular Formula:C6H3BrN2 Molecular Weight:183.01 CAS No.:97483-77-7 Appearance:Similar White To Slight Brown Powder Appearance:Similar White To Slight Brown Powder Storage: Store in cool and dry place, away from
Appearance:White to Light yellow to Light orange powder Storage:room temperature Package:25kg/drum Application:5-Bromo-2-pyridinecarbonitrile can be used in the synthesis of aza-terphenyl diamidine analogs, which exhibits potent antiprotozoal activ
Cas:97483-77-7
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White powder Storage:Store in sealed containers at cool & dr
Cas:97483-77-7
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Cas:97483-77-7
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1744.html Product Name 5-Bromo-2-pyridinecarbonitrile
Cas:97483-77-7
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inquiry5-Bromo-2-pyridinecarbonitrile CAS:97483-77-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality or
Cas:97483-77-7
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By Se
Cas:97483-77-7
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:97483-77-7
Min.Order:1 Gram
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:97483-77-7
Min.Order:4 Kilogram
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inquiry5-bromo-pyridine-2-carbaldehyde
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
With ammonium hydroxide; iodine In tetrahydrofuran at 20℃; for 4h; | 100% |
With ammonia; iodine In tetrahydrofuran; water at 20℃; for 0.25h; | 85% |
3-bromopyridine N-oxide
trimethylsilyl cyanide
A
3-bromopyridine-2-carbonitrile
B
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
With triethylamine In acetonitrile for 4h; Heating; | A 86% B 9% |
With triethylamine In acetonitrile for 4h; Product distribution / selectivity; Reflux; | |
With triethylamine In acetonitrile for 4h; Heating / reflux; |
Conditions | Yield |
---|---|
In sulfolane at 160℃; for 6h; Temperature; Solvent; | 83% |
In N,N-dimethyl-formamide at 150℃; for 7h; | 70% |
P-toluenesulfonyl cyanide
2-iodo-5-bromopyridine
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
Stage #1: 2-iodo-5-bromopyridine With isopropylmagnesium chloride In tetrahydrofuran; dichloromethane at 0℃; for 0.75h; Stage #2: P-toluenesulfonyl cyanide In tetrahydrofuran; dichloromethane at 20℃; for 2h; | 82% |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 110 - 120℃; for 12h; | 74% |
With sodium cyanide In N,N-dimethyl-formamide for 3h; Heating; | 65% |
In 1-methyl-pyrrolidin-2-one at 110℃; for 20h; | 28% |
In 1-methyl-pyrrolidin-2-one at 110℃; for 20h; | 28% |
2,5-dibromopyridine
sodium cyanide
copper(I) cyanide
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
In DMF (N,N-dimethyl-formamide) at 20 - 150℃; for 7h; | 70% |
Conditions | Yield |
---|---|
With sodium cyanide In N,N-dimethyl-formamide at 150℃; for 7h; Inert atmosphere; | 70% |
3-Bromopyridine
trimethylsilyl cyanide
A
3-bromopyridine-2-carbonitrile
B
3-bromo-4-cyanopyridine
C
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
Stage #1: 3-Bromopyridine With trifluoromethylsulfonic anhydride In chloroform at 20℃; for 1h; Inert atmosphere; Sealed tube; Stage #2: trimethylsilyl cyanide In chloroform at 60℃; for 3h; Inert atmosphere; Sealed tube; Stage #3: With 4-methyl-morpholine In chloroform at 60℃; for 17h; Inert atmosphere; Sealed tube; Overall yield = 79 %; | A 13% B 55% C 11% |
Conditions | Yield |
---|---|
With copper(l) cyanide In N,N-dimethyl-formamide at 150℃; for 5h; | 53% |
2,5-dibromopyridine
sodium cyanide
copper(I) cyanide
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 150℃; for 5h; | 53% |
Conditions | Yield |
---|---|
In 1-methyl-pyrrolidin-2-one at 110℃; for 20h; | 28% |
In 1-methyl-pyrrolidin-2-one at 110℃; for 20h; | 28% |
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
With trichlorophosphate In toluene at 110℃; for 5h; |
2,5-dibromopyridine
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
With zinc In ethyl acetate; N,N-dimethyl-formamide |
2,5-dibromopyridine
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 85 percent / NaI; AcCl / acetonitrile / 3 h / Heating 2.1: iPrMgCl / CH2Cl2; tetrahydrofuran / 0.75 h / 0 °C 2.2: 82 percent / CH2Cl2; tetrahydrofuran / 2 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: n-butyllithium / toluene / 2 h / -78 °C 1.2: toluene / 1 h / -78 °C 2.1: POCl3 / toluene / 5 h / 110 °C View Scheme | |
In N-methyl-acetamide | |
