Argatroban(CAS No. 74863-84-6)is a peptidomimetic synthetic direct thrombin inhibitor with reversible and specific properties resulting in predictable anticoagulant effects. In most clinical studies, argatroban effects have been monitored by aPTT (activated partial thromboplastin time) (in prevention/treatment of thrombosis in HIT) or ACT (predominantly in high-dose therapy, eg, PCI setting).
For example, when it is used in Percutaneous Coronary Interventions (PCI) in HIT/HITTS Patients, an infusion of Argatroban should be started at 25 mcg/kg/min and a bolus of 350 mcg/kg administered via a large bore intravenous (IV) line over 3 to 5 minutes. Activated clotting time (ACT) should be checked 5 to 10 minutes after the bolus dose is completed. The procedure may proceed if the ACT is greater than 300 seconds. This is the initial dosage of argatroban.
After the dosage adjustment, the next is the argatroban monitoring therapy. In general, Therapy with Argatroban is monitored using ACT. ACTs should be obtained before dosing, 5 to 10 minutes after bolus dosing and after change in the infusion rate, and at the end of the PCI procedure. Additional ACTs should be drawn about every 20 to 30 minutes during a prolonged procedure.
Hangzhou Holypharm biotech Co.,Ltd., professional supplier of active pharmaceutical ingredients and intermediates; agrochemicals and Veterinary products, often do some research in the argatroban. And they found that through the argatroban monitoring, Argatroban, with ACT monitoring, might be safely used for anticoagulation during cardiac surgery.
HANGZHOU HOLYPHARM BIOTECH CO.,LTD is a professional supplier of active pharmaceutical ingredients and intermediates; agrochemicals and Veterinary products. We are specialized in contract R&D and custom manufacturing. we have rich experience on a wide range of chemical reactions and fermentation from multi gram scale to hundred tons scale according to customers' requirement. Moreover, we are quite strong on registration. Our products have been registered in India, Vietnam, Latin America, Turkey, etc.
HANGZHOU HOLYPHARM BIOTECH CO.,LTD is mainly engaged in the importing and exporting of pharmaceutical raw materials and intermediates to the markets of Europe and North America, and B2B e-commerce platform is undoubtedly an important platform for foreign trade enterprises who are looking for domestic opportunities. Holypharm forges their products to the foreign buyers' accustomed searching mode, which is the most effective way to advertise.
We have three departments, PHARM DEPT. ,VETERINARY DEPT., AGROCHMICAL DEPT. We gather most qualified staffs with years of practical experience and knowledge in each department . They have better ideas on quality control, registration data, excellent packaging & labeling and logistics. To provide clients with more technology support, we will present efficient regulatory documents to show professional abilities in this field.
Professional services
The enterprise armed with knowledge will always keep its vitality and development. The human resources department in HANGZHOU HOLYPHARM will train its staff at regular intervals, to help them have a in-depth understanding of business regulations, foreign trade processes, chemical knowledge, communication skills, and so on. After foreign buyers gives the order, the company will give the one-stop services with factory-auditing, inspection, order management, export declaration to freight logistics.
In addition, HANGZHOU HOLYPHARM will provide free extra services for foreign buyers like investigation of domestic market and consulting services, which is highly appraised by customers. As a company in the field of chemical export industry for many years, HOLYPHARM is engaged in improving the professional competence of the business staff and their professional services, which is not only the best way to win customers, but also helps to dig out the potential value of the chemical industry chain which are negligent.
Basic Information
- Company Name:HANGZHOU HOLYPHARM BIOTECH CO.,LTD
- Number of Employees:11 - 50
- Contact person:Leonard
- Street Address:Room D808, Block 4 NO.176, Zixia Rd
- City:Hangzhou
- Province/State:Zhejiang
- Country/Region:China (Mainland)
- Zip:310007
- Business type:Other
- Tel:86 571 86853097
- Fax:86 571 87357695
- Website:
- Year Established:2009
Company picturepad
-
2012 CPHI
-
2012 CPHI
-
Plant
-
Plant
-
Production facility
-
Production facility