Conditions | Yield |
---|---|
With sodium dihydrogenphosphate In water at 20 - 92℃; under 150.015 Torr; Temperature; Large scale; | 95.4% |
With cation-exchange resin KU-2 and KU-2-8 In water at 20 - 30℃; | 40% |
With water at 150℃; |
Conditions | Yield |
---|---|
With acetic acid In water for 1h; | 86% |
With boric acid; oxalic acid | |
With boric acid; oxalic acid |
Conditions | Yield |
---|---|
With 1H-imidazole; sodium periodate; MnCl-TPP-(PEO750)4 In water; acetonitrile at 20℃; for 24h; | 99% |
With W-MCM41; dihydrogen peroxide In tert-butyl alcohol at 35℃; for 24h; | 71% |
With sodium periodate; water In 1,2-dichloro-ethane at 20℃; for 1h; | 70.9% |
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide In acetonitrile at 82℃; for 6h; Inert atmosphere; | |
With tert.-butylhydroperoxide In acetonitrile at 29.84℃; for 36h; Reagent/catalyst; | A n/a B 5.6 %Chromat. |
With Ca0.3Co0.7Fe2O4; dihydrogen peroxide In N,N-dimethyl-formamide at 60℃; for 10h; Schlenk technique; |
Conditions | Yield |
---|---|
With hydrogenchloride | |
Multi-step reaction with 2 steps 1: TsOH / Heating 2: (hydrolysis) View Scheme | |
Multi-step reaction with 2 steps 1: TsOH / Heating 2: (hydrolysis) View Scheme | |
With acetic acid In methanol; water | |
With acetic acid In methanol; water |
Conditions | Yield |
---|---|
With sodium hydroxide; sodium ruthenate(VI); potassium hexacyanoferrate(III) at 30℃; Equilibrium constant; Kinetics; Further Variations:; concentration dependence; | |
With Pd-Ce nanoparticles supported on functional Fe-MIL-101-NH2 In water; acetonitrile at 60℃; under 1034.32 Torr; | |
at 20℃; |
Conditions | Yield |
---|---|
With periodic acid In tetrachloromethane; water; acetonitrile at 25℃; for 1h; |
Conditions | Yield |
---|---|
With cis-[Ru(1,4,7-trimethyl-1,4,7-triazacyclononane)O2(trifluoroacetate)]ClO4 In acetonitrile at 20℃; for 14h; | A 10% B 73% |
Conditions | Yield |
---|---|
With C11H10N2O2Pd(1+)*ClO4(1-); water In [D3]acetonitrile at 50℃; for 2h; | 95 %Spectr. |
Conditions | Yield |
---|---|
With 1-(3-sulfopropyl)-2-methyl-3-isopropylimidazolium periodate In water at 35℃; for 12h; | 99 %Chromat. |
cyclopentene
A
cyclopent-2-enone
B
Glutaraldehyde
C
cyclopentanone
Conditions | Yield |
---|---|
With Ca0.3Co0.7Fe2O4; dihydrogen peroxide In N,N-dimethyl-formamide at 90℃; for 8h; Temperature; Schlenk technique; |
Conditions | Yield |
---|---|
With [bis(acetoxy)iodo]benzene In dichloromethane at 25℃; for 0.25h; Inert atmosphere; | 92% |
With C21H12Cl6NO4V In toluene at 100℃; under 760.051 Torr; Reagent/catalyst; chemoselective reaction; | 70% |
With N-Bromosuccinimide; water; potassium carbonate; triphenylbismuthane In acetonitrile for 2h; | 63% |
Conditions | Yield |
---|---|
With oxygen; [(n-Bu)4N]3H2[IMo6O24] In acetonitrile at 80℃; under 1520.1 Torr; for 15h; | A 17 % Chromat. B 83 % Chromat. |
Conditions | Yield |
---|---|
With 3-carboxypyridinium dichromate In acetonitrile at 20℃; for 0.0833333h; | 97% |
With zinc dichromate trihydrate at 20℃; grinding; neat (no solvent); chemoselective reaction; | 90% |
With oxygen; potassium iodide; sodium nitrite In water; acetonitrile for 12h; Reflux; | 70% |
Glutaraldehyde
Conditions | Yield |
---|---|
With diisobutylaluminium hydride In dichloromethane at -10 - 20℃; for 0.5h; | 72% |
Conditions | Yield |
---|---|
With C21H12Cl6NO4V In toluene at 100℃; under 760.051 Torr; Reagent/catalyst; chemoselective reaction; | 72% |