With zinc(II) cyanide; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In DMF (N,N-dimethyl-formamide) for 5h; Heating / reflux; |
Conditions | Yield |
---|---|
With zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In dichloromethane; N,N-dimethyl-formamide for 5h; Heating / reflux; | |
tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 135℃; for 0.25h; microwave irradiation; |
5-bromoisonicotinic acid
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: thionyl chloride / 3 h / Reflux 1.2: 20 °C / Cooling with ice 2.1: trichlorophosphate / toluene / 2 h / Reflux 2.2: pH 12 / Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1.1: thionyl chloride / 3 h / Reflux 1.2: Cooling with ice 2.1: trichlorophosphate / toluene / 2 h / Reflux View Scheme |
5-bromo-2-pyridinecarboxamide
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
Stage #1: 5-bromo-2-pyridinecarboxamide With trichlorophosphate In toluene for 2h; Reflux; Stage #2: With sodium hydroxide pH=12; Cooling with ice; | |
With trichlorophosphate In toluene for 2h; Reflux; | 43.6 g |
2-Cyano-5-bromopyridine
2-cyano-5-iodopyridine
Conditions | Yield |
---|---|
With copper(l) iodide; sodium iodide; N,N`-dimethylethylenediamine at 110℃; for 24h; Finkelstein reaction; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 20 - 50℃; | 100% |
With 1-methyl-pyrrolidin-2-one; potassium carbonate at 50℃; for 0.5h; | 100% |
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 20 - 50℃; | 100% |
2-Cyano-5-bromopyridine
sodium thiomethoxide
5-(methylsulfanyl)pyridine-2-carbonitrile
Conditions | Yield |
---|---|
With potassium carbonate In 1-methyl-pyrrolidin-2-one | 99% |
With potassium carbonate In 1-methyl-pyrrolidin-2-one | 99% |
With sodium t-butanolate In water; acetonitrile at 0 - 20℃; for 16h; |
tert-butyl 2-[(R)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate
2-Cyano-5-bromopyridine
tert-butyl 2-[(R)-5-(6-cyanopyridin-3-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water Suzuki Coupling; Inert atmosphere; Heating; | 99% |
Conditions | Yield |
---|---|
With hydrogen bromide at 0 - 25℃; for 16h; | 99% |
Conditions | Yield |
---|---|
With hydrogenchloride at -20 - 0℃; for 16h; | 99% |
Conditions | Yield |
---|---|
With hydrogenchloride at -5 - 5℃; for 16h; | 99% |
2-Cyano-5-bromopyridine
5-bromo-N-hydroxypyridine-2-carboxamidine
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; potassium tert-butylate In dimethyl sulfoxide at 20℃; | 98% |
With sodium hydroxide; hydroxylamine hydrochloride In ethanol; water at 60 - 65℃; for 16h; | 64% |
2-Cyano-5-bromopyridine
6-chloropyridin-3-ylboronic acid
5-(2'-chloropyridin-5'-yl)-2-pyridinecarbonitrile
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In methanol; water; toluene at 80℃; Suzuki coupling; Inert atmosphere; | 98% |
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 100℃; | 98% |
With caesium carbonate In N,N-dimethyl-formamide at 100℃; | 19 g |
4-methoxyphenylboronic acid
2-Cyano-5-bromopyridine
4-(2-Cyano-5-pyridyl)anisole
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium acetate In tetrahydrofuran; water at 80℃; for 18h; Inert atmosphere; | 98% |
2-Cyano-5-bromopyridine
trimethylsilylacetylene
5-[(trimethylsilyl)ethynyl]pyridine-2-carbonitrile
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine In tetrahydrofuran at 50℃; for 5h; Inert atmosphere; | 96% |
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 20℃; for 24h; Sonogashira coupling; Inert atmosphere; | 86% |
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 95℃; for 16h; Buchwald-Hartwig Coupling; | 96% |
diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
2-Cyano-5-bromopyridine
A
2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester
Conditions | Yield |
---|---|
With 4,4'-di-tert-butyl-2,2'-bipyridine nickel(II) bromide In N,N-dimethyl acetamide at 20℃; for 24h; Mechanism; Irradiation; Inert atmosphere; | A 96% B 72% |
1-(4-Nitrophenyl)piperazine
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
With palladium diacetate; caesium carbonate; ruphos In 1,4-dioxane at 90℃; for 4h; Sealed tube; | 94% |
2-Cyano-5-bromopyridine
2-(2-amino-1-oxime)-5-bromopyridine
Conditions | Yield |
---|---|
With hydroxylamine; sodium hydrogencarbonate In ethanol for 2h; Heating; | 93% |
(2R)-methylpiperazine
2-Cyano-5-bromopyridine
1-[(3R)-3-methylpiperazin-1-yl]pyridine-2-carbonitrile
Conditions | Yield |
---|---|
With modified hectorite-loaded ionic liquid In dimethyl sulfoxide at 100 - 110℃; for 8h; Inert atmosphere; | 93% |
