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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one

Cas:881386-01-2

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 881386-01-2 3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone Manufacturer

Cas:881386-01-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

cas881386-01-2 Manufacturers Supply High Purity Pharmaceutical Intermediate Powder

Cas:881386-01-2

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 881386-01-2 with fast shipping

Cas:881386-01-2

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: 3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone CAS No.: 881386-01-2 MF: C11H10Cl2N2O3 Appearance: White Fine Powder purity > 99.0

3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone

Cas:881386-01-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-

Cas:881386-01-2

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

Cas:881386-01-2

Min.Order:1 Kilogram

FOB Price: $40.0

Type:Trading Company

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 881386-01-2 2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-

Cas:881386-01-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

881386-01-2

Cas:881386-01-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

Cas:881386-01-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one

Cas:881386-01-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 3,3-Dichloro-1-(4-Nitrophenyl)-2-Piperidinone CAS No.: 881386-01-2 Molecule Formula:C11H10Cl2N2O3 Molecule Weight:289.11 Purity: 99.0% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterp

Lower Price 3,3-Dichloro-1-(4-Nitrophenyl)-2-Piperidinone

Cas:881386-01-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-,881386-01-2

Cas:881386-01-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

Cas:881386-01-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one Chemical Properties Boiling point 520.2±50.0 °C(Predicted) density 1.50 storage temp. Sealed in dry,2-8°C pka -7.38±0.40(Predicted)

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

Cas:881386-01-2

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-

Cas:881386-01-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-

Cas:881386-01-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

SAGECHEM/3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone /Manufacturer in China

Cas:881386-01-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Apixaban Intermediates

Cas:881386-01-2

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one

Cas:881386-01-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Shandong Jiling Chemical Co., Ltd

Appearance:Powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthesis of various pesticides, medicines, surfactants, polymer monomers, and antifungal agents Trans

Apixaban intermediate

Cas:881386-01-2

Min.Order:0

Negotiable

Type:Other

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Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

Cas:881386-01-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

Cas:881386-01-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-

Cas:881386-01-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

3,3-Dichloro-1-(4-nitrophenyl)-2-piperidinone CAS No.881386-01-2

Cas:881386-01-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

Cas:881386-01-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-

Cas:881386-01-2

Min.Order:0

Negotiable

Type:Other

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one

Cas:881386-01-2

Min.Order:0

Negotiable

Type:Other

inquiry

Shanghai Scochem Technology Co., Ltd.

High quality suppliers Application:healing drugs

3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one

Cas:881386-01-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

2-Piperidinone, 3,3-dichloro-1-(4-nitrophenyl)-

Cas:881386-01-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-(4-nitrophenyl)piperidine-2-one
38560-30-4

1-(4-nitrophenyl)piperidine-2-one

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

Conditions
ConditionsYield
With phosphorus pentachloride In chlorobenzene at 55℃; for 5h;94.9%
With phosphorus pentachloride In dichloromethane at 40℃; Cooling with ice; Inert atmosphere;93.1%
With phosphorus pentachloride In chloroform for 0.5h; Reflux;88.58%
5-Chlorovaleroyl chloride
1575-61-7

5-Chlorovaleroyl chloride

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
2: phosphorus pentachloride / dichloromethane / Reflux
View Scheme
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 - 25 °C / Inert atmosphere
2: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
3: phosphorus pentachloride / dichloromethane / 40 °C / Cooling with ice; Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: trimethylamine / tetrahydrofuran / 0 - 20 °C
2: potassium carbonate; dimethyl sulfoxide / 6 h / 80 °C
3: phosphorus pentachloride / dichloromethane / 5 h / Reflux
View Scheme
4-nitro-aniline
100-01-6

4-nitro-aniline

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
2: phosphorus pentachloride / dichloromethane / Reflux
View Scheme
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 - 25 °C / Inert atmosphere
2: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
3: phosphorus pentachloride / dichloromethane / 40 °C / Cooling with ice; Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: trimethylamine / tetrahydrofuran / 0 - 20 °C
2: potassium carbonate; dimethyl sulfoxide / 6 h / 80 °C
3: phosphorus pentachloride / dichloromethane / 5 h / Reflux
View Scheme
5-chloro-N-(4-nitrophenyl)pentanamide
1039914-85-6

5-chloro-N-(4-nitrophenyl)pentanamide

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
2: phosphorus pentachloride / dichloromethane / 40 °C / Cooling with ice; Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate; dimethyl sulfoxide / 6 h / 80 °C
2: phosphorus pentachloride / dichloromethane / 5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / dimethyl sulfoxide / 6 h / 80 °C
2: phosphorus pentachloride / dichloromethane / 5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: tetrabutylammomium bromide; potassium hydroxide / water; tetrahydrofuran / 0 - 20 °C
2: phosphorus pentachloride / toluene / 1 h / 25 - 80 °C
View Scheme
5-bromovaleroyl chloride
4509-90-4