With sodium periodate In water; ethyl acetate; acetonitrile at 0℃; for 2h; | 43% |
With cobalt(III) acetate In acetic acid at 50℃; Rate constant; Mechanism; | |
With cobalt(III) acetate In acetic acid at 25℃; Kinetics; Thermodynamic data; Mechanism; var. temp.; ΔH(excit.), ΔS(excit.), ΔG(excit.); |
Conditions | Yield |
---|---|
With cation exchange resin In benzene at 70℃; for 3.5h; | 80% |
piperidine
3-nitro-benzaldehyde
diethyl oxaloacetate
Glutaraldehyde
Conditions | Yield |
---|---|
With acetic acid In ethanol |
2-methoxy-3,4-dihydro-2H-pyran
methanol
A
cis- and trans-2,6-Dimethoxytetrahydropyran
B
Glutaraldehyde
Conditions | Yield |
---|---|
With water at 41℃; |
isopropyl alcohol
cyclopentene
A
cyclopentane-1,2-diol
B
2-Isopropoxy-cyclopentanol
C
Glutaraldehyde
Conditions | Yield |
---|---|
With dihydrogen peroxide; tungsten(VI) oxide at 35℃; for 20h; | A 16.2% B 10.2% C 68.4% |
Glutaraldehyde
Conditions | Yield |
---|---|
With Lindlar's catalyst; ethyl acetate Hydrogenation; | |
With titanium(III) chloride; sodium acetate; acetic acid at 40℃; Reagens 4: Wasser; | |
With water |
2-methoxy-3,4-dihydro-2H-pyran
methanol
A
1,1,5,5-tetramethoxy-pentane
B
5,5-dimethoxypentanal
C
Glutaraldehyde
Conditions | Yield |
---|---|
With water at 90 - 93℃; |
6,7-dioxa-bicyclo[3.2.2]nonane
A
ethene
B
cis-1,4-dihydrocycloheptane
C
cycloheptane-1,4-dione
D
Glutaraldehyde
Conditions | Yield |
---|---|
With cobalt(II) 5,10,15,20-tetraphenylporphyrin In chloroform at 60℃; for 13h; | A 4% B 60% C 8% D 4% |
Conditions | Yield |
---|---|
With oxygen; (t-Bu)4; Cl(ON)Ru(salen) substituted with Me4 In diethyl ether at 20℃; Irradiation; | A 95 % Spectr. B 5 % Spectr. |
diazomethane
cyclopentene
A
methyl 4-formylbutanoate
B
Dimethyl glutarate
C
Glutaraldehyde
Conditions | Yield |
---|---|
Stage #1: cyclopentene With ozone In dichloromethane at -78℃; Stage #2: With Merrifield resin-bound piperidine In dichloromethane at 20℃; for 24h; Stage #3: diazomethane In dichloromethane; ethyl acetate | A 59% B 14% C 23% |
Conditions | Yield |
---|---|
With cation-exchange resin KU-2 and KU-2-8 In water at 20 - 30℃; for 2.5h; | 40% |
cis-1,2-cyclopentanediol
A
2-Methylsulfanylmethoxy-cyclopentanol
B
Glutaraldehyde
Conditions | Yield |
---|---|
With dimethyl sulfoxide; molybdenum peroxide In toluene Heating; | A 35% B 10% |
ethanol
cyclopentene
A
cyclopentane-1,2-diol
B
2-Ethoxycyclopentanol
C
Glutaraldehyde
Conditions | Yield |
---|---|
With dihydrogen peroxide; tungsten(VI) oxide at 35℃; for 20h; | A 18.7% B 34.6% C 47.4% |
cyclopentene
tert-butyl alcohol
trans-cyclopentane-1,2-diol
B
Glutaraldehyde
Conditions | Yield |
---|---|
With dihydrogen peroxide; tungsten(VI) oxide; silica gel In tert-butyl alcohol at 34.85℃; for 24h; Product distribution; Further Variations:; Catalysts; Solvents; | A n/a B 60% C n/a |
Conditions | Yield |
---|---|
With hydrogenchloride at 80℃; for 1.5h; |
4-amino-1-tert-butoxycarbonyl-5-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-1H-indazole
Glutaraldehyde
1-tert-butoxycarbonyl-5-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-4-(piperidin-1-yl)-1H-indazole
Conditions | Yield |
---|---|
With hydrogen; 5%-palladium/activated carbon In ethanol; water at 20℃; for 7h; | 89% |
With hydrogen; 5%-palladium/activated carbon In ethanol; water at 20℃; for 7h; | 89% |
With hydrogen; 5% palladium over charcoal In ethanol; water at 20℃; for 7h; | 89% |
Reported in EPA TSCA Inventory.
