The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:881386-01-2
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inquiryName: 3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone CAS No.: 881386-01-2 MF: C11H10Cl2N2O3 Appearance: White Fine Powder purity > 99.0
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inquiry1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,
Cas:881386-01-2
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inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryProduct name: 3,3-Dichloro-1-(4-Nitrophenyl)-2-Piperidinone CAS No.: 881386-01-2 Molecule Formula:C11H10Cl2N2O3 Molecule Weight:289.11 Purity: 99.0% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterp
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:881386-01-2
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
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inquiry3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Chemical Properties Boiling point 520.2±50.0 °C(Predicted) density 1.50 storage temp. Sealed in dry,2-8°C pka -7.38±0.40(Predicted)
Cas:881386-01-2
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inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:881386-01-2
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inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in
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inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou
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inquiryAppearance:Powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthesis of various pesticides, medicines, surfactants, polymer monomers, and antifungal agents Trans
TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
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inquiryOur own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin
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inquiryFactory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
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inquirygood quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran
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inquiry2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiryHigh quality suppliers Application:healing drugs
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inquirybulk?production Application:Pharmaceutical intermediates
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inquiry1-(4-nitrophenyl)piperidine-2-one
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
With phosphorus pentachloride In chlorobenzene at 55℃; for 5h; | 94.9% |
With phosphorus pentachloride In dichloromethane at 40℃; Cooling with ice; Inert atmosphere; | 93.1% |
With phosphorus pentachloride In chloroform for 0.5h; Reflux; | 88.58% |
5-Chlorovaleroyl chloride
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: phosphorus pentachloride / dichloromethane / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 - 25 °C / Inert atmosphere 2: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 3: phosphorus pentachloride / dichloromethane / 40 °C / Cooling with ice; Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: trimethylamine / tetrahydrofuran / 0 - 20 °C 2: potassium carbonate; dimethyl sulfoxide / 6 h / 80 °C 3: phosphorus pentachloride / dichloromethane / 5 h / Reflux View Scheme |
4-nitro-aniline
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: phosphorus pentachloride / dichloromethane / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 - 25 °C / Inert atmosphere 2: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 3: phosphorus pentachloride / dichloromethane / 40 °C / Cooling with ice; Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: trimethylamine / tetrahydrofuran / 0 - 20 °C 2: potassium carbonate; dimethyl sulfoxide / 6 h / 80 °C 3: phosphorus pentachloride / dichloromethane / 5 h / Reflux View Scheme |
5-chloro-N-(4-nitrophenyl)pentanamide
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 2: phosphorus pentachloride / dichloromethane / 40 °C / Cooling with ice; Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate; dimethyl sulfoxide / 6 h / 80 °C 2: phosphorus pentachloride / dichloromethane / 5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / dimethyl sulfoxide / 6 h / 80 °C 2: phosphorus pentachloride / dichloromethane / 5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: tetrabutylammomium bromide; potassium hydroxide / water; tetrahydrofuran / 0 - 20 °C 2: phosphorus pentachloride / toluene / 1 h / 25 - 80 °C View Scheme |
5-bromovaleroyl chloride
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine; dmap / tetrahydrofuran / 1 h / 0 - 100 °C 2: phosphorus pentachloride / chloroform / 0.5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: water; tetrahydrofuran / 1 h / 20 °C / Green chemistry 1.2: 4 h / 20 °C / Green chemistry 2.1: phosphorus pentachloride / chlorobenzene / 2 h / 53 °C / Green chemistry View Scheme |
aniline
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 1 h / 0 - 5 °C 1.2: 20 °C 2.1: nitric acid; sulfuric acid / 0 - 5 °C 3.1: phosphorus pentachloride / toluene / 1 h / 25 - 80 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 1 h / 25 - 30 °C 2: potassium hydroxide / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere 3: nitric acid; sulfuric acid / 0 - 5 °C 4: phosphorus pentachloride / toluene / 1 h / 25 - 80 °C View Scheme |