With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 110℃; for 0.583333h; Microwave irradiation; | 39.1% |
With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 110℃; for 0.583333h; Microwave irradiation; | 39.1% |
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
With bis(1,5-cyclooctadiene)nickel (0); dipotassium hydrogenphosphate; Ir(dF(CF3)ppy)2(bpy)PF6; 4,4'-di-tert-butyl-2,2'-bipyridine In 1,4-dioxane at 24℃; for 24h; Inert atmosphere; Irradiation; Sealed tube; | 93% |
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; CyJohnPhos In toluene at 100℃; for 24h; Inert atmosphere; | 93% |
2,2,2-trifluoroethanol
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
With C43H59NO2PPd(1+)*CH3O3S(1-); caesium carbonate In toluene at 80℃; Schlenk technique; Inert atmosphere; | 93% |
1,4-Phenyldiboronic acid
2-Cyano-5-bromopyridine
1,4-bis-(2'-cyanopyridin-5'-yl)phenylene
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In methanol; water; toluene at 80℃; Suzuki coupling; Inert atmosphere; | 92% |
(R)‐3‐(3‐fluoro‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenyl)‐5‐(hydroxymethyl)‐oxazolidin‐2‐one
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; ethanol; water at 90 - 95℃; for 3h; Inert atmosphere; | 92% |
2-Cyano-5-bromopyridine
5-bromo-2-(2H-tetrazol-5-yl)pyridine
Conditions | Yield |
---|---|
With pyridine; sodium azide; zinc(II) chloride at 40 - 120℃; for 2h; | 91.8% |
With sodium azide; ammonium chloride In N,N-dimethyl-formamide at 120℃; for 1h; | 84% |
With sodium azide; ammonium chloride In DMF (N,N-dimethyl-formamide) at 120℃; for 1h; |
methylmagnesium bromide
2-Cyano-5-bromopyridine
1-(5-bromopyridin-2-yl)ethanamine
Conditions | Yield |
---|---|
Stage #1: methylmagnesium bromide; 2-Cyano-5-bromopyridine In tetrahydrofuran at 0 - 20℃; for 0.5h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol for 10h; | 91% |
Stage #1: methylmagnesium bromide; 2-Cyano-5-bromopyridine In tetrahydrofuran at -20 - 0℃; Inert atmosphere; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; methanol at 20℃; for 10h; Stage #3: With sodium hydroxide In tetrahydrofuran; methanol; water | 59% |
Stage #1: methylmagnesium bromide; 2-Cyano-5-bromopyridine In tetrahydrofuran at -20 - 20℃; for 0.5h; Stage #2: With methanol; sodium tetrahydroborate In tetrahydrofuran at 20℃; for 15h; | |
Stage #1: methylmagnesium bromide; 2-Cyano-5-bromopyridine In tetrahydrofuran at -20 - 20℃; for 1h; Inert atmosphere; Stage #2: With methanol; sodium tetrahydroborate In tetrahydrofuran for 1h; |
benzenesulfinic acid sodium dihydrate
2-Cyano-5-bromopyridine
5-(benzenesulfonyl)pyridin-2-carbonitrile
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 120℃; for 4h; | 91% |
2-Cyano-5-bromopyridine
(S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester With sodium hydride In N,N-dimethyl-formamide at 0 - 25℃; for 0.5h; Inert atmosphere; Stage #2: 2-Cyano-5-bromopyridine In N,N-dimethyl-formamide at 0 - 25℃; for 2h; Inert atmosphere; | 91% |
piperidine
2-Cyano-5-bromopyridine
2-cyano-5-(1-piperidinyl)pyridine
Conditions | Yield |
---|---|
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); XPhos In 1,2-dimethoxyethane at 80℃; for 24h; Inert atmosphere; | 90% |
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); XPhos In 1,2-dimethoxyethane at 80℃; sealed tube; Inert atmosphere; | 63% |
Stage #1: 2-Cyano-5-bromopyridine With XPhos; tris-(dibenzylideneacetone)dipalladium(0) In 1,2-dimethoxyethane for 0.166667h; Inert atmosphere; Stage #2: piperidine With potassium phosphate In 1,2-dimethoxyethane at 80℃; Inert atmosphere; | 63% |
Conditions | Yield |
---|---|
With 2,6-dimethylpyridine; bis(1,5-cyclooctadiene)nickel (0); Ir(dF(CF3)ppy)2(bpy)PF6; 4,4'-di-tert-butyl-2,2'-bipyridine In methanol; acetone at 20℃; for 24h; Irradiation; | 90% |
ethylmagnesium bromide
2-Cyano-5-bromopyridine
Conditions | Yield |
---|---|
Stage #1: ethylmagnesium bromide; 2-Cyano-5-bromopyridine In tetrahydrofuran; diethyl ether at -20 - 20℃; for 2h; Stage #2: With hydrogenchloride; water In tetrahydrofuran; diethyl ether | 90% |
In tetrahydrofuran; diethyl ether at -20 - 20℃; for 2h; | 85% |
Stage #1: ethylmagnesium bromide; 2-Cyano-5-bromopyridine In diethyl ether at -15 - 20℃; for 3h; Inert atmosphere; Stage #2: With hydrogenchloride In diethyl ether; water at 20℃; for 0.25h; Inert atmosphere; | 78% |
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