OSHA PEL: CL 0.2 ppm
ACGIH TLV: CL 0.05 ppm (skin, sensitizer); Not Classifiable as a Human Carcinogen
DFG MAK: 0.1 ppm (0.42 mg/m3)
For occupational chemical analysis use OSHA: #ID-64 or NIOSH: Glutaraldehyde 2531.
The Glutaraldehyde, with the CAS registry number 111-30-8,is also known as Glutaraldehyde. It belongs to the product categories of Pharmaceutical Intermediates;INORGANIC & ORGANIC CHEMICALS. This chemical's molecular formula is C5H8O2 and molecular weight is 100.12.Its EINECS number is 203-856-5. What's more,Its systematic name is Glutaraldehyde. It is a clear solution which is one of the protein cross-linking reagents that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative. It is used to disinfect medical and dental equipment. It is also used for industrial water treatment and as a chemical preservative. Besides, it is also used in biological electron microscopy as a fixative and used in SDS-PAGE to fix proteins and peptides prior to staining.
Physical properties about Glutaraldehyde are:
(1)ACD/LogP: -0.264; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.26; (4)ACD/LogD (pH 7.4): -0.26; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 17.11; (8)ACD/KOC (pH 7.4): 17.11; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Index of Refraction: 1.399; (13)Molar Refractivity: 25.587 cm3; (14)Molar Volume: 105.706 cm3; (15)Surface Tension: 30.7089996337891 dyne/cm; (16)Density: 0.947 g/cm3; (17)Flash Point: 65.956 °C; (18)Enthalpy of Vaporization: 42.52 kJ/mol; (19)Boiling Point: 188.987 °C at 760 mmHg; (20)Vapour Pressure: 0.583000004291534 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES:O=CCCCC=O;
(2)Std. InChI:InChI=1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2;
(3)Std. InChIKey:SXRSQZLOMIGNAQ-UHFFFAOYSA-N.
Safety Information of Glutaraldehyde:
The Glutaraldehyde is Irritating to eyes, respiratory system and skin and toxic by inhalation and if swallowed . It may cause sensitization by inhalation and skin contact.And it is harmful by inhalation and if swallowed .Also it is very toxic to aquatic organisms,so it should be avoided release to the environment. Refer to special instructions / safety data sheets.In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) .When you use it ,wear suitable protective clothing, gloves and eye/face protection ans do not breathe vapour.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
The toxicity data of Glutaraldehyde are as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
duck | LD50 | oral | 820mg/kg (820mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) | National Technical Information Service. Vol. OTS0526410-1, |
guinea pig | LD50 | oral | 50mg/kg (50mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(3), Pg. 77, 1987. |
mouse | LD50 | intraperitoneal | 13900ug/kg (13.9mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979. | |
mouse | LD50 | intravenous | 15400ug/kg (15.4mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 503, 1980. | |
mouse | LD50 | oral | 100mg/kg (100mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 503, 1980. | |
mouse | LD50 | skin | > 5840mg/kg (5840mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 11, 1976. |
mouse | LD50 | subcutaneous | > 590mg/kg (590mg/kg) | Drugs in Japan Vol. -, Pg. 395, 1995. | |
rabbit | LD50 | skin | 560uL/kg (0.56mL/kg) | Union Carbide Data Sheet. Vol. 11/4/1971, | |
rat | LC50 | inhalation | 480mg/m3/4H (480mg/m3) | United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-1290-1008, | |
rat | LD50 | intraperitoneal | 17900ug/kg (17.9mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979. | |
rat | LD50 | intravenous | 9800ug/kg (9.8mg/kg) | United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-1290-1008, | |
rat | LD50 | oral | 134mg/kg (134mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 503, 1980. | |
rat | LD50 | skin | > 2500mg/kg (2500mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 11, 1976. |
rat | LD50 | subcutaneous | > 750mg/kg (750mg/kg) | Drugs in Japan Vol. -, Pg. 395, 1995. |
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