The following Bortezomib  MSDS detailed information are provided by Hangzhou Holypharm biotech Co.,Ltd., a professional supplier of active pharmaceutical ingredients and intermediates.

1. Identification of substance:

Trade name: Bortezomib (Velcade)
Product Number: S1013
Form: Solid
Bortezomib Solubility: Solubility: Soluble in Chloroform, Dimethyl Sulfoxide, Ethanol and Methanol
Melting Point: 124-140 ºC
Manufacturer/Supplier: Selleck Chemicals

2. Composition/data on components:

Chemical Name: Bortezomib (Velcade)
Synonyms: MG-341, PS-341
Hazardous Ingredient: Bortezomib (Velcade)
CAS NO : 179324-69-7
Bortezomib Molecular Weight: 384.24
Molecular Formula: C₁₉H₂₅BN₄O₄

3. Hazards identification:

Hazard Description:
Toxic. Contains a pharmaceutically active ingredient.
Handling should only be performed by personnel trained and familiar
with handling of potent active pharmaceutical ingredients
Moderate to severe irritant to the skin and eyes

4. First aid measures:

After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

5. Fire fighting measures:

Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: emits toxic fumes such as carbon monoxide, etc.

6. Accidental release measures:

Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting:absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13.

7. Handling and storage:

Information for safe handling: avoid inhalation and contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20°C.

Exposure controls and personal protection:
Personal protective equipment as follows:
1) Breathing equipment: NIOSH/MSHA-approved respirator
2) Protection of hands: chemical-resistant rubber gloves
3) Eye protection: chemical safety goggles

Physical and chemical properties:
Solubility in / Miscibility with water: <1
Solvent content:none
Stability and reactivity:
Stability:stable if stored as directed; avoid strong oxidizing agents
Thermal decomposition / conditions to be avoided:protect from light and heat
Dangerous products of decomposition:thermal ecomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides.

Toxicological information:
RTECS#:
1) Acute toxicity: none known
2) Primary irritant effect:not known
3) On the skin:none known
4) On the eye:not known; may be an irritant

Ecological information:
General notes: no data available
Disposal consideration:
Dispose of in accordance with prevailing country, federal, state and local regulations

14. Transport information:
DOT:
1) Proper shipping name: none
2) Non-Hazardous for transport:this substance is considered to be non-hazardous for transport
IATA class:
1) Proper shipping name: none
2) Non-Hazardous for transport:this substance is considered to be non-hazardous for transport

15. Regulations:

Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:
1) S24/25: Avoid contact with skin and eyes
2)S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
3) S28: After contact with skin, wash immediately with plenty of water
4) S36/37/39: Wear protective clothing, gloves and eye/face protection
5) R28: Very toxic if swallowed
6) R38: Irritating to skin
7) R41: Risk of serious damages to eyes
8) R48: Toxic; danger of serious damage to health by prolonged exposure
9) R62: Possible risk of impaired fertility
10) R63: Possible risk of harm to unborn child

16. Other information:

The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. SELLECK CHEMICALS disclaims all liability for any damage resulting from use of this material.