pharmacologic action, caspofungin, Candida

HANGZHOU HOLYPHARM BIOTECH CO.,LTD

Country:China (Mainland)

Year Established: 2009Business type: Other

Integral:

1. The overview of caspofungin
Caspofungin (CAS NO.179463-17-3) is a lipopeptide antifungal drug. It for injection was originally approved by both the Food and Drug Administration (FDA), in the US, and the EMEA, in Europe, in 2001. It is a member of a new class of antifungals termed the echinocandins. Caspofungin is usally administered intravenously.

2. Pharmacologic action of Caspofungin
Caspofungin is half synthetic lipopeptide (echinocandin) compound. The echinocandin lipopeptide caspofungin is the first of a new class of antifungal compounds that inhibit the synthesis of 1,3-β-D-glucan. This homopolysaccharide is a major component of the cell wall of many pathogenic fungi and yet is absent in mammalian cells. It provides osmotic stability and is important for cell growth and cell division.

In vitro, caspofungin has broad-spectrum antifungal activity against Candida and Aspergillus spp without cross-resistance to existing agents. The compound exerts prolonged post-antifungal effects and fungicidal activity against Candida spp and causes severe damage of Aspergillus fumigatus at the sites of hyphal growth.

Animal models have demonstrated efficacy against disseminated candidiasis and disseminated and pulmonary aspergillosis, both in normal and in immunocompromised animals. Caspofungin possesses favourable pharmacokinetic properties and is not metabolised through the cytochrome P450 (CYP) enzyme system.

Tips: Caspofungin has been shown in animal studies to have embroyotoxic properties, and therefore has been assigned to class C. It should only be given to pregnant women if the benefit to the mother clearly outweighs the potential risk to her fetus. The drug is found in the milk of lactating rats, but it is not known whether this is seen in humans. Thus, lactating women should be treated cautiously.

HANGZHOU HOLYPHARM BIOTECH CO.,LTD is a professional supplier of active pharmaceutical ingredients and intermediates; agrochemicals and Veterinary products. We are specialized in contract R&D and custom manufacturing. we have rich experience on a wide range of chemical reactions and fermentation from multi gram scale to hundred tons scale according to customers' requirement. Moreover, we are quite strong on registration. Our products have been registered in India, Vietnam, Latin America, Turkey, etc. HANGZHOU HOLYPHARM BIOTECH CO.,LTD is mainly engaged in the importing and exporting of pharmaceutical raw materials and intermediates to the markets of Europe and North America, and B2B e-commerce platform is undoubtedly an important platform for foreign trade enterprises who are looking for domestic opportunities. Holypharm forges their products to the foreign buyers' accustomed searching mode, which is the most effective way to advertise. We have three departments, PHARM DEPT. ,VETERINARY DEPT., AGROCHMICAL DEPT. We gather most qualified staffs with years of practical experience and knowledge in each department . They have better ideas on quality control, registration data, excellent packaging & labeling and logistics. To provide clients with more technology support, we will present efficient regulatory documents to show professional abilities in this field. Professional services The enterprise armed with knowledge will always keep its vitality and development. The human resources department in HANGZHOU HOLYPHARM will train its staff at regular intervals, to help them have a in-depth understanding of business regulations, foreign trade processes, chemical knowledge, communication skills, and so on. After foreign buyers gives the order, the company will give the one-stop services with factory-auditing, inspection, order management, export declaration to freight logistics. In addition, HANGZHOU HOLYPHARM will provide free extra services for foreign buyers like investigation of domestic market and consulting services, which is highly appraised by customers. As a company in the field of chemical export industry for many years, HOLYPHARM is engaged in improving the professional competence of the business staff and their professional services, which is not only the best way to win customers, but also helps to dig out the potential value of the chemical industry chain which are negligent.

Basic Information

Company Name：HANGZHOU HOLYPHARM BIOTECH CO.,LTD
Number of Employees：11 - 50
Contact person：Leonard
Street Address：Room D808, Block 4 NO.176, Zixia Rd
City：Hangzhou
Province/State：Zhejiang
Country/Region：China (Mainland)
Zip：310007
Business type：Other
Tel：86 571 86853097
Fax：86 571 87357695
Website：
Year Established：2009

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