5-bromovaleroyl chloride

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine; dmap / tetrahydrofuran / 1 h / 0 - 100 °C
2: phosphorus pentachloride / chloroform / 0.5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: water; tetrahydrofuran / 1 h / 20 °C / Green chemistry
1.2: 4 h / 20 °C / Green chemistry
2.1: phosphorus pentachloride / chlorobenzene / 2 h / 53 °C / Green chemistry
View Scheme
aniline
62-53-3

aniline

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 1 h / 0 - 5 °C
1.2: 20 °C
2.1: nitric acid; sulfuric acid / 0 - 5 °C
3.1: phosphorus pentachloride / toluene / 1 h / 25 - 80 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 1 h / 25 - 30 °C
2: potassium hydroxide / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere
3: nitric acid; sulfuric acid / 0 - 5 °C
4: phosphorus pentachloride / toluene / 1 h / 25 - 80 °C
View Scheme
1-phenylpiperidin-2-one
4789-09-7

1-phenylpiperidin-2-one

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: nitric acid; sulfuric acid / 0 - 5 °C
2: phosphorus pentachloride / toluene / 1 h / 25 - 80 °C
View Scheme
5-chloro-pentanoic acid phenylamide
91131-23-6

5-chloro-pentanoic acid phenylamide

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium hydroxide / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere
2: nitric acid; sulfuric acid / 0 - 5 °C
3: phosphorus pentachloride / toluene / 1 h / 25 - 80 °C
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

C11H12Cl2N2O

C11H12Cl2N2O

Conditions
ConditionsYield
With tin(II) chloride dihdyrate In N,N-dimethyl-formamide at 60 - 65℃; for 0.5h; Solvent; Temperature; Reagent/catalyst;90.89%
morpholine
110-91-8

morpholine

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

3-(morpholin-4-yl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
503615-03-0

3-(morpholin-4-yl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

Conditions
ConditionsYield
at 120℃; for 2h; Inert atmosphere;90.4%
at 130℃; for 1.5h;87.6%
at 130℃; for 5h;64.5%
at 130℃; for 1.5h;
In N,N-dimethyl-formamide for 1h; Reflux;85.73 g
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

Conditions
ConditionsYield
With lithium carbonate; lithium chloride In N,N-dimethyl-formamide at 105℃; for 4h; Green chemistry;90%
With lithium carbonate; lithium chloride In N,N-dimethyl-formamide at 45 - 110℃;
With lithium carbonate In N,N-dimethyl-formamide at 100 - 105℃; for 5h; Inert atmosphere;257.2 g
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo- 1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo- 1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere
2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux
3: triethylamine / toluene / 5 h / 90 °C / Inert atmosphere
4: trichloroacetic acid / dichloromethane / 1.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 1.5 h / 130 °C
2: triethylamine / ethyl acetate / 6 h / 80 °C
3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 5 h / 130 °C
2.1: triethylamine; potassium iodide / ethyl acetate / 4.5 h / Reflux
2.2: 4 h / 5 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: lithium chloride; lithium carbonate / N,N-dimethyl-formamide / 4 h / 105 °C / Green chemistry
2: triethylamine / toluene / 2 h / 96 °C / Green chemistry
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

C26H29N5O7

C26H29N5O7

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere
2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux
3: triethylamine / toluene / 5 h / 90 °C / Inert atmosphere
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

1-(4-methoxyphenyl)-6-(4-aminophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

1-(4-methoxyphenyl)-6-(4-aminophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere
2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux
3: triethylamine / toluene / 5 h / 90 °C / Inert atmosphere
4: trichloroacetic acid / dichloromethane / 1.5 h / 20 °C
5: 5%-palladium/activated carbon; hydrogen / 1-methyl-pyrrolidin-2-one / 23 h / 20 °C / 4500.45 Torr / Autoclave; Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: 1.5 h / 130 °C
2: triethylamine / ethyl acetate / 6 h / 80 °C
3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
4: hydrogenchloride; iron; ammonium chloride / water; ethanol / 2.5 h / 80 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 5 h / 130 °C
2.1: triethylamine; potassium iodide / ethyl acetate / 4.5 h / Reflux
2.2: 4 h / 5 - 20 °C
3.1: acetic acid; zinc / ethanol; dichloromethane / 3 h / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1: lithium chloride; lithium carbonate / N,N-dimethyl-formamide / 4 h / 105 °C / Green chemistry
2: triethylamine / toluene / 2 h / 96 °C / Green chemistry
3: 5%-palladium/activated carbon; hydrogen / ethanol / 4 h / 50 - 55 °C / 2250.23 - 3000.3 Torr / Green chemistry
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

1-(4-methoxyphenyl)-7-oxo-6-(4-aminophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
1423803-24-0