1-phenylpiperidin-2-one
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid / 0 - 5 °C 2: phosphorus pentachloride / toluene / 1 h / 25 - 80 °C View Scheme |
5-chloro-pentanoic acid phenylamide
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium hydroxide / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere 2: nitric acid; sulfuric acid / 0 - 5 °C 3: phosphorus pentachloride / toluene / 1 h / 25 - 80 °C View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
With tin(II) chloride dihdyrate In N,N-dimethyl-formamide at 60 - 65℃; for 0.5h; Solvent; Temperature; Reagent/catalyst; | 90.89% |
morpholine
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
3-(morpholin-4-yl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Conditions | Yield |
---|---|
at 120℃; for 2h; Inert atmosphere; | 90.4% |
at 130℃; for 1.5h; | 87.6% |
at 130℃; for 5h; | 64.5% |
at 130℃; for 1.5h; | |
In N,N-dimethyl-formamide for 1h; Reflux; | 85.73 g |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
With lithium carbonate; lithium chloride In N,N-dimethyl-formamide at 105℃; for 4h; Green chemistry; | 90% |
With lithium carbonate; lithium chloride In N,N-dimethyl-formamide at 45 - 110℃; | |
With lithium carbonate In N,N-dimethyl-formamide at 100 - 105℃; for 5h; Inert atmosphere; | 257.2 g |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere 2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux 3: triethylamine / toluene / 5 h / 90 °C / Inert atmosphere 4: trichloroacetic acid / dichloromethane / 1.5 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 1.5 h / 130 °C 2: triethylamine / ethyl acetate / 6 h / 80 °C 3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: 5 h / 130 °C 2.1: triethylamine; potassium iodide / ethyl acetate / 4.5 h / Reflux 2.2: 4 h / 5 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: lithium chloride; lithium carbonate / N,N-dimethyl-formamide / 4 h / 105 °C / Green chemistry 2: triethylamine / toluene / 2 h / 96 °C / Green chemistry View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere 2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux 3: triethylamine / toluene / 5 h / 90 °C / Inert atmosphere View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere 2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux 3: triethylamine / toluene / 5 h / 90 °C / Inert atmosphere 4: trichloroacetic acid / dichloromethane / 1.5 h / 20 °C 5: 5%-palladium/activated carbon; hydrogen / 1-methyl-pyrrolidin-2-one / 23 h / 20 °C / 4500.45 Torr / Autoclave; Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: 1.5 h / 130 °C 2: triethylamine / ethyl acetate / 6 h / 80 °C 3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 4: hydrogenchloride; iron; ammonium chloride / water; ethanol / 2.5 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 5 h / 130 °C 2.1: triethylamine; potassium iodide / ethyl acetate / 4.5 h / Reflux 2.2: 4 h / 5 - 20 °C 3.1: acetic acid; zinc / ethanol; dichloromethane / 3 h / 20 °C / Cooling with ice View Scheme | |
Multi-step reaction with 3 steps 1: lithium chloride; lithium carbonate / N,N-dimethyl-formamide / 4 h / 105 °C / Green chemistry 2: triethylamine / toluene / 2 h / 96 °C / Green chemistry 3: 5%-palladium/activated carbon; hydrogen / ethanol / 4 h / 50 - 55 °C / 2250.23 - 3000.3 Torr / Green chemistry View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
1-(4-methoxyphenyl)-7-oxo-6-(4-aminophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere 2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux 3: triethylamine / toluene / 5 h / 90 °C / Inert atmosphere 4: trichloroacetic acid / dichloromethane / 1.5 h / 20 °C 5: 5%-palladium/activated carbon; hydrogen / 1-methyl-pyrrolidin-2-one / 23 h / 20 °C / 4500.45 Torr / Autoclave; Inert atmosphere 6: ammonia / methanol / 18 h / 100 °C / Autoclave View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
6-(4-(5-bromopentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere 2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux 3: triethylamine / toluene / 5 h / 90 °C / Inert atmosphere 4: trichloroacetic acid / dichloromethane / 1.5 h / 20 °C 5: 5%-palladium/activated carbon; hydrogen / 1-methyl-pyrrolidin-2-one / 23 h / 20 °C / 4500.45 Torr / Autoclave; Inert atmosphere 6: ammonia / methanol / 18 h / 100 °C / Autoclave 7: potassium carbonate / tetrahydrofuran; water / 1.33 h / Cooling View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere 2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux 3: triethylamine / toluene / 5 h / 90 °C / Inert atmosphere 4: trichloroacetic acid / dichloromethane / 1.5 h / 20 °C 5: 5%-palladium/activated carbon; hydrogen / 1-methyl-pyrrolidin-2-one / 23 h / 20 °C / 4500.45 Torr / Autoclave; Inert atmosphere 6: ammonia / methanol / 18 h / 100 °C / Autoclave 7: potassium carbonate / tetrahydrofuran; water / 1.33 h / Cooling 8: potassium ethoxide / tetrahydrofuran; ethanol / 0.5 h View Scheme | |
Multi-step reaction with 6 steps 1: 120 - 130 °C 2: sodiumsulfide nonahydrate / water / 35 - 40 °C 3: triethylamine / dichloromethane / 25 - 35 °C 4: potassium iodide; triethylamine / ethyl acetate / Reflux 5: hydrogenchloride / 25 - 35 °C 6: ammonia / methanol / 45 °C / 6000.6 Torr / Autoclave View Scheme | |
