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HANGZHOU HOLYPHARM BIOTECH CO.,LTD

Country:China (Mainland)

Year Established: 2009Business type: Other

Integral:

ArgatrobanCAS No. 74863-84-6)is a peptidomimetic synthetic direct thrombin inhibitor with reversible and specific properties resulting in predictable anticoagulant effects. In most clinical studies, argatroban effects have been monitored by aPTT (activated partial thromboplastin time) (in prevention/treatment of thrombosis in HIT) or ACT (predominantly in high-dose therapy, eg, PCI setting).

For example, when it is used in Percutaneous Coronary Interventions (PCI) in HIT/HITTS Patients, an infusion of Argatroban should be started at 25 mcg/kg/min and a bolus of 350 mcg/kg administered via a large bore intravenous (IV) line over 3 to 5 minutes. Activated clotting time (ACT) should be checked 5 to 10 minutes after the bolus dose is completed. The procedure may proceed if the ACT is greater than 300 seconds. This is the initial dosage of argatroban.

After the dosage adjustment, the next is the argatroban monitoring therapy. In general, Therapy with Argatroban is monitored using ACT. ACTs should be obtained before dosing, 5 to 10 minutes after bolus dosing and after change in the infusion rate, and at the end of the PCI procedure. Additional ACTs should be drawn about every 20 to 30 minutes during a prolonged procedure.

Hangzhou Holypharm biotech Co.,Ltd., professional supplier of active pharmaceutical ingredients and intermediates; agrochemicals and Veterinary products, often do some research in the argatroban. And they found that through the argatroban monitoring, Argatroban, with ACT monitoring, might be safely used for anticoagulation during cardiac surgery.

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Azilsartan

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argatroban inr

Argatroban is indicated as an anticoagulant for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia and an anticoagulant in patients.

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