1-(4-methoxyphenyl)-7-oxo-6-(4-aminophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere
2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux
3: triethylamine / toluene / 5 h / 90 °C / Inert atmosphere
4: trichloroacetic acid / dichloromethane / 1.5 h / 20 °C
5: 5%-palladium/activated carbon; hydrogen / 1-methyl-pyrrolidin-2-one / 23 h / 20 °C / 4500.45 Torr / Autoclave; Inert atmosphere
6: ammonia / methanol / 18 h / 100 °C / Autoclave
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

6-(4-(5-bromopentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
1437577-94-0

6-(4-(5-bromopentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere
2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux
3: triethylamine / toluene / 5 h / 90 °C / Inert atmosphere
4: trichloroacetic acid / dichloromethane / 1.5 h / 20 °C
5: 5%-palladium/activated carbon; hydrogen / 1-methyl-pyrrolidin-2-one / 23 h / 20 °C / 4500.45 Torr / Autoclave; Inert atmosphere
6: ammonia / methanol / 18 h / 100 °C / Autoclave
7: potassium carbonate / tetrahydrofuran; water / 1.33 h / Cooling
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

apixaban

apixaban

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere
2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux
3: triethylamine / toluene / 5 h / 90 °C / Inert atmosphere
4: trichloroacetic acid / dichloromethane / 1.5 h / 20 °C
5: 5%-palladium/activated carbon; hydrogen / 1-methyl-pyrrolidin-2-one / 23 h / 20 °C / 4500.45 Torr / Autoclave; Inert atmosphere
6: ammonia / methanol / 18 h / 100 °C / Autoclave
7: potassium carbonate / tetrahydrofuran; water / 1.33 h / Cooling
8: potassium ethoxide / tetrahydrofuran; ethanol / 0.5 h
View Scheme
Multi-step reaction with 6 steps
1: 120 - 130 °C
2: sodiumsulfide nonahydrate / water / 35 - 40 °C
3: triethylamine / dichloromethane / 25 - 35 °C
4: potassium iodide; triethylamine / ethyl acetate / Reflux
5: hydrogenchloride / 25 - 35 °C
6: ammonia / methanol / 45 °C / 6000.6 Torr / Autoclave
View Scheme
Multi-step reaction with 7 steps
1: 1.5 h / 130 °C
2: triethylamine / ethyl acetate / 6 h / 80 °C
3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
4: hydrogenchloride; iron; ammonium chloride / water; ethanol / 2.5 h / 80 °C
5: trimethylamine / tetrahydrofuran / 6.5 h / 0 - 25 °C
6: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C
7: sodium methylate; formamide / N,N-dimethyl-formamide / 5 h / 50 °C
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

6-(4-(5-chloropentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
1449510-64-8

6-(4-(5-chloropentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere
2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux
3: triethylamine / toluene / 5 h / 90 °C / Inert atmosphere
4: trichloroacetic acid / dichloromethane / 1.5 h / 20 °C
5: 5%-palladium/activated carbon; hydrogen / 1-methyl-pyrrolidin-2-one / 23 h / 20 °C / 4500.45 Torr / Autoclave; Inert atmosphere
6: ammonia / methanol / 18 h / 100 °C / Autoclave
7: potassium carbonate / 1-methyl-pyrrolidin-2-one
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

3-(morpholin-4-yl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
503615-03-0

3-(morpholin-4-yl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium carbonate / N,N-dimethyl-formamide / 5 h / 100 - 105 °C / Inert atmosphere
2: triethylamine / tetrahydrofuran / 46 h / Inert atmosphere; Reflux
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

1-(4-aminophenyl)-5,6-dihydro-3-(4-methylpiperazine-1-yl)pyridin-2(1H)-one

1-(4-aminophenyl)-5,6-dihydro-3-(4-methylpiperazine-1-yl)pyridin-2(1H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 120 - 130 °C
2: sodiumsulfide nonahydrate / water / 35 - 40 °C
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

5,6-dihydro-3-(4-methylpiperazin-1-yl)-1-(4-(2-oxopiperidin-1-yl)phenyl)pyridine-2(1H)-one

5,6-dihydro-3-(4-methylpiperazin-1-yl)-1-(4-(2-oxopiperidin-1-yl)phenyl)pyridine-2(1H)-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 120 - 130 °C
2: sodiumsulfide nonahydrate / water / 35 - 40 °C
3: triethylamine / dichloromethane / 25 - 35 °C
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
503614-91-3