Multi-step reaction with 7 steps 1: 1.5 h / 130 °C 2: triethylamine / ethyl acetate / 6 h / 80 °C 3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 4: hydrogenchloride; iron; ammonium chloride / water; ethanol / 2.5 h / 80 °C 5: trimethylamine / tetrahydrofuran / 6.5 h / 0 - 25 °C 6: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 7: sodium methylate; formamide / N,N-dimethyl-formamide / 5 h / 50 °C View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
6-(4-(5-chloropentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere 2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux 3: triethylamine / toluene / 5 h / 90 °C / Inert atmosphere 4: trichloroacetic acid / dichloromethane / 1.5 h / 20 °C 5: 5%-palladium/activated carbon; hydrogen / 1-methyl-pyrrolidin-2-one / 23 h / 20 °C / 4500.45 Torr / Autoclave; Inert atmosphere 6: ammonia / methanol / 18 h / 100 °C / Autoclave 7: potassium carbonate / 1-methyl-pyrrolidin-2-one View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
3-(morpholin-4-yl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere 2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 120 - 130 °C 2: sodiumsulfide nonahydrate / water / 35 - 40 °C View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 120 - 130 °C 2: sodiumsulfide nonahydrate / water / 35 - 40 °C 3: triethylamine / dichloromethane / 25 - 35 °C View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 120 - 130 °C 2: sodiumsulfide nonahydrate / water / 35 - 40 °C 3: triethylamine / dichloromethane / 25 - 35 °C 4: potassium iodide; triethylamine / ethyl acetate / Reflux 5: hydrogenchloride / 25 - 35 °C View Scheme | |
Multi-step reaction with 6 steps 1: 1.5 h / 130 °C 2: triethylamine / ethyl acetate / 6 h / 80 °C 3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 4: hydrogenchloride; iron; ammonium chloride / water; ethanol / 2.5 h / 80 °C 5: trimethylamine / tetrahydrofuran / 6.5 h / 0 - 25 °C 6: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C View Scheme | |
Multi-step reaction with 5 steps 1: tin(II) chloride dihdyrate / N,N-dimethyl-formamide / 0.5 h / 60 - 65 °C 2: pyridine; dmap / dichloromethane / 0.5 h / 20 °C 3: lithium tert-butoxide / dichloromethane / 3 h / 20 °C 4: lithium carbonate / N,N-dimethyl-formamide / 3 h / 105 - 110 °C 5: triethylamine / toluene / 3.5 h / 95 - 100 °C View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 120 - 130 °C 2: sodiumsulfide nonahydrate / water / 35 - 40 °C 3: triethylamine / dichloromethane / 25 - 35 °C 4: potassium iodide; triethylamine / ethyl acetate / Reflux View Scheme |
1-methyl-piperazine
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
at 120 - 130℃; |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2 h / 120 °C / Inert atmosphere 2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 1 h / Reflux 2: hydrazine hydrate / water; ethanol / 0.5 h / 60 - 65 °C View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 2 h / 120 °C / Inert atmosphere 2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / 1 h / Reflux 2: hydrazine hydrate / water; ethanol / 0.5 h / 60 - 65 °C 3: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 1 h / 0 - 5 °C View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
5,6‑dihydro‑3‑(4‑morpholinyl)‑1‑[4‑(2‑oxo‑1‑piperidinyl)phenyl]‑2(1H)‑pyridone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 2 h / 120 °C / Inert atmosphere 2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: N,N-dimethyl-formamide / 1 h / Reflux 2.1: hydrazine hydrate / water; ethanol / 0.5 h / 60 - 65 °C 3.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 1 h / 0 - 5 °C 3.2: 20 °C View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 2 h / 120 °C / Inert atmosphere 2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 5: triethylamine / ethyl acetate / 80 °C / Inert atmosphere View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 2 h / 120 °C / Inert atmosphere 2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 5: triethylamine / ethyl acetate / 80 °C / Inert atmosphere 6: ammonium hydroxide / methanol / 55 °C / Inert atmosphere View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 2 h / 120 °C / Inert atmosphere 2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 5: triethylamine / ethyl acetate / 80 °C / Inert atmosphere View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 2 h / 120 °C / Inert atmosphere 2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 5: triethylamine / ethyl acetate / 80 °C / Inert atmosphere 6: ammonium hydroxide / methanol / 55 °C / Inert atmosphere View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 2 h / 120 °C / Inert atmosphere 2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 5: triethylamine / ethyl acetate / 80 °C / Inert atmosphere View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 2 h / 120 °C / Inert atmosphere 2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 5: triethylamine / ethyl acetate / 80 °C / Inert atmosphere 6: ammonium hydroxide / methanol / 55 °C / Inert atmosphere View Scheme |
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 2 h / 120 °C / Inert atmosphere 2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere 5: triethylamine / ethyl acetate / 80 °C / Inert atmosphere View Scheme |
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