1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 120 - 130 °C
2: sodiumsulfide nonahydrate / water / 35 - 40 °C
3: triethylamine / dichloromethane / 25 - 35 °C
4: potassium iodide; triethylamine / ethyl acetate / Reflux
5: hydrogenchloride / 25 - 35 °C
View Scheme
Multi-step reaction with 6 steps
1: 1.5 h / 130 °C
2: triethylamine / ethyl acetate / 6 h / 80 °C
3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
4: hydrogenchloride; iron; ammonium chloride / water; ethanol / 2.5 h / 80 °C
5: trimethylamine / tetrahydrofuran / 6.5 h / 0 - 25 °C
6: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C
View Scheme
Multi-step reaction with 5 steps
1: tin(II) chloride dihdyrate / N,N-dimethyl-formamide / 0.5 h / 60 - 65 °C
2: pyridine; dmap / dichloromethane / 0.5 h / 20 °C
3: lithium tert-butoxide / dichloromethane / 3 h / 20 °C
4: lithium carbonate / N,N-dimethyl-formamide / 3 h / 105 - 110 °C
5: triethylamine / toluene / 3.5 h / 95 - 100 °C
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

C32H40N6O5

C32H40N6O5

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 120 - 130 °C
2: sodiumsulfide nonahydrate / water / 35 - 40 °C
3: triethylamine / dichloromethane / 25 - 35 °C
4: potassium iodide; triethylamine / ethyl acetate / Reflux
View Scheme
1-methyl-piperazine
109-01-3

1-methyl-piperazine

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

5,6-dihydro-3-(4-methylpiperazine-1-yl)-1-(4-nitrophenyl)pyridin-2(1H)-one

5,6-dihydro-3-(4-methylpiperazine-1-yl)-1-(4-nitrophenyl)pyridin-2(1H)-one

Conditions
ConditionsYield
at 120 - 130℃;
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one
1267610-26-3

1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2 h / 120 °C / Inert atmosphere
2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 1 h / Reflux
2: hydrazine hydrate / water; ethanol / 0.5 h / 60 - 65 °C
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

5-chloropentanoic acid [4-(5-morpholin-4-yl-6-oxo-3,6-dihydro-2H-pyridin-1-yl)phenyl]amide

5-chloropentanoic acid [4-(5-morpholin-4-yl-6-oxo-3,6-dihydro-2H-pyridin-1-yl)phenyl]amide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 2 h / 120 °C / Inert atmosphere
2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide / 1 h / Reflux
2: hydrazine hydrate / water; ethanol / 0.5 h / 60 - 65 °C
3: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 1 h / 0 - 5 °C
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

5,6‑dihydro‑3‑(4‑morpholinyl)‑1‑[4‑(2‑oxo‑1‑piperidinyl)phenyl]‑2(1H)‑pyridone
545445-44-1

5,6‑dihydro‑3‑(4‑morpholinyl)‑1‑[4‑(2‑oxo‑1‑piperidinyl)phenyl]‑2(1H)‑pyridone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 2 h / 120 °C / Inert atmosphere
2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: N,N-dimethyl-formamide / 1 h / Reflux
2.1: hydrazine hydrate / water; ethanol / 0.5 h / 60 - 65 °C
3.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 1 h / 0 - 5 °C
3.2: 20 °C
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

C27H28N4O4

C27H28N4O4

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 2 h / 120 °C / Inert atmosphere
2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
5: triethylamine / ethyl acetate / 80 °C / Inert atmosphere
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

1-(4-methylphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

1-(4-methylphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 2 h / 120 °C / Inert atmosphere
2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
5: triethylamine / ethyl acetate / 80 °C / Inert atmosphere
6: ammonium hydroxide / methanol / 55 °C / Inert atmosphere
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

C27H28N4O4S

C27H28N4O4S

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 2 h / 120 °C / Inert atmosphere
2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
5: triethylamine / ethyl acetate / 80 °C / Inert atmosphere
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

1-(4-methylthiophenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

1-(4-methylthiophenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 2 h / 120 °C / Inert atmosphere
2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
5: triethylamine / ethyl acetate / 80 °C / Inert atmosphere
6: ammonium hydroxide / methanol / 55 °C / Inert atmosphere
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

C26H25FN4O4

C26H25FN4O4

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 2 h / 120 °C / Inert atmosphere
2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
5: triethylamine / ethyl acetate / 80 °C / Inert atmosphere
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

1-(2-fluorophenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

1-(2-fluorophenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 2 h / 120 °C / Inert atmosphere
2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
5: triethylamine / ethyl acetate / 80 °C / Inert atmosphere
6: ammonium hydroxide / methanol / 55 °C / Inert atmosphere
View Scheme
3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one
881386-01-2

3,3-dichloro-1-(4-nitrophenyl)piperidine-2-one

C27H27FN4O5

C27H27FN4O5

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 2 h / 120 °C / Inert atmosphere
2: water; sodium sulfide / ethanol / 50 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
4: sodium hydride / tetrahydrofuran / 10 - 25 °C / Inert atmosphere
5: triethylamine / ethyl acetate / 80 °C / Inert atmosphere
View Scheme
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